Detailed information for compound 1344910

Basic information

Technical information
  • TDR Targets ID: 1344910
  • Name: N-[2-(cyclopentylamino)-1-(4-morpholin-4-ylph enyl)-2-oxoethyl]-N-(phenylmethyl)furan-2-car boxamide
  • MW: 487.59 | Formula: C29H33N3O4
  • H donors: 1 H acceptors: 2 LogP: 4.33 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C(c1ccc(cc1)N1CCOCC1)C(=O)NC1CCCC1)Cc1ccccc1)c1ccco1
  • InChi: 1S/C29H33N3O4/c33-28(30-24-9-4-5-10-24)27(23-12-14-25(15-13-23)31-16-19-35-20-17-31)32(21-22-7-2-1-3-8-22)29(34)26-11-6-18-36-26/h1-3,6-8,11-15,18,24,27H,4-5,9-10,16-17,19-21H2,(H,30,33)
  • InChiKey: KPDGLDYXJILDTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(cyclopentylamino)-1-(4-morpholinophenyl)-2-oxo-ethyl]-N-(phenylmethyl)furan-2-carboxamide
  • N-[2-(cyclopentylamino)-1-(4-morpholinophenyl)-2-oxoethyl]-N-(phenylmethyl)-2-furancarboxamide
  • N-(benzyl)-N-[2-(cyclopentylamino)-2-keto-1-(4-morpholinophenyl)ethyl]-2-furamide
  • N-[2-(cyclopentylamino)-1-(4-morpholin-4-ylphenyl)-2-oxo-ethyl]-N-(phenylmethyl)furan-2-carboxamide
  • MLS000889257
  • Oprea1_737403
  • ASN 05256050
  • Furan-2-carboxylic acid benzyl-[cyclopentylcarbamoyl-(4-morpholin-4-yl-phenyl)-methyl]-amide
  • MLS000031053
  • SMR000004246

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1368 0.2776 0.2775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Loa Loa (eye worm) hypothetical protein 0.2515 0.5135 0.5134
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0011 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0159 0.0158
Plasmodium vivax vivapain-2 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0578 0.1149 0.2205
Echinococcus granulosus cysteine protease 0.1368 0.2776 0.2775
Echinococcus multilocularis acetylcholinesterase 0.007 0.0105 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.2097 0.4275 0.4263
Echinococcus granulosus GPCR family 2 0.0032 0.0025 0.0024
Trypanosoma cruzi metacaspase, putative 0.0044 0.005 0.0029
Schistosoma mansoni jumonji domain containing protein 0.0116 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0646 0.1289 0.248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Plasmodium falciparum metacaspase-like protein 0.0044 0.005 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0022 0.0002
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0578 0.1149 0.2918
Giardia lamblia Cathepsin B precursor 0.0578 0.1149 0.2918
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0023 0.0022
Echinococcus multilocularis protoporphyrinogen oxidase 0.0114 0.0194 0.0193
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0009
Echinococcus granulosus mitogen activated protein kinase 14 0.0131 0.023 0.0228
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Echinococcus multilocularis cysteine protease 0.2515 0.5135 0.5134
Schistosoma mansoni caspase-7 (C14 family) 0.0085 0.0134 0.0133
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Plasmodium falciparum serine repeat antigen 6 0.0578 0.1149 0.2205
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0116 0.0199 0.0197
Schistosoma mansoni amine oxidase 0.0114 0.0194 0.0193
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.023 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1724 0.3508 0.6819
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0022 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0116 0.0199 0.0197
Onchocerca volvulus 0.0114 0.0194 0.0376
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0024
Echinococcus granulosus c-Jun N-terminal kinases 0.024 0.0453 0.0452
Trypanosoma cruzi cysteine peptidase, putative 0.0791 0.1586 0.1569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0578 0.1149 0.2205
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0025 0.0025
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0044 0.0042
Echinococcus granulosus muscleblind protein 0.0155 0.0279 0.0278
Entamoeba histolytica cysteine proteinase, putative 0.1368 0.2776 0.5387
Loa Loa (eye worm) hypothetical protein 0.1724 0.3508 0.3507
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0688 0.1375 0.2648
Leishmania major hypothetical protein, conserved 0.0031 0.0023 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.2515 0.5135 0.5125
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0022
Loa Loa (eye worm) abnormal epIthelia family member 0.0025 0.0011 0.0009
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.062 0.1235 0.2373
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0114 0.0194 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0024
Echinococcus multilocularis cysteine protease 0.2515 0.5135 0.5134
Entamoeba histolytica cysteine protease, putative 0.2515 0.5135 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0023 0.0022
Brugia malayi jmjC domain containing protein 0.0116 0.0199 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.0194 0.0285
Trypanosoma brucei metacaspase 5, putative 0.0044 0.005 0.0049
Plasmodium falciparum serine repeat antigen 3 0.0578 0.1149 0.2205
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0688 0.1375 0.3504
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0023 0.0022
Brugia malayi Cathepsin L-like cysteine proteinase 0.1724 0.3508 0.3508
Leishmania major cathepsin L-like protease 0.2888 0.5902 1
Plasmodium falciparum serine repeat antigen 4 0.0578 0.1149 0.2205
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.011 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.2515 0.5135 0.5134
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0159 0.0158
Mycobacterium ulcerans dehydrogenase 0.0114 0.0194 0.0264
Brugia malayi Flap endonuclease-1 0.003 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0453 0.0452
Brugia malayi steroid hormone receptor 0.002 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0159 0.0158
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0023 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0578 0.1149 0.2205
Loa Loa (eye worm) hypothetical protein 0.0085 0.0134 0.0133
Brugia malayi EGF-like domain containing protein 0.0025 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Onchocerca volvulus 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2515 0.5135 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0114 0.0194 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Echinococcus granulosus acetylcholinesterase 0.007 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.007 0.0105 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0159 0.0158
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0002 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0031 0.0023 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Brugia malayi SWIRM domain containing protein 0.0114 0.0194 0.0194
Onchocerca volvulus 0.0041 0.0044 0.0082
Giardia lamblia Encystation-specific protease 0.062 0.1235 0.314
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4879 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Onchocerca volvulus Cathepsin F homolog 0.2515 0.5135 1
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0024
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0578 0.1149 0.2205
Brugia malayi cathepsin L-like precursor 0.1724 0.3508 0.3508
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.1598 0.1597
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.2515 0.5135 0.8696
Schistosoma mansoni cell polarity protein 0.0025 0.0011 0.0009
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0578 0.1149 0.2205
Echinococcus granulosus cathepsin l1 0.1724 0.3508 0.3507
Toxoplasma gondii cathepsin CPL 0.2515 0.5135 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0578 0.1149 0.1147
Brugia malayi Carboxylesterase family protein 0.007 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1908 0.3886 0.3873
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.005 0.0057
Echinococcus granulosus microtubule associated protein 2 0.0685 0.137 0.1368
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0578 0.1149 0.2205
Giardia lamblia Cathepsin B precursor 0.0697 0.1394 0.3551
Plasmodium vivax serine-repeat antigen (SERA) 0.0578 0.1149 0.2205
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.005 0.0029
Echinococcus granulosus lysine specific histone demethylase 1A 0.0114 0.0194 0.0193
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Plasmodium vivax vivapain-2 0.2515 0.5135 1
Echinococcus granulosus slit 2 protein 0.0025 0.0011 0.0009
Echinococcus granulosus flap endonuclease 1 0.003 0.0021 0.0019
Echinococcus granulosus cathepsin b 0.4879 1 1
Echinococcus granulosus caspase 2 0.0085 0.0134 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0159 0.0158
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0023 0.0022
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0578 0.1149 0.2205
Brugia malayi Cathepsin L-like precursor 0.0791 0.1586 0.1586
Trypanosoma cruzi major cysteine proteinase, putative 0.095 0.1915 0.1898
Echinococcus multilocularis cathepsin b 0.4879 1 1
Schistosoma mansoni lamin 0.0033 0.0027 0.0025
Echinococcus granulosus mitogen activated protein kinase 11 0.0131 0.023 0.0228
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1368 0.2776 0.276
Echinococcus granulosus intermediate filament protein 0.0033 0.0027 0.0025
Onchocerca volvulus 0.0033 0.0027 0.0049
Loa Loa (eye worm) ctsf protein 0.2515 0.5135 0.5134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0159 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0002 0.0002
Echinococcus granulosus caspase 3 0.0072 0.0108 0.0107
Onchocerca volvulus 0.0578 0.1149 0.2235
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0021 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Brugia malayi Papain family cysteine protease containing protein 0.0578 0.1149 0.1149
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2515 0.5135 1
Onchocerca volvulus 0.1724 0.3508 0.6831
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0101 0.0101
Leishmania major cathepsin L-like protease 0.2515 0.5135 0.8696
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1368 0.2776 0.4684
Trypanosoma cruzi cysteine peptidase, putative 0.2888 0.5902 0.5893
Trypanosoma cruzi metacaspase, putative 0.0044 0.005 0.0029
Onchocerca volvulus 0.2515 0.5135 1
Echinococcus granulosus cathepsin L 0.1368 0.2776 0.2775
Echinococcus granulosus lamin dm0 0.0033 0.0027 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.2888 0.5902 0.5893
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.1368 0.2776 0.276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0697 0.1394 0.2684
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4879 1 1
Onchocerca volvulus 0.2515 0.5135 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0697 0.1394 0.1394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Brugia malayi Papain family cysteine protease containing protein 0.0578 0.1149 0.1149
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Brugia malayi cathepsin L-like cysteine proteinase 0.0578 0.1149 0.1149
Brugia malayi cathepsin Z-like cysteine proteinase 0.0697 0.1394 0.1394
Schistosoma mansoni hypothetical protein 0.0171 0.0311 0.031
Giardia lamblia Cathepsin B precursor 0.0578 0.1149 0.2918
Loa Loa (eye worm) hypothetical protein 0.0155 0.0279 0.0278
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0025 0.0011 0.0011
Echinococcus multilocularis caspase 2 0.0085 0.0134 0.0133
Loa Loa (eye worm) hypothetical protein 0.1724 0.3508 0.3507
Echinococcus granulosus cathepsin b 0.4879 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.137 0.1368
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Echinococcus multilocularis flap endonuclease 1 0.003 0.0021 0.0019
Brugia malayi P38 map kinase family protein 2 0.0131 0.023 0.023
Schistosoma mansoni cathepsin B (C01 family) 0.0578 0.1149 0.1147
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Giardia lamblia Cathepsin B precursor 0.1908 0.3886 1
Schistosoma mansoni cathepsin F (C01 family) 0.1724 0.3508 0.3507
Echinococcus multilocularis caspase 0.0116 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Trypanosoma cruzi metacaspase, putative 0.0044 0.005 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1908 0.3886 0.7558
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2515 0.5135 0.5134
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0167 0.0167
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0114 0.0194 0.0339
Plasmodium vivax vivapain-1 0.1368 0.2776 0.5387
Giardia lamblia Cathepsin L-like protease 0.0578 0.1149 0.2918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Schistosoma mansoni amine oxidase 0.0114 0.0194 0.0193
Echinococcus multilocularis lamin dm0 0.0033 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0041 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0791 0.1586 0.1585
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Onchocerca volvulus Cathepsin L homolog 0.0578 0.1149 0.2235
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0791 0.1586 0.1586
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Plasmodium vivax hypothetical protein, conserved 0.0044 0.005 0.0057
Trypanosoma brucei cysteine peptidase C (CPC) 0.1908 0.3886 0.6573
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0023 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.1368 0.2776 0.5387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0009
Brugia malayi jmjC domain containing protein 0.0116 0.0199 0.0199
Onchocerca volvulus 0.2515 0.5135 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0023 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Trypanosoma cruzi cruzipain precursor, putative 0.0791 0.1586 0.1569
Leishmania major hypothetical protein, conserved 0.003 0.0022 0.0002
Toxoplasma gondii cathepsin CPC2 0.062 0.1235 0.2373
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0114 0.0194 0.0339
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0199 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.062 0.1235 0.2373
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1724 0.3508 0.6819
Giardia lamblia Cysteine protease 0.0578 0.1149 0.2918
Plasmodium vivax unspecified product 0.0578 0.1149 0.2205
Brugia malayi laminin alpha chain 0.0025 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Echinococcus multilocularis caspase 8 0.0044 0.005 0.0048
Leishmania major cathepsin L-like protease 0.2515 0.5135 0.8696
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0025
Mycobacterium tuberculosis Possible oxidoreductase 0.0114 0.0194 0.0285
Schistosoma mansoni cathepsin C 0.0578 0.1149 0.1147
Loa Loa (eye worm) hypothetical protein 0.0044 0.005 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.011 0.0109
Giardia lamblia Dipeptidyl-peptidase I precursor 0.062 0.1235 0.314
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4879 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0578 0.1149 0.2205
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0578 0.1149 0.2205
Echinococcus granulosus cathepsin L cysteine protease 0.1368 0.2776 0.2775
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.062 0.1235 0.314
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.011 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0024
Plasmodium falciparum serine repeat antigen 7 0.0578 0.1149 0.2205
Echinococcus multilocularis musashi 0.0033 0.0027 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.2515 0.5135 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0688 0.1375 0.1374
Onchocerca volvulus 0.2515 0.5135 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.1368 0.2776 0.5387
Onchocerca volvulus Cathepsin L homolog 0.2515 0.5135 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0114 0.0194 0.0339
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.023 0.0209
Brugia malayi cathepsin F-like cysteine proteinase 0.0578 0.1149 0.1149
Echinococcus multilocularis muscleblind protein 0.0155 0.0279 0.0278
Brugia malayi Cell death protein 3 precursor 0.0085 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.1724 0.3508 0.3507
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0131 0.023 0.0355
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0031 0.0023 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0114 0.0194 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Onchocerca volvulus Cathepsin L homolog 0.2515 0.5135 1
Giardia lamblia Cathepsin L-like protease 0.0578 0.1149 0.2918
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.024 0.0453 0.0452
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0578 0.1149 0.2205
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.011 0.0109
Echinococcus multilocularis acetylcholinesterase 0.007 0.0105 0.0103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0578 0.1149 0.1147
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0022 0.0001
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0023 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0578 0.1149 0.1147
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0011 0.0009
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0025 0.0011 0.0009
Plasmodium falciparum serine repeat antigen 5 0.0578 0.1149 0.2205
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Mycobacterium ulcerans monoamine oxidase 0.0114 0.0194 0.0264
Entamoeba histolytica hypothetical protein 0.0578 0.1149 0.2205
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0114 0.0194 0.0193
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0022 0.0002
Schistosoma mansoni cathepsin S (C01 family) 0.0578 0.1149 0.1147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Trypanosoma cruzi cysteine protease, putative 0.1368 0.2776 0.276
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2515 0.5135 0.5134
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0688 0.1375 0.2648
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4879 1 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.162 0.3293 1
Brugia malayi intermediate filament protein 0.0033 0.0027 0.0027
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Giardia lamblia Cysteine protease 0.0578 0.1149 0.2918
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0578 0.1149 0.1147
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1368 0.2776 0.2775
Echinococcus granulosus lysine specific demethylase 5A 0.0116 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0697 0.1394 0.2684
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0697 0.1394 0.1392
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0022 0.0002
Plasmodium falciparum protoporphyrinogen oxidase 0.0114 0.0194 0.0339
Giardia lamblia Cathepsin B precursor 0.1908 0.3886 1
Schistosoma mansoni hypothetical protein 0.0069 0.0101 0.01
Trypanosoma cruzi cruzipain precursor, putative 0.2888 0.5902 0.5893
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0688 0.1375 0.2648
Schistosoma mansoni cathepsin F (C01 family) 0.2515 0.5135 0.5134
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0022
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0022 0.0002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0114 0.0194 0.0339
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Loa Loa (eye worm) cathepsin B 0.1908 0.3886 0.3885
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.011 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0578 0.1149 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0578 0.1149 0.2205
Entamoeba histolytica cysteine proteinase, putative 0.1724 0.3508 0.6819
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.002 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1368 0.2776 0.5387
Loa Loa (eye worm) hypothetical protein 0.0155 0.0279 0.0278
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0022
Brugia malayi fibroinase precursor 0.0578 0.1149 0.1149
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0114 0.0194 0.0339
Echinococcus multilocularis cathepsin L 0.0578 0.1149 0.1147
Brugia malayi amine oxidase, flavin-containing family protein 0.0114 0.0194 0.0194
Brugia malayi nuclear receptor NHR-88 0.002 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0279 0.0278
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.005 0.0057
Entamoeba histolytica cysteine proteinase 2 0.1368 0.2776 0.5387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1368 0.2776 0.4684
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0578 0.1149 0.2205
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0578 0.1149 0.1147
Leishmania major cysteine peptidase A (CPA) 0.2515 0.5135 0.8696
Schistosoma mansoni hypothetical protein 0.0171 0.0311 0.031
Loa Loa (eye worm) jmjC domain-containing protein 0.0116 0.0199 0.0197
Entamoeba histolytica cysteine proteinase, putative 0.1368 0.2776 0.5387
Echinococcus granulosus acetylcholinesterase 0.007 0.0105 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Toxoplasma gondii cathepsin B 0.1908 0.3886 0.7558
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0578 0.1149 0.1149
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0011 0.0009
Brugia malayi hypothetical protein 0.0041 0.0044 0.0044
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0044 0.005 0.0048
Plasmodium falciparum serine repeat antigen 2 0.0578 0.1149 0.2205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0002 0.0002
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.023 0.0228
Echinococcus granulosus caspase 8 0.0044 0.005 0.0048
Brugia malayi Papain family cysteine protease containing protein 0.2515 0.5135 0.5135
Echinococcus multilocularis GPCR, family 2 0.0032 0.0025 0.0024
Leishmania major cathepsin L-like protease 0.2888 0.5902 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0578 0.1149 0.2205
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0114 0.0194 0.0193
Schistosoma mansoni caspase-3 (C14 family) 0.0116 0.0199 0.0197
Echinococcus granulosus cathepsin L 0.0578 0.1149 0.1147
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.023 0.0228
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0578 0.1149 0.1147
Plasmodium falciparum serine repeat antigen 8 0.0578 0.1149 0.2205
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Schistosoma mansoni lamin 0.0033 0.0027 0.0025
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.137 0.1368
Brugia malayi hypothetical protein 0.003 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0697 0.1394 0.2684
Onchocerca volvulus Cell death protein 3 homolog 0.0085 0.0134 0.0258
Plasmodium falciparum serine repeat antigen 9 0.0578 0.1149 0.2205
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Echinococcus multilocularis 0.0114 0.0194 0.0193
Leishmania major metacaspase, putative 0.0044 0.005 0.0049
Brugia malayi laminin-like protein K08C7.3 precursor 0.0025 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Echinococcus granulosus cathepsin l1 0.2515 0.5135 0.5134
Echinococcus multilocularis carboxylesterase 5A 0.007 0.0105 0.0103
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.0105 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0044 0.0042
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0023 0.0005
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0023 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2515 0.5135 0.5134
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.023 0.0228
Trypanosoma cruzi cysteine proteinase, putative 0.1368 0.2776 0.276
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0194 0.0339
Echinococcus granulosus pikachurin 0.0025 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0194 0.0339
Loa Loa (eye worm) carboxylesterase 0.007 0.0105 0.0103
Giardia lamblia Hypothetical protein 0.0578 0.1149 0.2918
Trypanosoma brucei metacaspase 0.0044 0.005 0.0049
Echinococcus multilocularis geminin 0.0171 0.0311 0.031
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0023 0.0022
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0131 0.023 0.0228
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Echinococcus multilocularis cathepsin L 0.1368 0.2776 0.2775
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0023 0.0005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4879 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0116 0.0199 0.0197
Loa Loa (eye worm) fibroinase 0.2515 0.5135 0.5134
Entamoeba histolytica cysteine proteinase, putative 0.1368 0.2776 0.5387
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0105 0.0103
Brugia malayi Stress-activated protein kinase jnk-1 0.024 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0791 0.1586 0.1585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0578 0.1149 0.2205
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Mycobacterium ulcerans oxidoreductase 0.0114 0.0194 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Onchocerca volvulus 0.2515 0.5135 1
Leishmania major cathepsin L-like protease 0.2515 0.5135 0.8696
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2515 0.5135 0.5134
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0578 0.1149 0.2205
Brugia malayi Papain family cysteine protease containing protein 0.0578 0.1149 0.1149
Loa Loa (eye worm) hypothetical protein 0.0791 0.1586 0.1585
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0697 0.1394 0.2684
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1506 0.3058 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0114 0.0194 0.5
Schistosoma mansoni cathepsin s 0.0791 0.1586 0.1585
Onchocerca volvulus 0.2515 0.5135 1
Trypanosoma cruzi metacaspase 5, putative 0.0044 0.005 0.0029
Trypanosoma brucei metacaspase MCA3 0.0044 0.005 0.0049
Echinococcus multilocularis lysine specific demethylase 5A 0.0116 0.0199 0.0197
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0578 0.1149 0.1147
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0116 0.0199 0.0197
Plasmodium falciparum cysteine proteinase falcipain 3 0.2515 0.5135 1
Loa Loa (eye worm) hypothetical protein 0.0578 0.1149 0.1147
Giardia lamblia Cathepsin B precursor 0.1908 0.3886 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Brugia malayi Cathepsin L-like precursor 0.1724 0.3508 0.3508
Loa Loa (eye worm) cysteine protease 0.2515 0.5135 0.5134
Echinococcus multilocularis pikachurin 0.0025 0.0011 0.0009
Brugia malayi Cathepsin L-like precursor 0.1724 0.3508 0.3508
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.162 0.3293 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0578 0.1149 0.1147
Echinococcus granulosus caspase 0.0116 0.0199 0.0197
Trypanosoma cruzi major cysteine proteinase, putative 0.0578 0.1149 0.113
Loa Loa (eye worm) hypothetical protein 0.0069 0.0101 0.01
Plasmodium vivax serine-repeat antigen (SERA) 0.0578 0.1149 0.2205
Trypanosoma brucei metacaspase MCA2 0.0044 0.005 0.0049
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.023 0.0209
Leishmania major cathepsin L-like protease 0.2515 0.5135 0.8696
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1908 0.3886 0.6573
Giardia lamblia Cathepsin B precursor 0.0578 0.1149 0.2918
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Brugia malayi ecdysteroid receptor 0.002 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0688 0.1375 0.2648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0159 0.0159
Echinococcus granulosus carboxylesterase 5A 0.007 0.0105 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Toxoplasma gondii cathepsin CPC1 0.0688 0.1375 0.2648
Entamoeba histolytica cysteine proteinase 1, putative 0.1368 0.2776 0.5387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0578 0.1149 0.2205
Echinococcus granulosus geminin 0.0171 0.0311 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0159 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0002 0.0002
Brugia malayi Muscleblind-like protein 0.0155 0.0279 0.0279
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0044 0.005 0.0057
Echinococcus multilocularis lamin 0.0033 0.0027 0.0025
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Trypanosoma brucei Metacaspase-4 0.0044 0.005 0.0049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1908 0.3886 0.3885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2888 0.5902 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Schistosoma mansoni flap endonuclease-1 0.0027 0.0015 0.0014
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Toxoplasma gondii preprocathepsin c precursor, putative 0.0688 0.1375 0.2648
Trypanosoma cruzi cysteine peptidase, putative 0.2888 0.5902 0.5893
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.011 0.0109
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0044 0.005 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0022 0.0001
Schistosoma mansoni intermediate filament proteins 0.0033 0.0027 0.0025
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0023 0.0002
Brugia malayi cathepsin L precursor 0.0578 0.1149 0.1149
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Plasmodium falciparum serine repeat antigen 1 0.0578 0.1149 0.2205
Plasmodium vivax JmjC domain containing protein 0.0031 0.0023 0.0005
Trypanosoma cruzi cysteine proteinase, putative 0.1368 0.2776 0.276
Trypanosoma cruzi metacaspase, putative 0.0044 0.005 0.0029
Giardia lamblia Cathepsin B precursor 0.0578 0.1149 0.2918
Plasmodium falciparum metacaspase 1 0.0044 0.005 0.0057
Echinococcus granulosus cathepsin L cysteine proteinase 0.2515 0.5135 0.5134
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0578 0.1149 0.1147
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0023 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0025 0.0025
Plasmodium vivax unspecified product 0.0791 0.1586 0.3061
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Echinococcus multilocularis c Jun NH2 terminal kinase 0.024 0.0453 0.0452
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0027 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0159 0.0158
Giardia lamblia Hypothetical protein 0.0578 0.1149 0.2918
Echinococcus multilocularis cathepsin b 0.4879 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0105 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2515 0.5135 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0114 0.0194 0.0193
Giardia lamblia Cysteine protease 0.0578 0.1149 0.2918
Brugia malayi Papain family cysteine protease containing protein 0.1368 0.2776 0.2776
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0023 0.0022
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0023 0.0022
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0116 0.0199 0.0197
Echinococcus multilocularis slit 2 protein 0.0025 0.0011 0.0009
Brugia malayi hypothetical protein 0.0114 0.0194 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0002 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.2515 0.5135 0.5134
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0791 0.1586 0.1585
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0578 0.1149 0.1147
Loa Loa (eye worm) hypothetical protein 0.0114 0.0194 0.0193
Entamoeba histolytica cysteine protease, putative 0.1368 0.2776 0.5387
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1368 0.2776 0.5387
Loa Loa (eye worm) hypothetical protein 0.0101 0.0167 0.0165
Schistosoma mansoni slit 0.0025 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0022
Toxoplasma gondii histone lysine-specific demethylase 0.0114 0.0194 0.0339
Onchocerca volvulus 0.0033 0.0027 0.0049
Leishmania major cathepsin L-like protease 0.2888 0.5902 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.005 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.0021
Echinococcus granulosus lamin 0.0033 0.0027 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2515 0.5135 1
Schistosoma mansoni caspase-7 (C14 family) 0.0116 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2515 0.5135 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0114 0.0194 0.0174
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1368 0.2776 0.2775
Giardia lamblia Cysteine protease 0.0578 0.1149 0.2918
Echinococcus granulosus cathepsin l cysteine peptidase 0.2515 0.5135 0.5134
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0027 0.0025
Entamoeba histolytica cysteine protease, putative 0.0578 0.1149 0.2205
Brugia malayi Carboxylesterase family protein 0.007 0.0105 0.0105
Echinococcus multilocularis cathepsin L cysteine protease 0.2515 0.5135 0.5134
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0024
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0131 0.023 0.0355
Echinococcus multilocularis caspase 3 0.0072 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0024
Plasmodium vivax vivapain-3 0.1368 0.2776 0.5387
Brugia malayi cathepsin F-like cysteine proteinase 0.0791 0.1586 0.1586
Brugia malayi Papain family cysteine protease containing protein 0.1368 0.2776 0.2776
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0044 0.005 0.0057
Giardia lamblia Cathepsin L precursor 0.0578 0.1149 0.2918
Echinococcus granulosus lysine specific histone demethylase 1A 0.0114 0.0194 0.0193
Plasmodium vivax unspecified product 0.1368 0.2776 0.5387
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0044 0.0042
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Plasmodium vivax metacaspase 1, putative 0.0044 0.005 0.0057
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0578 0.1149 0.2205
Brugia malayi Cathepsin L-like precursor 0.2515 0.5135 0.5135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0167 0.0165
Brugia malayi jmjC domain containing protein 0.0031 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0002 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0025 0.0024
Leishmania major UDP-galactopyranose mutase 0.0114 0.0194 0.0295
Echinococcus granulosus phd:f box containing protein 0.0031 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.4879 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 125.8925 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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