TDR Targets

Basic information

Technical information

TDR Targets ID: 1346147
Name: N-(3-fluorophenyl)-3-pyrrol-1-ylpropanamide
MW: 232.254 | Formula: C13H13FN2O
H donors: 1 H acceptors: 1 LogP: 1.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)F)CCn1cccc1
InChi: 1S/C13H13FN2O/c14-11-4-3-5-12(10-11)15-13(17)6-9-16-7-1-2-8-16/h1-5,7-8,10H,6,9H2,(H,15,17)
InChiKey: RETCOAKVWDFNOI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-fluorophenyl)-3-pyrrol-1-yl-propanamide
N-(3-fluorophenyl)-3-(1-pyrrolyl)propanamide
N-(3-fluorophenyl)-3-pyrrol-1-yl-propionamide
MLS000094082
N-(3-fluorophenyl)-3-(1H-pyrrol-1-yl)propanamide
SMR000029697

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0161	0.315	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Onchocerca volvulus	Bile acid receptor homolog	0.0161	0.315	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0161	0.315	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0076	0.14	0.1387
Brugia malayi	nuclear receptor NHR-88	0.0076	0.14	0.4345
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0161	0.315	0.3139
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0085	0.1588	0.1574
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0161	0.315	0.3139
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0076	0.14	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0076	0.14	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1588	0.4946
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0552	0.1594
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0161	0.315	0.3139
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.119	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0161	0.315	1
Brugia malayi	Nuclear hormone receptor E75	0.0076	0.14	0.4345
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0161	0.315	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0161	0.315	0.3139
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0161	0.315	0.3139
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0076	0.14	0.1387
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0161	0.315	0.3139
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0161	0.315	0.3139
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0085	0.1588	0.4946
Brugia malayi	Nuclear hormone receptor-like 1	0.0085	0.1588	0.4951
Leishmania major	hypothetical protein, conserved	0.003	0.0465	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0161	0.315	0.3139
Schistosoma mansoni	cpg binding protein	0.0035	0.0552	0.0537
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0465	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0161	0.315	0.3139
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0161	0.315	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0161	0.315	1
Brugia malayi	steroid hormone receptor	0.0161	0.315	1
Brugia malayi	hypothetical protein	0.002	0.0243	0.0602
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0161	0.315	0.3139
Schistosoma mansoni	RAR-like nuclear receptor	0.0161	0.315	0.3139
Schistosoma mansoni	cpg binding protein	0.0037	0.0593	0.0578
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0076	0.14	0.1387
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0076	0.14	0.3266
Schistosoma mansoni	hypothetical protein	0.0014	0.0119	0.0104
Brugia malayi	Nuclear hormone receptor-like 1	0.0161	0.315	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0161	0.315	1
Echinococcus multilocularis	cpg binding protein	0.0037	0.0593	0.0578
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0161	0.315	0.3139
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0119	0.0104
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1352	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0076	0.14	0.1387
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0161	0.315	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Trichomonas vaginalis	helicase, putative	0.0008	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1588	0.4946
Brugia malayi	hypothetical protein	0.0085	0.1588	0.4951
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0076	0.14	0.4345
Loa Loa (eye worm)	steroid hormone receptor	0.0161	0.315	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0059	0.0044
Schistosoma mansoni	nuclear receptor	0.0076	0.14	0.1387
Brugia malayi	ecdysteroid receptor	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0161	0.315	1
Brugia malayi	nuclear hormone receptor	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Schistosoma mansoni	nuclear hormone receptor	0.0076	0.14	0.1387
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0161	0.315	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0161	0.315	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1588	0.4946
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0465	0.5
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0076	0.14	0.4345
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0119	0.0104
Echinococcus granulosus	ecdysone induced protein 78C	0.0161	0.315	0.3139
Brugia malayi	nuclear receptor NHR-67	0.0076	0.14	0.4345
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0161	0.315	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Loa Loa (eye worm)	DR-78	0.0076	0.14	0.434
Loa Loa (eye worm)	nuclear hormone receptor	0.0076	0.14	0.434
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0161	0.315	1
Brugia malayi	nuclear hormone receptor	0.0076	0.14	0.4345
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0076	0.14	0.1387
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0076	0.14	0.1387
Brugia malayi	Nuclear hormone receptor E75	0.0076	0.14	0.4345
Brugia malayi	Steroid receptor seven-up type 2	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1588	0.4946
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0161	0.315	0.3139
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0161	0.315	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0076	0.14	0.1387
Brugia malayi	hypothetical protein	0.0076	0.14	0.4345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0161	0.315	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0076	0.14	0.434
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0076	0.14	0.434
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0161	0.315	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0465	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Brugia malayi	hypothetical protein	0.003	0.0465	0.132
Brugia malayi	nuclear receptor RXR	0.0076	0.14	0.4345
Brugia malayi	hypothetical protein	0.0085	0.1588	0.4951
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0059	0.0044
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0161	0.315	0.3139
Onchocerca volvulus		0.0161	0.315	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0076	0.14	0.1387
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0085	0.1588	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1588	0.4946
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0552	0.1602
Brugia malayi	ecdysone receptor	0.0076	0.14	0.4345
Brugia malayi	nuclear receptor RXR	0.0085	0.1588	0.4951
Brugia malayi	nuclear receptor NHR-88	0.0161	0.315	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0161	0.315	0.3139
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0465	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0161	0.315	0.3139
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0161	0.315	0.3139
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0161	0.315	0.3139
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0076	0.14	0.1387
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0161	0.315	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0076	0.14	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Schistosoma mansoni	zinc finger protein	0.0076	0.14	0.1387
Loa Loa (eye worm)	hypothetical protein	0.003	0.0465	0.1312
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0161	0.315	0.3139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0161	0.315	1
Echinococcus granulosus	cpg binding protein	0.0037	0.0593	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0161	0.315	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0161	0.315	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0593	0.0578
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0161	0.315	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Brugia malayi	conserved hypotetical protein	0.0076	0.14	0.4345
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0161	0.315	0.3139
Brugia malayi	tailless protein	0.0076	0.14	0.4345
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Onchocerca volvulus		0.0076	0.14	0.3266
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0465	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0161	0.315	0.3139
Echinococcus multilocularis	dnaJ subfamily B	0.0494	1	1
Onchocerca volvulus		0.0076	0.14	0.3266
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Brugia malayi	hypothetical protein	0.0076	0.14	0.4345
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0085	0.1588	0.1574
Schistosoma mansoni	coup transcription factor	0.0161	0.315	0.3139
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0076	0.14	0.1387
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0076	0.14	0.4345
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0161	0.315	0.3139
Echinococcus granulosus	thyroid hormone receptor alpha	0.0076	0.14	0.1387
Echinococcus multilocularis	ecdysone induced protein 78C	0.0161	0.315	0.3139
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Echinococcus multilocularis	nuclear receptor nhr 48	0.0076	0.14	0.1387
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0076	0.14	0.1387
Schistosoma mansoni	hypothetical protein	0.0494	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0	0.5
Schistosoma mansoni	nuclear receptor	0.0076	0.14	0.1387
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0161	0.315	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0076	0.14	0.4345
Loa Loa (eye worm)	hypothetical protein	0.0076	0.14	0.434
Loa Loa (eye worm)	hypothetical protein	0.0161	0.315	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0085	0.1588	0.4951
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0161	0.315	0.3139
Schistosoma mansoni	nuclear hormone receptor	0.0161	0.315	0.3139
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0161	0.315	0.3139
Schistosoma mansoni	nuclear hormone receptor	0.0076	0.14	0.1387
Echinococcus multilocularis	FTZ F1 alpha	0.0161	0.315	0.3139
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0465	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0085	0.1588	0.1574

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0329 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	0.1 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (binding)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1482971

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1346147