Detailed information for compound 1344936

Basic information

Technical information
  • TDR Targets ID: 1344936
  • Name: but-2-enedioic acid; N,N-dimethyl-3-(11-methy l-6,11-dihydrobenzo[c][1]benzothiepin-6-yl)pr opan-1-amine
  • MW: 427.556 | Formula: C24H29NO4S
  • H donors: 2 H acceptors: 4 LogP: 2.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C\C(=O)O.CN(CCCC1Sc2ccccc2C(c2c1cccc2)C)C
  • InChi: 1S/C20H25NS.C4H4O4/c1-15-16-9-4-5-11-18(16)20(13-8-14-21(2)3)22-19-12-7-6-10-17(15)19;5-3(6)1-2-4(7)8/h4-7,9-12,15,20H,8,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey: BADKQZZVPZOAQD-BTJKTKAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • but-2-enedioic acid; dimethyl-[3-(11-methyl-6,11-dihydrobenzo[c][1]benzothiepin-6-yl)propyl]amine
  • MLS000705783
  • N,N-dimethyl-N-[3-(11-methyl-6,11-dihydrodibenzo[b,e]thiepin-6-yl)propyl]amine
  • SMR000225003

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase A (CPA) 0.0675 0.4874 0.6359
Trypanosoma cruzi cruzipain precursor, putative 0.1055 0.7664 0.7664
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0013 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.3364 1
Toxoplasma gondii cathepsin CPC1 0.0155 0.1049 0.2153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Echinococcus granulosus tumor protein p63 0.0369 0.262 0.262
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0448 0.1332
Entamoeba histolytica cysteine protease, putative 0.0675 0.4874 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.1049 0.1049
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.1049 0.2331
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0077 0.01
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0054 0.0304 0.0304
Echinococcus multilocularis lamin dm0 0.0027 0.0104 0.0104
Leishmania major cathepsin L-like protease 0.1055 0.7664 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0448 0.1332
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1049 0.1755
Echinococcus granulosus intermediate filament protein 0.0027 0.0104 0.0104
Plasmodium falciparum serine repeat antigen 3 0.0155 0.1049 0.2076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.0101
Echinococcus granulosus cysteine protease 0.0366 0.26 0.26
Schistosoma mansoni cathepsin C 0.0155 0.1049 0.1049
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.1049 0.1755
Entamoeba histolytica hypothetical protein 0.0155 0.1049 0.1803
Giardia lamblia Cathepsin B precursor 0.0155 0.1049 0.2331
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.1457 0.1457
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.1049 0.2076
Trypanosoma cruzi cysteine peptidase, putative 0.0675 0.4874 0.4874
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0077 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0313 0.0313
Plasmodium falciparum cysteine proteinase falcipain 3 0.0675 0.4874 1
Brugia malayi beta-lactamase family protein 0.0074 0.0448 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0155 0.1049 0.1755
Toxoplasma gondii ABC1 family protein 0.0074 0.0448 0.0919
Onchocerca volvulus 0.0675 0.4874 1
Giardia lamblia Cathepsin B precursor 0.0155 0.1049 0.2331
Echinococcus granulosus lamin 0.0027 0.0104 0.0104
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.035 0.035
Brugia malayi beta-lactamase 0.0074 0.0448 0.0448
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0047 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0047 0.0097
Echinococcus multilocularis cysteine protease 0.0675 0.4874 0.4874
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1372 1 1
Giardia lamblia Cysteine protease 0.0155 0.1049 0.2331
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0155 0.1049 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0675 0.4874 1
Echinococcus granulosus cathepsin L 0.0155 0.1049 0.1049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0465 0.3323 0.6657
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0047 0.0047
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0675 0.4874 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.26 0.5097
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0047 0.014
Schistosoma mansoni cathepsin F (C01 family) 0.0675 0.4874 0.4874
Giardia lamblia Cathepsin B precursor 0.0155 0.1049 0.2331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0313 0.0313
Entamoeba histolytica cysteine proteinase, putative 0.0465 0.3323 0.6677
Mycobacterium tuberculosis Conserved protein 0.0074 0.0448 0.1332
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0155 0.1049 0.2331
Leishmania major cathepsin L-like protease 0.0675 0.4874 0.6359
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0155 0.1049 0.2076
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0532 0.3817 0.7723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0448 0.0459
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.1049 0.1049
Brugia malayi isocitrate dehydrogenase 0.0019 0.0047 0.0047
Echinococcus multilocularis cathepsin L 0.0366 0.26 0.26
Trypanosoma cruzi cysteine proteinase, putative 0.0366 0.26 0.26
Loa Loa (eye worm) beta-lactamase 0.0074 0.0448 0.0448
Onchocerca volvulus 0.0675 0.4874 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 1 1
Mycobacterium leprae Probable lipase LipE 0.0074 0.0448 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0992 0.0992
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.1049 0.1755
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0155 0.1049 0.1049
Brugia malayi cathepsin F-like cysteine proteinase 0.0211 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0047 0.0047
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0047 0.0062
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Toxoplasma gondii preprocathepsin c precursor, putative 0.0155 0.1049 0.2153
Schistosoma mansoni hypothetical protein 0.0169 0.1149 0.1149
Onchocerca volvulus Cathepsin F homolog 0.0675 0.4874 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.1049 0.2076
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0448 0.1332
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0448 0.1332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Onchocerca volvulus 0.0675 0.4874 1
Plasmodium falciparum serine repeat antigen 4 0.0155 0.1049 0.2076
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0235 0.0482
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0155 0.1049 0.2076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.1049 0.1049
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0077 0.0077
Echinococcus multilocularis cathepsin L 0.0155 0.1049 0.1049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 1 1
Plasmodium vivax vivapain-2 0.0675 0.4874 1
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.26 0.5126
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.1049 0.1049
Plasmodium vivax unspecified product 0.0155 0.1049 0.2076
Leishmania major cathepsin L-like protease 0.0675 0.4874 0.6359
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0448 0.0459
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0047 0.0047
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0675 0.4874 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Plasmodium vivax vivapain-1 0.0366 0.26 0.5288
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0155 0.1049 0.2076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1372 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0366 0.26 0.26
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0155 0.1049 0.2076
Loa Loa (eye worm) fibroinase 0.0675 0.4874 0.4874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0235 0.0235
Giardia lamblia Cysteine protease 0.0155 0.1049 0.2331
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0047 0.0047
Giardia lamblia Cysteine protease 0.0155 0.1049 0.2331
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0448 0.0448
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.1049 0.1049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0675 0.4874 0.4874
Brugia malayi cathepsin L-like precursor 0.0465 0.3323 0.3323
Plasmodium vivax unspecified product 0.0366 0.26 0.5288
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0047 0.0047
Mycobacterium tuberculosis Conserved protein 0.0074 0.0448 0.1332
Plasmodium falciparum serine repeat antigen 1 0.0155 0.1049 0.2076
Brugia malayi cathepsin F-like cysteine proteinase 0.0155 0.1049 0.1049
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.1049 0.1049
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.26 0.5126
Echinococcus multilocularis geminin 0.0169 0.1149 0.1149
Schistosoma mansoni hypothetical protein 0.0169 0.1149 0.1149
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0448 0.0448
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.5222 0.5222
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.1049 0.2076
Leishmania major cathepsin L-like protease 0.1055 0.7664 1
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0448 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Plasmodium falciparum serine repeat antigen 7 0.0155 0.1049 0.2076
Mycobacterium ulcerans hypothetical protein 0.0074 0.0448 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0155 0.1049 0.1049
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.26 0.26
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0448 0.1332
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Brugia malayi Papain family cysteine protease containing protein 0.0675 0.4874 0.4874
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.1049 0.1049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0448 0.0448
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Giardia lamblia Cathepsin B precursor 0.0532 0.3817 1
Loa Loa (eye worm) hypothetical protein 0.0675 0.4874 0.4874
Plasmodium falciparum serine repeat antigen 5 0.0155 0.1049 0.2076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0235 0.0482
Toxoplasma gondii cathepsin B 0.0532 0.3817 0.7833
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0448 0.0448
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0077 0.1716
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0465 0.3323 0.3323
Entamoeba histolytica cysteine proteinase, putative 0.0675 0.4874 1
Plasmodium falciparum serine repeat antigen 6 0.0155 0.1049 0.2076
Mycobacterium ulcerans lipase LipD 0.0074 0.0448 1
Leishmania major hypothetical protein, conserved 0.0074 0.0448 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0366 0.26 0.3392
Entamoeba histolytica cysteine proteinase, putative 0.0675 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.1457 0.1457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0155 0.1049 0.1049
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0866 0.0866
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0448 0.0459
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0313 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.1049 0.1755
Brugia malayi MH2 domain containing protein 0.013 0.0866 0.0866
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0532 0.3817 0.4981
Entamoeba histolytica cysteine proteinase 2 0.0366 0.26 0.5126
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Brugia malayi Papain family cysteine protease containing protein 0.0366 0.26 0.26
Onchocerca volvulus 0.0465 0.3323 0.6749
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0047 0.0047
Onchocerca volvulus Cathepsin L homolog 0.0155 0.1049 0.1981
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0313 0.0313
Echinococcus multilocularis cathepsin L cysteine protease 0.0675 0.4874 0.4874
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1023 0.1023
Onchocerca volvulus Cathepsin L homolog 0.0675 0.4874 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0155 0.1049 0.2076
Onchocerca volvulus 0.0074 0.0448 0.072
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0448 0.0831
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Mycobacterium ulcerans beta-lactamase 0.0074 0.0448 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.1049 0.2076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Echinococcus multilocularis lamin 0.0027 0.0104 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0047 0.0047
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0209 0.0209
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0675 0.4874 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1372 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1457 0.1457
Plasmodium falciparum cysteine proteinase falcipain 1 0.0366 0.26 0.5288
Brugia malayi beta-lactamase family protein 0.0074 0.0448 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.1049 0.1049
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0448 0.0585
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0448 0.0459
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Loa Loa (eye worm) cysteine protease 0.0675 0.4874 0.4874
Giardia lamblia Cysteine protease 0.0155 0.1049 0.2331
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0448 1
Schistosoma mansoni cathepsin B (C01 family) 0.0155 0.1049 0.1049
Plasmodium vivax vivapain-2 0.0675 0.4874 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0532 0.3817 0.4981
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0313 0.0313
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0155 0.1049 0.2076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0313 0.0313
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.26 0.26
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.1457 0.1457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Echinococcus granulosus lamin dm0 0.0027 0.0104 0.0104
Brugia malayi fibroinase precursor 0.0155 0.1049 0.1049
Brugia malayi Papain family cysteine protease containing protein 0.0366 0.26 0.26
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Leishmania major cytochrome p450-like protein 0.0023 0.0077 0.01
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0047 0.0047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.1049 0.1049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0675 0.4874 0.4874
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0208 0.0333
Trypanosoma cruzi cysteine peptidase, putative 0.1055 0.7664 0.7664
Echinococcus multilocularis cathepsin b 0.1372 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0047 0.0047
Giardia lamblia Cathepsin L-like protease 0.0155 0.1049 0.2331
Trichomonas vaginalis esterase, putative 0.0074 0.0448 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0366 0.26 0.3392
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.1049 0.1049
Schistosoma mansoni cathepsin F (C01 family) 0.0675 0.4874 0.4874
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.035 0.035
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0155 0.1049 0.2076
Echinococcus granulosus cathepsin l cysteine peptidase 0.0675 0.4874 0.4874
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.1049 0.2331
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.1049 0.1049
Onchocerca volvulus 0.0074 0.0448 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Leishmania major cathepsin L-like protease 0.0675 0.4874 0.6359
Echinococcus granulosus cathepsin L cysteine protease 0.0366 0.26 0.26
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0155 0.1049 0.2076
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Leishmania major cathepsin L-like protease 0.0675 0.4874 0.6359
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0304 0.0304
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.26 0.5126
Plasmodium falciparum serine repeat antigen 2 0.0155 0.1049 0.2076
Schistosoma mansoni cathepsin S (C01 family) 0.0155 0.1049 0.1049
Onchocerca volvulus 0.0054 0.0304 0.0418
Trypanosoma cruzi cysteine proteinase, putative 0.0366 0.26 0.26
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0002 0.0002
Entamoeba histolytica cysteine proteinase 1, putative 0.0366 0.26 0.5126
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Echinococcus multilocularis cathepsin L cysteine protease 0.0675 0.4874 0.4874
Loa Loa (eye worm) hypothetical protein 0.0041 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0465 0.3323 0.3323
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.585 0.585
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0448 0.0448
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0448 0.1332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0448 1
Echinococcus multilocularis cysteine protease 0.0675 0.4874 0.4874
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0104 0.0104
Brugia malayi cathepsin L precursor 0.0155 0.1049 0.1049
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0047 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.1049 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0155 0.1049 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0313 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Onchocerca volvulus 0.0675 0.4874 1
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.1049 0.1049
Brugia malayi Cytochrome P450 family protein 0.0023 0.0077 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0047 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.1049 0.1755
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0675 0.4874 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.1049 0.1803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0313 0.0313
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.1049 0.2331
Loa Loa (eye worm) hypothetical protein 0.1372 1 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.1457 0.1457
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Plasmodium vivax unspecified product 0.0211 0.1457 0.2922
Giardia lamblia Hypothetical protein 0.0155 0.1049 0.2331
Trypanosoma cruzi cruzipain precursor, putative 0.0211 0.1457 0.1457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.26 0.5097
Echinococcus multilocularis GPCR, family 2 0.0019 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Echinococcus granulosus cathepsin b 0.1372 1 1
Brugia malayi Cathepsin L-like precursor 0.0465 0.3323 0.3323
Onchocerca volvulus 0.0675 0.4874 1
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Loa Loa (eye worm) hypothetical protein 0.006 0.035 0.035
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Giardia lamblia Cathepsin B precursor 0.0155 0.1049 0.2331
Trypanosoma cruzi major cysteine proteinase, putative 0.0535 0.3839 0.3839
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0155 0.1049 0.2076
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0077 0.0077
Echinococcus granulosus cathepsin L cysteine proteinase 0.0675 0.4874 0.4874
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.5222 0.5222
Schistosoma mansoni cathepsin F (C01 family) 0.0465 0.3323 0.3323
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0448 0.0448
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0675 0.4874 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0448 0.1332
Echinococcus granulosus cathepsin l1 0.0675 0.4874 0.4874
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0675 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0465 0.3323 0.6657
Loa Loa (eye worm) hypothetical protein 0.0465 0.3323 0.3323
Echinococcus granulosus cathepsin l1 0.0465 0.3323 0.3323
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0448 0.0448
Giardia lamblia Hypothetical protein 0.0155 0.1049 0.2331
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0844 0.6113 0.6113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0448 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0532 0.3817 0.3817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.4874 1
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0155 0.1049 0.1049
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0047 0.0047
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Echinococcus granulosus cathepsin L 0.0366 0.26 0.26
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.1049 0.1049
Echinococcus multilocularis musashi 0.0027 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0155 0.1049 0.1049
Trypanosoma cruzi cysteine protease, putative 0.0366 0.26 0.26
Trypanosoma cruzi cysteine peptidase, putative 0.1055 0.7664 0.7664
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0047 0.0047
Leishmania major cathepsin L-like protease 0.1055 0.7664 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0366 0.26 0.26
Giardia lamblia Cathepsin L-like protease 0.0155 0.1049 0.2331
Onchocerca volvulus Cathepsin L homolog 0.0675 0.4874 1
Echinococcus granulosus geminin 0.0169 0.1149 0.1149
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Loa Loa (eye worm) acetyltransferase 0.0152 0.1023 0.1023
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0866 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1049 0.1755
Echinococcus granulosus cathepsin b 0.1372 1 1
Onchocerca volvulus 0.0675 0.4874 1
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.1049 0.1049
Plasmodium falciparum serine repeat antigen 8 0.0155 0.1049 0.2076
Entamoeba histolytica cysteine protease, putative 0.0366 0.26 0.5126
Brugia malayi Cathepsin L-like cysteine proteinase 0.0465 0.3323 0.3323
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.1049 0.1803
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1023 0.1023
Leishmania major cathepsin L-like protease 0.0675 0.4874 0.6359
Schistosoma mansoni cathepsin s 0.0211 0.1457 0.1457
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0002 0.0002
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0155 0.1049 0.2076
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.26 0.5126
Schistosoma mansoni intermediate filament proteins 0.0027 0.0104 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0313 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0155 0.1049 0.1755
Onchocerca volvulus 0.0074 0.0448 0.072
Echinococcus multilocularis cathepsin b 0.1372 1 1
Giardia lamblia Cathepsin B precursor 0.0532 0.3817 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.1049 0.1755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1049 0.1755
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0448 0.1332
Onchocerca volvulus 0.0155 0.1049 0.1981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Brugia malayi Cathepsin L-like precursor 0.0465 0.3323 0.3323
Echinococcus granulosus microtubule associated protein 2 0.0723 0.5222 0.5222
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0047 0.0047
Loa Loa (eye worm) cathepsin B 0.0532 0.3817 0.3817
Toxoplasma gondii cathepsin CPL 0.0675 0.4874 1
Trypanosoma cruzi cysteine peptidase, putative 0.1055 0.7664 0.7664
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0155 0.1049 0.2076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0047 0.0047
Brugia malayi intermediate filament protein 0.0027 0.0104 0.0104
Brugia malayi Cytochrome P450 family protein 0.0023 0.0077 0.0077
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Toxoplasma gondii cathepsin CPC2 0.0155 0.1049 0.2153
Giardia lamblia Cathepsin B precursor 0.0155 0.1049 0.2331
Brugia malayi cathepsin L-like cysteine proteinase 0.0155 0.1049 0.1049
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0448 0.0459
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0047 0.0047
Plasmodium falciparum serine repeat antigen 9 0.0155 0.1049 0.2076
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0532 0.3817 0.3817
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.26 0.26
Giardia lamblia Cathepsin L precursor 0.0155 0.1049 0.2331
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0047 0.0047
Echinococcus granulosus GPCR family 2 0.0019 0.0047 0.0047
Echinococcus multilocularis tumor protein p63 0.0369 0.262 0.262
Schistosoma mansoni hypothetical protein 0.0041 0.0209 0.0209
Onchocerca volvulus 0.0675 0.4874 1
Entamoeba histolytica cysteine protease, putative 0.0155 0.1049 0.1803
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.035 0.035
Brugia malayi Cathepsin L-like precursor 0.0675 0.4874 0.4874
Giardia lamblia Encystation-specific protease 0.0155 0.1049 0.2331
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.1049 0.1049
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1023 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.1049 0.1755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1055 0.7664 1
Brugia malayi Cathepsin L-like precursor 0.0211 0.1457 0.1457
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0235 0.039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0211 0.1457 0.1457
Giardia lamblia Cathepsin B precursor 0.0532 0.3817 1
Loa Loa (eye worm) ctsf protein 0.0675 0.4874 0.4874
Plasmodium vivax vivapain-3 0.0366 0.26 0.5288

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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