Detailed information for compound 1345854

Basic information

Technical information
  • TDR Targets ID: 1345854
  • Name: (hydroxy-phenylmethyl)-(2-phenylethyl)phosphi nic acid
  • MW: 276.267 | Formula: C15H17O3P
  • H donors: 2 H acceptors: 3 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(P(=O)(CCc1ccccc1)O)c1ccccc1
  • InChi: 1S/C15H17O3P/c16-15(14-9-5-2-6-10-14)19(17,18)12-11-13-7-3-1-4-8-13/h1-10,15-16H,11-12H2,(H,17,18)
  • InChiKey: CUALNQVZGAFGBK-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (hydroxy-phenyl-methyl)-(2-phenylethyl)phosphinic acid
  • STOCK2S-62223
  • (Hydroxy-phenyl-methyl)-phenethyl-phosphinic acid
  • MLS000554124
  • SMR000146441

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.0715
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0072 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0332 0.1277
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0332 0.2086
Trichomonas vaginalis MYB, putative 0.002 0.0078 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0159 0.0613
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0131 0.0589
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0159 0.0613
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0041 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0074 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0159 0.0571
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0159 0.0613
Echinococcus multilocularis 0.0011 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0404 0.1725
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0204 0.0269
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0159 0.0965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0159 0.0571
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0397 0.2773 0.2746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0041 0.016
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0186 0.0715
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.4301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Brugia malayi RNA, U transporter 1 0.0099 0.0645 0.4123
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0125 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0159 0.0965
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0074 0.0306
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.028 0.1752
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0232 0.1087
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1972 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0159 0.0613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0159 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0159 0.0965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.2039 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0131 0.4894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0131 0.4894
Brugia malayi hypothetical protein 0.0027 0.0131 0.0782
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0159 0.0965
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0603 0.0827
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0533
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0095 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0172 0.0662
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0115 0.0398
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0159 0.0613
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0109 0.0137
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0159 0.0613
Onchocerca volvulus 0.0046 0.0268 0.1312
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0603 0.0827
Brugia malayi ecdysone receptor 0.0015 0.0041 0.02
Leishmania major trypanothione reductase 0.0041 0.0229 0.107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.062
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.2039 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0186 0.0858
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0932 0.4537
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0159 0.0613
Giardia lamblia Myb 1-like protein 0.002 0.0078 0.0207
Brugia malayi nuclear hormone receptor 0.0031 0.0159 0.0965
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0014 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0677 0.0931
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.028 0.138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0332 0.1277
Brugia malayi hypothetical protein 0.0155 0.1047 0.6739
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0045 0.0033
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.012 0.4301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0159 0.0965
Schistosoma mansoni ran 0.0026 0.012 0.0461
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0041 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1549 0.5948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0159 0.0965
Echinococcus multilocularis cpg binding protein 0.0033 0.0171 0.0658
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0014 0.0052
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0038 0.0128
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0038 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0332 0.1277
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0041 0.016
Brugia malayi nuclear receptor RXR 0.0016 0.0054 0.0281
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0208
Onchocerca volvulus 0.0026 0.0121 0.0458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0159 0.0613
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0172 0.0662
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0931 0.1285
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0041 0.016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0041 0.0116
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1407 1 1
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0121 0.0458
Brugia malayi Cytochrome P450 family protein 0.0019 0.0074 0.0409
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0232 0.1087
Entamoeba histolytica hypothetical protein 0.0028 0.0138 0.0324
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0662
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.012 0.0461
Echinococcus multilocularis snurportin 1 0.0372 0.2596 1
Brugia malayi ecdysteroid receptor 0.0031 0.0159 0.0965
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Schistosoma mansoni zinc finger protein 0.0015 0.0041 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0159 0.0613
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0121 0.0153
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0159 0.0613
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0159 0.068
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0041 0.02
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0074 0.0062
Loa Loa (eye worm) glutathione reductase 0.0041 0.0229 0.084
Mycobacterium ulcerans hypothetical protein 0.0155 0.1044 0.1034
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.0715
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0159 0.0613
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0041 0.02
Brugia malayi nuclear receptor NHR-88 0.0031 0.0159 0.0965
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1972 1
Brugia malayi nuclear receptor NHR-88 0.0015 0.0041 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0332 0.1277
Onchocerca volvulus Peroxidase homolog 0.0026 0.0121 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0159 0.0965
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0045 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0603 0.0827
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0041 0.016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0138 0.0521
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0131 0.0589
Onchocerca volvulus 0.0256 0.1771 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0164
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0024 0.0048
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0365 0.128
Plasmodium falciparum thioredoxin reductase 0.0041 0.0229 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0425
Brugia malayi hypothetical protein 0.0015 0.0041 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0128
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0229 0.0303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0159 0.0965
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0932 0.4537
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0159 0.0613
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0281
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0074 0.0306
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0041 0.016
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0404 0.1556
Schistosoma mansoni hypothetical protein 0.0372 0.2596 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Brugia malayi hypothetical protein 0.0016 0.0054 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0159 0.0613
Echinococcus granulosus peroxidasin 0.0026 0.0121 0.0465
Schistosoma mansoni nuclear receptor 0.0015 0.0041 0.016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0159 0.0965
Brugia malayi Peroxidasin 0.0026 0.0121 0.0715
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1771 0.8961
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0415 0.16
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0128
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0404 0.2556
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0019 0.0075 0.0088
Plasmodium falciparum glutathione reductase 0.0041 0.0229 1
Brugia malayi nuclear receptor NHR-67 0.0015 0.0041 0.02
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0115 0.0144
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0121 0.0153
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0159 0.0613
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0041 0.0116
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.0422
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0204 0.0269
Leishmania major cytochrome p450-like protein 0.0019 0.0074 0.0306
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0121 0.0153
Brugia malayi steroid hormone receptor 0.0031 0.0159 0.0965
Trichomonas vaginalis C-MYB, putative 0.002 0.0077 0.0204
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.101 0.7163 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0397 0.2773 0.3862
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0131 0.0433
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0159 0.068
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0186 0.0673
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0145
Onchocerca volvulus 0.0026 0.0121 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0159 0.0965
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0041 0.016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0041 0.016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0172 0.0662
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0012 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0332 0.1238
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0041 0.016
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0054 0.0281
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0074 0.024
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0121 0.0458
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0159 0.0571
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0229 0.107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1044 0.1444
Brugia malayi hypothetical protein 0.0026 0.0121 0.0715
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0074 0.0306
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0332 0.1277
Onchocerca volvulus 0.0033 0.0172 0.0754
Schistosoma mansoni coup transcription factor 0.0031 0.0159 0.0613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Trichomonas vaginalis MYB72, putative 0.002 0.0077 0.0204
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0172 0.0662
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0158 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0159 0.0965
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0045 0.0046
Onchocerca volvulus 0.0031 0.0158 0.0675
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0054 0.0208
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0232 0.0896
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Echinococcus granulosus snurportin 1 0.0372 0.2596 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0041 0.016
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0397 0.2773 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0121 0.0153
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0159 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0164
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0054 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0131 0.4894
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0229 0.084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0159 0.0613
Trypanosoma brucei trypanothione reductase 0.0041 0.0229 0.107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0038 0.0128
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0138 0.0521
Schistosoma mansoni hypothetical protein 0.0174 0.1182 0.4553
Mycobacterium ulcerans polyketide synthase 0.0024 0.0109 0.0098
Onchocerca volvulus 0.0031 0.0159 0.068
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0207 0.0797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0332 0.1277
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0121 0.0397
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0109 0.0098
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0159 0.0965
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0159 0.0613
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0677 0.0931
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0159 0.0571
Trichomonas vaginalis ran, putative 0.0026 0.012 0.0425
Echinococcus multilocularis peroxidasin 0.0026 0.0121 0.0465
Echinococcus multilocularis geminin 0.0174 0.1182 0.4553
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Schistosoma mansoni cpg binding protein 0.0031 0.0158 0.061
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0109 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0041 0.016
Leishmania major importin beta-1 subunit, putative 0.0028 0.0138 0.0625
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0041 0.016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Brugia malayi Cytochrome P450 family protein 0.0011 0.0012 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0159 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0164
Schistosoma mansoni ran 0.0026 0.012 0.0461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0533
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0121 0.011
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0041 0.016
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.006 0.0176
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0404 0.1935
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0677 0.0931
Schistosoma mansoni peroxidasin 0.0026 0.0121 0.0465
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.0422
Toxoplasma gondii thioredoxin reductase 0.0041 0.0229 0.0786
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0041 0.016
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.0715
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0038 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0159 0.0613
Toxoplasma gondii hypothetical protein 0.0047 0.0276 0.0956
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0159 0.0613
Plasmodium vivax importin-beta 2, putative 0.0035 0.0186 0.7746
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0131 0.0589
Brugia malayi glutathione reductase 0.0041 0.0229 0.1416
Echinococcus granulosus geminin 0.0174 0.1182 0.4553
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0014 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0159 0.0571
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0072 0.0061
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0931 0.1285
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0109 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0159 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0159 0.0965
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0159 0.0965
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0072 0.0219
Loa Loa (eye worm) DR-78 0.0015 0.0041 0.0116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0038 0.0026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0038 0.0128
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0147 0.0523
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.0422
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0158 0.0611
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0159 0.0613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0159 0.0613
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0186 0.0858
Mycobacterium ulcerans polyketide synthase 0.0026 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2596 1
Leishmania major GTP-binding protein, putative 0.0026 0.012 0.0533
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0159 0.0613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0229 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0204 0.0269
Mycobacterium ulcerans thioesterase 0.0022 0.0095 0.0084
Schistosoma mansoni importin beta-1 0.0035 0.0186 0.0715
Entamoeba histolytica Ran family GTPase 0.0026 0.012 0.0225
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0054 0.0164
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0041 0.0116
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0013 0.0033 0.0077
Schistosoma mansoni cpg binding protein 0.0033 0.0171 0.0658
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0159 0.0613
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0045 0.0046
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0109 0.0641
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0121 0.0153
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1972 0.1941
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0077 0.0204
Trichomonas vaginalis C-MYB, putative 0.002 0.0077 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0095 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0159 0.0613
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0109 0.0137
Brugia malayi hypothetical protein 0.0016 0.0054 0.0281
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0677 0.0931
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0159 0.0965
Trichomonas vaginalis MYB3r3, putative 0.002 0.0077 0.0204
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0404 0.1935
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0078 0.0239
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0014 0.0007
Brugia malayi Pre-SET motif family protein 0.0033 0.0172 0.1047
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0404 0.1935
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0121 0.0458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0054
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0159 0.0613
Brugia malayi Blistered cuticle protein 3 0.0026 0.0121 0.0715
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0164
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0072 0.0061
Onchocerca volvulus 0.0155 0.1047 0.5815
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.012 0.0392
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0091
Brugia malayi nuclear receptor RXR 0.0015 0.0041 0.02
Schistosoma mansoni cpg binding protein 0.0033 0.0171 0.0658
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0041 0.016
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0073 0.0086
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0024 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0115 0.0675
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0159 0.0965
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1972 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0404 0.1556
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0121 0.0153
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0041 0.02
Schistosoma mansoni peroxidasin 0.0026 0.0121 0.0465
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0462
Brugia malayi Thioredoxin reductase 0.0041 0.0229 0.1416
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Brugia malayi Cytochrome P450 family protein 0.0019 0.0074 0.0409
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0121 0.0458
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0109 0.0137
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0159 0.0613
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0603 0.0827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Brugia malayi cytochrome P450 0.0011 0.0012 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0159 0.068
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Plasmodium vivax SET domain protein, putative 0.0033 0.0172 0.7027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0172 0.058
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.012 0.0461
Plasmodium falciparum importin beta, putative 0.0035 0.0186 0.7746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0603 0.0827
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0138 0.0521
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0159 0.0613
Brugia malayi Cytochrome P450 family protein 0.0029 0.0147 0.0884
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0931 0.092
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0121 0.0153
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.0715
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0709
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0074 0.024
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0204 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0404 0.1518
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0109 0.0137
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0404 0.1556
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.101 0.7163 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1972 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.2039 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0239 0.088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0159 0.0571
Onchocerca volvulus Peroxidase homolog 0.0026 0.0121 0.0458
Schistosoma mansoni nuclear receptor 0.0015 0.0041 0.016
Brugia malayi nuclear hormone receptor 0.0015 0.0041 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0041 0.02
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0078 0.0207
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0038 0.0128
Echinococcus granulosus cpg binding protein 0.0033 0.0171 0.0658
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0186 0.063
Leishmania major hypothetical protein, conserved 0.0027 0.0131 0.0589
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0078 0.0207
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0397 0.2773 0.2765
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0404 0.1935
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0932 0.4537
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0159 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0332 0.1277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.0422
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0041 0.02
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0054 0.0208
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0041 0.016
Brugia malayi Importin beta-1 subunit 0.0035 0.0186 0.1136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0172 0.0662
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0232 0.1087
Brugia malayi hypothetical protein 0.0015 0.0041 0.02
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0121 0.0153
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0207 0.0797
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Loa Loa (eye worm) hypothetical protein 0.0155 0.1047 0.4007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0038 0.0128
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0077 0.0204
Brugia malayi tailless protein 0.0015 0.0041 0.02
Plasmodium vivax glutathione reductase, putative 0.0041 0.0229 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0095 0.0117
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0232 0.1087
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0571
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0603 0.0827
Mycobacterium tuberculosis Probable reductase 0.0093 0.0603 0.0827
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0038 0.0145
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0109 0.0098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0232 0.0896
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Schistosoma mansoni hypothetical protein 0.0174 0.1182 0.4553
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Onchocerca volvulus 0.0025 0.0115 0.0423
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.0715
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0116
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1407 1 1
Schistosoma mansoni cytochrome P450 0.0011 0.0012 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0038 0.0175
Onchocerca volvulus 0.0026 0.0121 0.0458
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0138 0.0625
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0109 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0038 0.0128
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0038 0.0128
Brugia malayi Pre-SET motif family protein 0.0225 0.1549 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0121 0.011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0159 0.0613
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.2039 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0158 0.0959
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0041 0.02
Brugia malayi conserved hypotetical protein 0.0015 0.0041 0.02
Echinococcus granulosus importin subunit beta 1 0.0035 0.0186 0.0715
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0121 0.0422
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1407 1 1
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0077 0.0204
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0038 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0297 0.1406
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0038 0.0026
Brugia malayi hypothetical protein 0.0018 0.0062 0.0334
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0013 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0024 0.0091

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 35.48133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.