Detailed information for compound 1343491

Basic information

Technical information
  • TDR Targets ID: 1343491
  • Name: 4-(cycloheptylamino)-6,7-dimethoxy-1H-quinazo line-2-thione
  • MW: 333.448 | Formula: C17H23N3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)S
  • InChi: 1S/C17H23N3O2S/c1-21-14-9-12-13(10-15(14)22-2)19-17(23)20-16(12)18-11-7-5-3-4-6-8-11/h9-11H,3-8H2,1-2H3,(H2,18,19,20,23)
  • InChiKey: ZSTNWTKQUGGXAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • IDI1_027087
  • ChemDiv3_009177
  • EU-0092826
  • 4-(cycloheptylamino)-6,7-dimethoxyquinazoline-2(1H)-thione
  • MLS000871724
  • SMR000309243

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0019 0.0463 0.2483
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.021 0.0198
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0819 0.0808
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0218 0.0206
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.4422
Schistosoma mansoni coup transcription factor 0.0012 0.0218 0.1171
Echinococcus multilocularis survival motor neuron protein 1 0.0286 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0218 0.1171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0463 0.0451
Schistosoma mansoni DNA helicase recq5 0.0012 0.021 0.1125
Brugia malayi nuclear receptor NHR-88 0.0012 0.0218 0.0206
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0218 0.1171
Brugia malayi steroid hormone receptor 0.0012 0.0218 0.0206
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0218 0.0206
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0336 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0218 0.0206
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.021 0.0198
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0218 0.1171
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0218 0.1171
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0819 1
Echinococcus granulosus GPCR family 2 0.0019 0.0463 0.0451
Schistosoma mansoni hypothetical protein 0.0019 0.0463 0.2483
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0218 0.0206
Schistosoma mansoni DNA helicase recq1 0.0012 0.021 0.1125
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0218 0.1171
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0218 0.0206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0218 0.0206
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0218 0.1171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0012 0.0067
Schistosoma mansoni hypothetical protein 0.0019 0.0463 0.2483
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0218 0.0206
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.021 0.0198
Loa Loa (eye worm) hypothetical protein 0.006 0.1936 0.1926
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0463 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0218 0.0206
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1866 0.1856
Loa Loa (eye worm) hypothetical protein 0.0146 0.5003 0.4997
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0218 0.0206
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0218 0.1171
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0336 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0218 0.0206
Schistosoma mansoni hypothetical protein 0.0019 0.0463 0.2483
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0218 0.1171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0218 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0218 0.0206
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0218 0.0206
Brugia malayi ecdysteroid receptor 0.0012 0.0218 0.0206
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.021 0.0198
Onchocerca volvulus 0.0058 0.1866 1
Loa Loa (eye worm) hypothetical protein 0.0286 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Brugia malayi nuclear hormone receptor 0.0012 0.0218 0.0206
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.021 0.0198
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0218 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0218 0.0206
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0463 0.0451
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0218 0.0206
Loa Loa (eye worm) RecQ helicase 0.0029 0.0819 0.0808
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1254 0.1243
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0336 0.5
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0218 0.0206
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0693 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0218 0.0206
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0218 0.1171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0218 0.1171
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0218 0.1171
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.021 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0463 0.0451
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0218 0.0206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0483 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0475 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0218 0.0206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0218 0.0206
Echinococcus multilocularis GPCR, family 2 0.0019 0.0463 0.0451
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1936 0.1926
Echinococcus granulosus bloom syndrome protein 0.0029 0.0819 0.0808
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0012 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0463 0.0451
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0336 0.5
Schistosoma mansoni survival motor neuron protein 0.0058 0.1866 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0463 0.0451
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0218 0.0206
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0819 0.0808
Loa Loa (eye worm) hypothetical protein 0.0041 0.1254 0.1243
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0218 0.1171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0218 0.0206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.021 0.0198
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0218 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0218 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0218 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1936 0.1926
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.021 0.4422
Schistosoma mansoni hypothetical protein 0.0041 0.1254 0.6722
Echinococcus granulosus survival motor neuron protein 1 0.0286 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0218 0.0206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0463 0.0451
Schistosoma mansoni hypothetical protein 0.0058 0.1866 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0218 0.0206
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0819 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0218 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1936 0.1926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0218 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0463 0.0451
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0601 0.322

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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