Detailed information for compound 1345437

Basic information

Technical information
  • TDR Targets ID: 1345437
  • Name: NCGC00024918-01
  • MW: 364.502 | Formula: C19H28N2O3S
  • H donors: 0 H acceptors: 2 LogP: 2.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)CCN1[C@H]2C[C@H]2[C@H](C1)CCCN2S(=O)(=O)CC
  • InChi: 1S/C19H28N2O3S/c1-3-25(22,23)21-9-4-5-15-13-20-10-8-14-11-16(24-2)6-7-17(14)19(20)12-18(15)21/h6-7,11,15,18-19H,3-5,8-10,12-13H2,1-2H3/t15-,18-,19-/m0/s1
  • InChiKey: UMGBFFAJXFXOIL-SNRMKQJTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCGC00024918-02
  • Tocris-0987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0153 0.0301
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0153 0.0301
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0112 0.0112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0105 0.0105
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0023 0.0112 0.0013
Giardia lamblia DNA repair protein RAD52 0.0355 0.5388 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0153 0.0301
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0112 0.0112
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0112 0.0112
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0112 0.0112
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0112 0.0112
Toxoplasma gondii exonuclease III APE 0.0023 0.0105 0.0206
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0335 0.5074 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0112 0.0112
Brugia malayi PXA domain containing protein 0.0023 0.0112 0.0112
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0112 0.0112
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0153 0.0301
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0112 0.0112
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0112 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0553 0.0553
Chlamydia trachomatis dihydrofolate reductase 0.0645 1 0.5
Brugia malayi hypothetical protein 0.0017 0.0008 0.0008
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0112 0.0112
Echinococcus multilocularis dihydrofolate reductase 0.0645 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0112 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0105 0.0105
Brugia malayi hypothetical protein 0.0023 0.0112 0.0112
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0335 0.5074 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0112 0.0112
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0112 0.0112
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0105 0.5
Loa Loa (eye worm) dihydrofolate reductase 0.0645 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Brugia malayi PXA domain containing protein 0.0023 0.0112 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0101 0.135 0.2356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0105 0.0206
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0112 0.0112
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0112 0.0112
Leishmania major hypothetical protein, conserved 0.0026 0.0153 0.0301
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0112 0.0112
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0112 0.0112
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0051 0.0553 0.0553
Brugia malayi hypothetical protein 0.0023 0.0112 0.0112
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0101 0.135 0.2356
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0105 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0112 0.0112
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0112 0.0112
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0335 0.5074 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0105 0.5
Schistosoma mansoni dihydrofolate reductase 0.0645 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0112 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0112 0.0112
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0105 0.0105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0553 0.0553
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0553 0.0553
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0645 1 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0335 0.5074 1
Echinococcus granulosus expressed protein 0.0451 0.6911 0.6911
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0645 1 0.5
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0035 0.0297 0.0297
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0112 0.0112
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0153 0.0301
Schistosoma mansoni ap endonuclease 0.0023 0.0105 0.0105
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0112 0.0112
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0105 0.0105
Echinococcus multilocularis expressed protein 0.0451 0.6911 0.6911
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0105 0.0206
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0335 0.5074 1
Brugia malayi hypothetical protein 0.0026 0.0153 0.0153
Schistosoma mansoni ap endonuclease 0.0023 0.0105 0.0105
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0112 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0112 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0153 0.0301
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0645 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0112
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0112 1
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0112 0.0112
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0335 0.5074 1
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0112 0.0112
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0112 0.0112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0105 0.0206
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0112 0.0112
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0112 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0153 0.0301
Entamoeba histolytica hypothetical protein 0.0023 0.0112 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0105 0.0206
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0105 0.0206
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0023 0.0112 0.0013
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0112 0.0112
Brugia malayi Dihydrofolate reductase 0.0645 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0297 0.0297
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0112 0.0112
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0355 0.5388 1
Echinococcus granulosus dihydrofolate reductase 0.0645 1 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.0752 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.