Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0424 | 0.1485 | 0.0952 |
Brugia malayi | Carboxylesterase family protein | 0.0424 | 0.1485 | 0.1485 |
Onchocerca volvulus | 0.0424 | 0.1485 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Schistosoma mansoni | gliotactin | 0.0424 | 0.1485 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Echinococcus granulosus | neuroligin | 0.0424 | 0.1485 | 0.0952 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0424 | 0.1485 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Onchocerca volvulus | 0.0424 | 0.1485 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0424 | 0.1485 | 0.0952 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0424 | 0.1485 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0424 | 0.1485 | 0.1485 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0424 | 0.1485 | 0.0952 |
Brugia malayi | Carboxylesterase family protein | 0.251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Echinococcus multilocularis | neuroligin | 0.0424 | 0.1485 | 0.0952 |
Brugia malayi | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Onchocerca volvulus | 0.0424 | 0.1485 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0424 | 0.1485 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0424 | 0.1485 | 0.1485 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0424 | 0.1485 | 0.0952 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0424 | 0.1485 | 0.5 |
Onchocerca volvulus | 0.0424 | 0.1485 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.251 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.251 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Loa Loa (eye worm) | carboxylesterase | 0.251 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0424 | 0.1485 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Echinococcus multilocularis | acetylcholinesterase | 0.251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.1485 | 0.1485 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0424 | 0.1485 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.251 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0424 | 0.1485 | 0.0952 |
Brugia malayi | Carboxylesterase family protein | 0.0424 | 0.1485 | 0.1485 |
Onchocerca volvulus | 0.0424 | 0.1485 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0424 | 0.1485 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.251 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0424 | 0.1485 | 0.1485 |
Echinococcus granulosus | carboxylesterase 5A | 0.251 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.251 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.251 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0424 | 0.1485 | 0.1485 |
Echinococcus multilocularis | carboxylesterase 5A | 0.251 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 29.905 um | PUBCHEM_BIOASSAY: Fluorescence-based cell-based high throughput dose response assay for agonists of the Oxytocin Receptor (OXTR). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate))] | ChEMBL. | No reference |
EC50 (functional) | > 29.905 um | PUBCHEM_BIOASSAY: Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput dose response assay to identify agonists of the vasopressin 1 receptor (V1R). (Class of assay: confirmatory) [Related pubchem assays: 2435 (Primary screen (OXTR agonists in singlicate)), 434991 (Counterscreen (V1R agonists in triplicate)), 2482 (Summary (OXTR agonists)), 434963 (Confirmation screen (OXTR agonists in triplicate)), 2797 (Counterscreen (V1R agonists in singlicate))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.