TDR Targets

Basic information

Technical information

TDR Targets ID: 1343422
Name: ethyl 1-[(E)-(1-ethyl-4,6-dioxo-2-sulfanylide ne-1,3-diazinan-5-ylidene)methyl]piperidine-4 -carboxylate
MW: 339.41 | Formula: C15H21N3O4S
H donors: 1 H acceptors: 3 LogP: 1.1 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CCN(CC1)/C=C/1\C(=O)NC(=S)N(C1=O)CC
InChi: 1S/C15H21N3O4S/c1-3-18-13(20)11(12(19)16-15(18)23)9-17-7-5-10(6-8-17)14(21)22-4-2/h9-10H,3-8H2,1-2H3,(H,16,19,23)/b11-9+
InChiKey: PQFFTNWUDRLYRF-PKNBQFBNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-[(E)-(1-ethyl-4,6-dioxo-2-thioxo-hexahydropyrimidin-5-ylidene)methyl]piperidine-4-carboxylate
1-[(E)-(1-ethyl-4,6-dioxo-2-thioxo-5-hexahydropyrimidinylidene)methyl]-4-piperidinecarboxylic acid ethyl ester
1-[(E)-(1-ethyl-4,6-diketo-2-thioxo-hexahydropyrimidin-5-ylidene)methyl]isonipecotic acid ethyl ester
SMR000292319
ethyl 1-[(1-ethyl-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-4-piperidinecarboxylate
ZINC00465976
MLS000663807

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	flap structure-specific endonuclease 1	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus granulosus	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Plasmodium yoelii	flap endonuclease-1-related	Get druggable targets OG5_127472	All targets in OG5_127472
Giardia lamblia	Flap structure-specific endonuclease	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium berghei	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium knowlesi	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Entamoeba histolytica	Flap nuclease, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Cryptosporidium hominis	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania infantum	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Brugia malayi	Flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Leishmania major	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	ko:K04799 flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma mansoni	flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Plasmodium vivax	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Plasmodium falciparum	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Cryptosporidium parvum	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania braziliensis	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma congolense	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Trichomonas vaginalis	flap endonuclease-1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Leishmania donovani	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Theileria parva	flap endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Leishmania mexicana	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Trypanosoma brucei gambiense	flap endonuclease-1 (FEN-1), putative	Get druggable targets OG5_127472	All targets in OG5_127472
Loa Loa (eye worm)	flap endonuclease-1	Get druggable targets OG5_127472	All targets in OG5_127472
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	Get druggable targets OG5_127472	All targets in OG5_127472
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	flap endonuclease 1	Get druggable targets OG5_127472	All targets in OG5_127472
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Babesia bovis	XPG N-terminal domain and XPG I-region domain containing protein	Get druggable targets OG5_127472	All targets in OG5_127472

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	exonuclease, putative	flap structure-specific endonuclease 1	380 aa	322 aa	24.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0011	0.0041	0.1257
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0011	0.0041	0.1257
Leishmania major	proteasome beta-1 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0011	0.0041	0.1858
Giardia lamblia	20S proteasome alpha subunit 5	0.0011	0.0041	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0011	0.0041	0.0124
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0011	0.0041	0.0785
Entamoeba histolytica	hypothetical protein	0.0043	0.0234	1
Leishmania major	proteasome beta 5 subunit, putative	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome subunit beta t family	0.0011	0.0041	0.0096
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0011	0.0041	0.1257
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0011	0.0041	0.1858
Mycobacterium ulcerans	proteasome PrcA	0.1678	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0367	1
Plasmodium falciparum	proteasome subunit beta type-5	0.0011	0.0041	0.1858
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0011	0.0041	0.1257
Entamoeba histolytica	hypothetical protein	0.0043	0.0234	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Echinococcus granulosus	flap endonuclease 1	0.0031	0.0163	0.0514
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0011	0.0041	0.0096
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0011	0.0041	0.0785
Schistosoma mansoni	cpg binding protein	0.0037	0.0194	0.0648
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0011	0.0041	0.1858
Brugia malayi	proteasome subunit alpha type 3	0.0011	0.0041	0.0144
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0011	0.0041	0.1858
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0011	0.0041	0.0785
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	flap endonuclease-1, putative	0.0006	0.0013	0.0067
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0011	0.0041	0.0096
Loa Loa (eye worm)	glutaminase 2	0.033	0.1947	1
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0011	0.0041	0.1858
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Giardia lamblia	20S proteasome alpha subunit 3	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0011	0.0041	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Trichomonas vaginalis	helicase, putative	0.0008	0.0022	0.0112
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0011	0.0041	0.0124
Toxoplasma gondii	heat shock protein hslv, putative	0.0011	0.0041	0.0785
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0011	0.0041	0.0124
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	flap endonuclease-1	0.0028	0.0145	0.048
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0011	0.0041	0.0096
Mycobacterium ulcerans	glutaminase	0.033	0.1947	0.1914
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0039	0.0089
Brugia malayi	proteasome subunit alpha type 2	0.0011	0.0041	0.0144
Brugia malayi	Proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0011	0.0041	0.1257
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0026	0.0074
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0011	0.0041	0.0124
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0011	0.0041	0.0096
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0011	0.0041	0.1257
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Giardia lamblia	Proteasome subunit beta type 3	0.0011	0.0041	0.1858
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome subunit beta type 6	0.0011	0.0041	0.0096
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0011	0.0041	0.0144
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0011	0.0041	0.0124
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Brugia malayi	proteasome subunit beta type 1	0.0011	0.0041	0.0144
Brugia malayi	Proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	flap endonuclease-1, putative	0.0031	0.0163	0.0836
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0011	0.0041	0.1858
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0011	0.0041	0.1858
Loa Loa (eye worm)	PAS-3 protein	0.0011	0.0041	0.0144
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0011	0.0041	0.0785
Echinococcus granulosus	cpg binding protein	0.0037	0.0194	0.0621
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0011	0.0041	0.0124
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0011	0.0041	0.0096
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome subunit alpha type 2	0.0011	0.0041	0.0096
Giardia lamblia	20S proteasome alpha subunit 1	0.0011	0.0041	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Brugia malayi	Proteasome subunit alpha type 1	0.0011	0.0041	0.0144
Entamoeba histolytica	hypothetical protein	0.0043	0.0234	1
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Plasmodium falciparum	flap endonuclease 1	0.0031	0.0163	1
Leishmania major	proteasome alpha 3 subunit, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0011	0.0041	0.0124
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0011	0.0041	0.0096
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0039	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Trypanosoma brucei	proteasome beta 6 subunit	0.0011	0.0041	0.1858
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.2926	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0234	0.076
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0414	0.1403
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0031	0.0163	1
Leishmania major	proteasome alpha 1 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0011	0.0041	0.1858
Giardia lamblia	Proteasome subunit beta type 1	0.0011	0.0041	0.1858
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0011	0.0041	0.1257
Brugia malayi	proteasome subunit alpha type 6	0.0011	0.0041	0.0144
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0011	0.0041	0.1858
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0011	0.0041	0.0144
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0011	0.0041	0.1858
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0011	0.0041	0.0785
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0011	0.0041	0.1858
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0011	0.0041	0.1257
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0011	0.0041	0.1257
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0011	0.0041	0.0096
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Toxoplasma gondii	proteasome beta subunit	0.0011	0.0041	0.0785
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0026	0.0046
Trichomonas vaginalis	exonuclease%2C+putative	0.0006	0.0013	0.0067
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0011	0.0041	0.0096
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0011	0.0041	0.0096
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0011	0.0041	0.0144
Echinococcus granulosus	proteasome prosome macropain	0.0011	0.0041	0.0096
Toxoplasma gondii	peptidase, T1 family protein	0.0011	0.0041	0.0785
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0011	0.0041	0.0785
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0031	0.0163	0.4224
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0011	0.0041	0.0785
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0011	0.0041	0.1858
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0031	0.0163	1
Brugia malayi	proteasome subunit beta type 2	0.0011	0.0041	0.0144
Schistosoma mansoni	exonuclease	0.0006	0.0013	0.0029
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0011	0.0041	0.0144
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0234	0.0787
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0011	0.0041	0.0144
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0011	0.0041	0.0144
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0011	0.0041	0.0096
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0011	0.0041	0.1858
Leishmania major	proteasome alpha 1 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0234	0.076
Brugia malayi	glutaminase DH11.1	0.033	0.1947	1
Brugia malayi	proteasome subunit beta type 3	0.0011	0.0041	0.0144
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0011	0.0041	0.0096
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0011	0.0041	0.0096
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0011	0.0041	0.1858
Leishmania major	proteasome beta 7 subunit, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0026	0.0046
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0011	0.0041	0.1858
Leishmania major	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0011	0.0041	0.0124
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0011	0.0041	0.0124
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0011	0.0041	0.0096
Trichomonas vaginalis	glutaminase, putative	0.033	0.1947	1
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0011	0.0041	0.0096
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0011	0.0041	0.1858
Brugia malayi	proteasome subunit alpha type 1	0.0011	0.0041	0.0144
Echinococcus multilocularis	cpg binding protein	0.0037	0.0194	0.0621
Leishmania major	proteasome beta 2 subunit, putative	0.0011	0.0041	0.1858
Brugia malayi	proteasome subunit alpha type 4	0.0011	0.0041	0.0144
Echinococcus granulosus	Proteasome subunit alpha beta	0.0011	0.0041	0.0096
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0011	0.0041	0.1858
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0011	0.0041	0.0096
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0038	0.013
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0011	0.0041	0.0096
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0011	0.0041	0.1858
Schistosoma mansoni	cpg binding protein	0.0035	0.0182	0.0608
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0011	0.0041	0.0096
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0011	0.0041	0.5
Loa Loa (eye worm)	flap endonuclease-1	0.0031	0.0163	0.0774
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0011	0.0041	0.1257
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	proteasome subunit beta type 6	0.0011	0.0041	0.0096
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	hypothetical protein	0.0494	0.2926	1
Toxoplasma gondii	proteasome subunit beta type, putative	0.0011	0.0041	0.0785
Echinococcus granulosus	proteasome subunit beta type 7	0.0011	0.0041	0.0096
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family	0.0006	0.0013	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0011	0.0041	0.0124
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0031	0.0163	1
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0011	0.0041	0.0124
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0011	0.0041	0.0124
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0011	0.0041	0.1858
Echinococcus multilocularis	flap endonuclease 1	0.0031	0.0163	0.0514
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0011	0.0041	0.1858
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0011	0.0041	0.1858
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0011	0.0041	0.1257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0011	0.0041	0.0096
Giardia lamblia	20S proteasome alpha subunit 2	0.0011	0.0041	0.1858
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0011	0.0041	0.0124
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0011	0.0041	0.1858
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0011	0.0041	0.1257
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Leishmania major	proteasome alpha 2 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0011	0.0041	0.1858
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0011	0.0041	0.1858
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0039	0.0134
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Echinococcus granulosus	proteasome subunit alpha type 6	0.0011	0.0041	0.0096
Giardia lamblia	Proteasome subunit beta type 2	0.0011	0.0041	0.1858
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Brugia malayi	20S proteasome alpha5 subunit	0.0011	0.0041	0.0144
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0011	0.0041	0.0124
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0182	0.0874
Schistosoma mansoni	glutaminase	0.033	0.1947	0.665
Leishmania major	proteasome alpha 7 subunit, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	cpg binding protein	0.0037	0.0194	0.0648
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0011	0.0041	0.0785
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0011	0.0041	0.1858
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0011	0.0041	0.1858
Loa Loa (eye worm)	glutaminase	0.033	0.1947	1
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0011	0.0041	0.1858
Giardia lamblia	20S proteasome alpha subunit 4	0.0011	0.0041	0.1858
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0011	0.0041	0.0096
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0011	0.0041	0.1858
Entamoeba histolytica	hypothetical protein	0.0043	0.0234	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0006	0.0013	0.0067
Trypanosoma brucei	proteasome beta 7 subunit	0.0011	0.0041	0.1858
Schistosoma mansoni	xp-G/rad2 DNA repair endonuclease family member	0.0006	0.0013	0.0029
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0011	0.0041	0.1858
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0046
Leishmania major	proteasome beta 3 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0011	0.0041	0.1858
Leishmania major	proteasome beta 2 subunit, putative	0.0011	0.0041	0.1858
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0011	0.0041	0.1257
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0011	0.0041	0.1858
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.2926	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0011	0.0041	0.1257
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0011	0.0041	0.1858
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0011	0.0041	0.0124
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0011	0.0041	0.0096
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0011	0.0041	0.1858
Giardia lamblia	Flap structure-specific endonuclease	0.0031	0.0163	1
Giardia lamblia	20S proteasome alpha subunit 7	0.0011	0.0041	0.1858
Plasmodium vivax	flap endonuclease 1, putative	0.0031	0.0163	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Trypanosoma brucei	proteasome alpha 7 subunit	0.0011	0.0041	0.1858
Toxoplasma gondii	proteasome subunit	0.0011	0.0041	0.0785
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0182	0.0874
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0022	0.0112
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0011	0.0041	0.1257
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Trypanosoma cruzi	20S proteasome subunit	0.0011	0.0041	0.1858
Brugia malayi	Proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0011	0.0041	0.0096
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0011	0.0041	0.1257
Echinococcus multilocularis	proteasome subunit beta type 7	0.0011	0.0041	0.0096
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0022	0.0112
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0011	0.0041	0.1257
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0011	0.0041	0.0124
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0011	0.0041	0.1257
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0011	0.0041	0.1858
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0011	0.0041	0.1858
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0011	0.0041	0.1858
Onchocerca volvulus		0.0035	0.0182	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0006	0.0013	0.0067
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0011	0.0041	0.1858
Brugia malayi	Proteasome subunit alpha type 7-1	0.0011	0.0041	0.0144
Brugia malayi	Flap endonuclease-1	0.0031	0.0163	0.0774
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0011	0.0041	0.1858
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0011	0.0041	0.0144
Giardia lamblia	20S proteasome alpha subunit 6	0.0011	0.0041	0.1858
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0022	0.0112
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0011	0.0041	0.0124
Trichomonas vaginalis	flap endonuclease-1, putative	0.0006	0.0013	0.0067
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0011	0.0041	0.021
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0011	0.0041	0.1858
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0026	0.0046
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0011	0.0041	0.1257
Schistosoma mansoni	hypothetical protein	0.0043	0.0234	0.0787
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0011	0.0041	0.0124
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0011	0.0041	0.1858
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.1678	1	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0011	0.0041	0.0124
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0011	0.0041	0.0144
Plasmodium falciparum	proteasome subunit beta type-4	0.0011	0.0041	0.1858
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0022	0.0112
Brugia malayi	hypothetical protein	0.0043	0.0234	0.1145
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0011	0.0041	0.1858
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0011	0.0041	0.021
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0011	0.0041	0.0144
Entamoeba histolytica	Flap nuclease, putative	0.0031	0.0163	0.6762
Brugia malayi	Proteasome A-type and B-type family protein	0.0011	0.0041	0.0144
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0011	0.0041	0.0785
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0011	0.0041	0.1858

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]	ChEMBL.	No reference
Potency (functional)	5.8048 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 79.4328 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1483016

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1343422