TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.39 | Formula: C19H22N2O3
H donors: 2 H acceptors: 1 LogP: 3.15 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)ccc1NC(=O)NC1CCCc2c1cccc2
InChi: 1S/C19H22N2O3/c1-23-14-10-11-17(18(12-14)24-2)21-19(22)20-16-9-5-7-13-6-3-4-8-15(13)16/h3-4,6,8,10-12,16H,5,7,9H2,1-2H3,(H2,20,21,22)
InChiKey: DHDMYWRSKMHVRN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.3548	0.322
Plasmodium vivax	unspecified product	0.0039	0.3548	0.2757
Loa Loa (eye worm)	hypothetical protein	0.006	0.7142	0.7142
Loa Loa (eye worm)	cysteine protease	0.0077	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0039	0.3548	0.322
Leishmania major	cathepsin L-like protease	0.0077	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.5601	0.5377
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.1093	0.1093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0077	1	1
Onchocerca volvulus		0.0077	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.3548	0.3548
Brugia malayi	Cathepsin L-like precursor	0.0077	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0051	0.5601	0.5601
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0077	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Leishmania major	cathepsin L-like protease	0.0077	1	1
Echinococcus granulosus	serine protein kinase ATM	0.003	0.19	0.19
Echinococcus multilocularis	cysteine protease	0.0077	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.3548	0.3548
Plasmodium vivax	vivapain-2	0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5601	0.5601
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0484	0.0484
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Onchocerca volvulus		0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1093	0.1093
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Entamoeba histolytica	cysteine proteinase 1, putative	0.0039	0.3548	0.322
Entamoeba histolytica	cysteine proteinase, putative	0.0051	0.5601	0.5377
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.3548	0.322
Toxoplasma gondii	cathepsin CPL	0.0077	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.1171	0.0722
Brugia malayi	Cathepsin L-like precursor	0.0051	0.5601	0.5601
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0484	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0077	1	1
Brugia malayi	cathepsin L-like precursor	0.0051	0.5601	0.5601
Onchocerca volvulus		0.0077	1	1
Plasmodium vivax	vivapain-2	0.0077	1	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.0492	0.0008
Brugia malayi	Cathepsin L-like precursor	0.0077	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.3548	0.322
Onchocerca volvulus		0.0077	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0051	0.5601	0.5377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.3548	0.322
Brugia malayi	Cathepsin L-like precursor	0.0077	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0077	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.19	0.1488
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0484	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Loa Loa (eye worm)	ctsf protein	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.7142	0.7142
Schistosoma mansoni	hypothetical protein	0.0041	0.3836	0.3836
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Echinococcus granulosus	cysteine protease	0.0039	0.3548	0.3548
Entamoeba histolytica	hypothetical protein	0.003	0.19	0.1488
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0039	0.3548	0.322
Echinococcus multilocularis	cathepsin L	0.0039	0.3548	0.3548
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0077	1	1
Giardia lamblia	GTOR	0.0022	0.0484	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.3548	0.322
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1093	0.1093
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.7142	0.7142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.19	0.19
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0484	0.0484
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.19	0.19
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0484	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Onchocerca volvulus		0.0077	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0039	0.3548	0.322
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1093	0.1093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0077	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.19	0.1488
Echinococcus multilocularis	cathepsin L cysteine protease	0.0077	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0484	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.1093	0.0639
Entamoeba histolytica	cysteine proteinase, putative	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0077	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.7142	0.7142
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Onchocerca volvulus		0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.3836	0.3836
Entamoeba histolytica	cysteine protease, putative	0.0077	1	1
Plasmodium vivax	vivapain-3	0.0039	0.3548	0.2757
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.3836	0.3836
Brugia malayi	Cathepsin L-like precursor	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.3548	0.322
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.1093	0.1093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Loa Loa (eye worm)	fibroinase	0.0077	1	1
Echinococcus granulosus	cathepsin l1	0.0051	0.5601	0.5601
Onchocerca volvulus		0.0077	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.3548	0.322
Brugia malayi	Cathepsin L-like precursor	0.0025	0.1093	0.1093
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0484	0.0484
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0077	1	1
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.5601	0.5377
Entamoeba histolytica	cysteine proteinase, putative	0.0077	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.1093	0.0639
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0039	0.3548	0.322
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0484	0.0484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.1093	0.1093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0077	1	1
Plasmodium vivax	vivapain-1	0.0039	0.3548	0.2757
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.19	0.19
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0484	0.0484
Echinococcus granulosus	cathepsin l1	0.0077	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.3548	0.3548
Toxoplasma gondii	FATC domain-containing protein	0.003	0.19	0.1488
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0077	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1171	0.1171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0051	0.5601	0.5601
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.3548	0.3548
Schistosoma mansoni	cathepsin s	0.0025	0.1093	0.1093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0077	1	1
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.3548	0.322
Onchocerca volvulus	Cathepsin F homolog	0.0077	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0077	1	1
Brugia malayi	Cathepsin L-like precursor	0.0051	0.5601	0.5601
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0484	0.0484
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0492	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5601	0.5601
Leishmania major	cathepsin L-like protease	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0077	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0039	0.3548	0.3548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.3548	0.3548
Echinococcus multilocularis	cysteine protease	0.0077	1	1
Echinococcus granulosus	cathepsin L	0.0039	0.3548	0.3548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.5601	0.5601
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0077	1	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.19	0.1488
Brugia malayi	Cathepsin L-like precursor	0.0077	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.3548	0.322
Leishmania major	cysteine peptidase A (CPA)	0.0077	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.3548	0.322
Entamoeba histolytica	cysteine protease, putative	0.0039	0.3548	0.322

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1485063

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1346507