Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1955 | 0.2325 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0894 | 0.0667 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3853 | 0.2673 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1214 | 0.1287 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1955 | 0.1847 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1955 | 0.1847 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.8037 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4261 | 0.4413 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Schistosoma mansoni | lamin | 0.0033 | 0.1955 | 0.2432 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1955 | 0.2432 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.1955 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3864 | 0.3972 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1214 | 0.1287 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1955 | 0.2325 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1872 | 0.1755 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0397 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9283 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3456 | 0.4427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7437 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0294 | 0.0366 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0717 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1955 | 0.1847 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1214 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4581 | 0.4769 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1955 | 0.2325 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0717 | 0.0592 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1955 | 0.0411 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0894 | 0.1112 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0294 | 0.0366 |
Schistosoma mansoni | lamin | 0.0033 | 0.1955 | 0.2432 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1955 | 0.0411 |
Onchocerca volvulus | 0.0033 | 0.1955 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (binding) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.