Detailed information for compound 1346740

Basic information

Technical information
  • TDR Targets ID: 1346740
  • Name: ethyl 3-[(3aS,5aR,6Z,8R,9S,9aS,9bS)-8,9-dihyd roxy-6-(2-methylpropoxyimino)-1,3-dioxo-4,5,5 a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol- 2-yl]propanoate
  • MW: 424.488 | Formula: C21H32N2O7
  • H donors: 2 H acceptors: 5 LogP: 0.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCN1C(=O)[C@@H]2[C@@H](C1=O)CC[C@@H]1[C@@H]2[C@H](O)[C@H](O)C/C/1=N/OCC(C)C
  • InChi: 1S/C21H32N2O7/c1-4-29-16(25)7-8-23-20(27)13-6-5-12-14(22-30-10-11(2)3)9-15(24)19(26)17(12)18(13)21(23)28/h11-13,15,17-19,24,26H,4-10H2,1-3H3/b22-14-/t12-,13-,15+,17-,18+,19+/m0/s1
  • InChiKey: SYMGGFAIOFOURH-CABBBPIMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 3-[(3aS,5aR,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-isobutoxyimino-1,3-dioxo-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-2-yl]propanoate
  • 3-[(3aS,5aR,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-isobutoxyimino-1,3-dioxo-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-2-yl]propanoic acid ethyl ester
  • 3-[(3aS,5aR,6Z,8R,9S,9aS,9bS)-8,9-dihydroxy-6-isobutoxyimino-1,3-diketo-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-2-yl]propionic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0044 0.0062 0.0057
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0516 0.1307 0.2113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0064 0.0096
Loa Loa (eye worm) hypothetical protein 0.0133 0.0297 0.0307
Schistosoma mansoni ap endonuclease 0.0023 0.0004 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0004 0.0005
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0045 0.0062 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0108 0.1372
Brugia malayi hypothetical protein 0.0038 0.0045 0.0047
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0516 0.1307 0.3455
Echinococcus granulosus c-Jun N-terminal kinases 0.3521 0.9248 0.9248
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0221 0.0575
Echinococcus granulosus protein kinase C gamma type 0.0027 0.0015 0.0015
Toxoplasma gondii cell-cycle-assocaited protein kinase ERK7, putative 0.0039 0.0048 0.0043
Plasmodium falciparum glutathione reductase 0.005 0.0077 0.0101
Echinococcus granulosus serine:threonine protein kinase N2 0.0027 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0014
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0516 0.1307 0.3056
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0027 0.0015 0.0015
Giardia lamblia Kinase, AGC PKA 0.004 0.0049 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1449 0.3775 1
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0133 0.0297 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0048 0.057
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0009 0.0006
Trypanosoma cruzi rac serine-threonine kinase, putative 0.004 0.0049 0.0072
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0221 0.0221
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0133 0.0297 0.0292
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0133 0.0297 0.0474
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0175 0.0175
Treponema pallidum pyruvate carboxylase subunit B 0.0133 0.0297 0.3862
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Echinococcus granulosus serine/threonine protein kinase 0.004 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0133 0.0297 0.0775
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0015 0.0015
Echinococcus granulosus nervana 2 0.0027 0.0014 0.0014
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0133 0.0297 0.0474
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0027 0.0015 0.0015
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0133 0.0297 0.0405
Echinococcus multilocularis Glutaredoxin protein 5 0.0027 0.0014 0.0014
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0605 0.0605
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0077 0.0118
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0246
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0027 0.0015 0.0015
Echinococcus granulosus cyclin dependent kinase 7 0.0087 0.0175 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0026 0.0027
Schistosoma mansoni serine/threonine-protein kinase rio2 (rio kinase 2) 0.0044 0.0062 0.0062
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0221 0.0221
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0649 0.1659 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0133 0.0297 0.0292
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1449 0.3775 1
Echinococcus granulosus serine threonine protein kinase nrc 0.004 0.0049 0.0049
Trypanosoma brucei acetyl-CoA carboxylase 0.3805 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0004 0.0004
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1449 0.3775 0.3775
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0048 0.0048
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0516 0.1307 0.2113
Echinococcus multilocularis serine threonine protein kinase 0.0027 0.0015 0.0015
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0108 0.0108
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0108 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0346 0.0554
Echinococcus multilocularis mitogen activated protein kinase 11 0.0135 0.03 0.03
Loa Loa (eye worm) AGC/AKT protein kinase 0.0053 0.0085 0.0088
Schistosoma mansoni pyruvate carboxylase 0.1449 0.3775 0.3775
Schistosoma mansoni hypothetical protein 0.0045 0.0062 0.0062
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0221 0.0229
Onchocerca volvulus Kinase homolog 0.0158 0.0362 0.475
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1449 0.3775 0.3775
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0343 0.0343
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1449 0.3775 1
Echinococcus granulosus netrin receptor unc 5 0.0045 0.0062 0.0062
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0108 0.0108
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0328 0.081 0.2137
Leishmania major trypanothione reductase 0.005 0.0077 0.0073
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0019 0.002
Echinococcus granulosus nervana 2 0.0027 0.0014 0.0014
Echinococcus multilocularis mitogen activated protein kinase 14 0.0135 0.03 0.03
Brugia malayi RIO1 family protein 0.0044 0.0062 0.0064
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0133 0.0297 0.0775
Echinococcus granulosus dnaJ subfamily B 0.0432 0.1087 0.1087
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0133 0.0297 0.0292
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0133 0.0297 0.0474
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0133 0.0297 0.0815
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0048 0.057
Onchocerca volvulus 0.0051 0.0079 0.1039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0079 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0291 0.0291
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0135 0.03 0.0296
Mycobacterium tuberculosis Probable reductase 0.0115 0.0247 0.0645
Entamoeba histolytica mitogen-activated protein kinase 0.0039 0.0048 0.0261
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0037
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0247 0.0645
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1449 0.3775 0.3772
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0133 0.0297 0.0292
Schistosoma mansoni tar DNA-binding protein 0.007 0.013 0.013
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0133 0.0297 0.0775
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0077 0.0077
Brugia malayi Serine/threonine-protein kinase F42G10.2 0.0158 0.0362 0.0375
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0108 0.0168
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0025 0.0026
Echinococcus multilocularis nervana 2 0.0027 0.0014 0.0014
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0286 0.0286
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0108 0.1372
Echinococcus granulosus mitogen activated protein kinase 14 0.0135 0.03 0.03
Brugia malayi protein kinase C II. 0.0027 0.0015 0.0015
Mycobacterium ulcerans pyruvate carboxylase 0.1449 0.3775 1
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0133 0.0297 0.0212
Echinococcus multilocularis nervana 2 0.0027 0.0014 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0048 0.057
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0019 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0044 0.0044
Trichomonas vaginalis RIO family atypical protein kinase 0.0044 0.0062 0.076
Brugia malayi cyclin-dependent kinase 7 homolog 0.0087 0.0175 0.0181
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1449 0.3775 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0135 0.03 0.0296
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0027 0.0015 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0391 0.1026
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0019 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Echinococcus granulosus Glutaredoxin protein 5 0.0027 0.0014 0.0014
Entamoeba histolytica protein kinase, putative 0.0053 0.0085 0.0485
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0133 0.0297 0.0307
Echinococcus multilocularis serine:threonine protein kinase 38 0.0027 0.0015 0.0015
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0027 0.0015 0.0015
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0516 0.1307 0.3455
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0096 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0175 0.0175
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0019 0.002
Trypanosoma brucei rac serine-threonine kinase, putative 0.0053 0.0085 0.008
Leishmania major hypothetical protein, conserved 0.0024 0.0009 0.0004
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0133 0.0297 0.0292
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0019 0.0195
Loa Loa (eye worm) glutathione reductase 0.005 0.0077 0.008
Brugia malayi Protein kinase domain containing protein 0.0082 0.0162 0.0168
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0133 0.0297 0.0405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.013 0.0287 0.0297
Trypanosoma cruzi Protein kinase B 0.004 0.0049 0.0072
Brugia malayi Uncoordinated protein 44 0.0045 0.0062 0.0065
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0015 0.0015
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1449 0.3775 0.3772
Brugia malayi phosphofructokinase 0.0105 0.0221 0.0229
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0077 0.0077
Echinococcus granulosus NDR protein kinase 0.0027 0.0015 0.0015
Trypanosoma brucei unspecified product 0.0953 0.2462 0.2459
Brugia malayi p70 ribosomal S6 kinase beta 0.0053 0.0085 0.0088
Mycobacterium ulcerans hypothetical protein 0.0169 0.0391 0.1026
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0108 0.1372
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0019 0.0015
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0246
Echinococcus multilocularis mitogen activated protein kinase 11 0.0135 0.03 0.03
Schistosoma mansoni serine/threonine protein kinase 0.3521 0.9248 0.9248
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0516 0.1307 0.3455
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0247 0.0645
Plasmodium falciparum serine/threonine protein kinase RIO2 0.0044 0.0062 0.008
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0027 0.0015 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0221 0.2866
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0291 0.076
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0133 0.0297 0.0815
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0133 0.0297 0.0292
Leishmania major protein kinase, putative,mitogen-activated protein kinase, putative 0.0039 0.0048 0.0043
Echinococcus granulosus cpg binding protein 0.0032 0.0029 0.0029
Echinococcus multilocularis cyclin dependent kinase 7 0.0087 0.0175 0.0175
Plasmodium vivax serine/threonine protein kinase RIO2, putative 0.0044 0.0062 0.008
Entamoeba histolytica PH domain containing protein kinase, putative 0.004 0.0049 0.0269
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0605 0.0605
Plasmodium vivax glutathione reductase, putative 0.005 0.0077 0.0101
Brugia malayi P38 map kinase family protein 2 0.0135 0.03 0.0311
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0009 0.0007
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0029
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0516 0.1307 0.3455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0038
Brugia malayi MAP kinase sur-1 0.0062 0.0108 0.0112
Brugia malayi RNA recognition motif domain containing protein 0.007 0.013 0.0135
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0516 0.1307 0.3056
Trypanosoma brucei Serine/threonine-protein kinase RIO2, putative 0.0044 0.0062 0.0057
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0247 0.0074
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0516 0.1307 0.3455
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0328 0.081 0.1116
Loa Loa (eye worm) hypothetical protein 0.0309 0.0761 0.0789
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0221 0.0229
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0221 0.0221
Loa Loa (eye worm) CAMK/DAPK/DAPK protein kinase 0.0038 0.0044 0.0045
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0133 0.0297 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0133 0.0297 0.0815
Trypanosoma brucei trypanothione reductase 0.005 0.0077 0.0073
Loa Loa (eye worm) hypothetical protein 0.0133 0.0297 0.0307
Mycobacterium ulcerans hypothetical protein 0.0133 0.0297 0.0775
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0062 0.0065
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.3672 0.9648 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0015 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0079 0.0082
Brugia malayi hypothetical protein 0.0024 0.0009 0.0009
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0516 0.1307 0.3455
Brugia malayi RNA binding protein 0.007 0.013 0.0135
Schistosoma mansoni thyroid hormone receptor 0.015 0.0341 0.0341
Loa Loa (eye worm) AGC/NDR protein kinase 0.0027 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.001
Echinococcus granulosus death associated protein kinase 1 0.0573 0.1457 0.1457
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0291 0.076
Loa Loa (eye worm) hypothetical protein 0.0133 0.0297 0.0307
Leishmania major acetyl-CoA carboxylase, putative 0.3805 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0281 0.0734
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.004 0.0049 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0516 0.1307 0.1307
Trypanosoma cruzi serine/threonine protein kinase RIO2, putative 0.0044 0.0062 0.0093
Brugia malayi Protein kinase domain containing protein 0.0053 0.0085 0.0088
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0108 0.0168
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0108 0.0108
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0133 0.0297 0.0297
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0516 0.1307 0.3784
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0281 0.0169
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0064 0.0096
Brugia malayi CXXC zinc finger family protein 0.003 0.0025 0.0026
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1449 0.3775 1
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0133 0.0297 0.0405
Echinococcus granulosus Ankyrin 0.0045 0.0062 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.0461 0.0461
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0133 0.0297 0.0474
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0133 0.0297 0.0307
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1449 0.3775 1
Schistosoma mansoni ankyrin 23/unc44 0.0045 0.0062 0.0062
Loa Loa (eye worm) TAR-binding protein 0.007 0.013 0.0135
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0133 0.0297 0.0297
Entamoeba histolytica protein kinase, putative 0.0027 0.0015 0.0061
Schistosoma mansoni tar DNA-binding protein 0.007 0.013 0.013
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0133 0.0297 0.0405
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0079 0.0082
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0343 0.0899
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0221 0.2866
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0221 0.0352
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0516 0.1307 0.2113
Echinococcus granulosus muscleblind protein 0.0158 0.0362 0.0362
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0045 0.0045
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0045 0.0062 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0108 0.0108
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0221 0.131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0135 0.03 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0135 0.03 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0221 0.2866
Schistosoma mansoni serine/threonine-protein kinase 0.004 0.0049 0.0049
Echinococcus multilocularis Ankyrin 0.0045 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0051 0.0079 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0281 0.0734
Brugia malayi Protein kinase domain containing protein 0.0027 0.0015 0.0015
Onchocerca volvulus Huntingtin homolog 0.013 0.0287 0.3764
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0516 0.1307 0.3455
Echinococcus multilocularis muscleblind protein 0.0158 0.0362 0.0362
Brugia malayi TAR-binding protein 0.007 0.013 0.0135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0062 0.0065
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1449 0.3775 0.6115
Onchocerca volvulus Huntingtin homolog 0.013 0.0287 0.3764
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0049
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0328 0.081 0.2137
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0133 0.0297 0.0474
Brugia malayi glutathione reductase 0.005 0.0077 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.0793 0.1279
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0133 0.0297 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0291 0.076
Trypanosoma brucei protein kinase, putative 0.0062 0.0108 0.0104
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0133 0.0297 0.0297
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0133 0.0297 0.0292
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0516 0.1307 0.1307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.013 0.0135
Brugia malayi Carboxyl transferase domain containing protein 0.3672 0.9648 1
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0025
Brugia malayi hypothetical protein 0.013 0.0287 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0108 0.1372
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.0761 0.4572
Schistosoma mansoni hypothetical protein 0.0038 0.0045 0.0045
Brugia malayi Hr1 repeat family protein 0.0027 0.0015 0.0015
Trypanosoma cruzi rac serine-threonine kinase, putative 0.004 0.0049 0.0072
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0135 0.03 0.0311
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2754 0.7221 1
Schistosoma mansoni serine/threonine kinase 0.0027 0.0015 0.0015
Brugia malayi hypothetical protein 0.0309 0.0761 0.0789
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0108 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0516 0.1307 0.1303
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0077 0.0193
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0328 0.081 0.1307
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.004 0.0049 0.0062
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.0793 0.1279
Echinococcus multilocularis Biotin lipoyl attachment 0.0133 0.0297 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0291 0.076
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0247 0.0645
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0045 0.0045
Echinococcus multilocularis protein kinase c epsilon type 0.0027 0.0015 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0053 0.0085 0.0088
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0246
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0045
Entamoeba histolytica protein kinase, putative 0.0053 0.0085 0.0485
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.0761 1
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0221 0.0229
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0286 0.0286
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.0793 0.0789
Schistosoma mansoni tar DNA-binding protein 0.007 0.013 0.013
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0516 0.1307 0.3455
Schistosoma mansoni serine/threonine-protein kinase 0.004 0.0049 0.0049
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0516 0.1307 0.3056
Schistosoma mansoni tar DNA-binding protein 0.007 0.013 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.013 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0343 0.0899
Brugia malayi Thioredoxin reductase 0.005 0.0077 0.008
Toxoplasma gondii RIO1 family protein 0.0044 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.0051 0.0079 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0048 0.057
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.0793 0.0789
Plasmodium falciparum carbamoyl phosphate synthetase 0.0328 0.081 0.1116
Loa Loa (eye worm) hypothetical protein 0.0069 0.0127 0.0132
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0516 0.1307 0.3455
Schistosoma mansoni thyroid hormone receptor 0.015 0.0341 0.0341
Loa Loa (eye worm) CAMK/DAPK/DAPK protein kinase 0.0038 0.0044 0.0045
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0247 0.0645
Onchocerca volvulus 0.0309 0.0761 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0048 0.0048
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.3805 1 1
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0133 0.0297 0.0775
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0027 0.0015 0.0015
Plasmodium falciparum thioredoxin reductase 0.005 0.0077 0.0101
Loa Loa (eye worm) AGC/PKN protein kinase 0.0027 0.0015 0.0015
Echinococcus granulosus Biotin lipoyl attachment 0.0133 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0015
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0048 0.0261
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0133 0.0297 0.0292
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0108 0.0104
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0133 0.0297 0.0775
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2754 0.7221 1
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0516 0.1307 0.1307
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0133 0.0297 0.0405
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.3805 1 1
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0328 0.081 0.1307
Echinococcus granulosus protein kinase c epsilon type 0.0027 0.0015 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0015 0.0134
Leishmania major carboxylase, putative 0.1449 0.3775 0.3772
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0133 0.0297 0.0297
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0019 0.0015
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.3521 0.9248 0.9586
Toxoplasma gondii carbamoylphosphate synthetase 0.0328 0.081 0.0806
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0133 0.0297 0.0297
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0133 0.0297 0.0775
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0019 0.002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.0761 0.4572
Onchocerca volvulus 0.003 0.0025 0.0323
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0221 0.131
Loa Loa (eye worm) hypothetical protein 0.0045 0.0062 0.0065
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0027 0.0015 0.0015
Trypanosoma cruzi serine/threonine protein kinase RIO2, putative 0.0029 0.002 0.0025
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1449 0.3775 0.3775
Loa Loa (eye worm) hypothetical protein 0.0158 0.0362 0.0375
Echinococcus granulosus dual specificity mitogen activated protein 0.0158 0.0362 0.0362
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.009 0.0138
Trypanosoma brucei Mitogen-activated protein kinase 6 0.0039 0.0048 0.0043
Schistosoma mansoni acetyl-CoA carboxylase 0.3805 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0291 0.0291
Schistosoma mansoni kinase 0.0158 0.0362 0.0362
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0077 0.008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0221 0.2866
Schistosoma mansoni survival motor neuron protein 0.0051 0.0079 0.0079
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0221 0.0575
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0108 0.0104
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0133 0.0297 0.0292
Toxoplasma gondii hypothetical protein 0.0052 0.0081 0.0077
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0221 0.0217
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0108 0.0112
Echinococcus granulosus mitogen activated protein kinase 11 0.0135 0.03 0.03
Brugia malayi Muscleblind-like protein 0.0158 0.0362 0.0375
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0133 0.0297 0.0307
Echinococcus granulosus protein kinase c iota type 0.0027 0.0015 0.0015
Toxoplasma gondii pyruvate carboxylase 0.1449 0.3775 0.3772
Loa Loa (eye worm) RNA binding protein 0.007 0.013 0.0135
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0247 0.0645
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.004 0.0049 0.0049
Echinococcus multilocularis tar DNA binding protein 0.007 0.013 0.013
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1449 0.3775 0.6115
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0015 0.0134
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0027 0.0014 0.0014
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0133 0.0297 0.0292
Echinococcus multilocularis mitogen activated protein kinase 14 0.0135 0.03 0.03
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0328 0.081 0.081
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0048 0.057
Echinococcus multilocularis serine:threonine protein kinase rio2 0.0044 0.0062 0.0062
Echinococcus multilocularis dual specificity mitogen activated protein 0.0158 0.0362 0.0362
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0019 0.0195
Echinococcus multilocularis mitogen activated protein kinase 15 0.0039 0.0048 0.0048
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0221 0.0221
Echinococcus granulosus mitogen activated protein kinase 15 0.0039 0.0048 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0009 0.0006
Plasmodium vivax mitogen-activated protein kinase 1, putative 0.0039 0.0048 0.006
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0045 0.0062 0.0062
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0328 0.081 0.081
Entamoeba histolytica protein kinase, putative 0.0053 0.0085 0.0485
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0045 0.0045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0004 0.0004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0346 0.0342
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1449 0.3775 0.3772
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0291 0.0287
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.3805 1 1
Brugia malayi Protein kinase domain containing protein 0.0027 0.0015 0.0015
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0291 0.0291
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.0761 0.4572
Trypanosoma cruzi Mitogen-activated protein kinase 6 0.0039 0.0048 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0004 0.0005
Loa Loa (eye worm) atypical/RIO/RIO2 protein kinase 0.0044 0.0062 0.0064
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0027 0.0015 0.0015
Brugia malayi Cytochrome P450 family protein 0.0031 0.0026 0.0027
Echinococcus multilocularis cpg binding protein 0.0032 0.0029 0.0029
Entamoeba histolytica RIO1 family protein 0.0044 0.0062 0.0347
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1449 0.3775 0.3775
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0328 0.081 0.0806
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0064 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0441 0.1111 0.1111
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.004 0.0049 0.0049
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0516 0.1307 0.1303
Loa Loa (eye worm) hypothetical protein 0.0158 0.0362 0.0375
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0029
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.025 0.0605 0.0627
Schistosoma mansoni hypothetical protein 0.0129 0.0286 0.0286
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0346 0.0342
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0281 0.0734
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0133 0.0297 0.0474
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0516 0.1307 0.1303
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Leishmania major carbamoyl-phosphate synthase, putative 0.0328 0.081 0.0806
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0108 0.0168
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0009 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0009 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0341 0.0341
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0246
Echinococcus multilocularis c Jun NH2 terminal kinase 0.3521 0.9248 0.9248
Echinococcus granulosus serine:threonine protein kinase rio2 0.0044 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0432 0.1087 0.1087
Echinococcus multilocularis rac serine:threonine kinase 0.004 0.0049 0.0049
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0108 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0133 0.0297 0.0212
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0108 0.0168
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0019 0.0089
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0291 0.0287
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0133 0.0297 0.0292
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0019 0.0089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0291 0.0291
Brugia malayi Stress-activated protein kinase jnk-1 0.3521 0.9248 0.9586
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1449 0.3775 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0019 0.0195
Echinococcus multilocularis netrin receptor unc 5 0.0045 0.0062 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0037 0.0038
Brugia malayi hypothetical protein 0.025 0.0605 0.0627
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0027 0.0015 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.1087 0.1087
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0221 0.0217
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0133 0.0297 0.0775
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0649 0.1659 1
Plasmodium falciparum mitogen-activated protein kinase 1 0.0039 0.0048 0.006
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0133 0.0297 0.0297
Trypanosoma cruzi acetyl-CoA carboxylase 0.2356 0.617 1
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Brugia malayi Death domain containing protein 0.0045 0.0062 0.0065
Trypanosoma cruzi Mitogen-activated protein kinase 6 0.0039 0.0048 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Brugia malayi 6-phosphofructokinase 0.0105 0.0221 0.0229
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0077 0.0101
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0221 0.131
Schistosoma mansoni ap endonuclease 0.0023 0.0004 0.0004
Onchocerca volvulus Netrin receptor homolog 0.0045 0.0062 0.0818
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0087 0.0175 0.0181
Echinococcus granulosus tar DNA binding protein 0.007 0.013 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0079 0.0082
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0015 0.0134
Schistosoma mansoni atypical protein kinase C 0.0027 0.0015 0.0015
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0133 0.0297 0.0292
Echinococcus multilocularis death associated protein kinase 1 0.08 0.2057 0.2057
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0221 0.2866
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0085 0.106
Chlamydia trachomatis biotin carboxylase 0.1316 0.3422 1
Giardia lamblia Serine/threonine protein kinase 0.0044 0.0062 0.0347
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0027 0.0014 0.0014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0064 0.0059
Loa Loa (eye worm) STE/STE7/MEK4 protein kinase 0.0158 0.0362 0.0375
Entamoeba histolytica protein kinase 2, putative 0.004 0.0049 0.0269
Toxoplasma gondii thioredoxin reductase 0.005 0.0077 0.0073
Echinococcus multilocularis protein kinase c iota type 0.0027 0.0015 0.0015
Echinococcus granulosus death domain containing protein 0.0045 0.0062 0.0062
Toxoplasma gondii AGC kinase 0.0053 0.0085 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.0761 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0009 0.0004
Schistosoma mansoni aspartate carbamoyltransferase 0.0328 0.081 0.081
Schistosoma mansoni netrin receptor unc5 0.0045 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0015 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.004 0.0049 0.0269
Brugia malayi 6-phosphofructokinase 0.0105 0.0221 0.0229
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0516 0.1307 0.1303
Loa Loa (eye worm) hypothetical protein 0.013 0.0287 0.0297
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0009 0.0004
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0133 0.0297 0.0815
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0362 0.0362
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0133 0.0297 0.0474

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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