Detailed information for compound 1344443

Basic information

Technical information
  • TDR Targets ID: 1344443
  • Name: 6-(4-methoxyphenyl)-4-methyl-2-(2-morpholin-4 -ylethyl)-7,8-dihydropurino[8,7-b]imidazole-1 ,3-dione
  • MW: 426.469 | Formula: C21H26N6O4
  • H donors: 0 H acceptors: 3 LogP: 0.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CCn2c1nc1c2c(=O)n(c(=O)n1C)CCN1CCOCC1
  • InChi: 1S/C21H26N6O4/c1-23-18-17(19(28)27(21(23)29)8-7-24-11-13-31-14-12-24)26-10-9-25(20(26)22-18)15-3-5-16(30-2)6-4-15/h3-6H,7-14H2,1-2H3
  • InChiKey: PTJQVSGWRWCBNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-7,8-dihydropurino[8,7-b]imidazole-1,3-dione
  • 6-(4-methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)-7,8-dihydropurino[8,7-b]imidazole-1,3-quinone
  • MLS000084631
  • STOCK5S-29424
  • SMR000047297

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum importin beta, putative 0.0029 0.0109 0.0278
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.007
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0299 0.3146 0.957
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.3287 0.3287
Echinococcus granulosus chromobox protein 1 0.0071 0.0574 0.1746
Schistosoma mansoni kinase 0.0049 0.0327 0.0995
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.253 0.7695
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0022
Schistosoma mansoni inositol monophosphatase 0.0045 0.0282 0.0857
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0856 0.0856
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0299 0.3146 0.957
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0299 0.3146 0.3146
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0022
Trypanosoma brucei polo-like protein kinase 0.0096 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.004 0.0225 0.0225
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0909 1 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0299 0.3146 0.3146
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0909 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.0282 0.0282
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0282 0.0282
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0868 0.2641
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0182 0.0554
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0047 0.0047
Brugia malayi Bromodomain containing protein 0.003 0.0112 0.0112
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0047 0.0047
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0856 0.0856
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0574 0.0574
Brugia malayi Importin beta-1 subunit 0.0029 0.0109 0.0109
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0299 0.3146 0.3146
Schistosoma mansoni hypothetical protein 0.005 0.0341 0.1037
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0299 0.3146 0.3131
Echinococcus multilocularis chromobox protein 1 0.0071 0.0574 0.1746
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0109 0.0109
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0282 0.026
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0225 0.0372
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0341 0.0341
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0909 1 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0282 0.0857
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0242 0.0737
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0856 0.0856
Onchocerca volvulus 0.0299 0.3146 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0109 0.0109
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0299 0.3146 0.957
Plasmodium vivax hypothetical protein, conserved 0.003 0.0112 0.0289
Onchocerca volvulus 0.0031 0.0129 0.0055
Brugia malayi hypothetical protein 0.0244 0.253 0.253
Echinococcus multilocularis chromobox protein 1 0.0071 0.0574 0.1746
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0109 0.0087
Entamoeba histolytica hypothetical protein 0.0024 0.0047 0.0047
Schistosoma mansoni ran 0.0021 0.0022 0.0067
Echinococcus multilocularis snurportin 1 0.0312 0.3287 1
Brugia malayi Heterochromatin protein 1 0.0071 0.0574 0.0574
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0229 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0259 0.0483
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0856 0.0856
Brugia malayi PHD-finger family protein 0.003 0.0112 0.0112
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0229 0.5
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0644 0.196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0182 0.0554
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0299 0.3146 0.3146
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0282 0.0282
Leishmania major importin beta-1 subunit, putative 0.0024 0.0047 0.0047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0282 0.0282
Brugia malayi Synaptic glycoprotein SC2 0.0299 0.3146 0.3146
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0037 0.0198 0.0198
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0259 0.0259
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0242 0.0737
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0299 0.3146 0.3146
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0856 0.2605
Plasmodium vivax polyprenol reductase, putative 0.0299 0.3146 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0022 0.0067
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0182 0.0554
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0112 0.0342
Schistosoma mansoni survival motor neuron protein 0.005 0.0341 0.1037
Plasmodium vivax importin-beta 2, putative 0.0029 0.0109 0.0278
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0112 0.0091
Onchocerca volvulus 0.005 0.0341 0.0754
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0112 0.0342
Plasmodium falciparum phd finger protein, putative 0.003 0.0112 0.0289
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0299 0.3146 0.957
Mycobacterium ulcerans hypothetical protein 0.0909 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0244 0.253 0.253
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0856 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0299 0.3146 0.3146
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0282 0.0282
Entamoeba histolytica hypothetical protein 0.0037 0.0198 0.0198
Schistosoma mansoni chromobox protein 0.0071 0.0574 0.1746
Schistosoma mansoni ran 0.0021 0.0022 0.0067
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0112 0.0342
Echinococcus granulosus synaptic glycoprotein sc2 0.0299 0.3146 0.957
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0022
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0299 0.3146 0.3146
Brugia malayi hypothetical protein 0.0037 0.0198 0.0198
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0299 0.3146 1
Echinococcus granulosus snurportin 1 0.0312 0.3287 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0282 0.0857
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0022 0.0067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0198 0.0604
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0856 0.2605
Brugia malayi Inositol-1 0.0045 0.0282 0.0282
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0109 0.0331
Echinococcus granulosus importin subunit beta 1 0.0029 0.0109 0.0331
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0868 0.2641
Leishmania major GTP-binding protein, putative 0.0021 0.0022 0.0022
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0909 1 1
Plasmodium falciparum polyprenol reductase, putative 0.0299 0.3146 1
Schistosoma mansoni chromobox protein 0.0071 0.0574 0.1746
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0909 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0037 0.0198 0.0198
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0574 0.0574
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0198 0.0604
Schistosoma mansoni hypothetical protein 0.0037 0.0198 0.0604
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0282 0.0282
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0182 0.0554
Loa Loa (eye worm) hypothetical protein 0.0051 0.035 0.035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0856 0.2605
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0299 0.3146 0.3131
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0282 0.5
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0909 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0112 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0225 0.0225
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0112 0.0091
Schistosoma mansoni hypothetical protein 0.0312 0.3287 1
Echinococcus granulosus peregrin 0.003 0.0112 0.0342
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0299 0.3146 0.3146
Giardia lamblia Kinase, PLK 0.0096 0.0856 0.2722
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0259 0.0259
Brugia malayi jmjC domain containing protein 0.0097 0.0868 0.0868
Schistosoma mansoni importin beta-1 0.0029 0.0109 0.0331
Brugia malayi chromobox protein homolog 3 0.004 0.0225 0.0225
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0282 0.0282
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0225 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0299 0.3146 0.3146
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0909 1 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0909 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0112 0.0112
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0856 0.0856
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0282 0.0282
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0299 0.3146 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0909 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0909 1 1
Echinococcus granulosus chromobox protein 1 0.0071 0.0574 0.1746
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.253 0.7695
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0198 0.0604
Entamoeba histolytica Ran family GTPase 0.0021 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0095
Echinococcus multilocularis synaptic glycoprotein sc2 0.0299 0.3146 0.957
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0856 0.2453
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0299 0.3146 0.3146
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0182 0.0182
Brugia malayi jmjC domain containing protein 0.0036 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0299 0.3146 0.3146
Giardia lamblia Synaptic glycoprotein SC2 0.0299 0.3146 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0313 0.0313
Trichomonas vaginalis ran, putative 0.0021 0.0022 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0282 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0095 0.0095
Entamoeba histolytica hypothetical protein 0.0037 0.0198 0.0198
Brugia malayi RNA, U transporter 1 0.0083 0.0714 0.0714
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0299 0.3146 0.3146
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0856 0.0856
Giardia lamblia PHD finger protein 15 0.003 0.0112 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0299 0.3146 0.3146
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0047 0.0047
Echinococcus multilocularis peregrin 0.003 0.0112 0.0342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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