Detailed information for compound 1344256

Basic information

Technical information
  • TDR Targets ID: 1344256
  • Name: 4-methyl-N-[1-[(4-methylphenyl)sulfonylamino] propan-2-yl]benzenesulfonamide
  • MW: 382.498 | Formula: C17H22N2O4S2
  • H donors: 2 H acceptors: 4 LogP: 2.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)NCC(NS(=O)(=O)c1ccc(cc1)C)C
  • InChi: 1S/C17H22N2O4S2/c1-13-4-8-16(9-5-13)24(20,21)18-12-15(3)19-25(22,23)17-10-6-14(2)7-11-17/h4-11,15,18-19H,12H2,1-3H3
  • InChiKey: JJGLDZUABHRMDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-N-[1-methyl-2-[(4-methylphenyl)sulfonylamino]ethyl]benzenesulfonamide
  • MLS000088806
  • N,N'-1,2-propanediylbis(4-methylbenzenesulfonamide)
  • AK-968/41926823
  • IVK/9188316
  • SMR000071952

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0116 0.0084 0.0314
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0041 0.0022 0.0071
Echinococcus multilocularis protein patched 0.0034 0.0016 0.0048
Schistosoma mansoni integrin alpha-ps 0.0025 0.0009 0.0022
Echinococcus granulosus nuclear receptor nhr 48 0.0145 0.0108 0.0408
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0024 0.0079
Brugia malayi hypothetical protein 0.0051 0.003 0.003
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.002 0.0004 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0308 0.0243 0.0932
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0041 0.0022 0.0018
Schistosoma mansoni hypothetical protein 0.0054 0.0033 0.0114
Brugia malayi Histone deacetylase family protein 0.0263 0.0206 0.0206
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0007 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0023 0.0019
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Giardia lamblia Histone deacetylase 0.0219 0.0169 0.0634
Plasmodium vivax telomerase reverse transcriptase, putative 0.0203 0.0157 0.0595
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0022 0.0006 0.0003
Mycobacterium ulcerans hypothetical protein 0.0042 0.0023 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0163 0.0123 0.012
Loa Loa (eye worm) histone deacetylase 11 0.0109 0.0079 0.0075
Echinococcus multilocularis GPCR, family 2 0.0025 0.0008 0.002
Echinococcus granulosus histone deacetylase 0.0263 0.0206 0.0786
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0163 0.0123 0.0464
Echinococcus multilocularis histone deacetylase 7 0.0263 0.0206 0.0786
Echinococcus multilocularis integrin alpha ps 0.0023 0.0007 0.0015
Trypanosoma brucei histone deacetylase 2 0.0109 0.0079 0.0075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0379 0.0303 0.1162
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0007 0.0003
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Plasmodium vivax SET domain protein, putative 0.0037 0.0018 0.0057
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0308 0.0243 0.0932
Brugia malayi ecdysteroid receptor 0.0308 0.0243 0.0243
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 1.2046 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2046 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0308 0.0243 0.0932
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0308 0.0243 0.0243
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0219 0.0169 0.0166
Leishmania major histone deacetylase, putative 0.0263 0.0206 0.0203
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.3121 0.2582 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3121 0.2582 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0308 0.0243 0.0243
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0308 0.0243 0.0932
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0006 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0079 0.0053 0.2508
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0163 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Brugia malayi Kelch motif family protein 0.0075 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Loa Loa (eye worm) nuclear hormone receptor 0.0145 0.0108 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0308 0.0243 0.0932
Schistosoma mansoni retinoic acid receptor RXR 0.0308 0.0243 0.0932
Trypanosoma brucei NAD(p)-dependent steroid dehydrogenase-like protein 0.002 0.0004 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0023 0.1053
Brugia malayi photoreceptor-specific nuclear receptor 0.0308 0.0243 0.0243
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.0033 0.0033
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0022 0.0006 0.0003
Loa Loa (eye worm) beta-lactamase 0.0042 0.0023 0.0019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0006 0.0011
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0145 0.0108 0.0408
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0007 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0007 0.0004
Echinococcus granulosus geminin 0.0116 0.0084 0.0314
Echinococcus multilocularis histone deacetylase 8 0.0109 0.0079 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0308 0.0243 0.0243
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0024 0.0079
Entamoeba histolytica hypothetical protein 0.3121 0.2582 0.2579
Echinococcus multilocularis tar DNA binding protein 0.0043 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0018
Plasmodium vivax glutathione reductase, putative 0.0035 0.0016 0.0051
Brugia malayi Histone deacetylase family protein 0.0263 0.0206 0.0206
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0308 0.0243 0.0932
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0006 0.0011
Onchocerca volvulus 0.0145 0.0108 0.0408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0023 0.0075
Trypanosoma cruzi histone deacetylase, putative 0.0263 0.0206 0.0203
Echinococcus multilocularis dnaJ subfamily B 0.0329 0.0261 0.1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0006 0.0003
Leishmania major NAD(p)-dependent steroid dehydrogenase-like protein 0.002 0.0004 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0308 0.0243 0.0932
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0008 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0197 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0308 0.0243 0.0932
Mycobacterium ulcerans cholesterol dehydrogenase 0.002 0.0004 0.0004
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0041 0.0022 0.0071
Loa Loa (eye worm) hypothetical protein 0.0163 0.0123 0.012
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0096 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Brugia malayi beta-lactamase family protein 0.0042 0.0023 0.0023
Brugia malayi Integrin alpha pat-2 precursor 0.0109 0.0078 0.0078
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 1.2046 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0145 0.0108 0.0408
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Brugia malayi Histone deacetylase 1 0.0219 0.0169 0.0169
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0049 0.0045
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0219 0.0169 0.0166
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0022 0.0006 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0023 0.0075
Trypanosoma cruzi histone deacetylase 1, putative 0.0219 0.0169 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0024 0.0079
Echinococcus granulosus Nuclear hormone receptor HR96 0.0145 0.0108 0.0408
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0051 0.003 0.0104
Schistosoma mansoni nuclear hormone receptor 0.0145 0.0108 0.0408
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0024 0.0079
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0044
Loa Loa (eye worm) thioredoxin reductase 0.0035 0.0016 0.0013
Onchocerca volvulus 0.0042 0.0023 0.0075
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0022 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0111 0.008 0.0076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0079 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0006 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0007 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0007 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0308 0.0243 0.024
Schistosoma mansoni nuclear receptor nhr-48 0.0145 0.0108 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0308 0.0243 0.024
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0018 0.0015
Onchocerca volvulus 0.0111 0.008 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0042 0.0151
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.0081 0.0301
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0023 0.0019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0079 0.0053 0.2508
Trichomonas vaginalis hydroxysteroid dehydrogenase, putative 0.002 0.0004 0.0001
Onchocerca volvulus 0.0136 0.0101 0.0379
Loa Loa (eye worm) DR-78 0.0145 0.0108 0.0105
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 1.2046 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0016 0.0013
Brugia malayi steroid hormone receptor 0.0308 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 1.2046 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0043 0.0024 0.0024
Brugia malayi histone deacetylase 1 (HD1) 0.0219 0.0169 0.0169
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0007 0.0004
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0075 0.005 0.0047
Echinococcus granulosus synaptic glycoprotein sc2 0.3121 0.2582 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Trypanosoma brucei NAD(P)-dependent steroid dehydrogenase protein, putative 0.002 0.0004 0.0001
Onchocerca volvulus 0.0037 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.3121 0.2582 0.2579
Brugia malayi Steroid receptor seven-up type 2 0.0308 0.0243 0.0243
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0308 0.0243 0.0243
Onchocerca volvulus Matrilysin homolog 0.0213 0.0165 0.0626
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0145 0.0108 0.0408
Brugia malayi Matrixin family protein 0.0232 0.0181 0.0181
Brugia malayi nuclear hormone receptor 0.0308 0.0243 0.0243
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0024 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0029 0.0102
Brugia malayi hypothetical protein 0.0111 0.008 0.008
Entamoeba histolytica hypothetical protein 0.0051 0.003 0.0027
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0219 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0012
Schistosoma mansoni histone deacetylase 4 5 0.0263 0.0206 0.0786
Loa Loa (eye worm) hypothetical protein 0.0117 0.0085 0.0082
Brugia malayi beta-lactamase 0.0042 0.0023 0.0023
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0006 0.0003
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0041 0.0022 0.0018
Schistosoma mansoni synaptic glycoprotein sc2 related 0.3121 0.2582 1
Echinococcus multilocularis integrin alpha ps 0.0049 0.0028 0.0097
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0163 0.0123 0.0464
Brugia malayi histone deacetylase 3 (HD3) 0.0219 0.0169 0.0169
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0041 0.0022 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0145 0.0108 0.0408
Echinococcus granulosus integrin alpha ps 0.0023 0.0007 0.0015
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3121 0.2582 0.2579
Schistosoma mansoni integrin beta subunit 0.0281 0.0221 0.0845
Loa Loa (eye worm) hypothetical protein 0.0079 0.0054 0.005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Brugia malayi BRCA1-associated protein 2 containing protein 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Probable reductase 0.0079 0.0053 0.2508
Echinococcus multilocularis protein dispatched 1 0.0038 0.002 0.0063
Echinococcus multilocularis expressed conserved protein 0.0074 0.0049 0.0177
Schistosoma mansoni niemann-pick C1 (NPC1) 0.008 0.0054 0.0196
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0219 0.0169 0.0166
Brugia malayi nuclear receptor RXR 0.0163 0.0123 0.0123
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3121 0.2582 0.2579
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0023 0.0019
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.3121 0.2582 0.2579
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0024 0.002
Schistosoma mansoni thyroid hormone receptor 0.0308 0.0243 0.0932
Mycobacterium tuberculosis Probable dehydrogenase 0.0079 0.0053 0.2508
Echinococcus multilocularis histone deacetylase 1 0.0219 0.0169 0.0644
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Schistosoma mansoni hypothetical protein 0.0136 0.0101 0.0379
Schistosoma mansoni nuclear hormone receptor 0.0145 0.0108 0.0408
Brugia malayi nuclear receptor NHR-88 0.0308 0.0243 0.0243
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0041 0.0022 0.0022
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.3121 0.2582 0.2579
Plasmodium falciparum histone deacetylase 1 0.0219 0.0169 0.0644
Brugia malayi ecdysone receptor 0.0145 0.0108 0.0108
Echinococcus granulosus tm gpcr rhodopsin 0.0379 0.0303 0.1162
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0744 0.0606 0.2338
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0024 0.0068
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0022 0.0006 0.0003
Echinococcus granulosus histone deacetylase 6 0.0263 0.0206 0.0786
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0308 0.0243 0.0932
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0006 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0024 0.0079
Brugia malayi nuclear receptor RXR 0.0145 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0153 0.0115 0.0112
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0041 0.0022 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0193 0.0148 0.0145
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.0081 0.0301
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3121 0.2582 0.2579
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0057
Echinococcus multilocularis integrin alpha ps 0.0049 0.0028 0.0097
Onchocerca volvulus Matrix metalloproteinase homolog 0.0213 0.0165 0.0626
Trichomonas vaginalis esterase, putative 0.0042 0.0023 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0308 0.0243 0.0932
Loa Loa (eye worm) steroid hormone receptor 0.0308 0.0243 0.024
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0049 0.0176
Brugia malayi nuclear hormone receptor family member odr-7 0.0145 0.0108 0.0108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0008 0.0005
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2046 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0163 0.0123 0.0123
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0716 0.0583 0.2248
Onchocerca volvulus 0.0308 0.0243 0.0932
Echinococcus granulosus histone deacetylase 8 0.0109 0.0079 0.0292
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0818 0.0668 0.2578
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0024 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus granulosus histone deacetylase 1 0.0219 0.0169 0.0644
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0308 0.0243 0.0932
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0308 0.0243 0.0932
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3121 0.2582 0.2579
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0096 0.0067 0.0064
Brugia malayi oxidoreductase 0.002 0.0004 0.0004
Leishmania major histone deacetylase, putative 0.0263 0.0206 0.0203
Entamoeba histolytica hypothetical protein 0.0051 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0079 0.0053 0.6082
Leishmania major hypothetical protein, conserved 0.0042 0.0023 0.0019
Echinococcus granulosus histone deacetylase 6 0.0281 0.0221 0.0846
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.3121 0.2582 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0007 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0007 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0079 0.0054 0.0054
Loa Loa (eye worm) glutathione reductase 0.0035 0.0016 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0066 0.0042 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0018 0.0015
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0022 0.0006 0.0011
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3121 0.2582 0.2579
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0079 0.0053 0.2508
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0023 0.0019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0007 0.0006
Brugia malayi nuclear receptor NHR-67 0.0145 0.0108 0.0108
Onchocerca volvulus 0.0096 0.0067 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0007 0.0003
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0006 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0308 0.0243 0.0932
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0007 0.0004
Brugia malayi nuclear receptor NHR-88 0.0145 0.0108 0.0108
Onchocerca volvulus 0.0023 0.0007 0.0014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0023 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0008 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0088 0.0061 0.2856
Trypanosoma brucei histone deacetylase, putative 0.0263 0.0206 0.0203
Brugia malayi hypothetical protein 0.0163 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0329 0.0261 0.1
Plasmodium falciparum histone deacetylase, putative 0.0263 0.0206 0.0786
Trypanosoma brucei telomerase reverse transcriptase 0.0203 0.0157 0.0153
Plasmodium vivax histone deacetylase 1, putative 0.0219 0.0169 0.0644
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0349 0.0278 0.1065
Brugia malayi Matrixin family protein 0.0096 0.0067 0.0067
Mycobacterium tuberculosis 3-beta-hydroxysteroid dehydrogenase 0.002 0.0004 0.0179
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0023 0.0019
Toxoplasma gondii histone deacetylase HDAC4 0.0109 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0023 0.0019
Brugia malayi Pre-SET motif family protein 0.0037 0.0018 0.0018
Plasmodium falciparum histone deacetylase 2 0.0263 0.0206 0.0786
Trypanosoma brucei trypanothione reductase 0.0035 0.0016 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.3121 0.2582 0.2579
Loa Loa (eye worm) hypothetical protein 0.0109 0.0079 0.0075
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3121 0.2582 1
Echinococcus granulosus histone deacetylase 3 0.0219 0.0169 0.0644
Entamoeba histolytica hypothetical protein 0.0051 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0008
Echinococcus granulosus tar DNA binding protein 0.0043 0.0024 0.0079
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0023 0.1053
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0007 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0163 0.0123 0.0464
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0203 0.0157 0.0153
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0024 0.002
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.3121 0.2582 0.2579
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0006 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0308 0.0243 0.0932
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0007 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0016 0.0051
Echinococcus multilocularis histone deacetylase 0.0263 0.0206 0.0786
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.0033 0.0029
Echinococcus multilocularis sterol regulatory element binding protein 0.0034 0.0016 0.0048
Onchocerca volvulus 0.0287 0.0226 0.0863
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0024 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0057
Schistosoma mansoni hypothetical protein 0.0051 0.003 0.0104
Schistosoma mansoni integrin alpha 0.0109 0.0078 0.0291
Brugia malayi Thioredoxin reductase 0.0035 0.0016 0.0016
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0041 0.0022 0.0071
Onchocerca volvulus Histone deacetylase 10 homolog 0.0109 0.0079 0.0292
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0145 0.0108 0.0408
Brugia malayi Nuclear hormone receptor E75 0.0145 0.0108 0.0108
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0006 0.0011
Brugia malayi beta-lactamase family protein 0.0042 0.0023 0.0023
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0078 0.0053 0.005
Loa Loa (eye worm) TAR-binding protein 0.0043 0.0024 0.0021
Giardia lamblia Synaptic glycoprotein SC2 0.3121 0.2582 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0006 0.0003
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2046 1 1
Plasmodium falciparum glutathione reductase 0.0035 0.0016 0.0051
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0049 0.0045
Loa Loa (eye worm) RNA binding protein 0.0043 0.0024 0.0021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Echinococcus granulosus dnaJ subfamily B 0.0329 0.0261 0.1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0149 0.0111 0.0419
Brugia malayi hypothetical protein 0.0075 0.005 0.005
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0096 0.0067 0.0249
Onchocerca volvulus 0.0042 0.0023 0.0075
Brugia malayi Phospholipase A2 family protein 0.012 0.0087 0.0087
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0006 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0023 0.1053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0023 0.0022
Echinococcus granulosus cpg binding protein 0.0024 0.0008 0.0018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0145 0.0108 0.0408
Schistosoma mansoni histone deacetylase hda2 0.0281 0.0221 0.0846
Schistosoma mansoni cpg binding protein 0.0024 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0163 0.0123 0.012
Loa Loa (eye worm) integrin alpha pat-2 0.0168 0.0128 0.0124
Brugia malayi Hemopexin family protein 0.0136 0.0101 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0007 0.0004
Echinococcus multilocularis synaptic glycoprotein sc2 0.3121 0.2582 1
Brugia malayi histone deacetylase 11 0.0109 0.0079 0.0079
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0145 0.0108 0.0408
Echinococcus multilocularis cpg binding protein 0.0024 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0018 0.0057
Loa Loa (eye worm) matrixin family protein 0.0232 0.0181 0.0178
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Echinococcus granulosus Protein patched homolog 1 0.0034 0.0016 0.0048
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0203 0.0157 0.0153
Schistosoma mansoni histone deacetylase hda2 0.0109 0.0079 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0308 0.0243 0.024
Loa Loa (eye worm) hypothetical protein 0.012 0.0087 0.0084
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0049 0.0176
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0018 0.0057
Echinococcus granulosus integrin alpha ps 0.0049 0.0028 0.0097
Loa Loa (eye worm) hypothetical protein 0.012 0.0087 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0051 0.003 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0042 0.0151
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0163 0.0123 0.0464
Brugia malayi Nuclear hormone receptor E75 0.0145 0.0108 0.0108
Onchocerca volvulus 0.002 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0116 0.0084 0.0314
Plasmodium falciparum thioredoxin reductase 0.0035 0.0016 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Toxoplasma gondii exonuclease III APE 0.0023 0.0007 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0024 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0018
Schistosoma mansoni histone deacetylase 0.0219 0.0169 0.0644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0042 0.0151
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0041 0.0022 0.0071
Onchocerca volvulus 0.0042 0.0023 0.0075
Mycobacterium tuberculosis Conserved protein 0.0042 0.0023 0.1053
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Brugia malayi nuclear hormone receptor 0.0145 0.0108 0.0108
Echinococcus granulosus integrin beta 2 0.0356 0.0283 0.1086
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0308 0.0243 0.0932
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0308 0.0243 0.0932
Loa Loa (eye worm) histone deacetylase 0.0263 0.0206 0.0203
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0308 0.0243 0.0243
Brugia malayi Niemann-Pick C1 protein precursor 0.0078 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0041 0.0022 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0308 0.0243 0.0932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0043 0.0024 0.0021
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0006 0.0011
Mycobacterium tuberculosis Probable oxidoreductase 0.0088 0.0061 0.2856
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0006 0.0003
Schistosoma mansoni nuclear receptor 0.0145 0.0108 0.0408
Brugia malayi Matrixin family protein 0.0096 0.0067 0.0067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0308 0.0243 0.0932
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0145 0.0108 0.0408
Echinococcus multilocularis histone deacetylase 3 0.0219 0.0169 0.0644
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0023 0.1053
Echinococcus granulosus sterol regulatory element binding protein 0.0034 0.0016 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0308 0.0243 0.024
Onchocerca volvulus Matrilysin homolog 0.0096 0.0067 0.0249
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0145 0.0108 0.0408
Plasmodium vivax histone deacetylase, putative 0.0109 0.0079 0.0292
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0019
Toxoplasma gondii RNA-directed DNA polymerase 0.0203 0.0157 0.0153
Echinococcus granulosus FTZ F1 alpha 0.0308 0.0243 0.0932
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0023 0.0075
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0117 0.0085 0.0085
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0008 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0051 0.003 0.0104
Loa Loa (eye worm) histone deacetylase 1 0.0219 0.0169 0.0166
Toxoplasma gondii histone deacetylase HDAC2 0.0219 0.0169 0.0166
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0145 0.0108 0.0105
Brugia malayi hypothetical protein 0.002 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0044
Echinococcus multilocularis histone deacetylase 6 0.0263 0.0206 0.0786
Entamoeba histolytica histone deacetylase, putative 0.0219 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Trypanosoma brucei histone deacetylase 3 0.0263 0.0206 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.3121 0.2582 0.2579
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0145 0.0108 0.0408
Brugia malayi hypothetical protein 0.0145 0.0108 0.0108
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2046 1 1
Loa Loa (eye worm) integrin beta-2 0.0483 0.0389 0.0386
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Mycobacterium ulcerans beta-lactamase 0.0042 0.0023 0.0022
Leishmania major hypothetical protein, conserved 0.002 0.0004 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0145 0.0108 0.0108
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0041 0.0022 0.0018
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0172 0.0131 0.0127
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Onchocerca volvulus Phospholipase A2 homolog 0.012 0.0087 0.0326
Brugia malayi MH2 domain containing protein 0.0193 0.0148 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0024 0.0079
Mycobacterium ulcerans hydrolase 0.0117 0.0085 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0049 0.0176
Schistosoma mansoni ap endonuclease 0.0023 0.0007 0.0013
Mycobacterium tuberculosis Conserved protein 0.0042 0.0023 0.1053
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Onchocerca volvulus Bile acid receptor homolog 0.0308 0.0243 0.0932
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Schistosoma mansoni synaptic glycoprotein sc2 related 0.3121 0.2582 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0053 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0049 0.0176
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0023 0.1053
Brugia malayi hypothetical protein 0.0163 0.0123 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0308 0.0243 0.024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0023 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0308 0.0243 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0004 0.0001
Brugia malayi Synaptic glycoprotein SC2 0.3121 0.2582 0.2582
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Entamoeba histolytica steroid 5-alpha reductase, putative 1.2046 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0016 0.0051
Brugia malayi conserved hypotetical protein 0.0145 0.0108 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0024 0.0079
Mycobacterium tuberculosis Conserved protein 0.0042 0.0023 0.1053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0007 0.0003
Loa Loa (eye worm) histone deacetylase 3 0.0219 0.0169 0.0166
Mycobacterium leprae PROBABLE HYDROLASE 0.0117 0.0085 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0308 0.0243 0.024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0308 0.0243 0.0932
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0308 0.0243 0.0932
Brugia malayi Nuclear hormone receptor-like 1 0.0163 0.0123 0.0123
Echinococcus multilocularis ecdysone induced protein 78C 0.0308 0.0243 0.0932
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0007 0.0014
Onchocerca volvulus 0.0145 0.0108 0.0408
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0308 0.0243 0.0932
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0041 0.0022 0.0071
Mycobacterium ulcerans hypothetical protein 1.2046 1 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.005 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0308 0.0243 0.0243
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0041 0.0022 0.0018
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0024 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0035 0.0016 0.0759
Echinococcus multilocularis histone deacetylase 6 0.0263 0.0206 0.0786
Brugia malayi CXXC zinc finger family protein 0.0023 0.0007 0.0007
Brugia malayi orphan nuclear receptor NR2E1 0.0145 0.0108 0.0108
Brugia malayi hypothetical protein 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0018 0.0057
Echinococcus multilocularis integrin beta 2 0.0356 0.0283 0.1086
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0041 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0086 0.0059 0.0056
Brugia malayi Pre-SET motif family protein 0.0252 0.0197 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0042 0.0151
Toxoplasma gondii histone deacetylase HDAC3 0.0219 0.0169 0.0166
Entamoeba histolytica G protein alpha subunit, putative 0.0041 0.0022 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0308 0.0243 0.0932
Schistosoma mansoni zinc finger protein 0.0145 0.0108 0.0408
Toxoplasma gondii ABC1 family protein 0.0042 0.0023 0.0019
Trypanosoma cruzi histone deacetylase, putative 0.0263 0.0206 0.0203
Brugia malayi Integrin beta pat-3 precursor 0.0483 0.0389 0.0389
Schistosoma mansoni steroid hormone receptor ad4bp 0.0308 0.0243 0.0932
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0308 0.0243 0.0243
Trichomonas vaginalis histone deacetylase, putative 0.0219 0.0169 0.0166
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0049 0.2286
Schistosoma mansoni ap endonuclease 0.0023 0.0007 0.0013
Plasmodium vivax histone deacetylase, putative 0.0263 0.0206 0.0786
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0349 0.0278 0.1065
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0308 0.0243 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0004 0.0001
Echinococcus multilocularis integrin alpha 3 0.0084 0.0057 0.0209
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0145 0.0108 0.0408
Loa Loa (eye worm) hypothetical protein 0.3121 0.2582 0.2579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0145 0.0108 0.0408
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0006 0.0003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0034 0.0016 0.0012
Schistosoma mansoni coup transcription factor 0.0308 0.0243 0.0932
Leishmania major histone deacetylase, putative 0.0219 0.0169 0.0166
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.002
Toxoplasma gondii histone deacetylase HDAC5 0.0109 0.0079 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0008 0.002
Plasmodium vivax thioredoxin reductase, putative 0.0035 0.0016 0.0051
Loa Loa (eye worm) hypothetical protein 0.0145 0.0108 0.0105
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0041 0.0022 0.0071
Schistosoma mansoni cpg binding protein 0.0024 0.0008 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0066 0.0042 0.0042
Schistosoma mansoni nuclear receptor 0.0145 0.0108 0.0408
Leishmania major histone deacetylase, putative 0.0219 0.0169 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0018 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0049 0.0048
Brugia malayi tailless protein 0.0145 0.0108 0.0108
Plasmodium falciparum telomerase reverse transcriptase 0.0203 0.0157 0.0595
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0308 0.0243 0.0243
Plasmodium falciparum polyprenol reductase, putative 0.3121 0.2582 1
Schistosoma mansoni hypothetical protein 0.0032 0.0015 0.0044
Brugia malayi CHE-14 protein 0.0034 0.0016 0.0016
Echinococcus granulosus Niemann Pick C1 protein 0.0078 0.0053 0.0192
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0007 0.0014
Brugia malayi Matrixin family protein 0.0096 0.0067 0.0067
Brugia malayi nuclear hormone receptor family member nhr-6 0.0145 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.002
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0041 0.0022 0.0071
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0006 0.0003
Plasmodium vivax polyprenol reductase, putative 0.3121 0.2582 1
Echinococcus granulosus histone deacetylase 7 0.0263 0.0206 0.0786
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0079 0.0053 0.2508
Trypanosoma brucei histone deacetylase 4 0.0263 0.0206 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0308 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0041 0.0022 0.0071
Trypanosoma brucei histone deacetylase 1 0.0219 0.0169 0.0166
Brugia malayi Cytochrome P450 family protein 0.0036 0.0018 0.0018
Loa Loa (eye worm) histone deacetylase 7A 0.0263 0.0206 0.0203
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0006 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0308 0.0243 0.0932
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0088 0.0061 0.699
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0023 0.2282
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0006 0.0003
Schistosoma mansoni histone deacetylase 0.0219 0.0169 0.0644
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0041 0.0022 0.0071
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0001
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0022 0.0006 0.0011
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0006 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0088 0.0061 0.2856
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.002 0.0004 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0007 0.0002
Mycobacterium leprae Probable lipase LipE 0.0042 0.0023 0.2282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0042 0.0151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0023 0.0075
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.002
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0024 0.0079
Schistosoma mansoni histone deacetylase 1 2 3 0.0109 0.0079 0.0292
Entamoeba histolytica hypothetical protein 0.0051 0.003 0.0027
Loa Loa (eye worm) matrix metalloproteinase 0.0096 0.0067 0.0064
Schistosoma mansoni cpg binding protein 0.0023 0.0007 0.0014
Trypanosoma cruzi histone deacetylase 1, putative 0.0219 0.0169 0.0166
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0163 0.0123 0.012
Toxoplasma gondii thioredoxin reductase 0.0035 0.0016 0.0013
Echinococcus granulosus thyroid hormone receptor alpha 0.0145 0.0108 0.0408
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0041 0.0022 0.0071
Leishmania major trypanothione reductase 0.0035 0.0016 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0308 0.0243 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0308 0.0243 0.0243
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0226 0.0223
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0018 0.0057
Echinococcus multilocularis Niemann Pick C1 protein 0.0078 0.0053 0.0192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.0211 1
Plasmodium vivax histone deacetylase 2, putative 0.0263 0.0206 0.0786
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0308 0.0243 0.0932
Leishmania major hypothetical protein, conserved 0.0023 0.0007 0.0004
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.002
Brugia malayi glutathione reductase 0.0035 0.0016 0.0016
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0041 0.0022 0.0018
Onchocerca volvulus Phospholipase A2 homolog 0.012 0.0087 0.0326
Echinococcus granulosus integrin alpha 3 0.0084 0.0057 0.0209
Brugia malayi Telomerase reverse transcriptase 0.0541 0.0437 0.0437
Schistosoma mansoni integrin alpha-ps 0.0049 0.0028 0.0097
Brugia malayi RNA binding protein 0.0043 0.0024 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0023 0.1053
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 1.2046 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0042 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0024 0.0079
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.3121 0.2582 0.2579
Trypanosoma brucei nadh-ubiquinone oxidoreductase 39 kda subunit 0.002 0.0004 0.0001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0024 0.0079
Echinococcus granulosus GPCR family 2 0.0025 0.0008 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0308 0.0243 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0145 0.0108 0.0408
Loa Loa (eye worm) matrixin family protein 0.0213 0.0165 0.0162
Echinococcus granulosus histone deacetylase 6 0.0263 0.0206 0.0786
Loa Loa (eye worm) hypothetical protein 0.0096 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0083 0.0056 0.0056
Brugia malayi hypothetical protein 0.0145 0.0108 0.0108
Schistosoma mansoni histone deacetylase 4 5 0.0263 0.0206 0.0786
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0022 0.0006 0.0011
Echinococcus multilocularis histone deacetylase 6 0.0281 0.0221 0.0846
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0001
Trypanosoma cruzi histone deacetylase, putative 0.0109 0.0079 0.0075
Schistosoma mansoni patched 1 0.0034 0.0016 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0308 0.0243 0.0243
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0016 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0308 0.0243 0.024
Loa Loa (eye worm) hypothetical protein 0.0163 0.0123 0.012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0079 0.0054 0.005
Onchocerca volvulus 0.3121 0.2582 1
Leishmania major telomerase reverse transcriptase, putative 0.0203 0.0157 0.0153
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0117 0.0085 0.4009
Trypanosoma cruzi histone deacetylase, putative 0.0263 0.0206 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0049 0.0048
Brugia malayi Matrixin family protein 0.0096 0.0067 0.0067
Echinococcus granulosus expressed conserved protein 0.0074 0.0049 0.0177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0023 0.1053
Mycobacterium ulcerans lipase LipD 0.0042 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0308 0.0243 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0007 0.0004
Brugia malayi TAR-binding protein 0.0043 0.0024 0.0024
Trichomonas vaginalis dihydroflavonal-4-reductase, putative 0.002 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0308 0.0243 0.0243
Schistosoma mansoni RAR-like nuclear receptor 0.0308 0.0243 0.0932
Loa Loa (eye worm) hypothetical protein 0.0083 0.0056 0.0053
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0015
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0007 0.5
Trypanosoma cruzi histone deacetylase, putative 0.0109 0.0079 0.0075
Loa Loa (eye worm) nuclear receptor NHR-67 0.0145 0.0108 0.0105
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0127 0.0094 0.035
Echinococcus multilocularis geminin 0.0116 0.0084 0.0314
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.3121 0.2582 0.2579
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0016 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0007 0.0289
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0004 0.0001
Giardia lamblia Telomerase catalytic subunit 0.0203 0.0157 0.0584
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0042 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0193 0.0148 0.0145
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0024 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0008 0.002
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0023 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0004 0.0001
Toxoplasma gondii histone deacetylase HDAC1 0.0263 0.0206 0.0203
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0024 0.0079

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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