Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.5833 | 0.5833 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.5833 | 0.5833 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.5833 | 0.5833 |
Onchocerca volvulus | 0.0033 | 0.5833 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.5833 | 0.5833 |
Echinococcus multilocularis | musashi | 0.0033 | 0.5833 | 0.5833 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.5833 | 0.5833 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.8382 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.5833 | 0.5833 |
Onchocerca volvulus | 0.0033 | 0.5833 | 0.5 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.8382 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.5833 | 0.5568 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0599 | 0.0599 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.5833 | 0.5568 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.5833 | 0.5833 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5627 | 0.5627 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.5833 | 0.5833 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.