Detailed information for compound 1344226

Basic information

Technical information
  • TDR Targets ID: 1344226
  • Name: 4-[[2,4-dioxo-1-(2-oxo-2-pyrrolidin-1-ylethyl )thieno[3,2-d]pyrimidin-3-yl]methyl]-N-propan -2-ylcyclohexane-1-carboxamide
  • MW: 460.59 | Formula: C23H32N4O4S
  • H donors: 1 H acceptors: 4 LogP: 2.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)C1CCC(CC1)Cn1c(=O)c2sccc2n(c1=O)CC(=O)N1CCCC1)C
  • InChi: 1S/C23H32N4O4S/c1-15(2)24-21(29)17-7-5-16(6-8-17)13-27-22(30)20-18(9-12-32-20)26(23(27)31)14-19(28)25-10-3-4-11-25/h9,12,15-17H,3-8,10-11,13-14H2,1-2H3,(H,24,29)
  • InChiKey: GDOBEIAKGMLVAF-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[[2,4-dioxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)thieno[3,2-d]pyrimidin-3-yl]methyl]-N-isopropyl-cyclohexane-1-carboxamide
  • 4-[[2,4-dioxo-1-(2-oxo-2-1-pyrrolidinylethyl)-3-thieno[3,2-d]pyrimidinyl]methyl]-N-isopropyl-1-cyclohexanecarboxamide
  • 4-[[2,4-diketo-1-(2-keto-2-pyrrolidin-1-yl-ethyl)thieno[3,2-d]pyrimidin-3-yl]methyl]-N-isopropyl-cyclohexane-1-carboxamide
  • 4-[[2,4-dioxo-1-(2-oxo-2-pyrrolidin-1-yl-ethyl)thieno[3,2-d]pyrimidin-3-yl]methyl]-N-propan-2-yl-cyclohexane-1-carboxamide
  • G346-0314
  • NCGC00130275-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.2314 1
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.0315 0.134
Trypanosoma brucei unspecified product 0.0019 0.0059 0.0195
Mycobacterium ulcerans lipase LipD 0.0035 0.019 0.0173
Onchocerca volvulus Putative cubilin 0.0016 0.004 0.0123
Loa Loa (eye worm) DR-78 0.0024 0.0099 0.0384
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0444 0.066
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0099 0.0133
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0258 0.1033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0312 0.0459
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0312 0.0459
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0684 0.2973
Loa Loa (eye worm) glutathione reductase 0.0039 0.0222 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0312 0.1327
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0119 0.0474
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.62 0.9462
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0439 0.1887
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0099 0.0384
Trichomonas vaginalis C-MYB, putative 0.002 0.0064 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0312 0.0459
Leishmania major cytochrome p450-like protein 0.002 0.0066 0.0226
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Onchocerca volvulus 0.0049 0.0301 0.1278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0228
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0017 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0035 0.0099
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0161 0.0625
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0312 0.0459
Onchocerca volvulus 0.0035 0.019 0.0789
Echinococcus granulosus heat shock protein 0.0032 0.0161 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0154 0.0628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0684 0.2973
Echinococcus multilocularis heat shock protein 90 0.0025 0.011 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.019 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0312 0.1327
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0684 0.2973
Toxoplasma gondii ABC1 family protein 0.0035 0.019 0.065
Onchocerca volvulus 0.0035 0.019 0.0789
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0444 0.066
Echinococcus multilocularis cpg binding protein 0.0032 0.016 0.0226
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.004 0.0042
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.011 0.0102
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0226 0.0327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0312 0.0459
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.019 0.0775
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0312 0.1327
Onchocerca volvulus 0.0035 0.019 0.0789
Echinococcus granulosus protein jagged 1 0.0016 0.004 0.0042
Onchocerca volvulus 0.0051 0.0312 0.1327
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0059 0.0071
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Echinococcus multilocularis peroxidasin 0.0051 0.0315 0.0462
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0155 0.0598
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0315 0.1338
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0032 0.0161 0.0658
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0155 0.4734
Loa Loa (eye worm) hypothetical protein 0.0119 0.0859 0.3748
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0909 0.7155 1
Leishmania major hypothetical protein, conserved 0.0035 0.019 0.0748
Onchocerca volvulus Peroxidase homolog 0.0051 0.0315 0.1338
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Brugia malayi glutathione reductase 0.0039 0.0222 0.0927
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0099 0.0133
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0357 0.2754 0.2741
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0155 0.0218
Loa Loa (eye worm) hypothetical protein 0.0119 0.0859 0.3748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.1754 0.7708
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0155 0.0218
Brugia malayi Cytochrome P450 family protein 0.003 0.015 0.0608
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0312 0.1327
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1 0.1511
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0154 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0312 0.0459
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0161 0.0647
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0097 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni hypothetical protein 0.0023 0.009 0.0119
Schistosoma mansoni cpg binding protein 0.0032 0.016 0.0226
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0312 0.1327
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0017 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0155 0.0218
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0099 0.0384
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0485
Giardia lamblia Grp94/Hsp90 0.0025 0.011 0.0402
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0312 0.0459
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0222 0.088
Loa Loa (eye worm) hypothetical protein 0.0066 0.0439 0.1887
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0313 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.0048 0.0294 0.1248
Entamoeba histolytica hypothetical protein 0.0043 0.0255 0.1056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0022
Onchocerca volvulus 0.0051 0.0315 0.1338
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0673 0.101
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.2754 0.2741
Mycobacterium tuberculosis Conserved protein 0.0035 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0315 0.1338
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0335 0.1354
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.004 0.0042
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0625
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0065 0.0193
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0155 0.0218
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0099 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0195
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0099 0.0133
Leishmania major mitochondrial DNA polymerase beta 0.0312 0.2394 1
Schistosoma mansoni heat shock protein 0.0032 0.0161 0.0228
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.011 0.0093
Brugia malayi Pax transcription factor protein 2 0.0235 0.1784 0.7841
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.019 0.0266
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0312 0.0459
Echinococcus granulosus Smad4 0.0016 0.0035 0.0034
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0219 0.0316
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.004 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0217
Brugia malayi nuclear receptor RXR 0.0027 0.0122 0.0485
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0099
Trichomonas vaginalis MYB3r3, putative 0.002 0.0064 0.0227
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0315 0.1338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0127 0.011
Mycobacterium tuberculosis Conserved protein 0.0035 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0312 0.1327
Brugia malayi hypothetical protein 0.0297 0.2272 1
Schistosoma mansoni nuclear receptor 0.0024 0.0099 0.0133
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0096 0.0673 0.2922
Brugia malayi Pre-SET motif family protein 0.0217 0.1636 0.7183
Schistosoma mansoni septate junction protein 0.0016 0.004 0.0042
Mycobacterium ulcerans beta-lactamase 0.0035 0.019 0.0173
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0255 0.0372
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0315 0.1338
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0155 0.4734
Schistosoma mansoni hypothetical protein 0.0332 0.2553 0.3886
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0012 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0422 0.0626
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1084 0.1068
Schistosoma mansoni hypothetical protein 0.0043 0.0255 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0312 0.1327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0009
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0623 0.087
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0099 0.0384
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0008
Echinococcus granulosus geminin 0.0332 0.2553 0.3886
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0312 0.2394 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0313 1
Mycobacterium ulcerans polyketide synthase 0.0026 0.0113 0.0096
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0113 0.0096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Brugia malayi hypothetical protein 0.0119 0.0859 0.3748
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0066 0.0049
Brugia malayi ecdysone receptor 0.0024 0.0099 0.0384
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0008
Echinococcus multilocularis protein jagged 2 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0045 0.0267 0.1125
Brugia malayi Cytochrome P450 family protein 0.002 0.0066 0.0238
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0059 0.0041
Echinococcus granulosus tumor protein p63 0.033 0.2542 0.3868
Brugia malayi hypothetical protein 0.0027 0.0122 0.0485
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0099 0.0133
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0313 0.1097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0035 0.0034
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0097 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Trichomonas vaginalis MYB, putative 0.002 0.0065 0.023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0155 0.0598
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.005 0.031 0.1319
Brugia malayi Peroxidasin 0.0051 0.0315 0.1338
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0313 0.1263
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0625
Onchocerca volvulus 0.0016 0.004 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0312 0.1327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0127 0.0127
Brugia malayi nuclear receptor RXR 0.0024 0.0099 0.0384
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0059 0.0071
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0017 0.0019
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0122 0.0485
Plasmodium vivax hypothetical protein, conserved 0.0035 0.019 0.5928
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0064 0.0227
Schistosoma mansoni hypothetical protein 0.004 0.0225 0.0325
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1266 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0127 0.0178
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.004 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0155 0.0218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.019 0.0789
Plasmodium falciparum glutathione reductase 0.0039 0.0222 0.6969
Onchocerca volvulus 0.0297 0.2272 1
Trichomonas vaginalis heat shock protein, putative 0.0025 0.011 0.0424
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0099 0.0384
Schistosoma mansoni hypothetical protein 0.0066 0.0439 0.0652
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0122 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.019 0.0748
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0485
Echinococcus granulosus delta-like protein 1 0.0016 0.004 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0059 0.0205
Echinococcus granulosus notch 0.0016 0.004 0.0042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0147 0.0206
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Brugia malayi hypothetical protein 0.0051 0.0315 0.1338
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0225 0.0314
Schistosoma mansoni smad 0.0016 0.0035 0.0034
Onchocerca volvulus 0.0016 0.004 0.0123
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0312 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0312 0.1327
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0064 0.0227
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1085 0.4504
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0444 0.191
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0066 0.0226
Echinococcus multilocularis expressed conserved protein 0.009 0.0626 0.0939
Treponema pallidum heat shock protein 90 0.0025 0.011 0.0093
Echinococcus granulosus GPCR family 2 0.0031 0.0154 0.0217
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0161 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0673 0.101
Brugia malayi MH2 domain containing protein 0.0232 0.1754 0.7708
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0017 0.0019
Echinococcus granulosus fibropellin Ia 0.0016 0.004 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0017 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.019 0.0273
Plasmodium falciparum heat shock protein 90 0.0032 0.0161 0.4949
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0315 0.1338
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Trypanosoma brucei cytochrome P450, putative 0.002 0.0066 0.0226
Brugia malayi beta-lactamase 0.0035 0.019 0.0789
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0113 0.0107
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.009 0.0119
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0059 0.0082
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6551 1
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0161 0.0659
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0312 0.1327
Onchocerca volvulus Slit protein homolog 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0122 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0312 0.1327
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0312 0.1327
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Echinococcus multilocularis heat shock protein 90 0.0032 0.0161 0.0228
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.019 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Schistosoma mansoni hypothetical protein 0.0332 0.2553 0.3886
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0623 0.087
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0072 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.2394 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0065 0.023
Onchocerca volvulus Huntingtin homolog 0.0119 0.0859 0.3748
Brugia malayi beta-lactamase family protein 0.0035 0.019 0.0789
Trichomonas vaginalis MYB72, putative 0.002 0.0064 0.0227
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0037 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0122 0.0168
Brugia malayi Smad1 0.0016 0.0035 0.0099
Brugia malayi nuclear receptor NHR-88 0.0051 0.0312 0.1327
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1218 0.1702
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Plasmodium falciparum endoplasmin, putative 0.0019 0.0064 0.1708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0017 0.017
Brugia malayi hypothetical protein 0.0043 0.0255 0.1075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0113 0.0096
Loa Loa (eye worm) pax transcription factor protein 2 0.0235 0.1784 0.7841
Schistosoma mansoni notch 0.0016 0.004 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0225 0.0264
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0035 0.0034
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0222 0.6969
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.019 0.0273
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0034
Brugia malayi steroid hormone receptor 0.0051 0.0312 0.1327
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0217
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0127 0.0178
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0312 0.0459
Trichomonas vaginalis heat shock protein, putative 0.0025 0.011 0.0424
Brugia malayi Muscle positioning protein 4 0.0016 0.004 0.0123
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0315 0.1338
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Brugia malayi Cadherin domain containing protein 0.0016 0.004 0.0123
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0485
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0035 0.0099
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0064 0.0223
Echinococcus granulosus slit 2 protein 0.0016 0.004 0.0042
Schistosoma mansoni peroxidasin 0.0051 0.0315 0.0462
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0161 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0161 0.0228
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0127 0.0127
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Plasmodium falciparum glutathione reductase 0.0014 0.0017 0.017
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0099 0.0384
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.019 0.0775
Entamoeba histolytica hypothetical protein 0.0043 0.0255 0.1056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1708 0.2387
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0312 0.1327
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Onchocerca volvulus Huntingtin homolog 0.0119 0.0859 0.3748
Brugia malayi hypothetical protein 0.0024 0.0099 0.0384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0161 0.0625
Brugia malayi hypothetical protein 0.0027 0.0122 0.0485
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0195
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0099 0.0384
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0016 0.004 0.0042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0017 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.019 0.0273
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0154 0.0628
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0127 0.042
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0315 0.1338
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.019 0.0749
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0154 0.0217
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0099 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.019 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0312 0.1327
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0225 0.0208
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0155 0.0218
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Echinococcus multilocularis fibropellin Ia 0.0016 0.004 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0623 0.087
Entamoeba histolytica hypothetical protein 0.0043 0.0255 0.1056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0017 0.0022
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0127 0.0127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0154 0.0628
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0059 0.0195
Echinococcus granulosus protein jagged 2 0.0016 0.004 0.0042
Brugia malayi GCC2 and GCC3 family protein 0.0016 0.004 0.0123
Onchocerca volvulus 0.0016 0.004 0.0123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0154 0.0217
Onchocerca volvulus Neurogenic locus notch homolog 0.0016 0.004 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0059 0.0195
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0161 0.0625
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0155 0.0218
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0034
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Onchocerca volvulus 0.0051 0.0315 0.1338
Brugia malayi hypothetical protein 0.0024 0.0099 0.0384
Schistosoma mansoni endoplasmin 0.0032 0.0161 0.0228
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0155 0.0519
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0035 0.0034
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0127 0.0178
Echinococcus granulosus neurogenic locus protein delta 0.0016 0.004 0.0042
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0113 0.0447
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0055 0.0156
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0312 0.1327
Mycobacterium ulcerans thioesterase 0.0024 0.0097 0.0079
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0099 0.0133
Mycobacterium leprae conserved hypothetical protein 0.0035 0.019 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Onchocerca volvulus 0.0235 0.1784 0.7841
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0099 0.0133
Plasmodium vivax SET domain protein, putative 0.0032 0.0161 0.4948
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0037 0.002
Echinococcus multilocularis protein dispatched 1 0.0047 0.0283 0.0414
Giardia lamblia Myb 1-like protein 0.002 0.0065 0.0208
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.011 0.0409
Onchocerca volvulus 0.003 0.0146 0.0594
Brugia malayi Pre-SET motif family protein 0.0032 0.0161 0.0658
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.019 0.0266
Schistosoma mansoni hypothetical protein 0.004 0.0225 0.0325
Onchocerca volvulus 0.0051 0.0315 0.1338
Schistosoma mansoni coup transcription factor 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.019 0.0266
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0059 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.2314 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0059 0.0071
Echinococcus granulosus neurogenic locus notch protein 4 0.0016 0.004 0.0042
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0099
Plasmodium vivax endoplasmin, putative 0.0032 0.0161 0.4949
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0113 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0099
Echinococcus multilocularis fat cadherin tumor suppressor 0.0016 0.004 0.0042
Brugia malayi hypothetical protein 0.0051 0.0313 0.1331
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.0154 0.0628
Schistosoma mansoni nuclear receptor 0.0024 0.0099 0.0133
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0064 0.0227
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0099 0.0133
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.1754 0.7708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0099 0.0133
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Echinococcus granulosus smad 0.0016 0.0035 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0059 0.0082
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.2754 0.3817
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0017 0.0021
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0155 0.063
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0315 0.1338
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0161 0.4949
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0119 0.0167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0205
Schistosoma mansoni laminin gamma-3 chain 0.0016 0.004 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0312 0.0459
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0368 0.1298
Schistosoma mansoni DNA polymerase eta 0.0019 0.0059 0.0071
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Schistosoma mansoni zinc finger protein 0.0024 0.0099 0.0133
Brugia malayi nuclear receptor NHR-88 0.0024 0.0099 0.0384
Giardia lamblia DINP protein human, muc B family 0.0019 0.0059 0.018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0312 0.0459
Schistosoma mansoni hypothetical protein 0.004 0.0225 0.0325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0312 0.0459
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0312 0.0459
Schistosoma mansoni hypothetical protein 0.028 0.2144 0.326
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.004 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Brugia malayi tailless protein 0.0024 0.0099 0.0384
Echinococcus multilocularis GPCR, family 2 0.0031 0.0154 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0312 0.1327
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0037 0.002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0099 0.0384
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0225 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.009 0.0119
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0097 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0122 0.0485
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0312 0.0459
Leishmania major DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0237 0.0993
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0113 0.0158
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0222 0.0927
Mycobacterium ulcerans hypothetical protein 0.0035 0.019 0.0173
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0444 0.066
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0131 0.0527
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6551 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0066 0.0238
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0065 0.023
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0444 0.1813
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Echinococcus multilocularis endoplasmin 0.0025 0.011 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0119 0.0474
Brugia malayi CHE-14 protein 0.0041 0.0237 0.0993
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0312 0.1327
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0017 0.0022
Trichomonas vaginalis esterase, putative 0.0035 0.019 0.0775
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0099 0.0384
Entamoeba histolytica hypothetical protein 0.0043 0.0255 0.1056
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0016 0.004 0.0123
Brugia malayi Cadherin domain containing protein 0.0016 0.004 0.0123
Treponema pallidum fructose-bisphosphate aldolase 0.0302 0.2314 0.23
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0113 0.0096
Toxoplasma gondii hypothetical protein 0.005 0.031 0.1085
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0099 0.0133
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.1085 0.4504
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0294 0.0431
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0059 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0066 0.0238
Loa Loa (eye worm) hypothetical protein 0.0097 0.0684 0.2973
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0444 0.1813
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0099 0.0133
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0313 0.1263
Echinococcus multilocularis neural cadherin 0.0016 0.004 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1874 0.8087
Onchocerca volvulus 0.0032 0.0161 0.0658
Schistosoma mansoni cpg binding protein 0.0032 0.016 0.0226
Schistosoma mansoni peroxidasin 0.0051 0.0315 0.0462
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0059 0.0041
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0161 0.0543
Giardia lamblia Fructose-bisphosphate aldolase 0.0302 0.2314 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0312 0.0459
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0099 0.0133
Echinococcus granulosus endoplasmin 0.0025 0.011 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0312 0.1327
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0315 0.1338
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0312 0.0459
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0258 0.1033
Onchocerca volvulus 0.0024 0.0099 0.0384
Echinococcus granulosus protein jagged 1 0.0016 0.004 0.0042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0161 0.0626
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1266 1 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0222 0.6969
Loa Loa (eye worm) Smad1 0.0016 0.0035 0.0099
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0155 0.0598
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0161 0.0625
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.011 0.0409
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0064 0.0227
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0023 0.0038
Loa Loa (eye worm) notch protein 0.0016 0.004 0.0123
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0673 0.2922
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0022
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.0315 0.134
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0066 0.0238
Loa Loa (eye worm) CYP4Cod1 0.002 0.0066 0.0238
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0099 0.0133
Onchocerca volvulus 0.0246 0.1874 0.8236
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.004 0.0123
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0623 0.087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0122 0.0168
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0315 0.1338
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Plasmodium falciparum thioredoxin reductase 0.0014 0.0017 0.017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0155 0.0519
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0035 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0258 0.1033
Mycobacterium leprae Probable lipase LipE 0.0035 0.019 0.0216
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.011 0.0409
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1085 0.4504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0312 0.0459
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0154 0.0217
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0099 0.0133
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0237 0.0993
Echinococcus granulosus expressed conserved protein 0.009 0.0626 0.0939
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.019 0.0173
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0059 0.0195
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0444 0.191
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0161 0.0228
Mycobacterium ulcerans hypothetical protein 0.0164 0.1218 0.1203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0312 0.0459
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0255 0.0372
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0069 0.0045
Loa Loa (eye worm) hypothetical protein 0.0051 0.0313 0.1331
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0064 0.0227
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0315 0.1338
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0113 0.0158
Echinococcus multilocularis Smad4 0.0016 0.0035 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0312 0.1327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0017 0.017
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0258 0.1034
Echinococcus granulosus dna polymerase eta 0.0019 0.0059 0.0071
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0315 0.1338
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.011 0.0402
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0313 0.1263
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0161 0.0647
Brugia malayi CXXC zinc finger family protein 0.003 0.0146 0.0594
Trichomonas vaginalis heat shock protein, putative 0.0025 0.011 0.0424
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0059 0.0205
Echinococcus multilocularis protein patched 0.0041 0.0237 0.0343
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0315 0.1338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0161 0.0543
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6551 1
Loa Loa (eye worm) endoplasmin 0.0032 0.0161 0.0659
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0673 0.287
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0684 0.1028
Echinococcus granulosus cpg binding protein 0.0032 0.016 0.0226
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0035 0.0034
Leishmania major trypanothione reductase 0.0039 0.0222 0.088
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0625
Brugia malayi Delta serrate ligand family protein 0.0016 0.004 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0312 0.0459
Schistosoma mansoni notch 0.0016 0.004 0.0042
Brugia malayi nuclear hormone receptor 0.0024 0.0099 0.0384
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.004 0.0123
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0113 0.0158
Brugia malayi isocitrate dehydrogenase 0.0031 0.0155 0.063
Schistosoma mansoni Smad4 0.0016 0.0035 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Echinococcus multilocularis geminin 0.0332 0.2553 0.3886
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0237 0.0975
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0064 0.0227
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0099 0.0384
Brugia malayi notch-like transmembrane receptor 0.0016 0.004 0.0123
Mycobacterium ulcerans polyketide synthase 0.0027 0.0127 0.011
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Mycobacterium tuberculosis Probable reductase 0.009 0.0623 0.087
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0155 0.0216
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0017 0.0024
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1266 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0146 0.0594
Leishmania major DNA polymerase eta, putative 0.0019 0.0059 0.0195
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0155 0.063
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0217
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0113 0.0107
Schistosoma mansoni hypothetical protein 0.0031 0.0154 0.0217
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0099 0.0133
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.0205
Echinococcus granulosus X box binding protein 1 0.028 0.2144 0.326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0122 0.0485
Trichomonas vaginalis C-MYB, putative 0.002 0.0064 0.0227
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1084 0.147
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0315 0.1338
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.019 0.0748
Schistosoma mansoni notch 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Schistosoma mansoni notch 0.0016 0.004 0.0042
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0161 0.0543
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.019 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0161 0.0228
Echinococcus multilocularis slit 2 protein 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0237 0.0343
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0059 0.0202
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0312 0.0459
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Echinococcus granulosus dna polymerase kappa 0.0019 0.0059 0.0071
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1 0.1511
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0444 0.1813
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0312 0.1327
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0099 0.0133
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Schistosoma mansoni patched 1 0.0041 0.0237 0.0343
Brugia malayi heat shock protein 90 0.0032 0.0161 0.0659
Trypanosoma brucei trypanothione reductase 0.0039 0.0222 0.088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0099 0.0133
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0042
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0099 0.0384
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0064 0.0223
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0702 0.0935
Echinococcus multilocularis protein jagged 1 0.0016 0.004 0.0042
Loa Loa (eye worm) Notch2 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Schistosoma mansoni cell polarity protein 0.0016 0.004 0.0042
Giardia lamblia High cysteine protein 0.0016 0.004 0.0098
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0155 0.0598
Brugia malayi conserved hypotetical protein 0.0024 0.0099 0.0384
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0909 0.7155 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0255 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0312 0.1327
Schistosoma mansoni slit 0.0016 0.004 0.0042
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0017 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.015 0.0608
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0219 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0059 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0312 0.1327
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Brugia malayi Blistered cuticle protein 3 0.0051 0.0315 0.1338
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.011 0.0149
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0444 0.1876
Brugia malayi ecdysteroid receptor 0.0051 0.0312 0.1327
Schistosoma mansoni endoplasmin 0.0032 0.0161 0.0228
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0059 0.0071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0702 0.0982
Echinococcus granulosus heat shock protein 90 0.0025 0.011 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.2314 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0312 0.1327
Brugia malayi beta-lactamase family protein 0.0035 0.019 0.0789
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0312 0.0459
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1084 0.1515
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0058 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.019 0.0789
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0064 0.0227
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0222 0.031
Toxoplasma gondii EGF family domain-containing protein 0.0016 0.004 0.0101
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0161 0.0647
Mycobacterium tuberculosis Conserved protein 0.0035 0.019 0.0266
Echinococcus multilocularis smad 0.0016 0.0035 0.0034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.019 0.0266
Onchocerca volvulus 0.0016 0.004 0.0123
Echinococcus granulosus heat shock protein 90 0.0032 0.0161 0.0228
Brugia malayi Thioredoxin reductase 0.0039 0.0222 0.0927
Schistosoma mansoni heat shock protein 0.0032 0.0161 0.0228
Echinococcus multilocularis X box binding protein 1 0.028 0.2144 0.326
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0702 0.0982
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0625
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0312 0.0459
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0017 0.017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0059 0.0202
Onchocerca volvulus 0.0024 0.0099 0.0384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0059 0.0205
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.019 0.0775
Loa Loa (eye worm) hypothetical protein 0.0051 0.0315 0.1338
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Onchocerca volvulus 0.0026 0.0119 0.0474
Loa Loa (eye worm) beta-lactamase 0.0035 0.019 0.0789
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0099
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0071 0.0099
Schistosoma mansoni notch 0.0016 0.004 0.0042
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0237 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0312 0.1327
Schistosoma mansoni notch 0.0016 0.004 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.019 0.0273
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.019 0.0789
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0312 0.1327
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0069 0.0208
Echinococcus multilocularis tumor protein p63 0.033 0.2542 0.3868
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.2754 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Brugia malayi hypothetical protein 0.0033 0.017 0.0697
Echinococcus granulosus peroxidasin 0.0051 0.0315 0.0462
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0237 0.0343
Brugia malayi EGF-like domain containing protein 0.0016 0.004 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0123
Echinococcus granulosus protein jagged 2 0.0016 0.004 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0312 0.0459
Onchocerca volvulus Peroxidase homolog 0.0051 0.0315 0.1338
Onchocerca volvulus 0.0048 0.0294 0.1248
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0384
Echinococcus multilocularis protein jagged 1 0.0016 0.004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0297 0.2272 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0312 0.1327
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0623 0.087
Brugia malayi nuclear receptor NHR-67 0.0024 0.0099 0.0384
Brugia malayi nuclear hormone receptor 0.0051 0.0312 0.1327
Echinococcus multilocularis heat shock protein 0.0032 0.0161 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0312 0.0459
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0313 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0016 0.004 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0059 0.0195
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0702 0.0982
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0161 0.0228
Schistosoma mansoni hypothetical protein 0.004 0.0225 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.019 0.0775
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0064 0.0227
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0312 0.2394 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0623 0.0823
Plasmodium falciparum thioredoxin reductase 0.0039 0.0222 0.6969
Leishmania major hypothetical protein, conserved 0.0051 0.0313 0.1263
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0444 0.1813
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0226 0.0327
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.1636 0.7183
Brugia malayi Endoplasmin precursor 0.0032 0.0161 0.0659
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0017 0.0022
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0625
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.011 0.0153
Echinococcus multilocularis notch 0.0016 0.004 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0066 0.0226
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0069 0.0052
Toxoplasma gondii thioredoxin reductase 0.0039 0.0222 0.0765
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0312 0.0459
Mycobacterium ulcerans heat shock protein 90 0.0025 0.011 0.0093
Echinococcus granulosus neural cadherin 0.0016 0.004 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0017 0.0021
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0122 0.0168
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0059 0.0202
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0017 0.0008
Onchocerca volvulus 0.0016 0.004 0.0123
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0155 0.0598

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.0251 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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