Detailed information for compound 1345247

Basic information

Technical information
  • TDR Targets ID: 1345247
  • Name: 2-cyclohexyl-1-methylbenzimidazole
  • MW: 214.306 | Formula: C14H18N2
  • H donors: 0 H acceptors: 1 LogP: 3.64 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(nc2c1cccc2)C1CCCCC1
  • InChi: 1S/C14H18N2/c1-16-13-10-6-5-9-12(13)15-14(16)11-7-3-2-4-8-11/h5-6,9-11H,2-4,7-8H2,1H3
  • InChiKey: CPSWFAFTCAVDJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-cyclohexyl-1-methyl-benzimidazole
  • BAS 11135719
  • MLS001208642
  • SMR000524779
  • 2-Cyclohexyl-1-methyl-1H-benzoimidazole
  • A4295/0183253

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Importin beta-1 subunit 0.0035 0.014 0.014
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0683 1 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0267 0.3667 0.3667
Loa Loa (eye worm) TAR-binding protein 0.0198 0.2619 0.39
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0526 0.0526
Echinococcus multilocularis tar DNA binding protein 0.0198 0.2619 0.4973
Schistosoma mansoni alpha glucosidase 0.0038 0.019 0.019
Schistosoma mansoni eyes absent homolog 0.0087 0.0927 0.0927
Schistosoma mansoni hypothetical protein 0.0205 0.2724 0.2724
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.014 0.014
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0267 0.3667 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.019 0.019
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0683 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.2224 0.4222
Echinococcus granulosus importin subunit beta 1 0.0035 0.014 0.0266
Loa Loa (eye worm) hypothetical protein 0.0087 0.0927 0.1381
Schistosoma mansoni dihydroorotate dehydrogenase 0.0683 1 1
Plasmodium falciparum importin beta, putative 0.0035 0.014 0.014
Echinococcus multilocularis snurportin 1 0.0372 0.5267 1
Schistosoma mansoni hypothetical protein 0.0205 0.2724 0.2724
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0294 0.0558
Loa Loa (eye worm) runx1 0.0059 0.0501 0.0747
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.019 0.0361
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.2224 0.4222
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0683 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0569 0.0569
Brugia malayi RNA recognition motif domain containing protein 0.0198 0.2619 0.2619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0294 0.0558
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.2224 0.3311
Echinococcus multilocularis importin subunit beta 1 0.0035 0.014 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.019 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0294 0.0438
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0569 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0294 0.0558
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0294 0.0294
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5267 0.7842
Schistosoma mansoni alpha-glucosidase 0.0148 0.186 0.186
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0518
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0267 0.3667 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0267 0.3667 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0518
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0294 0.0558
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0526 0.0783
Schistosoma mansoni hypothetical protein 0.0372 0.5267 0.5267
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.019 0.0518
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.019 0.019
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0569 0.0569
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0518
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0526 0.0526
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2619 0.2619
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0683 1 1
Loa Loa (eye worm) hypothetical protein 0.0467 0.6716 1
Schistosoma mansoni alpha-glucosidase 0.0148 0.186 0.186
Entamoeba histolytica hypothetical protein 0.0028 0.004 0.0108
Trypanosoma brucei glucosidase, putative 0.0038 0.019 0.019
Leishmania major importin beta-1 subunit, putative 0.0028 0.004 0.004
Echinococcus granulosus snurportin 1 0.0372 0.5267 1
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0683 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0267 0.3667 0.6962
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0267 0.3667 0.3667
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0683 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.004 0.004
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.0927 0.1381
Brugia malayi RNA binding protein 0.0198 0.2619 0.2619
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0683 1 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.019 0.0361
Echinococcus granulosus tar DNA binding protein 0.0198 0.2619 0.4973
Brugia malayi TAR-binding protein 0.0198 0.2619 0.2619
Loa Loa (eye worm) hypothetical protein 0.0467 0.6716 1
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2619 0.2619
Schistosoma mansoni importin beta-1 0.0035 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2619 0.2619
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.006 0.0526 0.0783
Brugia malayi hypothetical protein 0.0087 0.0927 0.0927
Loa Loa (eye worm) RNA binding protein 0.0198 0.2619 0.39
Schistosoma mansoni lozenge 0.0059 0.0501 0.0501
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0267 0.3667 0.6962
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0683 1 0.5
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.019 0.0283
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0569 0.108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.019 0.0518
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0569 0.108
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0294 0.0294
Trichomonas vaginalis importin beta-1, putative 0.0028 0.004 0.0108
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0267 0.3667 0.6962
Brugia malayi hypothetical protein 0.0467 0.6716 0.6716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0294 0.0294
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.0108
Leishmania major dihydroorotate dehydrogenase 0.0683 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0518
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0267 0.3667 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.2224 0.2224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0294 0.0294
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.004 0.0108
Onchocerca volvulus 0.0467 0.6716 1
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2619 0.2619
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.019 0.019
Schistosoma mansoni tar DNA-binding protein 0.0198 0.2619 0.2619
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.2224 0.4222
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0267 0.3667 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0569 0.0569
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0683 1 1
Echinococcus multilocularis geminin 0.0205 0.2724 0.5172
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.014 0.014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.019 0.0518
Plasmodium falciparum dihydroorotate dehydrogenase 0.0683 1 1
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0683 1 0.5
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0267 0.3667 1
Echinococcus multilocularis Protein lozenge 0.0059 0.0501 0.0952
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0267 0.3667 1
Brugia malayi RNA, U transporter 1 0.0099 0.1117 0.1117
Echinococcus granulosus geminin 0.0205 0.2724 0.5172
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0683 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.014 0.014
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0041 0.0236 0.0236
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0267 0.3667 0.6962
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0198 0.2619 0.39
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0352
Plasmodium vivax importin-beta 2, putative 0.0035 0.014 0.014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.019 0.0518
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.019 0.0518
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.019 0.0518

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0073 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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