Detailed information for compound 1346228

Basic information

Technical information
  • TDR Targets ID: 1346228
  • Name: Oprea1_747619
  • MW: 387.496 | Formula: C20H25N3O3S
  • H donors: 1 H acceptors: 3 LogP: 1.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)C(=O)Nc1ccc(cc1)CN1CCS(=O)(=O)CC1)C
  • InChi: 1S/C20H25N3O3S/c1-22(2)19-9-5-17(6-10-19)20(24)21-18-7-3-16(4-8-18)15-23-11-13-27(25,26)14-12-23/h3-10H,11-15H2,1-2H3,(H,21,24)
  • InChiKey: ZKYDCYJCVJYJOZ-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-(dimethylamino)-N-{4-[(1,1-dioxo-1lambda~6~,4-thiazinan-4-yl)methyl]phenyl}benzamide
  • MLS000834835
  • SMR000458453
  • SR-01000631387-1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.004 0.004 0.004
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0056 0.0071 0.6115
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Onchocerca volvulus Tankyrase homolog 0.0056 0.0071 0.007
Echinococcus multilocularis multidrug resistance associated protein 1 0.0037 0.0033 0.0032
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0056 0.0071 0.6493
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0021 0.1069
Schistosoma mansoni coup transcription factor 0.0081 0.0121 0.0121
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0011 0.0796
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Leishmania major GTP-binding protein, putative 0.0026 0.0011 0.0112
Onchocerca volvulus 0.0964 0.1885 0.1885
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Schistosoma mansoni phd finger protein 0.0056 0.0071 0.007
Onchocerca volvulus 0.0037 0.0034 0.0034
Trypanosoma cruzi Kinesin-13 5, putative 0.0056 0.0071 0.6733
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0054 0.4402
Plasmodium vivax hypothetical protein, conserved 0.004 0.004 0.359
Echinococcus granulosus snurportin 1 0.0372 0.0702 0.0702
Echinococcus granulosus multidrug resistance associated protein 4 0.0022 0.0004 0.0004
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0021 0.1069
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0374 0.0707 0.0706
Loa Loa (eye worm) TK/EPH protein kinase 0.1183 0.2322 0.2322
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0036 0.0035
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0021 0.1919
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0056 0.0071 0.007
Loa Loa (eye worm) DR-78 0.0038 0.0036 0.0035
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.004 0.004
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0011 0.0951
Echinococcus multilocularis multidrug resistance associated protein 7 0.0037 0.0033 0.0032
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0121 0.0121
Trichomonas vaginalis ran, putative 0.0026 0.0011 0.1467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Echinococcus granulosus titin 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0037 0.0033 0.2447
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.004 0.004
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.004 0.037
Echinococcus granulosus fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0506 0.0971 0.0971
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0021 0.178
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0036 0.0035
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Schistosoma mansoni tripartite motif protein trim9 0.0037 0.0034 0.0034
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0121 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0476 0.435
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Brugia malayi multidrug resistance related protein 1 0.0037 0.0033 0.0032
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0021 0.1919
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Plasmodium vivax tyrosine kinase-like protein, putative 0.003 0.002 0.1652
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.001 0.0009
Onchocerca volvulus 0.0118 0.0196 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0121 0.0121
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Schistosoma mansoni sodium-bile acid cotransporter 0.2988 0.5929 0.5928
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0037 0.0033 0.2884
Onchocerca volvulus 0.004 0.004 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.1993
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Brugia malayi PAS domain containing protein 0.0097 0.0153 0.0152
Onchocerca volvulus 0.004 0.004 0.004
Onchocerca volvulus 0.0037 0.0034 0.0034
Schistosoma mansoni Protein aveugle 0.0056 0.0071 0.007
Schistosoma mansoni spingomyelin synthetase-related 0.0056 0.0071 0.007
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0021 0.1069
Brugia malayi ecdysone receptor 0.0038 0.0036 0.0035
Onchocerca volvulus 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Trypanosoma brucei hypothetical protein, conserved 0.004 0.004 0.3223
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Loa Loa (eye worm) AIDA-1b 0.0056 0.0071 0.007
Brugia malayi hypothetical protein 0.0043 0.0045 0.0044
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0121 0.0121
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0013 0.0012
Trypanosoma cruzi multidrug resistance protein E, putative 0.0037 0.0033 0.2884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0121 0.0121
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0102 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Schistosoma mansoni hypothetical protein 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.001 0.0578
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0034 0.0034
Plasmodium falciparum importin beta, putative 0.0035 0.0029 0.2524
Onchocerca volvulus 0.0071 0.0102 0.0102
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0062 0.5654
Echinococcus multilocularis polyhomeotic protein 2 0.0056 0.0071 0.007
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0029 0.1993
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0309 0.0309
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0036 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0036 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0121 0.0121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus multilocularis Netrin receptor DCC 0.0037 0.0034 0.0034
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0016 0.221
Leishmania major p-glycoprotein 0.0031 0.0021 0.1234
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0034 0.0034
Brugia malayi MH2 domain containing protein 0.0134 0.0228 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0121 0.0121
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0036 0.0035
Onchocerca volvulus 0.0038 0.0036 0.0035
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0036 0.0035
Plasmodium falciparum protein kinase, putative 0.003 0.002 0.1652
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0121 0.0121
Entamoeba histolytica hypothetical protein, conserved 0.0075 0.0109 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0016 0.221
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0054 0.4402
Echinococcus granulosus geminin 0.0374 0.0707 0.0706
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0032
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Brugia malayi ABC transporter transmembrane region family protein 0.0037 0.0033 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0036 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0568 0.1095 1
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.002
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0121 0.0121
Loa Loa (eye worm) myotactin form A 0.0037 0.0034 0.0034
Echinococcus granulosus Netrin receptor DCC 0.0037 0.0034 0.0034
Brugia malayi beta-lactamase family protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.004 0.037
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0017 0.0132
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypoxia-induced factor 1 0.0299 0.0557 0.0556
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0037 0.0033 0.2447
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Schistosoma mansoni hemicentin 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0029 0.0017 0.0016
Brugia malayi hypothetical protein 0.0043 0.0045 0.0044
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0324 0.0607 0.0607
Toxoplasma gondii hypothetical protein 0.0075 0.0109 1
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0037 0.0033 0.2447
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0121 0.0121
Echinococcus multilocularis ephrin type A receptor 4 A 0.1048 0.2054 0.2053
Brugia malayi ephrin receptor 1 precursor 0.0479 0.0916 0.0916
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0036 0.0035
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0121 0.0121
Plasmodium falciparum tyrosine kinase-like protein 0.003 0.002 0.1652
Giardia lamblia MRP-like ABC transporter 0.0037 0.0033 0.2225
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.004 0.004
Echinococcus granulosus nephrin 0.0037 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.3686
Echinococcus granulosus importin subunit beta 1 0.0035 0.0029 0.0029
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Onchocerca volvulus 0.0037 0.0034 0.0034
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Echinococcus granulosus ephrin type A receptor 4 A 0.1048 0.2054 0.2053
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Echinococcus multilocularis pdz domain containing protein 0.0056 0.0071 0.007
Schistosoma mansoni smdr2 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0075 0.0109 1
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Mycobacterium leprae conserved hypothetical protein 0.004 0.004 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0037 0.0033 0.0032
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0036 0.0035
Leishmania major importin beta-1 subunit, putative 0.0028 0.0016 0.0671
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0054 0.0053
Echinococcus granulosus contactin 0.0037 0.0034 0.0034
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.001 0.0578
Echinococcus multilocularis liprin alpha 2 0.0076 0.0112 0.0111
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0011 0.001
Schistosoma mansoni nephrin 0.0037 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0228 0.0227
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.004 0.5703
Schistosoma mansoni hypothetical protein 0.0145 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0411 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0121 0.0121
Giardia lamblia Kinesin-13 0.0056 0.0071 0.6115
Onchocerca volvulus 0.004 0.004 0.004
Loa Loa (eye worm) multidrug resistance-associated protein 0.0023 0.0005 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.004 0.037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.2291
Schistosoma mansoni ephrin receptor 0.0974 0.1905 0.1904
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Trypanosoma cruzi hypothetical protein 0.0056 0.0071 0.6733
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Brugia malayi ABC transporter family protein 0.0031 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0021 0.1069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0017 0.0132
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0075 0.0109 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0034 0.0034
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Giardia lamblia Multidrug resistance-associated protein 1 0.0037 0.0033 0.2225
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis cgi-62, putative 0.0056 0.0071 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.3073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0011 0.0684
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.025 0.025
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni ran 0.0026 0.0011 0.001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.009 0.8742
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0121 0.0121
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Brugia malayi nuclear receptor NHR-88 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Brugia malayi hypothetical protein 0.0324 0.0607 0.0607
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0056 0.0071 0.007
Schistosoma mansoni single-minded 0.0097 0.0153 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0071 1
Entamoeba histolytica hypothetical protein 0.0028 0.0016 0.0533
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0121 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0036 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.004 0.004
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0017 0.0016
Echinococcus multilocularis endonuclease reverse transcriptase 0.0075 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0029
Brugia malayi Shank2E 0.0056 0.0071 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Brugia malayi tailless protein 0.0038 0.0036 0.0035
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0103 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0029 0.0029
Brugia malayi myotactin form B 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0153 0.0152
Brugia malayi nuclear receptor NHR-88 0.0038 0.0036 0.0035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0036 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Onchocerca volvulus 0.0037 0.0034 0.0034
Entamoeba histolytica cysteine-rich surface protein, putative 0.0075 0.0109 1
Onchocerca volvulus 0.0056 0.0071 0.007
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.3686
Echinococcus multilocularis geminin 0.0374 0.0707 0.0706
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0121 0.0121
Schistosoma mansoni lip-related protein (liprin) alpha 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0016
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.004 0.037
Echinococcus granulosus Sterile alpha motif SAM 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0109 1
Onchocerca volvulus 0.0038 0.0036 0.0035
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0037 0.0033 0.2884
Leishmania major hypothetical protein, conserved 0.0037 0.0034 0.2648
Echinococcus granulosus liprin alpha 2 0.0056 0.0071 0.007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0021 0.2959
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0017 0.2291
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis sodium bile acid cotransporter 0.5025 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0054 0.0053
Loa Loa (eye worm) CAMK protein kinase 0.0037 0.0034 0.0034
Echinococcus multilocularis transfer RNA-Phe 0.0037 0.0034 0.0034
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.2565
Leishmania major cathepsin L-like protease 0.0072 0.0103 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0299 0.0299
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Entamoeba histolytica protein kinase, putative 0.0075 0.0109 1
Brugia malayi beta-lactamase family protein 0.004 0.004 0.004
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Schistosoma mansoni importin beta-1 0.0035 0.0029 0.0029
Echinococcus granulosus Fibronectin type III 0.0037 0.0034 0.0034
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0062 0.5727
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0034 0.0034
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.001
Echinococcus granulosus EG95 0.0037 0.0034 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Loa Loa (eye worm) beta-lactamase 0.004 0.004 0.004
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0076 0.0112 0.0111
Onchocerca volvulus 0.0031 0.0021 0.0021
Giardia lamblia ABC transporter, putative 0.0037 0.0033 0.2225
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0021 0.2959
Brugia malayi cask-interacting protein 2 0.0056 0.0071 0.007
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Onchocerca volvulus 0.0056 0.0071 0.007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0037 0.0034 0.0034
Plasmodium vivax importin-beta 2, putative 0.0035 0.0029 0.2524
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0017 0.0613
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0036 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0016 0.121
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.001 0.1318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.004 0.004 0.3299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Echinococcus multilocularis liprin alpha 2 0.0056 0.0071 0.007
Echinococcus multilocularis Fibronectin, type III 0.0037 0.0034 0.0034
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0011 0.0684
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Echinococcus multilocularis Sterile alpha motif SAM 0.0056 0.0071 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0002 0.0021
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0034 0.0034
Brugia malayi hypoxia-induced factor 1 0.0299 0.0557 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.1318
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0102 0.0102
Brugia malayi GCC2 and GCC3 family protein 0.0075 0.0109 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Entamoeba histolytica multidrug resistance protein, putative 0.0037 0.0033 0.2225
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0021 0.1069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0037 0.0034 0.0034
Loa Loa (eye worm) lethal protein 805 0.0037 0.0034 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Brugia malayi multidrug resistance protein 3 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0036 0.0035
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0056 0.0071 1
Leishmania major ABC-thiol transporter 0.0037 0.0033 0.2447
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0021 0.0021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0036 0.0035
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0071 0.007
Echinococcus granulosus cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0034 0.0034
Mycobacterium ulcerans short chain dehydrogenase 0.0568 0.1095 1
Mycobacterium leprae Probable lipase LipE 0.004 0.004 1
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0021 0.178
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni nuclear receptor 0.0038 0.0036 0.0035
Echinococcus multilocularis cell adhesion molecule 0.0037 0.0034 0.0034
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0036 0.0035
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0034 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0021 0.1069
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0121 0.0121
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0034 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0121 0.0121
Schistosoma mansoni multidrug resistance protein 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Giardia lamblia Multidrug resistance-associated protein 1 0.0037 0.0033 0.2225
Plasmodium falciparum cysteine repeat modular protein 3 0.0075 0.0109 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Onchocerca volvulus 0.0081 0.0121 0.0121
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0121 0.0121
Toxoplasma gondii kringle domain-containing protein 0.0075 0.0109 1
Loa Loa (eye worm) projectin 0.0037 0.0034 0.0034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0121 0.0121
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0011 0.001
Echinococcus granulosus Sterile alpha motif type 0.0056 0.0071 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.001 0.1318
Trypanosoma cruzi Kinesin-13 5, putative 0.0056 0.0071 0.6733
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0121 0.0121
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0037 0.0033 0.2362
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0036 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0045 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.5025 1 1
Echinococcus multilocularis histone acetyltransferase myst3 0.0056 0.0071 0.007
Entamoeba histolytica hypothetical protein 0.0037 0.0033 0.2225
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1916 0.1916
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi Liprin-alpha 2 0.0076 0.0112 0.0111
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0072 0.6898
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus histone acetyltransferase myst3 0.0056 0.0071 0.007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0036 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0121 0.0121
Echinococcus granulosus polyhomeotic protein 2 0.0056 0.0071 0.007
Plasmodium falciparum cysteine repeat modular protein 1 0.0075 0.0109 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0017 0.0132
Brugia malayi Lethal protein 805 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0108
Brugia malayi Importin beta-1 subunit 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0313 0.0586 0.0585
Brugia malayi nuclear hormone receptor 0.0038 0.0036 0.0035
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0021 0.0021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.0796
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0036 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0613
Schistosoma mansoni hypothetical protein 0.0374 0.0707 0.0706
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0121 0.0121
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0036 0.0035
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.025 0.025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0121 0.0121
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0309 0.0309
Schistosoma mansoni nuclear receptor 0.0038 0.0036 0.0035
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.001 0.0009
Echinococcus granulosus liprin alpha 2 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Entamoeba histolytica ATP-binding cassette protein, putative 0.0037 0.0033 0.2225
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0102 0.0102
Echinococcus granulosus anosmin 1 0.0037 0.0034 0.0034
Toxoplasma gondii ABC1 family protein 0.004 0.004 0.3698
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0021 0.1069
Echinococcus multilocularis Netrin receptor DCC 0.0037 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0372 0.0702 0.0702
Brugia malayi conserved hypotetical protein 0.0038 0.0036 0.0035
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0054 0.4848
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Loa Loa (eye worm) UNCoordinated family member 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Echinococcus granulosus G1Y162 protein 0.0037 0.0034 0.0034
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0037 0.0033 0.2964
Onchocerca volvulus 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0056 0.0071 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Trichomonas vaginalis esterase, putative 0.004 0.004 0.5703
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0121 0.0121
Echinococcus granulosus Netrin receptor DCC 0.0037 0.0034 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0017 0.0132
Echinococcus multilocularis snurportin 1 0.0372 0.0702 0.0702
Echinococcus multilocularis titin 0.0037 0.0034 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.004 0.5703
Schistosoma mansoni hypothetical protein 0.0056 0.0071 0.007
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.002 0.002
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.001 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Schistosoma mansoni polyhomeotic 0.0056 0.0071 0.007
Trypanosoma brucei multidrug resistance protein E 0.0037 0.0033 0.2362
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0056 0.0071 0.007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0036 0.0035
Echinococcus granulosus titin 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Mycobacterium ulcerans lipase LipD 0.004 0.004 0.0349
Brugia malayi SPRY domain containing protein 0.0037 0.0034 0.0034
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0036 0.0035
Brugia malayi Sphingomyelin synthase-related 1 0.0056 0.0071 0.007
Echinococcus granulosus sphingomyelin synthase protein 1 0.0056 0.0071 0.007
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0036 0.0035
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.3073
Schistosoma mansoni DNAj-like protein 0.0056 0.0071 0.007
Trypanosoma brucei p-glycoprotein 0.0037 0.0033 0.2362
Schistosoma mansoni hypothetical protein 0.0075 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0356 0.0671 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0121 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.004 0.037
Brugia malayi RNA, U transporter 1 0.0099 0.0157 0.0157
Brugia malayi bicaudal-C 0.0056 0.0071 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0121 0.0121
Schistosoma mansoni titin 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0121 0.0121
Echinococcus multilocularis roundabout 2 0.0037 0.0034 0.0034
Schistosoma mansoni sodium-bile acid cotransporter related 0.5025 1 1
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0121 0.0121
Schistosoma mansoni ephrin receptor 0.0047 0.0054 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0016 0.221
Brugia malayi nuclear receptor NHR-67 0.0038 0.0036 0.0035
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0075 0.0109 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0121 0.0121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0121 0.0121
Mycobacterium tuberculosis Conserved protein 0.004 0.004 0.037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0056 0.0071 0.007
Schistosoma mansoni cell adhesion molecule 0.0037 0.0034 0.0034
Brugia malayi Cytochrome P450 family protein 0.0027 0.0013 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0121 0.0121
Onchocerca volvulus 0.0037 0.0034 0.0034
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0037 0.0034 0.3073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0045 0.0044
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni myosin-binding protein-related 0.0037 0.0034 0.0034
Brugia malayi myotactin form A 0.0037 0.0034 0.0034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0011 0.001
Mycobacterium tuberculosis Probable hydrolase 0.004 0.004 0.037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0017 0.0756
Echinococcus granulosus pdz domain containing protein 0.0056 0.0071 0.007
Echinococcus granulosus multidrug resistance associated protein 7 0.0037 0.0033 0.0032
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0062 0.8832
Brugia malayi nuclear hormone receptor 0.0081 0.0121 0.0121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0071 0.007
Plasmodium falciparum cysteine repeat modular protein 4 0.0075 0.0109 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0017 0.0613
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0121 0.0121
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.001 0.3921
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.004 0.5703
Schistosoma mansoni Protein aveugle 0.0056 0.0071 0.007
Onchocerca volvulus 0.0075 0.0109 0.0108
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0076 0.0112 0.0111
Echinococcus multilocularis multidrug resistance associated protein 4 0.0022 0.0004 0.0004
Entamoeba histolytica ABC transporter, putative 0.0037 0.0033 0.2225
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0021 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.004 0.0349
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.001 0.1318
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0045 0.0044
Brugia malayi coiled-coil like protein 1 0.0076 0.0112 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0121 0.0121
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0037 0.0033 0.2447
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.004 0.037
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0029 0.265
Mycobacterium ulcerans beta-lactamase 0.004 0.004 0.0349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0017 0.0153
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0062 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0226 0.0411 0.0411
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0075 0.0109 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi nuclear receptor RXR 0.0043 0.0045 0.0044
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0037 0.0034 0.0034
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0021 0.2959
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0021 0.0021
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0056 0.0071 0.6493
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Echinococcus multilocularis neuroglian 0.0037 0.0034 0.0034
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0021 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Schistosoma mansoni neuroglian 0.0037 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0121 0.0121
Echinococcus multilocularis Sterile alpha motif type 0.0056 0.0071 0.007
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0037 0.0034 0.0034
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.001 0.1318
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0021 0.1234
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0017 0.0132
Loa Loa (eye worm) hypothetical protein 0.0964 0.1885 0.1885
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0121 0.0121
Echinococcus granulosus single minded 2 0.0071 0.0102 0.0102
Leishmania major pentamidine resistance protein 1 0.0037 0.0033 0.2447
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0309 0.0309
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0076 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0038 0.0036 0.0035
Brugia malayi protein unc-22 0.0037 0.0034 0.0034
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0037 0.0034 0.0034
Schistosoma mansoni multidrug resistance protein 0.0037 0.0033 0.0032
Brugia malayi Fibronectin type III domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.004 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.001 0.1318
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0121 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0121 0.0121
Mycobacterium ulcerans hypothetical protein 0.004 0.004 0.0349
Echinococcus multilocularis usherin 0.0037 0.0034 0.0034
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Onchocerca volvulus 0.0056 0.0071 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0318 0.0595 0.0594
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0021 0.0021
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0017 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0121 0.0121
Brugia malayi steroid hormone receptor 0.0081 0.0121 0.0121
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0037 0.0033 0.2362
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0034 0.0034
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Echinococcus granulosus neuroglian 0.0037 0.0034 0.0034
Echinococcus multilocularis titin 0.0037 0.0034 0.0034
Brugia malayi hypothetical protein 0.0038 0.0036 0.0035
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0021 0.0021
Echinococcus granulosus roundabout 2 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0103 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.001 0.0578
Schistosoma mansoni sodium-bile acid cotransporter related 0.2038 0.4031 0.4031
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0075 0.0109 1
Brugia malayi ecdysteroid receptor 0.0081 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0121 0.0121
Giardia lamblia Hypothetical protein 0.0075 0.0109 1
Plasmodium falciparum cysteine repeat modular protein 2 0.0075 0.0109 1
Onchocerca volvulus 0.0056 0.0071 0.007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.004 0.0349
Onchocerca volvulus 0.0037 0.0034 0.0034
Leishmania major p-glycoprotein e 0.0037 0.0033 0.2447
Echinococcus granulosus endonuclease reverse transcriptase 0.0075 0.0109 0.0108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0021 0.2959
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.001 0.1318
Schistosoma mansoni nephrin 0.0037 0.0034 0.0034
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0037 0.0034 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0121 0.0121
Schistosoma mansoni ran 0.0026 0.0011 0.001
Loa Loa (eye worm) acetyltransferase 0.0175 0.0309 0.0309
Brugia malayi AIDA-1b 0.0056 0.0071 0.007
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0037 0.0033 0.0032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0062 0.8832
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0062 0.5727
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.004
Brugia malayi Lethal protein 805 0.0037 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0109 1
Plasmodium falciparum conserved protein, unknown function 0.0075 0.0109 1
Trichomonas vaginalis taga, putative 0.0031 0.0021 0.2959
Onchocerca volvulus 0.0025 0.001 0.0009
Plasmodium vivax protein kinase, putative 0.0065 0.009 0.8248
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0021 0.0194
Giardia lamblia Multidrug resistance-associated protein 1 0.0036 0.0032 0.2123
Trichomonas vaginalis abcb9, putative 0.0031 0.0021 0.2959
Onchocerca volvulus 0.0037 0.0034 0.0034
Schistosoma mansoni factor for adipocyte differentiation 0.0037 0.0034 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0111
Echinococcus granulosus usherin 0.0037 0.0034 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0226 0.0411 0.0411
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0037 0.0034 0.0034
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0075 0.0109 1
Brugia malayi nuclear receptor RXR 0.0038 0.0036 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0034 0.0034
Schistosoma mansoni zinc finger protein 0.0038 0.0036 0.0035
Onchocerca volvulus 0.0075 0.0109 0.0108
Brugia malayi hypothetical protein 0.0056 0.0071 0.007
Echinococcus multilocularis anosmin 1 0.0037 0.0034 0.0034
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.003 0.002 0.002
Echinococcus granulosus sodium bile acid cotransporter 0.5025 1 1
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0021 0.2959
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0035
Mycobacterium ulcerans hypothetical protein 0.0029 0.0017 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0228 0.0227
Loa Loa (eye worm) tnks protein 0.0056 0.0071 0.007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0121 0.0121
Onchocerca volvulus 0.5025 1 1
Giardia lamblia CEGP1 protein 0.0075 0.0109 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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