TDR Targets

Basic information

Technical information

TDR Targets ID: 1345527
Name: N-[2-(2,5-dimethoxyphenyl)ethyl]-3-(6-piperid in-1-yl-[1,2,4]triazolo[5,4-f]pyridazin-3-yl) propanamide
MW: 438.523 | Formula: C23H30N6O3
H donors: 1 H acceptors: 4 LogP: 2.48 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1CCNC(=O)CCc1nnc2n1nc(cc2)N1CCCCC1)OC
InChi: 1S/C23H30N6O3/c1-31-18-6-7-19(32-2)17(16-18)12-13-24-23(30)11-10-21-26-25-20-8-9-22(27-29(20)21)28-14-4-3-5-15-28/h6-9,16H,3-5,10-15H2,1-2H3,(H,24,30)
InChiKey: HLBKEOACSCIYMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(2,5-dimethoxyphenyl)ethyl]-3-[6-(1-piperidyl)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]propanamide
N-[2-(2,5-dimethoxyphenyl)ethyl]-3-(6-piperidino-[1,2,4]triazolo[5,4-f]pyridazin-3-yl)propionamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	C-MYB, putative	0.0028	0.009	0.3027
Schistosoma mansoni	hypothetical protein	0.0504	0.2586	1
Giardia lamblia	DINP protein human, muc B family	0.0039	0.0147	1
Echinococcus granulosus	dna polymerase kappa	0.0039	0.0147	0.0568
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0216	0.1076	0.1452
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0028	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Plasmodium falciparum	DNA repair protein REV1, putative	0.0012	0.0006	0.0124
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0008	0.0244
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0273	0.1054
Echinococcus granulosus	Chromo domain	0.0011	0	0.0002
Trypanosoma brucei	trypanothione reductase	0.0095	0.044	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0216	0.1076	0.1452
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.005	0.1123
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000070125
Echinococcus granulosus	chromobox protein 2	0.0011	0	0.0002
Trypanosoma brucei	unspecified product	0.0027	0.0084	0.1789
Echinococcus granulosus	smad	0.0016	0.0028	0.0108
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.0443
Schistosoma mansoni	hypothetical protein	0.0019	0.0042	0.0164
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0065	0.2163
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000070125
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0028	0.009	0.2872
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0141	0.9031
Brugia malayi	hypothetical protein	0.0071	0.0313	0.2612
Trypanosoma brucei	DNA polymerase eta, putative	0.0065	0.0282	0.6367
Brugia malayi	TAR-binding protein	0.0063	0.0273	0.2274
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0006	0.0045
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.024	0.1203	0.0208
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0043	0.0844
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0232	0.0898
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1917	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0297	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0071	0.0587
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0273	0.2274
Brugia malayi	hypothetical protein	0.0016	0.0025	0.0207
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.0147	0.0568
Schistosoma mansoni	chromobox protein	0.0068	0.0297	0.1149
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0033	0.0115	0.0954
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0297	0.1149
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0011	0	0.0002
Leishmania major	hypothetical protein, conserved	0.0024	0.0071	0.1495
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0158	0.1318
Brugia malayi	chromobox protein homolog 3	0.0038	0.0141	0.1176
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0084	0.1789
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.0147	0.1224
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0232	0.1936
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0028	0.0108
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0043	0.0164
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.0147	0.0568
Entamoeba histolytica	hypothetical protein	0.0011	0	0.00000000066538
Trichomonas vaginalis	pc-MYB2, putative	0.0028	0.009	0.3027
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.0443
Trichomonas vaginalis	mercuric reductase, putative	0.0033	0.0115	0.385
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000066538
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0232	0.0898
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0541	0.2778	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0141	0.4746
Schistosoma mansoni	smad	0.0016	0.0028	0.0108
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.0028	0.0091	0.0326
Brugia malayi	Smad1	0.0016	0.0028	0.0229
Loa Loa (eye worm)	hypothetical protein	0.003	0.0098	0.0817
Echinococcus multilocularis	Chromo domain	0.0011	0	0.0002
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0065	0.2163
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0043	0.0351
Brugia malayi	ImpB/MucB/SamB family protein	0.0065	0.0282	0.2352
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0313	0.1211
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0071	0.1601
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0156	0.5254
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0273	0.1054
Echinococcus granulosus	geminin	0.0504	0.2586	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0313	1
Brugia malayi	MH2 domain containing protein	0.0016	0.0028	0.0229
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0028	0.0108
Mycobacterium tuberculosis	Probable oxidoreductase	0.024	0.1203	0.1629
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0028	0.0108
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Brugia malayi	MH2 domain containing protein	0.0016	0.0028	0.0229
Echinococcus granulosus	thioredoxin glutathione reductase	0.0095	0.044	0.1699
Trypanosoma cruzi	DNA polymerase eta, putative	0.0065	0.0282	0.6367
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0033	0.0115	0.771
Schistosoma mansoni	DNA polymerase IV / kappa	0.0012	0.0006	0.0023
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0042	0.035
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.0147	0.0568
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0297	0.2478
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0071	0.1495
Brugia malayi	polk-prov protein	0.0012	0.0006	0.0045
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000070125
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.0091	0.3051
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.1197	1
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA	0.1377	0.7165	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0095	0.044	0.1699
Trichomonas vaginalis	MYB3r3, putative	0.0028	0.009	0.3027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Schistosoma mansoni	hypothetical protein	0.0504	0.2586	1
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0147	0.0141
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0141	0.4746
Brugia malayi	Heterochromatin protein 1	0.0068	0.0297	0.2478
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0042	0.0164
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0039	0.0151
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0043	0.0351
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000070125
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0043	0.0957
Leishmania major	trypanothione reductase	0.0095	0.044	1
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0028	0.009	0.2872
Trichomonas vaginalis	pc-MYB2, putative	0.0028	0.009	0.3027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0042	0.0164
Schistosoma mansoni	chromobox protein	0.0011	0	0.0002
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0216	0.1076	0.1452
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0071	0.1601
Echinococcus granulosus	chromobox protein 1	0.0068	0.0297	0.1149
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0043	0.0151
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0258	0.2153
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.0109
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0147	0.3254
Loa Loa (eye worm)	CHromoDomain protein family member	0.0011	0	0.00000000017379
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0147	0.3254
Entamoeba histolytica	hypothetical protein	0.0071	0.0313	1
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0065	0.025
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0095	0.044	0.0557
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0065	0.025
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0	0.0002
Echinococcus multilocularis	Chromobox protein 3	0.0011	0	0.0002
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.0147	0.3254
Toxoplasma gondii	NADPH-glutathione reductase	0.0033	0.0115	0.0411
Plasmodium vivax	thioredoxin reductase, putative	0.0095	0.044	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.2508
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0065	0.0536
Plasmodium vivax	hypothetical protein, conserved	0.0011	0	0.00000000047383
Echinococcus granulosus	Smad4	0.0016	0.0028	0.0108
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000066538
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Plasmodium falciparum	thioredoxin reductase	0.0033	0.0115	0.2601
Trichomonas vaginalis	C-MYB, putative	0.0028	0.009	0.3027
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0042	0.0164
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000066538
Schistosoma mansoni	chromobox protein	0.0068	0.0297	0.1149
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0083	0.2789
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0039	0.0147	0.4939
Trichomonas vaginalis	DNA polymerase eta, putative	0.0039	0.0147	0.4939
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0043	0.0844
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0028	0.0229
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0156	0.5254
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0043	0.0844
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0273	0.2274
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0	0.0002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0232	0.0898
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0008	0.0042
Plasmodium falciparum	glutathione reductase	0.0033	0.0115	0.2601
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Schistosoma mansoni	hypothetical protein	0.0019	0.0042	0.0164
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0258	0.2153
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0273	0.1054
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0541	0.2778	0.2795
Onchocerca volvulus		0.003	0.0098	0.6276
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0084	0.1789
Echinococcus granulosus	chromobox protein 1	0.0068	0.0297	0.1149
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0216	0.1076	0.1452
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0028	0.0108
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Brugia malayi	CHD4 protein	0.0011	0	0.00000000017379
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0083	0.2789
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0043	0.0164
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0	0.00000000017379
Entamoeba histolytica	hypothetical protein	0.0071	0.0313	1
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0147	0.0141
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0071	0.1495
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0297	0.1149
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0156	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.024	0.1203	0.1629
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0043	0.0164
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0033	0.0115	0.0109
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0232	0.0898
Schistosoma mansoni	Smad4	0.0016	0.0028	0.0108
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0033	0.0115	0.2601
Trypanosoma brucei	unspecified product	0.0027	0.0084	0.1789
Mycobacterium tuberculosis	Probable dehydrogenase	0.0216	0.1076	0.1452
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0541	0.2778	0.2774
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0297	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0028	0.0108
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0033	0.0115	0.2508
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0025	0.056
Entamoeba histolytica	hypothetical protein	0.0071	0.0313	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0033	0.0115	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0084	0.1789
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0	0.00000000017379
Plasmodium falciparum	glutathione reductase	0.0095	0.044	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0024	0.0069	0.0572
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0232	0.0898
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0012	0.0006	0.002
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0141	0.3114
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0043	0.0164
Plasmodium vivax	glutathione reductase, putative	0.0095	0.044	1
Trichomonas vaginalis	MYB, putative	0.0028	0.0091	0.3051
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0043	0.0164
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0011	0	0.000000000074902
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.0147	0.4686
Loa Loa (eye worm)	hypothetical protein	0.006	0.0258	0.2153
Trichomonas vaginalis	glutathione reductase, putative	0.0033	0.0115	0.385
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0273	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0141	0.1176
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0033	0.0115	0.2508
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0	0.0002
Leishmania major	DNA polymerase eta, putative	0.0065	0.0282	0.6367
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0042	0.0164
Brugia malayi	MH1 domain containing protein	0.0016	0.0028	0.0229
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0033	0.0115	0.2508
Echinococcus granulosus	Chromobox protein 3	0.0011	0	0.0002
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0313	0.1211
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0028	0.0229
Echinococcus multilocularis	dna polymerase kappa	0.0039	0.0147	0.0568
Brugia malayi	glutathione reductase	0.0095	0.044	0.3668
Schistosoma mansoni	hypothetical protein	0.0011	0	0.0002
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0043	0.0957
Schistosoma mansoni	hypothetical protein	0.0071	0.0313	0.1211
Schistosoma mansoni	DNA polymerase eta	0.0065	0.0282	0.109
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0158	0.1318
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0043	0.0844
Schistosoma mansoni	hypothetical protein	0.0019	0.0042	0.0164
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0258	0.2153
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0043	0.0164
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0232	0.1936
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0011	0	0.0002
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0071	0.1495
Mycobacterium leprae	PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	0.1377	0.7165	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0033	0.0115	0.2508
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0024	0.0085
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0033	0.0115	0.0411
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0028	0.009	0.2872
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0	0.0002
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0033	0.0115	0.2508
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1917	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0282	0.2352
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0033	0.0115	0.2508
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0033	0.0115	0.0101
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0232	0.0898
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0028	0.0108
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0273	0.1054
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.0147	0.0147
Brugia malayi	hypothetical protein	0.0024	0.0071	0.0587
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0042	0.0164
Plasmodium falciparum	thioredoxin reductase	0.0095	0.044	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Loa Loa (eye worm)	glutathione reductase	0.0095	0.044	0.3668
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0011	0	0.00000000070125
Brugia malayi	Thioredoxin reductase	0.0095	0.044	0.3668
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0008	0.0042
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0273	0.1054
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0028	0.0108
Echinococcus granulosus	dna polymerase eta	0.0065	0.0282	0.109
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0273	0.2274
Echinococcus multilocularis	Smad4	0.0016	0.0028	0.0108
Leishmania major	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Loa Loa (eye worm)	Smad1	0.0016	0.0028	0.0229
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0	0.0002
Schistosoma mansoni	hypothetical protein	0.0041	0.0158	0.0612
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0232	0.0898
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0147	0.3254
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.0443
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0033	0.0115	0.2601
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0043	0.0151
Trypanosoma cruzi	trypanothione reductase, putative	0.0095	0.044	1
Echinococcus multilocularis	geminin	0.0504	0.2586	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0033	0.0115	0.2601
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0273	0.2274
Trichomonas vaginalis	MYB72, putative	0.0028	0.009	0.3027
Mycobacterium tuberculosis	Probable reductase	0.0216	0.1076	0.1452
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0033	0.0115	0.2508
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0065	0.0536
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0313	0.1211
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Brugia malayi	RNA binding protein	0.0063	0.0273	0.2274
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0541	0.2778	0.2694
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0071	0.1601
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Leishmania major	DNA polymerase eta, putative	0.0038	0.0141	0.3114
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0028	0.009	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0011	0	0.00000000017379
Schistosoma mansoni	chromobox protein	0.0011	0	0.0002
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.024	0.1203	0.1629
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0008	0.0232
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0043	0.0844
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0141	0.0506
Brugia malayi	MH1 domain containing protein	0.0016	0.0028	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0	0.00000000047383
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.009	0.3027
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0011	0	0.0002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0042	0.035
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.1197	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0	0.0002
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0043	0.0351
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.0028	0.0091	0.3051
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1917	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Echinococcus granulosus	GPCR family 2	0.0019	0.0042	0.0164
Brugia malayi	MH2 domain containing protein	0.0239	0.1197	1
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.0028	0.009	0.2872
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0012	0.0006	0.002
Loa Loa (eye worm)	thioredoxin reductase	0.0095	0.044	0.3668
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0147	0.3254
Trypanosoma brucei	unspecified product	0.0039	0.0147	0.3254
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.0147	0.0568
Echinococcus multilocularis	smad	0.0016	0.0028	0.0108
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0011	0	0.00000000070125
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0042	0.035
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0071	0.0253
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0033	0.0115	0.2601
Plasmodium vivax	DNA repair protein REV1, putative	0.0012	0.0006	0.0124
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0043	0.0164
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0147	0.0147
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0273	0.1054
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0008	0.0042
Echinococcus multilocularis	dna polymerase eta	0.0065	0.0282	0.109
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0147	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0558	0.4654
Giardia lamblia	Myb 1-like protein	0.0028	0.0091	0.6028
Schistosoma mansoni	hypothetical protein	0.0019	0.0042	0.0164
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0033	0.0115	0.2508
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0024	0.0069	0.0572
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0042	0.035
Echinococcus multilocularis	chromobox protein 2	0.0011	0	0.0002
Toxoplasma gondii	thioredoxin reductase	0.0095	0.044	0.1581
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0033	0.0115	0.2508
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0147	0.3254

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 112.219 um	PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)]	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1439683

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1345527