Detailed information for compound 1345952

Basic information

Technical information
  • TDR Targets ID: 1345952
  • Name: 2-[(4-chlorophenyl)methylsulfanyl]-N-(2-hydro xy-5-nitrophenyl)acetamide
  • MW: 352.793 | Formula: C15H13ClN2O4S
  • H donors: 2 H acceptors: 4 LogP: 3.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(ccc1O)[N+](=O)[O-])CSCc1ccc(cc1)Cl
  • InChi: 1S/C15H13ClN2O4S/c16-11-3-1-10(2-4-11)8-23-9-15(20)17-13-7-12(18(21)22)5-6-14(13)19/h1-7,19H,8-9H2,(H,17,20)
  • InChiKey: XLDYRTAPKQIASS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-chlorophenyl)methylsulfanyl]-N-(2-hydroxy-5-nitro-phenyl)acetamide
  • 2-[(4-chlorophenyl)methylthio]-N-(2-hydroxy-5-nitrophenyl)acetamide
  • 2-[(4-chlorobenzyl)thio]-N-(2-hydroxy-5-nitro-phenyl)acetamide
  • 2-[(4-chlorophenyl)methylsulfanyl]-N-(2-hydroxy-5-nitro-phenyl)ethanamide
  • 2-[(4-chlorobenzyl)thio]-N-(2-hydroxy-5-nitrophenyl)acetamide
  • MLS000676620
  • SMR000298506
  • STK091516

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0135 0.156 0.3298
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.007 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0157 0.182 0.3643
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.156 0.3075
Brugia malayi Cathepsin L-like cysteine proteinase 0.0262 0.3092 0.6537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Onchocerca volvulus 0.0398 0.473 1
Brugia malayi Papain family cysteine protease containing protein 0.0398 0.473 1
Brugia malayi cathepsin L precursor 0.0076 0.0836 0.1768
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Echinococcus multilocularis cathepsin b 0.0076 0.0836 0.0836
Brugia malayi Cathepsin L-like precursor 0.0135 0.156 0.3298
Leishmania major cysteine peptidase A (CPA) 0.0398 0.473 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0147
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0398 0.473 1
Onchocerca volvulus 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0152 0.0322
Trypanosoma cruzi cysteine proteinase, putative 0.0211 0.2474 0.5073
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Onchocerca volvulus 0.0076 0.0836 0.1645
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Trypanosoma cruzi cruzipain precursor, putative 0.0398 0.473 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0398 0.473 0.473
Brugia malayi cathepsin L-like cysteine proteinase 0.0076 0.0836 0.1768
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0135 0.156 0.3298
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0135 0.156 0.3298
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Onchocerca volvulus 0.0398 0.473 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.042 0.0887
Brugia malayi cathepsin B-like cysteine proteinase 0.0076 0.0836 0.1768
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Plasmodium falciparum serine repeat antigen 9 0.0076 0.0836 0.1494
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0076 0.0836 0.1494
Schistosoma mansoni cpg binding protein 0.0037 0.0365 0.0365
Entamoeba histolytica cysteine proteinase, putative 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.0836 0.1494
Echinococcus multilocularis cathepsin L 0.0211 0.2474 0.2474
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0147
Loa Loa (eye worm) cysteine protease 0.0398 0.473 1
Echinococcus granulosus cathepsin l1 0.0262 0.3092 0.3092
Echinococcus granulosus cathepsin l cysteine peptidase 0.0398 0.473 0.473
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0052 0.0109
Trypanosoma brucei cysteine peptidase C (CPC) 0.0076 0.0836 0.1494
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0211 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Echinococcus granulosus cathepsin L cysteine protease 0.0211 0.2474 0.2474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Plasmodium falciparum serine repeat antigen 5 0.0076 0.0836 0.1494
Trypanosoma cruzi cysteine protease, putative 0.0211 0.2474 0.5073
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Plasmodium falciparum serine repeat antigen 1 0.0076 0.0836 0.1494
Brugia malayi steroid hormone receptor 0.0012 0.007 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.2474 0.5214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Schistosoma mansoni cathepsin C 0.0076 0.0836 0.0836
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.029 0.3429 0.7158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.3092 0.6524
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.059 0.1248
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0076 0.0836 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0153 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.2474 0.4207
Brugia malayi ecdysteroid receptor 0.0012 0.007 0.0147
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0076 0.0836 0.0836
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0836 0.1768
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.007 0.007
Plasmodium falciparum serine repeat antigen 7 0.0076 0.0836 0.1494
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.2474 0.4207
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Plasmodium falciparum serine repeat antigen 3 0.0076 0.0836 0.1494
Echinococcus granulosus cysteine protease 0.0211 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0836 0.1739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.059 0.059
Toxoplasma gondii preprocathepsin c precursor, putative 0.029 0.3429 0.7158
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0836 0.1739
Echinococcus granulosus cathepsin L 0.0076 0.0836 0.0836
Schistosoma mansoni hypothetical protein 0.0019 0.0152 0.0152
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0717 0.1232
Schistosoma mansoni cathepsin B (C01 family) 0.0076 0.0836 0.0836
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0836 0.1768
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Plasmodium falciparum serine repeat antigen 6 0.0076 0.0836 0.1494
Trypanosoma cruzi cysteine peptidase, putative 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Schistosoma mansoni cpg binding protein 0.0035 0.0341 0.0341
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Echinococcus multilocularis cysteine protease 0.0398 0.473 0.473
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0836 0.1739
Schistosoma mansoni hypothetical protein 0.0019 0.0152 0.0152
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Onchocerca volvulus Cathepsin L homolog 0.0076 0.0836 0.1645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.059 0.059
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.059 0.059
Schistosoma mansoni coup transcription factor 0.0012 0.007 0.007
Plasmodium vivax vivapain-2 0.0398 0.473 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0076 0.0836 0.1494
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Schistosoma mansoni hypothetical protein 0.0019 0.0152 0.0152
Brugia malayi fibroinase precursor 0.0076 0.0836 0.1768
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Plasmodium vivax vivapain-2 0.0398 0.473 1
Schistosoma mansoni hypothetical protein 0.0494 0.5895 0.5895
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0836 0.1768
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.065 0.1374
Echinococcus granulosus FTZ F1 alpha 0.0012 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.006 0.065 0.1374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.059 0.059
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Echinococcus multilocularis cysteine protease 0.0398 0.473 0.473
Brugia malayi Cathepsin L-like precursor 0.0262 0.3092 0.6537
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0398 0.473 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0211 0.2474 0.2474
Plasmodium falciparum serine repeat antigen 4 0.0076 0.0836 0.1494
Onchocerca volvulus 0.0398 0.473 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Toxoplasma gondii cathepsin CPL 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0836 0.1739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0147
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0398 0.473 0.473
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.005 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.007 0.007
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Echinococcus granulosus cathepsin b 0.0076 0.0836 0.0836
Schistosoma mansoni hypothetical protein 0.0041 0.042 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.065 0.1374
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0076 0.0836 0.1739
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0836 0.1739
Onchocerca volvulus Cathepsin L homolog 0.0398 0.473 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0152 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.007 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Onchocerca volvulus Cathepsin F homolog 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0341 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0076 0.0836 0.1768
Loa Loa (eye worm) hypothetical protein 0.0135 0.156 0.3298
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.059 0.1248
Schistosoma mansoni cathepsin s 0.0135 0.156 0.156
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.007 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.0262 0.3092 0.3092
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Brugia malayi Cathepsin L-like precursor 0.0262 0.3092 0.6537
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0076 0.0836 0.1768
Onchocerca volvulus 0.0398 0.473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Toxoplasma gondii cathepsin B 0.0076 0.0836 0.1494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.007 0.0147
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0152 0.0322
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.029 0.3429 0.3429
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.2474 0.5073
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.029 0.3429 0.7158
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0157 0.182 0.3643
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0153 0.0153
Echinococcus multilocularis cpg binding protein 0.0037 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0147
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.007 0.007
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.2474 0.5232
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0076 0.0836 0.1494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0398 0.473 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.059 0.059
Plasmodium vivax unspecified product 0.0076 0.0836 0.1494
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0836 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0398 0.473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Plasmodium falciparum serine repeat antigen 8 0.0076 0.0836 0.1494
Plasmodium falciparum cysteine proteinase falcipain 1 0.0211 0.2474 0.5073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0836 0.1494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0153 0.0153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0076 0.0836 0.1739
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0836 0.0836
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.2474 0.4207
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0836 0.1494
Plasmodium falciparum serine repeat antigen 2 0.0076 0.0836 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Onchocerca volvulus Cathepsin L homolog 0.0398 0.473 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.0147
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0076 0.0836 0.1494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0147
Plasmodium vivax vivapain-1 0.0211 0.2474 0.5073
Trypanosoma cruzi cysteine peptidase, putative 0.0398 0.473 1
Entamoeba histolytica cysteine proteinase 2 0.0211 0.2474 0.4207
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0398 0.473 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.007 0.007
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.007 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0211 0.2474 0.5073
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5895 0.5895
Brugia malayi cathepsin F-like cysteine proteinase 0.0076 0.0836 0.1768
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0076 0.0836 0.1739
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0147
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Entamoeba histolytica cysteine protease, putative 0.0398 0.473 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.065 0.1374
Trypanosoma cruzi cysteine proteinase, putative 0.0211 0.2474 0.5073
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.3092 0.6524
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.007 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0341 0.0722
Toxoplasma gondii cathepsin CPC1 0.029 0.3429 0.7158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.007 0.007
Onchocerca volvulus 0.0398 0.473 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Loa Loa (eye worm) hypothetical protein 0.0135 0.156 0.3298
Entamoeba histolytica cysteine proteinase 1, putative 0.0211 0.2474 0.4207
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0398 0.473 1
Echinococcus multilocularis cathepsin L 0.0076 0.0836 0.0836
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.3092 0.5793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.059 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Onchocerca volvulus 0.0262 0.3092 0.6485
Echinococcus multilocularis cathepsin b 0.0076 0.0836 0.0836
Onchocerca volvulus 0.0398 0.473 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0153 0.0323
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0836 0.1494
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.007 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.2474 0.5073
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0836 0.1739
Echinococcus granulosus GPCR family 2 0.0019 0.0152 0.0152
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0153 0.0153
Echinococcus granulosus cathepsin l1 0.0398 0.473 0.473
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.0147
Giardia lamblia Encystation-specific protease 0.0157 0.182 0.3794
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0209 0.2445 0.5152
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0836 0.1768
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Schistosoma mansoni cathepsin F (C01 family) 0.0398 0.473 0.473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0147
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0076 0.0836 0.1494
Loa Loa (eye worm) hypothetical protein 0.0262 0.3092 0.6537
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0076 0.0836 0.1494
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.156 0.3075
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0398 0.473 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.007 0.007
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5895 0.5895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0836 0.1739
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0076 0.0836 0.1494
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.0836 0.1494
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0152 0.0322
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0398 0.473 1
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.2474 0.4207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0147
Brugia malayi isocitrate dehydrogenase 0.0019 0.0153 0.0323
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.007 0.0147
Toxoplasma gondii cathepsin CPC2 0.0157 0.182 0.3643
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.029 0.3429 0.7158
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.007 0.007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0211 0.2474 0.2474
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Echinococcus multilocularis GPCR, family 2 0.0019 0.0152 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0836 0.1768
Echinococcus multilocularis cathepsin L cysteine protease 0.0398 0.473 0.473
Brugia malayi Cathepsin L-like precursor 0.0398 0.473 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0041 0.042 0.0887
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0211 0.2474 0.5073
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0157 0.182 0.3794
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0157 0.182 0.3794
Loa Loa (eye worm) fibroinase 0.0398 0.473 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Entamoeba histolytica cysteine proteinase, putative 0.0398 0.473 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0076 0.0836 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.2474 0.5214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0812 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0147
Leishmania major cathepsin L-like protease 0.0398 0.473 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0152 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0076 0.0836 0.1739
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0262 0.3092 0.6421
Echinococcus granulosus cathepsin L cysteine proteinase 0.0398 0.473 0.473
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.029 0.3429 0.7158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0398 0.473 1
Loa Loa (eye worm) ctsf protein 0.0398 0.473 1
Echinococcus granulosus cathepsin L 0.0211 0.2474 0.2474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Echinococcus granulosus cpg binding protein 0.0037 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Schistosoma mansoni cpg binding protein 0.0037 0.0365 0.0365
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0152 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0398 0.473 1
Trypanosoma cruzi cysteine peptidase, putative 0.0398 0.473 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0398 0.473 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0153 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0262 0.3092 0.6537
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0153 0.0153
Schistosoma mansoni cathepsin F (C01 family) 0.0398 0.473 0.473
Loa Loa (eye worm) hypothetical protein 0.0262 0.3092 0.6537
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0153 0.0153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Plasmodium vivax unspecified product 0.0135 0.156 0.3075
Schistosoma mansoni cathepsin S (C01 family) 0.0076 0.0836 0.0836
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0398 0.473 1
Entamoeba histolytica cysteine protease, putative 0.0211 0.2474 0.4207
Schistosoma mansoni hypothetical protein 0.0019 0.0152 0.0152
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0836 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0836 0.1739
Plasmodium vivax vivapain-3 0.0211 0.2474 0.5073
Onchocerca volvulus 0.0035 0.0341 0.0583
Loa Loa (eye worm) cathepsin B 0.0076 0.0836 0.1768
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0836 0.1768
Plasmodium vivax unspecified product 0.0211 0.2474 0.5073
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0153 0.0323
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0836 0.1768
Brugia malayi cathepsin L-like precursor 0.0262 0.3092 0.6537
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0152 0.0152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0026 0.0026
Echinococcus granulosus cathepsin b 0.0076 0.0836 0.0836
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.0147
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0135 0.156 0.3298
Echinococcus multilocularis cathepsin L cysteine protease 0.0398 0.473 0.473
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0836 0.1739
Giardia lamblia Dipeptidyl-peptidase I precursor 0.029 0.3429 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0836 0.1739
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0836 0.0836
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0836 0.0836
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.2474 0.5232

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 150 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 0.2617 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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