Detailed information for compound 134444

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.474 | Formula: C24H26N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1Cn1ccc2c1cc(cc2)N(C1CCCC1)C(=O)C)C(=O)O
  • InChi: 1S/C24H26N2O4/c1-16(27)26(20-5-3-4-6-20)21-10-9-17-11-12-25(22(17)14-21)15-19-8-7-18(24(28)29)13-23(19)30-2/h7-14,20H,3-6,15H2,1-2H3,(H,28,29)
  • InChiKey: MTXSMUKOMZOKGH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0486 0.7275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0182 0.067
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Treponema pallidum thioredoxin reductase (trxB) 0.0145 0.0661 0.2231
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0283 0.1043
Mycobacterium tuberculosis Probable reductase 0.0356 0.1724 0.4567
Loa Loa (eye worm) hypothetical protein 0.0082 0.0344 0.1007
Echinococcus granulosus serine protein kinase ATM 0.0017 0.002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0023 0.0065
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0278 0.0401
Trypanosoma brucei trypanothione reductase 0.0692 0.3416 0.3416
Loa Loa (eye worm) hypothetical protein 0.0069 0.0279 0.0815
Onchocerca volvulus 0.0483 0.2367 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0093 0.0134
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0082 0.0184
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi Flap endonuclease-1 0.0026 0.0066 0.0191
Brugia malayi Muscleblind-like protein 0.0149 0.0685 0.2005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0545 0.2675 0.7832
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0044 0.0038
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0545 0.2675 0.3859
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0015 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.04 0.1948 0.5701
Brugia malayi Dopamine receptor 0.0016 0.0015 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0191 0.0376
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.004 0.0057
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0145 0.0661 0.2357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0206 0.0758
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0015 0.0042
Onchocerca volvulus 0.004 0.0133 0.0502
Echinococcus multilocularis cpg binding protein 0.0061 0.0241 0.0347
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0545 0.2675 1
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0015 0.002
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0145 0.0661 0.0953
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0278 0.0401
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0015 0.002
Brugia malayi Inositol-1 0.0074 0.0308 0.09
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1679 0.8389 0.8385
Schistosoma mansoni biogenic amine receptor 0.0016 0.0015 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0134
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0034 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0545 0.2675 0.3859
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0015 0.002
Echinococcus granulosus neuropeptide receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) histone methyltransferase 0.002 0.0034 0.01
Schistosoma mansoni opsin-like receptor 0.0016 0.0015 0.002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0439 0.1283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0661 0.0642
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0145 0.0661 0.1492
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0145 0.0661 0.0953
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0245 0.0353
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0069 0.0278 0.0813
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0015 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.001
Echinococcus multilocularis musashi 0.0056 0.0217 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0145 0.0661 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0145 0.0661 0.0633
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0023 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0242 0.0893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0943 0.4681 0.6752
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0145 0.0661 0.0953
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0082 0.0184
Echinococcus multilocularis muscleblind protein 0.0149 0.0685 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0023 0.0065
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0085 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0182 0.067
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.003 0.0029
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0044 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0023 0.0065
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0044 0.0053
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0044 0.0053
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0545 0.2675 0.3859
Schistosoma mansoni cpg binding protein 0.0061 0.0241 0.0347
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0545 0.2675 0.9886
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0015 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0356 0.0513
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0093 0.0134
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0049 0.007
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0145 0.0661 0.0661
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0023 0.0032
Brugia malayi Thioredoxin reductase 0.0692 0.3416 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0145 0.0661 0.0953
Loa Loa (eye worm) blistered cuticle protein 3 0.0073 0.0299 0.0874
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0145 0.0661 0.0661
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.004 0.0057
Brugia malayi RE15519p 0.0016 0.0015 0.0042
Loa Loa (eye worm) doublecortin family protein 0.004 0.0133 0.0387
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0015 0.002
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0105 0.0085
Schistosoma mansoni hypothetical protein 0.0069 0.0279 0.0401
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.004 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0093 0.0082
Trichomonas vaginalis glutathione reductase, putative 0.0545 0.2675 0.9887
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0181 0.0669
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni neuropeptide receptor 0.0016 0.0015 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0023 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0093 0.0134
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0044 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0044 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0145 0.0661 0.0642
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.004 0.0057
Trichomonas vaginalis glutamate synthase, putative 0.0145 0.0661 0.2441
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0486 0.1796
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni hypothetical protein 0.0824 0.4082 0.5888
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0015 0.002
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0082 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0023 0.0065
Echinococcus granulosus flap endonuclease 1 0.0026 0.0066 0.0094
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0145 0.0661 0.0953
Mycobacterium tuberculosis Probable dehydrogenase 0.0356 0.1724 0.4567
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.003 0.0043
Schistosoma mansoni lamin 0.0056 0.0217 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0073
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0145 0.0661 0.1934
Brugia malayi glutamate synthase 0.0145 0.0661 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0181 0.0669
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.003 0.011
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.0374 0.0539
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0023 0.0032
Toxoplasma gondii selenide, water dikinase 0.0145 0.0661 0.1887
Schistosoma mansoni inositol monophosphatase 0.0074 0.0308 0.0443
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0133 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0208 0.0768
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0015 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.0074 0.0107
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0093 0.0169
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.003 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0015 0.002
Echinococcus granulosus somatostatin receptor 0.0016 0.0015 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0023 0.0065
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0486 0.1796
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0023 0.0065
Echinococcus multilocularis sex peptide receptor 0.0016 0.0015 0.002
Brugia malayi Blistered cuticle protein 3 0.0073 0.0299 0.0874
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.004 0.0057
Schistosoma mansoni biogenic amine receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0278 0.0813
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0081 0.034 0.0994
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1999 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0308 0.0847
Leishmania major cytochrome p450-like protein 0.0022 0.0044 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Onchocerca volvulus 0.015 0.0689 0.2866
Brugia malayi cytochrome P450 0.0022 0.0044 0.0129
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0015 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi CXXC zinc finger family protein 0.0058 0.0224 0.0656
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.0374 0.0539
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0308 0.1136
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0133 0.02
Schistosoma mansoni flap endonuclease-1 0.0024 0.0053 0.0076
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0015 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0044 0.0129
Schistosoma mansoni rab6-interacting 0.004 0.0133 0.0191
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0145 0.0661 0.2357
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.004 0.0146
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0308 0.0288
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.002 0.0058
Brugia malayi steroid hormone receptor 0.0018 0.0023 0.0065
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0133 0.0191
Echinococcus multilocularis jun protein 0.0084 0.0356 0.0513
Brugia malayi larval opioid receptor 0.0016 0.0015 0.0042
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0066 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0015 0.002
Schistosoma mansoni amine GPCR 0.0016 0.0015 0.002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0354 0.1717 0.2476
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0044 0.0038
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0278 0.0401
Brugia malayi G-protein coupled receptor 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Trichomonas vaginalis apoptosis inducing factor, putative 0.0145 0.0661 0.2441
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni microtubule-associated protein tau 0.139 0.6933 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0073 0.03 0.027
Loa Loa (eye worm) inositol-1 0.0074 0.0308 0.09
Schistosoma mansoni lipoxygenase 0.0166 0.0768 0.1107
Plasmodium falciparum ferrodoxin reductase-like protein 0.0145 0.0661 0.1777
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0015 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0545 0.2675 0.2661
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0091 0.0394 0.5829
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0023 0.0032
Onchocerca volvulus 0.0056 0.0217 0.086
Plasmodium falciparum thioredoxin reductase 0.0692 0.3416 1
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0074 0.0107
Brugia malayi G protein-coupled receptor 0.0016 0.0015 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Schistosoma mansoni neuropeptide receptor 0.0016 0.0015 0.002
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0066 0.0134
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0082 0.0973
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0087 0.0057
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.004 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0044 0.0038
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0093 0.0215
Trypanosoma brucei NADH dehydrogenase 0.0145 0.0661 0.0661
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0015 0.002
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0237 0.1127 0.1625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni glutamate synthase 0.0145 0.0661 0.0953
Schistosoma mansoni lamin 0.0056 0.0217 0.0312
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0093 0.0093
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0066 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0545 0.2675 0.779
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.003 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0058
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0087 0.0126
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0015 0.002
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0044 0.0038
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0486 0.7275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0057 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0486 0.1796
Loa Loa (eye worm) programmed cell death 8 0.0145 0.0661 0.1934
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus intermediate filament protein 0.0056 0.0217 0.0312
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0299 0.1105
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.004 0.0057
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0023 0.0032
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0044 0.0038
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0145 0.0661 0.1934
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Schistosoma mansoni cpg binding protein 0.0058 0.0224 0.0323
Loa Loa (eye worm) hypothetical protein 0.0056 0.0217 0.0634
Treponema pallidum oxidoreductase 0.0145 0.0661 0.2231
Loa Loa (eye worm) hypothetical protein 0.015 0.0689 0.2016
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0015 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1465 0.731 0.7305
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0356 0.1724 0.4546
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0015 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0017 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0145 0.0661 1
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0023 0.0032
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.004 0.0057
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0093 0.0271
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0308 0.0443
Plasmodium vivax thioredoxin reductase, putative 0.0692 0.3416 1
Echinococcus multilocularis 0.0022 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Brugia malayi Melatonin receptor type 1A 0.0016 0.0015 0.0042
Brugia malayi glutaminase DH11.1 0.0551 0.2706 0.7922
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0308 0.0288
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0044 0.0038
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0486 0.0701
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0486 0.0486
Brugia malayi GnHR receptor homolog 0.0016 0.0015 0.0042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0692 0.3416 0.4926
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0044 0.0053
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0486 0.0701
Echinococcus granulosus orexin receptor type 2 0.0016 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0134
Loa Loa (eye worm) carboxylesterase 0.0069 0.0278 0.0813
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.003 0.0087
Schistosoma mansoni rab6-interacting 0.004 0.0133 0.0191
Loa Loa (eye worm) hypothetical protein 0.004 0.0133 0.0387
Entamoeba histolytica disulphide oxidoreductase, putative 0.0145 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0394 0.1454
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0085 0.0248
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0145 0.0661 0.1777
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0015 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.003
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0105 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0017 0.0023
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0486 0.1705
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0356 0.1724 0.4567
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0023 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0206 0.0758
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0015 0.002
Brugia malayi MH2 domain containing protein 0.0116 0.0519 0.152
Brugia malayi Dopamine receptor protein 1 0.0016 0.0015 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0015 0.002
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0145 0.0661 0.2441
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0044 0.0044
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0015 0.002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0145 0.0661 0.1934
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0015 0.002
Treponema pallidum NADH oxidase 0.0545 0.2675 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0545 0.2675 1
Mycobacterium ulcerans glutaminase 0.0551 0.2706 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0145 0.0661 0.2357
Schistosoma mansoni amine GPCR 0.0016 0.0015 0.002
Plasmodium falciparum glutathione reductase 0.0692 0.3416 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0232 0.0856
Brugia malayi Serotonin receptor 0.0016 0.0015 0.0042
Echinococcus granulosus neuropeptide s receptor 0.0943 0.4681 0.6752
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0074 0.0107
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0145 0.0661 0.2357
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0023 0.0032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0082 0.0051
Leishmania major cytochrome p450-like protein 0.0022 0.0044 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0023 0.0065
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0268 0.0642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0124 0.0124
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0044 0.0129
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0145 0.0661 0.1669
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0245 0.0353
Echinococcus multilocularis tumor protein p63 0.1026 0.5098 0.7353
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0015 0.0042
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0015 0.002
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0145 0.0661 0.1669
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0023 0.0032
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0044 0.0053
Brugia malayi hypothetical protein 0.0066 0.0265 0.0775
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0756 0.3738 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0486 0.1557
Echinococcus granulosus acetylcholinesterase 0.0069 0.0278 0.0401
Echinococcus granulosus allatostatin A receptor 0.0016 0.0015 0.002
Schistosoma mansoni cpg binding protein 0.0061 0.0241 0.0347
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0145 0.0661 0.2441
Echinococcus granulosus acetylcholinesterase 0.0069 0.0278 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Echinococcus multilocularis RUN 0.004 0.0133 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0044 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0023 0.0065
Echinococcus granulosus sex peptide receptor 0.0016 0.0015 0.002
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0145 0.0661 0.1669
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0133 0.0191
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0756 0.3738 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0756 0.3738 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0044 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0661 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0023 0.0065
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0145 0.0661 0.2441
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0015 0.002
Schistosoma mansoni polycystin 1-related 0.004 0.0133 0.0191
Brugia malayi Cytochrome P450 family protein 0.0022 0.0044 0.0129
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0145 0.0661 0.1701
Trichomonas vaginalis set domain proteins, putative 0.0483 0.2367 0.8749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0212 0.0619
Brugia malayi Carboxylesterase family protein 0.0069 0.0278 0.0813
Echinococcus granulosus serotonin receptor 0.0016 0.0015 0.002
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0145 0.0661 0.0953
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0015 0.002
Echinococcus multilocularis neuropeptide s receptor 0.0943 0.4681 0.6752
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.007
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0015 0.002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0093 0.0073
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0308 0.0443
Leishmania major hypothetical protein, conserved 0.0145 0.0661 0.0633
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0093 0.0134
Loa Loa (eye worm) hypothetical protein 0.0321 0.1548 0.4531
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0015 0.0042
Brugia malayi neuropeptide F receptor 0.0016 0.0015 0.0042
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0545 0.2675 0.7134
Brugia malayi AKH receptor 0.0016 0.0015 0.0042
Schistosoma mansoni adenoreceptor 0.0016 0.0015 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0023 0.0065
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0145 0.0661 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.003 0.0043
Trypanosoma cruzi NADH dehydrogenase, putative 0.0145 0.0661 0.0642
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0066 0.0035
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0015 0.002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0237 0.1127 0.1625
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0439 0.1283
Brugia malayi Cytochrome P450 family protein 0.0022 0.0044 0.0129
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0145 0.0661 0.0661
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0015 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.002 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.2073 0.6068
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0486 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0023 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.0074 0.0107
Brugia malayi sulfakinin receptor protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0091 0.0394 0.0374
Brugia malayi Dopamine receptor protein 2 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0087
Echinococcus granulosus cpg binding protein 0.0061 0.0241 0.0347
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0082 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0093 0.0134
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.4061 0.5857
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0015 0.002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0283 0.1043
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0145 0.0661 0.0633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.001
Onchocerca volvulus 0.0066 0.0265 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0023 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0023 0.0065
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0145 0.0661 0.0642
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0023 0.0032
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.003 0.003
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.04 0.1948 0.5701
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0023 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0023 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0145 0.0661 0.1701
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0661 0.0642
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0145 0.0661 0.2441
Brugia malayi nuclear receptor NHR-88 0.0018 0.0023 0.0065
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0015 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0208 0.0768
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0217 0.0634
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0268 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0074 0.0107
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0145 0.0661 0.0642
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0145 0.0661 0.2357
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0044 0.0038
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.004 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0394 0.1454
Schistosoma mansoni glutaminase 0.0551 0.2706 0.3903
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0087 0.0126
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0017 0.0023
Echinococcus multilocularis serotonin receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0025 0.0035
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0082 0.0304
Schistosoma mansoni inositol monophosphatase 0.0074 0.0308 0.0443
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0015 0.002
Leishmania major hypothetical protein, conserved 0.0145 0.0661 0.0633
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0145 0.0661 0.0953
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0015 0.0042
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.002
Brugia malayi neuropeptide F receptor 0.0016 0.0015 0.0042
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0545 0.2675 0.2675
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0015 0.002
Schistosoma mansoni cytochrome P450 0.0022 0.0044 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Brugia malayi hypothetical protein 0.004 0.0133 0.0387
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0023 0.0034
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0015 0.0042
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0145 0.0661 1
Echinococcus granulosus RUN 0.004 0.0133 0.0191
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0145 0.0661 0.1887
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0023 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0015 0.002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0017 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0308 0.1037
Mycobacterium tuberculosis Probable oxidoreductase 0.0756 0.3738 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0245 0.0717
Echinococcus multilocularis neuropeptide receptor A26 0.0943 0.4681 0.6752
Echinococcus granulosus fmrfamide receptor 0.0016 0.0015 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.011
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0486 0.0457
Plasmodium vivax SET domain protein, putative 0.0062 0.0245 0.0537
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Toxoplasma gondii NADPH-glutathione reductase 0.0545 0.2675 0.782
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0015 0.0042
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0015 0.0042
Toxoplasma gondii target of rapamycin (TOR), putative 0.0068 0.0276 0.0752
Schistosoma mansoni neuropeptide receptor 0.0016 0.0015 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0149 0.0685 0.2005
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0145 0.0661 0.1887
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni DNA polymerase eta 0.0019 0.003 0.0043
Schistosoma mansoni myosin xvIII 0.0016 0.0015 0.002
Mycobacterium ulcerans glutamate synthase subunit beta 0.0145 0.0661 0.2357
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0091 0.0394 0.0567
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0145 0.0661 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0044 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0093 0.0134
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.1278 0.3741
Brugia malayi 6-phosphofructokinase 0.011 0.0486 0.1423
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0356 0.1724 0.4567
Schistosoma mansoni loxhd1 0.004 0.0133 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0245 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0245 0.0353
Onchocerca volvulus 0.0056 0.0217 0.086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0356 0.0513
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0191 0.0172
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0044 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1465 0.731 0.731
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.004 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0023 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0322
Echinococcus granulosus jun protein 0.0084 0.0356 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0182 0.067
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0145 0.0661 0.0953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0145 0.0661 0.2357
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0545 0.2675 1
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0299 0.1105
Plasmodium falciparum glutathione reductase 0.0545 0.2675 0.779
Toxoplasma gondii thioredoxin reductase 0.0692 0.3416 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0091 0.0394 0.0374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0023 0.0032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0093 0.0134
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0545 0.2675 0.9886
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0015 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Plasmodium vivax glutathione reductase, putative 0.0692 0.3416 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Brugia malayi Serotonin receptor 0.0016 0.0015 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1999 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0023 0.0032
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0015 0.002
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0145 0.0661 0.1669
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0545 0.2675 0.2661
Echinococcus multilocularis lamin 0.0056 0.0217 0.0312
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0015 0.002
Echinococcus granulosus dna polymerase kappa 0.0019 0.003 0.0043
Brugia malayi hypothetical protein 0.004 0.0133 0.0387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) glutaminase 0.0551 0.2706 0.7922
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0023 0.0032
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0044 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0093 0.0271
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Leishmania major hypothetical protein, conserved 0.0051 0.0191 0.0162
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0044 0.0053
Echinococcus granulosus glutamate synthase 0.0145 0.0661 0.0953
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0023 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0044 0.0038
Brugia malayi hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi Cytochrome P450 family protein 0.0022 0.0044 0.0129
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0145 0.0661 0.1777
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0023 0.0065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0562 0.081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1999 1 1
Plasmodium vivax ferrodoxin reductase, putative 0.0145 0.0661 0.1777
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0015 0.002
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0044 0.0038
Echinococcus granulosus dnaJ subfamily B 0.0824 0.4082 0.5888
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0145 0.0661 1
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.4082 0.5888
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0023 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0299 0.1105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1679 0.8389 0.8385
Brugia malayi glutathione reductase 0.0692 0.3416 1
Echinococcus multilocularis microtubule associated protein 2 0.139 0.6933 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0145 0.0661 0.2357
Schistosoma mansoni jun-related protein 0.0068 0.0277 0.0399
Loa Loa (eye worm) cytochrome P450 0.0022 0.0044 0.0129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0091 0.0394 0.0394
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0023 0.0032
Echinococcus granulosus tumor protein p63 0.1026 0.5098 0.7353
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0023 0.0032
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0066 0.0709
Loa Loa (eye worm) hypothetical protein 0.0149 0.0685 0.2005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Trichomonas vaginalis glutamate synthase, putative 0.0145 0.0661 0.2441
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0145 0.0661 0.1492
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.004 0.0057
Brugia malayi hypothetical protein 0.0051 0.0191 0.0559
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0044 0.0053
Brugia malayi Cytochrome P450 family protein 0.0022 0.0044 0.0129
Schistosoma mansoni lipoxygenase 0.0237 0.1127 0.1625
Echinococcus granulosus g protein coupled receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.007 0.0204
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0486 0.0701
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0559
Onchocerca volvulus 0.0062 0.0245 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0044 0.0024
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.004 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0093 0.0271
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0091 0.0394 0.0365
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0044 0.0014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0044 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0023 0.0065
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0145 0.0661 0.0953
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0049 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0127 0.0371
Giardia lamblia Thioredoxin reductase 0.0145 0.0661 0.2384
Echinococcus granulosus microtubule associated protein 2 0.139 0.6933 1
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.002
Schistosoma mansoni opsin-like receptor 0.0016 0.0015 0.002
Giardia lamblia Glutamate synthase 0.0145 0.0661 0.2384
Brugia malayi Carboxylesterase family protein 0.0069 0.0278 0.0813
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0182 0.067
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0015 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0015 0.002
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0308 0.4487
Echinococcus multilocularis GPCR, family 2 0.0032 0.0093 0.0134
Entamoeba histolytica thioredoxin reductase, putative 0.0145 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni neuropeptide receptor 0.0016 0.0015 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0023 0.0032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1465 0.731 0.7302
Brugia malayi hypothetical protein 0.0123 0.0553 0.1617
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0145 0.0661 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0322
Onchocerca volvulus 0.004 0.0133 0.0502
Schistosoma mansoni hypothetical protein 0.0022 0.0044 0.0064
Schistosoma mansoni hypothetical protein 0.0068 0.0277 0.0399
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0133 0.0191
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0015 0.0042
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.004 0.0116
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0087 0.0255
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0044 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0023 0.0065
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0145 0.0661 0.1701
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0356 0.1724 0.4567
Echinococcus multilocularis lamin dm0 0.0056 0.0217 0.0312
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0308 0.1136
Mycobacterium ulcerans dehydrogenase 0.0145 0.0661 0.2357
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0145 0.0661 0.1887
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0308 0.0278
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0015 0.002
Mycobacterium ulcerans hypothetical protein 0.0145 0.0661 0.2357
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0023 0.0032
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0082 0.0051
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.004 0.0057
Schistosoma mansoni glutamate synthase 0.0145 0.0661 0.0953
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0066 0.0191
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0093 0.0271
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0191 0.0376
Echinococcus multilocularis glutamate synthase 0.0145 0.0661 0.0953
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0486 0.1796
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0145 0.0661 0.0953
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1465 0.731 0.7305
Echinococcus multilocularis somatostatin receptor 0.0016 0.0015 0.002
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0028 0.0074 0.0216
Trypanosoma cruzi trypanothione reductase, putative 0.0545 0.2675 0.2661
Brugia malayi phosphofructokinase 0.011 0.0486 0.1423
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0145 0.0661 0.1701
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0145 0.0661 0.1887
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0145 0.0661 0.0642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0093 0.0134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0087 0.0255
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0145 0.0661 0.1701
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0308 0.0308
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0145 0.0661 0.0953
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0545 0.2675 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0015 0.002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0015 0.002
Leishmania major trypanothione reductase 0.0692 0.3416 0.3396
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0044 0.0053
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0087 0.0087
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0044 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0015 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0015 0.002
Echinococcus granulosus g protein coupled receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0044 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.003 0.001
Echinococcus granulosus g protein coupled receptor 0.0016 0.0015 0.002
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0044 0.0038
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0145 0.0661 0.2441
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0191 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0093 0.0271
Leishmania major ferric reductase, putative 0.0034 0.0105 0.0075
Brugia malayi hypothetical protein 0.0033 0.01 0.0291
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0023 0.0032
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0145 0.0661 0.1701
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0023 0.0032
Brugia malayi nuclear hormone receptor 0.0018 0.0023 0.0065
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0015 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0015 0.002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0044 0.0053
Brugia malayi 6-phosphofructokinase 0.011 0.0488 0.1426
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0692 0.3416 0.913
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) glutaminase 2 0.0551 0.2706 0.7922
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trypanosoma cruzi NADH dehydrogenase, putative 0.0145 0.0661 0.0642
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0015 0.002
Brugia malayi follicle stimulating hormone receptor 0.0267 0.1278 0.3741
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0015 0.002
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.003 0.0087
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0015 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0015 0.002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.004 0.0146
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0228 0.0328
Brugia malayi intermediate filament protein 0.0056 0.0217 0.0634
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0023 0.0032
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0015 0.002
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0074 0.0216
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0023 0.0065
Schistosoma mansoni intermediate filament proteins 0.0056 0.0217 0.0312
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0044 0.0053
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0032 0.0093 0.0134
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0133 0.02
Trichomonas vaginalis mercuric reductase, putative 0.0545 0.2675 0.9887
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0191 0.0376
Schistosoma mansoni hypothetical protein 0.0145 0.0661 0.0953
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0091 0.0394 0.1152
Trichomonas vaginalis glutaminase, putative 0.0551 0.2706 1
Schistosoma mansoni sulfide quinone reductase 0.0145 0.0661 0.0953
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.002 0.0029
Schistosoma mansoni coup transcription factor 0.0018 0.0023 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0044 0.0038
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0015 0.002
Schistosoma mansoni disulfide oxidoreductase 0.0145 0.0661 0.0953
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0145 0.0661 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0208 0.0768
Loa Loa (eye worm) glutathione reductase 0.0692 0.3416 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0133 0.0387
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0486 0.0701
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0093 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni glutamate synthase 0.0145 0.0661 0.0953
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0015 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0245 0.0353
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0074 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0545 0.2675 0.779
Giardia lamblia GTOR 0.0091 0.0394 0.1374
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0044 0.0053
Leishmania major NADH dehydrogenase, putative 0.0145 0.0661 0.0633
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0145 0.0661 0.2384
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.007 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0519 0.152
Schistosoma mansoni histamine h1 receptor 0.0016 0.0015 0.002
Onchocerca volvulus 0.0058 0.0224 0.0892
Leishmania major cytochrome p450-like protein 0.0022 0.0044 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0044 0.0038
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0044 0.0129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0224 0.0656
Echinococcus granulosus GPCR family 2 0.0032 0.0093 0.0134
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0034 0.0105 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0044 0.0024
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0015 0.0042
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0191 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0276 0.1017
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0044 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0394 0.1454
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0519 0.152
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.002 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0685 0.0988
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.003 0.011
Onchocerca volvulus 0.0145 0.0661 0.2747
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0091 0.0394 0.5829
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0133 0.0191
Onchocerca volvulus 0.0018 0.0023 0.0034
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0023 0.0032
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0015 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0023 0.0032
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0217 0.0634
Onchocerca volvulus Dual oxidase homolog 0.0073 0.0299 0.1208
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.007 0.01
Brugia malayi Pre-SET motif family protein 0.0425 0.2073 0.6068
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0023 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0191 0.0172
Mycobacterium ulcerans ferredoxin reductase 0.0145 0.0661 0.2357
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1679 0.8389 0.8384
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0073 0.03 0.03
Mycobacterium ulcerans monoxygenase 0.0145 0.0661 0.2357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0326 0.1205
Plasmodium falciparum thioredoxin reductase 0.0545 0.2675 0.779
Loa Loa (eye worm) phosphatidylinositol 3 0.0091 0.0394 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0181 0.0669
Trypanosoma cruzi trypanothione reductase, putative 0.0692 0.3416 0.3403
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0081 0.034 0.0994
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0087 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0034 0.0049
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0044 0.0053
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0091 0.0394 0.0567
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0217 0.0634
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0486 0.1423
Brugia malayi Doublecortin family protein 0.004 0.0133 0.0387
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0145 0.0661 0.1777
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0015 0.0042
Schistosoma mansoni sulfide quinone reductase 0.0145 0.0661 0.0953
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0015 0.002
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0145 0.0661 0.0661
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0015 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0439 0.1283
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0066 0.0094
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0023 0.0032
Echinococcus multilocularis geminin 0.0354 0.1717 0.2476
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0486 0.1196
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.004 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0093 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0023 0.0065
Echinococcus granulosus lamin 0.0056 0.0217 0.0312
Loa Loa (eye worm) hypothetical protein 0.0069 0.0278 0.0813
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0015 0.002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0278 0.0401
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0091 0.0394 0.0365
Echinococcus granulosus thioredoxin glutathione reductase 0.0692 0.3416 0.4926
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni hypothetical protein 0.0354 0.1717 0.2476
Trypanosoma brucei unspecified product 0.0019 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0073
Mycobacterium ulcerans NADH dehydrogenase 0.0145 0.0661 0.2357
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0279 0.0815
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0044 0.0053
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0145 0.0661 0.1492
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0044 0.0053
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0081 0.034 0.049
Trypanosoma cruzi target of rapamycin kinase 3 0.0073 0.03 0.028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0093 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0023 0.0032
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0486 0.7275
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0093 0.0134
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0066 0.0134
Echinococcus granulosus hypothetical protein 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0015 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0023 0.0034
Brugia malayi ecdysteroid receptor 0.0018 0.0023 0.0065
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0486 0.123
Schistosoma mansoni biogenic amine receptor 0.0016 0.0015 0.002
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0278 0.0401
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0087 0.0087
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.003 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0093 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.003 0.001
Schistosoma mansoni cellular tumor antigen P53 0.015 0.0689 0.0993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0044 0.0038
Schistosoma mansoni opsin-like receptor 0.0016 0.0015 0.002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0091 0.0394 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0299 0.1105
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0044 0.0024
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0044 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0015 0.002
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0015 0.002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.003 0.003
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0145 0.0661 0.0953
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0545 0.2675 0.2653
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1679 0.8389 0.8389
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0044 0.0053
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0545 0.2675 0.779
Loa Loa (eye worm) thioredoxin reductase 0.0692 0.3416 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Brugia malayi Pre-SET motif family protein 0.0062 0.0245 0.0717
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0015 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0015 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0545 0.2675 0.779
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0356 0.1724 0.4567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.0322
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0015 0.0042
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0023 0.0034
Brugia malayi putative neuropeptide receptor 0.0016 0.0015 0.0042
Echinococcus granulosus lamin dm0 0.0056 0.0217 0.0312
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0145 0.0661 0.1777
Schistosoma mansoni amine GPCR 0.0016 0.0015 0.002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0087 0.0067
Brugia malayi isocitrate dehydrogenase 0.0032 0.0093 0.0271
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0082 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0299 0.1105
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0081 0.034 0.049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0545 0.2675 0.9886
Brugia malayi G-protein coupled receptor 0.0016 0.0015 0.0042
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0044 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.01 0.0439 0.1283
Echinococcus granulosus geminin 0.0354 0.1717 0.2476
Brugia malayi ORL1-like opioid receptor 0.0016 0.0015 0.0042
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0145 0.0661 0.1934
Chlamydia trachomatis thioredoxin reductase 0.0145 0.0661 0.2231
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0082 0.0184
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0093 0.0215
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.003 0.0043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0245 0.0353
Schistosoma mansoni amine GPCR 0.0016 0.0015 0.002
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.004 0.0116
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0044 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0245 0.0663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0245 0.0353
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0308 0.1136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0033 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0093 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0116
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0082 0.0304
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Echinococcus multilocularis dna polymerase kappa 0.0019 0.003 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0044 0.0038
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0087 0.0067
Brugia malayi bZIP transcription factor family protein 0.0084 0.0356 0.1041
Echinococcus granulosus dna polymerase eta 0.0019 0.003 0.0043
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0545 0.2675 0.782
Leishmania major hypothetical protein, conserved 0.0145 0.0661 0.0633
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0025 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0023 0.0065
Schistosoma mansoni hypothetical protein 0.0053 0.02 0.0288
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0091 0.0394 0.0394
Echinococcus granulosus muscleblind protein 0.0149 0.0685 0.0988
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.002 0.0029
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0093 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.003 0.0087
Echinococcus multilocularis serotonin receptor 0.0016 0.0015 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0015 0.0042
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0087 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0065
Loa Loa (eye worm) hypothetical protein 0.0071 0.0291 0.085
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0133 0.0191
Echinococcus granulosus neuropeptide receptor 0.0016 0.0015 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0015 0.002
Echinococcus multilocularis dna polymerase eta 0.0019 0.003 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0023 0.0032
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.004 0.0116
Schistosoma mansoni amine GPCR 0.0016 0.0015 0.002
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0015 0.002
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0017 0.002 0.002
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0486 0.1423
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0044 0.0044
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0496 0.1402
Loa Loa (eye worm) phosphofructokinase 0.011 0.0486 0.1423

Activities

Activity type Activity value Assay description Source Reference
Antagonism (functional) = 34 % In vitro antagonism of 8 nM of peptidoleukotriene (LTE4) induced contraction of guinea pig tracheal spirals at 1 X E-7M concentration ChEMBL. 2391686

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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