Detailed information for compound 1343461

Basic information

Technical information
  • TDR Targets ID: 1343461
  • Name: tert-butyl 4-[2-tert-butyl-4-[4-(2-methoxyphe nyl)piperazine-1-carbonyl]pyrazol-3-yl]piperi dine-1-carboxylate
  • MW: 525.683 | Formula: C29H43N5O4
  • H donors: 0 H acceptors: 3 LogP: 3.61 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1N1CCN(CC1)C(=O)c1cnn(c1C1CCN(CC1)C(=O)OC(C)(C)C)C(C)(C)C
  • InChi: 1S/C29H43N5O4/c1-28(2,3)34-25(21-12-14-33(15-13-21)27(36)38-29(4,5)6)22(20-30-34)26(35)32-18-16-31(17-19-32)23-10-8-9-11-24(23)37-7/h8-11,20-21H,12-19H2,1-7H3
  • InChiKey: CZWHXFILEMITTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-tert-butyl-4-[[4-(2-methoxyphenyl)-1-piperazinyl]-oxomethyl]-3-pyrazolyl]-1-piperidinecarboxylic acid tert-butyl ester
  • 4-[2-tert-butyl-4-[4-(2-methoxyphenyl)piperazine-1-carbonyl]pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester
  • tert-butyl 4-[2-tert-butyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]carbonyl-pyrazol-3-yl]piperidine-1-carboxylate
  • E951-0368
  • NCGC00126764-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.002 0.0028 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.009 0.0542
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0028 0.5311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Loa Loa (eye worm) hypothetical protein 0.006 0.0133 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0043
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0028 0.0038
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0267 0.3173
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0327 0.0451
Loa Loa (eye worm) hypothetical protein 0.2725 0.7245 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.001 0.0014
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0028 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.009 0.0844
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.2725 0.7245 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0031 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0135 0.0473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.001 0.0099
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0267 0.3173
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0158 0.0396 0.0366
Brugia malayi cathepsin L-like precursor 0.0014 0.001 0.0014
Echinococcus granulosus cathepsin l1 0.0014 0.001 0.0093
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0031 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0028 0.0038
Onchocerca volvulus 0.002 0.0028 0.0545
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0031 0.035
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0031 0.0104
Leishmania major DNA polymerase kappa, putative 0.0021 0.0031 0.0011
Trypanosoma cruzi DNA repair protein, putative 0.0037 0.0072 0.0249
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0051 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0051 0.0082
Loa Loa (eye worm) ctsf protein 0.002 0.0028 0.0038
Mycobacterium ulcerans beta-lactamase 0.0043 0.009 0.0542
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0428 0.1117 0.3156
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0028 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0041
Brugia malayi HSF-type DNA-binding domain containing protein 0.011 0.0267 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0031 0.0276
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0041
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3449 0.9176 0.9173
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0133 0.1191
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0013
Onchocerca volvulus 0.0043 0.009 0.1767
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.001 0.0099
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0158 0.0396 0.3363
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0013
Mycobacterium tuberculosis Conserved protein 0.0043 0.009 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Echinococcus granulosus flap endonuclease 1 0.0029 0.0051 0.0478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0051 0.0589
Leishmania major cathepsin L-like protease 0.0077 0.0179 0.0541
Onchocerca volvulus 0.002 0.0028 0.0545
Mycobacterium ulcerans hypothetical protein 0.0043 0.009 0.0542
Leishmania major cathepsin L-like protease 0.0077 0.0179 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0031 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0051 0.0478
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.0267 0.3173
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0031 0.0276
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0051 0.0174
Onchocerca volvulus 0.002 0.0028 0.0545
Echinococcus granulosus dna polymerase eta 0.0021 0.0031 0.029
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Echinococcus multilocularis cathepsin L 0.001 0.0002 0.0014
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0028 0.026
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.012 0.0293 0.0624
Plasmodium vivax hypothetical protein, conserved 0.0043 0.009 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Loa Loa (eye worm) fibroinase 0.002 0.0028 0.0038
Brugia malayi beta-lactamase 0.0043 0.009 0.0124
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0051 0.007
Onchocerca volvulus 0.0014 0.001 0.0194
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0031 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.001 0.0099
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.009 0.0059
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0028 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0031 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.009 0.0059
Brugia malayi N-terminal motif family protein 0.02 0.0508 0.0701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Onchocerca volvulus 0.002 0.0028 0.0545
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Onchocerca volvulus 0.002 0.0028 0.0545
Plasmodium falciparum flap endonuclease 1 0.0029 0.0051 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.009 0.0124
Mycobacterium ulcerans recombinase A 0.012 0.0293 0.2413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Plasmodium vivax vivapain-2 0.002 0.0028 0.2965
Echinococcus multilocularis tumor protein p63 0.0408 0.1062 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0158 0.0396 0.0941
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0002 0.0014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.001 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0002 0.0002
Brugia malayi Flap endonuclease-1 0.0029 0.0051 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0179 0.0628
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.009 0.0124
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0051 0.5657
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0031 0.029
Mycobacterium ulcerans lipase LipD 0.0043 0.009 0.0542
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.009 0.0312
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.009 0.0059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0028 0.026
Schistosoma mansoni DNA polymerase eta 0.0021 0.0031 0.0276
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0002 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0031 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Leishmania major hypothetical protein, conserved 0.0043 0.009 0.0221
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.009 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.009 0.1054
Brugia malayi putative malonyl-CoA decarboxylase 0.2725 0.7245 1
Toxoplasma gondii ABC1 family protein 0.0043 0.009 1
Onchocerca volvulus 0.0043 0.009 0.1767
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0179 0.0628
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1071 0.2831 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.001 0.0014
Echinococcus multilocularis dna polymerase eta 0.0021 0.0031 0.029
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.009 0.0124
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0028 0.5311
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0051 0.5583
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0428 0.1117 0.1185
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.009 0.1054
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.009 0.0059
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0031 0.029
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0327 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Mycobacterium tuberculosis Conserved protein 0.0043 0.009 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.0508 1
Treponema pallidum replicative DNA helicase (dnaB) 0.0428 0.1117 1
Trichomonas vaginalis esterase, putative 0.0043 0.009 0.1054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Plasmodium vivax vivapain-2 0.002 0.0028 0.2965
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.02 0.0508 0.0701
Entamoeba histolytica cysteine protease, putative 0.002 0.0028 0.0313
Echinococcus granulosus dna polymerase kappa 0.0021 0.0031 0.029
Mycobacterium leprae Conserved hypothetical protein 0.1263 0.3345 1
Onchocerca volvulus 0.0043 0.009 0.1767
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Leishmania major DNA polymerase eta, putative 0.0021 0.0031 0.0011
Mycobacterium tuberculosis Conserved protein 0.0043 0.009 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0179 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.0838 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0028 0.026
Brugia malayi beta-lactamase family protein 0.0043 0.009 0.0124
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1071 0.2831 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Leishmania major malonyl-coa decarboxylase-like protein 0.1071 0.2831 1
Trypanosoma brucei unspecified product 0.0021 0.0031 0.0104
Onchocerca volvulus Cathepsin L homolog 0.002 0.0028 0.0545
Echinococcus granulosus cysteine protease 0.001 0.0002 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Echinococcus multilocularis cysteine protease 0.002 0.0028 0.026
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0179 0.0628
Brugia malayi beta-lactamase family protein 0.0043 0.009 0.0124
Onchocerca volvulus 0.002 0.0028 0.0545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0031 0.0011
Loa Loa (eye worm) hypothetical protein 0.011 0.0267 0.0369
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0028 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.001 0.0088
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Onchocerca volvulus 0.002 0.0028 0.0545
Onchocerca volvulus Heat shock factor protein 2 homolog 0.011 0.0267 0.5259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0715 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.009 0.1054
Loa Loa (eye worm) cysteine protease 0.002 0.0028 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0028 0.5311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi MH2 domain containing protein 0.0132 0.0327 0.0451
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0028 0.026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0028 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0028 0.0313
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0161 0.0565
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0031 0.035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0028 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.009 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0037 0.0072 0.0249
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0051 0.0247
Giardia lamblia Fructose-bisphosphate aldolase 0.0324 0.0838 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0051 0.0589
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Loa Loa (eye worm) twinkle helicase 0.0122 0.03 0.0415
Leishmania major cathepsin L-like protease 0.0077 0.0179 0.0541
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.009 0.0803
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.009 0.1054
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Schistosoma mansoni Replicative DNA helicase 0.0428 0.1117 1
Toxoplasma gondii cathepsin CPL 0.002 0.0028 0.3083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1071 0.2831 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0428 0.1117 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.009 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.009 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0031 0.0104
Trypanosoma cruzi DNA repair protein, putative 0.0037 0.0072 0.0249
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.009 0.1054
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.009 0.0312
Chlamydia trachomatis replicative DNA helicase 0.0428 0.1117 1
Echinococcus multilocularis cysteine protease 0.002 0.0028 0.026
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0031 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0028 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.009 0.0844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0028 0.0313
Brugia malayi Cathepsin L-like precursor 0.002 0.0028 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Echinococcus granulosus cathepsin l1 0.002 0.0028 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0179 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0031 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0028 0.0313
Schistosoma mansoni flap endonuclease-1 0.0026 0.0043 0.0388
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0324 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0014
Echinococcus granulosus cathepsin L 0.001 0.0002 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0324 0.0838 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.009 0.0803
Onchocerca volvulus 0.006 0.0133 0.2621
Treponema pallidum fructose-bisphosphate aldolase 0.0324 0.0838 0.6619
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.009 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0028 0.0313
Echinococcus granulosus tumor protein p63 0.0408 0.1062 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0028 0.0545

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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