Detailed information for compound 1345752

Basic information

Technical information
  • TDR Targets ID: 1345752
  • Name: N-(5-ethyl-6-oxobenzo[b][1,4]benzothiazepin-3 -yl)acetamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1c2cc(ccc2Sc2c(C1=O)cccc2)NC(=O)C
  • InChi: 1S/C17H16N2O2S/c1-3-19-14-10-12(18-11(2)20)8-9-16(14)22-15-7-5-4-6-13(15)17(19)21/h4-10H,3H2,1-2H3,(H,18,20)
  • InChiKey: AUJRLHNDBRBFTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-ethyl-6-oxo-benzo[b][1,4]benzothiazepin-3-yl)acetamide
  • N-(5-ethyl-6-oxo-3-benzo[b][1,4]benzothiazepinyl)acetamide
  • N-(5-ethyl-6-keto-benzo[b][1,4]benzothiazepin-3-yl)acetamide
  • N-(5-ethyl-6-oxo-benzo[b][1,4]benzothiazepin-3-yl)ethanamide
  • G851-0060
  • NCGC00135064-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Echinococcus multilocularis cathepsin b 0.0501 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Loa Loa (eye worm) hypothetical protein 0.0501 1 1
Schistosoma mansoni lamin 0.0033 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Onchocerca volvulus Cathepsin F homolog 0.0238 0.4542 1
Echinococcus multilocularis cysteine protease 0.0238 0.4542 0.4542
Echinococcus granulosus intermediate filament protein 0.0033 0.0281 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.4542 1
Onchocerca volvulus Cathepsin L homolog 0.0238 0.4542 1
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.2287 0.1662
Brugia malayi fibroinase precursor 0.0055 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0749 0.0749
Brugia malayi Cathepsin L-like precursor 0.0164 0.3004 0.3004
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.2287 0.4054
Plasmodium vivax vivapain-2 0.0238 0.4542 1
Onchocerca volvulus 0.0238 0.4542 1
Echinococcus multilocularis cathepsin b 0.0501 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0238 0.4542 0.41
Loa Loa (eye worm) hypothetical protein 0.0074 0.1142 0.1142
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Loa Loa (eye worm) hypothetical protein 0.0164 0.3004 0.3004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0459 0.0459
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.4542 0.41
Echinococcus granulosus cysteine protease 0.0129 0.2287 0.2287
Trypanosoma cruzi cysteine protease, putative 0.0129 0.2287 0.1662
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0749 0.0749
Onchocerca volvulus 0.0238 0.4542 1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.1142 0.0425
Loa Loa (eye worm) hypothetical protein 0.0164 0.3004 0.3004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0238 0.4542 1
Schistosoma mansoni cathepsin s 0.0074 0.1142 0.1142
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0055 0.0749 0.0749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.4542 0.41
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Echinococcus granulosus lamin dm0 0.0033 0.0281 0.0281
Echinococcus multilocularis cysteine protease 0.0238 0.4542 0.4542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0238 0.4542 0.4542
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0129 0.2287 0.1662
Brugia malayi cathepsin L-like precursor 0.0164 0.3004 0.3004
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0749 0.0749
Plasmodium vivax vivapain-3 0.0129 0.2287 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0749 0.0749
Echinococcus granulosus cathepsin b 0.0501 1 1
Echinococcus granulosus lamin 0.0033 0.0281 0.0281
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Loa Loa (eye worm) ctsf protein 0.0238 0.4542 0.4542
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0501 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Loa Loa (eye worm) fibroinase 0.0238 0.4542 0.4542
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Brugia malayi cathepsin F-like cysteine proteinase 0.0074 0.1142 0.1142
Trypanosoma cruzi cysteine proteinase, putative 0.0129 0.2287 0.1662
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.4542 0.4542
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0129 0.2287 0.2287
Schistosoma mansoni cathepsin S (C01 family) 0.0055 0.0749 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Onchocerca volvulus 0.0238 0.4542 1
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.2287 0.2287
Echinococcus granulosus cathepsin L 0.0055 0.0749 0.0749
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0749 0.0749
Schistosoma mansoni cathepsin F (C01 family) 0.0164 0.3004 0.3004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Schistosoma mansoni hypothetical protein 0.0041 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0033 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.4542 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0238 0.4542 0.4542
Loa Loa (eye worm) cysteine protease 0.0238 0.4542 0.4542
Schistosoma mansoni lamin 0.0033 0.0281 0.0281
Echinococcus granulosus cathepsin L cysteine protease 0.0129 0.2287 0.2287
Onchocerca volvulus 0.0238 0.4542 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0501 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.4542 0.41
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0055 0.0749 0.0749
Echinococcus granulosus cathepsin l cysteine peptidase 0.0238 0.4542 0.4542
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0749 0.0749
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.2287 0.4054
Loa Loa (eye worm) cathepsin B 0.0193 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.0238 0.4542 0.4542
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0164 0.3004 0.2438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1142 0.1142
Entamoeba histolytica cysteine proteinase, putative 0.0164 0.3004 0.5946
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0238 0.4542 0.4542
Brugia malayi cathepsin L-like cysteine proteinase 0.0055 0.0749 0.0749
Onchocerca volvulus 0.0238 0.4542 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.006 0.0854 0.0854
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0281 0.0281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0238 0.4542 0.4542
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0749 0.0749
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Echinococcus multilocularis cathepsin L 0.0129 0.2287 0.2287
Plasmodium vivax vivapain-1 0.0129 0.2287 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.2287 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0164 0.3004 0.3004
Brugia malayi Cathepsin L-like precursor 0.0074 0.1142 0.1142
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0129 0.2287 0.2287
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0749 0.11
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0281 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0193 0.361 0.361
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0749 0.0749
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0749 0.0749
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.4542 0.4542
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0854 0.0854
Onchocerca volvulus 0.0164 0.3004 0.6392
Echinococcus multilocularis lamin dm0 0.0033 0.0281 0.0281
Toxoplasma gondii cathepsin B 0.0193 0.361 0.7543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Echinococcus multilocularis musashi 0.0033 0.0281 0.0281
Plasmodium vivax vivapain-2 0.0238 0.4542 1
Echinococcus granulosus cathepsin l1 0.0164 0.3004 0.3004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0749 0.0749
Echinococcus granulosus cathepsin b 0.0501 1 1
Brugia malayi Cathepsin L-like precursor 0.0164 0.3004 0.3004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0193 0.361 0.7543
Plasmodium vivax unspecified product 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.3004 0.5946
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.4542 0.4542
Trypanosoma brucei cysteine peptidase C (CPC) 0.0193 0.361 0.5868
Echinococcus multilocularis lamin 0.0033 0.0281 0.0281
Schistosoma mansoni cathepsin C 0.0055 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0749 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0749 0.0749
Trypanosoma cruzi cysteine peptidase, putative 0.0238 0.4542 0.41
Brugia malayi intermediate filament protein 0.0033 0.0281 0.0281
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0501 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0238 0.4542 1
Trypanosoma cruzi cysteine proteinase, putative 0.0129 0.2287 0.1662
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.0749 0.0749
Echinococcus multilocularis cathepsin L 0.0055 0.0749 0.0749
Schistosoma mansoni cathepsin F (C01 family) 0.0238 0.4542 0.4542
Echinococcus granulosus cathepsin L 0.0129 0.2287 0.2287
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Giardia lamblia Cathepsin B precursor 0.0193 0.361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Onchocerca volvulus 0.0055 0.0749 0.11
Brugia malayi Papain family cysteine protease containing protein 0.0238 0.4542 0.4542
Brugia malayi cathepsin L precursor 0.0055 0.0749 0.0749
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.2287 0.4054
Schistosoma mansoni intermediate filament proteins 0.0033 0.0281 0.0281
Brugia malayi Cathepsin L-like precursor 0.0238 0.4542 0.4542
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0238 0.4542 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0055 0.0749 0.0749
Entamoeba histolytica cysteine proteinase 2 0.0129 0.2287 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0129 0.2287 0.2287
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0749 0.0749
Plasmodium vivax unspecified product 0.0074 0.1142 0.1037
Plasmodium falciparum cysteine proteinase falcipain 3 0.0238 0.4542 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0193 0.361 0.3093
Onchocerca volvulus 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0129 0.2287 0.2287
Loa Loa (eye worm) hypothetical protein 0.0164 0.3004 0.3004
Entamoeba histolytica cysteine proteinase 1, putative 0.0129 0.2287 0.4054
Toxoplasma gondii cathepsin CPL 0.0238 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Leishmania major cathepsin L-like protease 0.0238 0.4542 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0238 0.4542 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0459 0.0459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0238 0.4542 1
Giardia lamblia Cathepsin B precursor 0.0193 0.361 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0281 0.0281
Schistosoma mansoni cathepsin B (C01 family) 0.0055 0.0749 0.0749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0501 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0164 0.3004 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.0238 0.4542 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0055 0.0749 0.0749
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Echinococcus granulosus cathepsin l1 0.0238 0.4542 0.4542
Onchocerca volvulus Cathepsin L homolog 0.0238 0.4542 1
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0501 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0074 0.1142 0.1142
Onchocerca volvulus 0.0238 0.4542 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1142 0.1142
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.1142 0.0425
Giardia lamblia Cathepsin B precursor 0.0193 0.361 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0238 0.4542 0.4542
Entamoeba histolytica cysteine protease, putative 0.0238 0.4542 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0238 0.4542 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0854 0.0854
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0074 0.1142 0.1142
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0854 0.0854
Entamoeba histolytica cysteine protease, putative 0.0129 0.2287 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0238 0.4542 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0749 0.0749

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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