Detailed information for compound 1347053

Basic information

Technical information
  • TDR Targets ID: 1347053
  • Name: 4-methyl-3,5,6,7-tetrahydrocyclopenta[d]pyrim idin-2-one
  • MW: 150.178 | Formula: C8H10N2O
  • H donors: 1 H acceptors: 3 LogP: 1.27 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(C)c2c(n1)CCC2
  • InChi: 1S/C8H10N2O/c1-5-6-3-2-4-7(6)10-8(11)9-5/h2-4H2,1H3,(H,9,10,11)
  • InChiKey: KQUXCKYKMCJICY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 11D-056
  • ZINC04002432
  • 4-methyl-1,5,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-2-one
  • MLS000756042
  • SMR000337710

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans dehydrogenase 0.0306 0.0693 0.1889
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0236 0.0476 0.0463
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0648 0.1743 0.1737
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0172 0.028 0.025
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.006 0.0084
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Plasmodium falciparum glutathione reductase 0.3332 1 1
Entamoeba histolytica protein kinase, putative 0.0135 0.0167 0.076
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0095 0.0043 0.0177
Brugia malayi Immunoglobulin domain containing protein 0.0176 0.0291 0.0284
Brugia malayi Protein kinase domain containing protein 0.0305 0.0688 0.0681
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Plasmodium vivax serine/threonine kinase-1, putative 0.0169 0.0271 0.024
Echinococcus granulosus Immunoglobulin 0.0569 0.15 0.1487
Schistosoma mansoni serine/threonine protein kinase 0.0427 0.1064 0.1054
Echinococcus granulosus tyrosine protein kinase ABL1 0.0109 0.0087 0.0073
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Loa Loa (eye worm) hypothetical protein 0.0198 0.0359 0.0352
Brugia malayi Delta serrate ligand family protein 0.0337 0.0786 0.0779
Brugia malayi Calcium binding EGF domain containing protein 0.0337 0.0786 0.0779
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0094 0.004 0.004
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0153 0.0222 0.0193
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0175 0.0289 0.0281
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0146 0.0198 0.0187
Trypanosoma brucei cdc2-related kinase 3 0.0132 0.0156 0.0126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.0096 0.0082
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0146 0.0198 0.0184
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0092 0.0033 0.0018
Giardia lamblia Kinase, AGC PKA 0.0126 0.0137 0.0302
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Loa Loa (eye worm) hypothetical protein 0.0162 0.025 0.0243
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0103 0.0067 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0122 0.0111
Echinococcus multilocularis C type lectin domian containing protein 0.0622 0.1663 0.1651
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0338 0.0791 0.0778
Echinococcus multilocularis glutamate synthase 0.0306 0.0693 0.068
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0059 0.0047
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Echinococcus multilocularis casein kinase ii subunit alpha 0.0112 0.0094 0.008
Toxoplasma gondii histone kinase SNF1, putative 0.01 0.0059 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0207 0.0387 0.0379
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0126 0.0137 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.0321 0.0309
Loa Loa (eye worm) AUR protein kinase 0.016 0.0244 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0137 0.0318
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0256 0.0539 0.0525
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0127 0.014 0.0133
Trypanosoma cruzi cdc2-related kinase 1 0.0132 0.0156 0.0156
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.0198 0.0191
Echinococcus granulosus titin 0.0146 0.0198 0.0184
Echinococcus multilocularis calcium activated potassium channel 0.0149 0.0209 0.0195
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus multilocularis tyrosine kinase 0.0109 0.0087 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.004 0.0029
Echinococcus granulosus NDR protein kinase 0.0184 0.0318 0.0304
Loa Loa (eye worm) hypothetical protein 0.0109 0.0087 0.008
Echinococcus multilocularis hemicentin 1 0.0321 0.0739 0.0726
Echinococcus multilocularis cyclin dependent kinase 9 0.0096 0.0046 0.0032
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0245 0.0503 0.0489
Trypanosoma cruzi casein kinase, putative 0.0121 0.0122 0.0122
Trypanosoma brucei NADH dehydrogenase 0.0306 0.0693 0.0665
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.0655 0.0655
Schistosoma mansoni tyrosine kinase 0.0373 0.0897 0.0887
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Schistosoma mansoni rap gtpase-activating protein 0.012 0.0119 0.0108
Onchocerca volvulus 0.0146 0.0198 0.1193
Brugia malayi SH2 domain containing protein 0.0109 0.0087 0.0079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Onchocerca volvulus 0.0337 0.0786 0.4727
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0306 0.0693 0.068
Brugia malayi Cam kinase protein 1 0.0113 0.0096 0.0089
Entamoeba histolytica protein kinase, putative 0.0317 0.0726 0.339
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0338 0.0791 0.0784
Loa Loa (eye worm) hypothetical protein 0.0099 0.0055 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0096 0.0195
Brugia malayi Immunoglobulin domain containing protein 0.0176 0.0291 0.0284
Echinococcus granulosus epidermal growth factor receptor 0.0657 0.1772 0.176
Echinococcus granulosus serine:threonine protein kinase N2 0.0324 0.0745 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.0516 0.1337 0.1327
Trypanosoma brucei protein kinase, putative 0.0142 0.0188 0.0158
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.3332 1 1
Schistosoma mansoni hypothetical protein 0.0306 0.0693 0.0682
Brugia malayi Protein kinase domain containing protein 0.0483 0.1236 0.1229
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Schistosoma mansoni titin 0.0146 0.0198 0.0187
Plasmodium vivax calcium-dependent protein kinase, putative 0.0113 0.0096 0.0066
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0306 0.0693 0.0693
Echinococcus granulosus N chimaerin 0.0103 0.0067 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Echinococcus multilocularis Immunoglobulin subtype 0.0176 0.0291 0.0277
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus granulosus tyrosine protein kinase shark 0.0338 0.0791 0.0778
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0175 0.0289 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0209 0.0197
Brugia malayi probable protein kinase 0.0288 0.0638 0.0631
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Loa Loa (eye worm) hypothetical protein 0.0162 0.025 0.0243
Entamoeba histolytica PH domain containing protein kinase, putative 0.0182 0.031 0.1433
Onchocerca volvulus 0.0162 0.025 0.1504
Onchocerca volvulus 0.0337 0.0786 0.4727
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0193 0.0343 0.0329
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0135 0.0167 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.0591 0.058
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1155 0.3302 0.3282
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0202 0.0372 0.0365
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0176 0.0291 0.028
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0306 0.0693 0.0665
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0156 0.0144
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0059 0.0251
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0435 0.1088 0.1075
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0222 0.0432 0.0425
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0103 0.0067 0.0056
Echinococcus multilocularis twitchin 0.0185 0.0321 0.0307
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.046 0.0449
Brugia malayi Prion-like- 0.0321 0.0739 0.0732
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0094 0.0038 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Brugia malayi Kinase associated domain 1 family protein 0.0109 0.0086 0.0079
Echinococcus granulosus dual specificity 0.0153 0.0222 0.0208
Brugia malayi Stress-activated protein kinase jnk-1 0.0288 0.0636 0.0628
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0264 0.0562 0.0548
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.0055 0.0044
Loa Loa (eye worm) hypothetical protein 0.0569 0.15 0.1493
Plasmodium falciparum calcium-dependent protein kinase 3 0.0113 0.0096 0.0066
Onchocerca volvulus 0.0202 0.0372 0.2239
Echinococcus multilocularis serine:threonine protein kinase 0.0127 0.014 0.0126
Echinococcus multilocularis protein kinase c iota type 0.0318 0.0729 0.0716
Entamoeba histolytica protein kinase, putative 0.0114 0.0101 0.0448
Entamoeba histolytica PH domain containing protein kinase, putative 0.0182 0.031 0.1433
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Schistosoma mansoni cell adhesion molecule 0.0176 0.0291 0.028
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0166 0.0261 0.0254
Brugia malayi Protein kinase domain containing protein 0.0327 0.0755 0.0748
Echinococcus multilocularis roundabout 2 0.0338 0.0791 0.0778
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0153 0.0222 0.0215
Trypanosoma cruzi NADH dehydrogenase, putative 0.0306 0.0693 0.0693
Schistosoma mansoni titin 0.0146 0.0198 0.0187
Brugia malayi Temporarily assigned gene name protein 59 0.012 0.0119 0.0111
Schistosoma mansoni tyrosine kinase 0.015 0.0213 0.0202
Echinococcus multilocularis nervana 2 0.0133 0.0158 0.0144
Loa Loa (eye worm) hypothetical protein 0.0367 0.088 0.0873
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0097 0.0048 0.0033
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.015 0.0213 0.0183
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0126 0.0137 0.0107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0113 0.0096 0.0082
Echinococcus granulosus dual specificity 0.0153 0.0222 0.0208
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0204 0.0377 0.0363
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0238 0.0482 0.0474
Echinococcus granulosus insulin growth factor binding 0.0146 0.0198 0.0184
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0169 0.0271 0.0241
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0306 0.0693 0.068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0113 0.0096 0.0082
Echinococcus granulosus serine:threonine protein kinase 3 0.028 0.0611 0.0597
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.006 0.0084
Onchocerca volvulus Netrin receptor homolog 0.0177 0.0294 0.1767
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0539 0.0528
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0338 0.0791 0.0778
Schistosoma mansoni serine/threonine kinase 0.0245 0.0505 0.0495
Plasmodium falciparum casein kinase 1 0.0121 0.0122 0.0092
Schistosoma mansoni ephrin receptor 0.012 0.0119 0.0108
Schistosoma mansoni basigin related 0.0176 0.0291 0.028
Brugia malayi Disorganized muscle protein 1 0.0146 0.0198 0.0191
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0162 0.025 0.0243
Schistosoma mansoni sulfide quinone reductase 0.0306 0.0693 0.0682
Schistosoma mansoni tyrosine kinase 0.0245 0.0503 0.0492
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0176 0.0291 0.0277
Schistosoma mansoni atypical protein kinase C 0.0325 0.0749 0.0739
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Brugia malayi putative serine/threonine kinase SADA gamma 0.01 0.0059 0.0051
Plasmodium falciparum calcium-dependent protein kinase 4 0.0113 0.0096 0.0066
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Brugia malayi Cyclin C 0.1529 0.4454 0.445
Loa Loa (eye worm) TK/ABL protein kinase 0.0109 0.0087 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0137 0.0125
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0176 0.0291 0.028
Brugia malayi Sushi domain 0.0622 0.1663 0.1656
Echinococcus multilocularis neurogenic locus protein delta 0.0337 0.0786 0.0773
Echinococcus multilocularis neurogenic locus notch protein 4 0.0337 0.0786 0.0773
Echinococcus multilocularis neuroglian 0.0338 0.0791 0.0778
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.004 0.0023
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0097 0.0048 0.0033
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0193 0.0343 0.0329
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0306 0.0693 0.068
Loa Loa (eye worm) glutathione reductase 0.3332 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Schistosoma mansoni tyrosine kinase 0.0657 0.1772 0.1762
Brugia malayi notch-like transmembrane receptor 0.0337 0.0786 0.0779
Loa Loa (eye worm) hypothetical protein 0.0129 0.0148 0.0141
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.012 0.0119 0.0105
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0306 0.0693 0.3237
Echinococcus multilocularis neurogenic locus protein delta 0.0337 0.0786 0.0773
Giardia lamblia Kinase, CMGC MAPK 0.0094 0.004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0128 0.0143 0.0135
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0306 0.0693 0.0094
Echinococcus granulosus notch 0.0337 0.0786 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0208 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0181 0.0453
Brugia malayi Casein kinase II, alpha chain 0.0112 0.0094 0.0087
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0176 0.0291 0.0277
Mycobacterium ulcerans hypothetical protein 0.0306 0.0693 0.1889
Trypanosoma cruzi casein kinase, putative 0.0121 0.0122 0.0122
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Onchocerca volvulus 0.0198 0.0359 0.2162
Brugia malayi Protein kinase domain containing protein 0.0648 0.1743 0.1737
Entamoeba histolytica hypothetical protein 0.0135 0.0167 0.076
Leishmania major protein kinase A catalytic subunit isoform 1 0.0126 0.0137 0.0107
Schistosoma mansoni tyrosine kinase 0.0398 0.0973 0.0963
Trichomonas vaginalis STE family protein kinase 0.0097 0.0048 0.0046
Toxoplasma gondii thioredoxin reductase 0.3332 1 1
Brugia malayi cyclin-dependent kinase 9 0.0088 0.002 0.0013
Giardia lamblia Kinase, CMGC GSK 0.0142 0.0188 0.046
Schistosoma mansoni vav2 0.0113 0.0097 0.0085
Echinococcus granulosus titin 0.0146 0.0198 0.0184
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0271 0.0259
Onchocerca volvulus 0.012 0.0119 0.0715
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.016 0.0244 0.1121
Trypanosoma cruzi casein kinase, putative 0.0121 0.0122 0.0122
Loa Loa (eye worm) AGC/PKA protein kinase 0.0126 0.0137 0.0129
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0095 0.0043 0.0043
Onchocerca volvulus 0.0146 0.0198 0.1193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Schistosoma mansoni protein kinase 0.0097 0.0048 0.0036
Echinococcus granulosus neurogenic locus notch protein 4 0.0337 0.0786 0.0773
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0153 0.0222 0.0222
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0306 0.0693 0.2007
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0569 0.15 0.149
Loa Loa (eye worm) AUR protein kinase 0.016 0.0244 0.0236
Echinococcus multilocularis thioredoxin glutathione reductase 0.3332 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.0337 0.0786 0.0773
Brugia malayi Prion-like- 0.0146 0.0198 0.0191
Schistosoma mansoni protein kinase 0.0121 0.0122 0.0111
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0245 0.0503 0.0489
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0306 0.0693 0.3237
Schistosoma mansoni septate junction protein 0.0321 0.0739 0.0729
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0306 0.0693 0.202
Leishmania major hypothetical protein, conserved 0.0306 0.0693 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.014 0.0181 0.0453
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0306 0.0693 0.3237
Schistosoma mansoni adapter molecule crk 0.0099 0.0055 0.0044
Brugia malayi EGF-like domain containing protein 0.0367 0.088 0.0873
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0169 0.0271 0.0271
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0091 0.0031 0.0001
Brugia malayi Cadherin domain containing protein 0.0337 0.0786 0.0779
Brugia malayi protein kinase C3,putative 0.0173 0.0284 0.0277
Onchocerca volvulus 0.0622 0.1663 1
Leishmania major hypothetical protein, conserved 0.0306 0.0693 0.0665
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0245 0.0503 0.0489
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Echinococcus multilocularis dual specificity 0.0153 0.0222 0.0208
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0306 0.0693 0.202
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0133 0.0158 0.0144
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0264 0.0562 0.0548
Brugia malayi Protein kinase domain containing protein 0.0206 0.0385 0.0378
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Trichomonas vaginalis AGC family protein kinase 0.01 0.0059 0.0079
Trichomonas vaginalis AGC family protein kinase 0.016 0.0244 0.0646
Brugia malayi Protein kinase domain containing protein 0.0132 0.0156 0.0148
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0092 0.0033 0.0025
Echinococcus multilocularis lachesin 0.0321 0.0739 0.0726
Echinococcus multilocularis 0.0146 0.0198 0.0184
Echinococcus granulosus hypothetical protein 0.0129 0.0148 0.0134
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.012 0.0119 0.0108
Onchocerca volvulus 0.0622 0.1663 1
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0095 0.0043 0.0177
Trypanosoma cruzi trypanothione reductase, putative 0.3332 1 1
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0055 0.0048
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0167 0.0263 0.0705
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Echinococcus granulosus insulin growth factor 1 receptor beta 0.05 0.1287 0.1275
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0109 0.0085 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0156 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0193 0.0344 0.0951
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Echinococcus multilocularis Immunoglobulin 0.0176 0.0291 0.0277
Echinococcus multilocularis 0.0186 0.0323 0.0309
Loa Loa (eye worm) hypothetical protein 0.0273 0.0591 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Schistosoma mansoni hypothetical protein 0.0109 0.0086 0.0075
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0097 0.0048 0.0033
Schistosoma mansoni protein kinase 0.0097 0.0048 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.0096 0.0082
Brugia malayi Protein kinase domain containing protein 0.1014 0.2871 0.2865
Echinococcus multilocularis roundabout 2 0.0338 0.0791 0.0778
Echinococcus granulosus Immunoglobulin 0.0176 0.0291 0.0277
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0176 0.0291 0.028
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0306 0.0693 0.068
Schistosoma mansoni growth factor receptor-bound protein 0.0101 0.0062 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0353 0.0836 0.0826
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0306 0.0693 0.1889
Loa Loa (eye worm) cyclin C 0.1529 0.4454 0.445
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.1155 0.3302 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.1155 0.3302 0.3281
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0236 0.0476 0.0463
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0126 0.0137 0.0137
Echinococcus granulosus insulin receptor 0.0483 0.1236 0.1223
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0306 0.0693 0.0665
Echinococcus multilocularis titin 0.0146 0.0198 0.0184
Schistosoma mansoni roundabout 0.0321 0.0739 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0271 0.0259
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Brugia malayi Protein kinase domain containing protein 0.0109 0.0087 0.0079
Schistosoma mansoni laminin gamma-3 chain 0.0337 0.0786 0.0775
Schistosoma mansoni protein kinase 0.0288 0.0638 0.0627
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0112 0.0094 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0216 0.0415 0.1169
Echinococcus granulosus protein jagged 2 0.0337 0.0786 0.0773
Echinococcus granulosus tyrosine kinase 0.0204 0.0377 0.0363
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.05 0.1287 0.1275
Toxoplasma gondii AGC kinase 0.0126 0.0137 0.0107
Trichomonas vaginalis STE family protein kinase 0.0095 0.0043 0.0032
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0099 0.0055 0.0048
Leishmania major protein kinase, putative 0.0113 0.0096 0.0066
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0193 0.0344 0.0336
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0763 0.2096 0.2085
Toxoplasma gondii EGF family domain-containing protein 0.0337 0.0786 0.0758
Loa Loa (eye worm) hypothetical protein 0.0153 0.0221 0.0214
Brugia malayi Serine/threonine-protein kinase SULU 0.0243 0.0497 0.049
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0245 0.0503 0.0489
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0569 0.15 0.149
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0306 0.0693 0.0665
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0306 0.0693 0.068
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0142 0.0188 0.0177
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0306 0.0693 0.068
Echinococcus multilocularis peroxidasin 0.0322 0.074 0.0727
Schistosoma mansoni tyrosine kinase 0.0383 0.0927 0.0917
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0378 0.0913 0.0906
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0436 0.1093 0.108
Echinococcus granulosus roundabout 2 0.0907 0.254 0.2529
Giardia lamblia Kinase, CMGC CDK 0.0132 0.0156 0.0361
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0258 0.0543 0.053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Leishmania major trypanothione reductase 0.3332 1 1
Plasmodium vivax protein kinase Crk2 0.0132 0.0156 0.0125
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Trichomonas vaginalis STE family protein kinase 0.015 0.0213 0.0552
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0128 0.0143 0.0129
Trypanosoma brucei aurora B kinase 0.016 0.0244 0.0214
Entamoeba histolytica thioredoxin reductase, putative 0.0306 0.0693 0.3237
Brugia malayi Calcium binding EGF domain containing protein 0.0337 0.0786 0.0779
Echinococcus granulosus nervana 2 0.0133 0.0158 0.0144
Trichomonas vaginalis AGC family protein kinase 0.016 0.0244 0.0646
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.012 0.0119 0.0089
Echinococcus granulosus protein kinase c iota type 0.0318 0.0729 0.0716
Schistosoma mansoni protein kinase 0.047 0.1195 0.1185
Plasmodium falciparum protein kinase 5 0.0132 0.0156 0.0126
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0103 0.0067 0.0053
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Loa Loa (eye worm) hypothetical protein 0.0096 0.0045 0.0037
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0306 0.0693 0.1889
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0094 0.004 0.004
Brugia malayi glutamate synthase 0.0306 0.0693 0.0686
Echinococcus multilocularis titin 0.0146 0.0198 0.0184
Loa Loa (eye worm) SRC-1 0.0245 0.0503 0.0496
Echinococcus multilocularis myosin iiia 0.0095 0.0043 0.0029
Schistosoma mansoni slit 0.0146 0.0199 0.0188
Schistosoma mansoni tyrosine kinase 0.0483 0.1236 0.1225
Loa Loa (eye worm) casein kinase 0.0193 0.0345 0.0338
Loa Loa (eye worm) hypothetical protein 0.0154 0.0224 0.0216
Echinococcus granulosus tyrosine protein kinase Blk 0.0204 0.0377 0.0363
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0338 0.0791 0.0778
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0184 0.0318 0.0304
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0176 0.0291 0.028
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.0198 0.0191
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0288 0.0636 0.0622
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0236 0.0476 0.0463
Mycobacterium tuberculosis Probable reductase 0.0306 0.0693 0.0094
Brugia malayi Protein kinase domain containing protein 0.0648 0.1743 0.1737
Schistosoma mansoni serine/threonine protein kinase 0.0294 0.0655 0.0645
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Brugia malayi Protein kinase domain containing protein 0.0127 0.014 0.0133
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0338 0.0791 0.0778
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0467 0.0456
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0204 0.0377 0.0369
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0306 0.0693 0.0664
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.1155 0.3302 0.3294
Mycobacterium ulcerans glutamate synthase subunit beta 0.0306 0.0693 0.1889
Onchocerca volvulus 0.0622 0.1663 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0172 0.028 0.028
Trichomonas vaginalis AGC family protein kinase 0.015 0.0213 0.0552
Echinococcus granulosus nephrin 0.0162 0.025 0.0236
Brugia malayi serine/threonine protein kinase 6 0.016 0.0244 0.0236
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0113 0.0096 0.0082
Schistosoma mansoni ste20-related kinase 0.0224 0.044 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1155 0.3302 1
Plasmodium falciparum cGMP-dependent protein kinase 0.0149 0.0208 0.0178
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0306 0.0693 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0222 0.0211
Echinococcus granulosus Immunoglobulin subtype 0.0176 0.0291 0.0277
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0306 0.0693 0.0665
Echinococcus multilocularis neural cadherin 0.0337 0.0786 0.0773
Brugia malayi serine/threonine-protein kinase PAK 7 0.0253 0.0529 0.0522
Echinococcus granulosus casein kinase I alpha 0.0121 0.0122 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0091 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0113 0.0096 0.0066
Trypanosoma cruzi SNF1-related protein kinases, putative 0.01 0.0059 0.0059
Echinococcus granulosus serine:threonine protein kinase 0.0127 0.014 0.0126
Brugia malayi serine/threonine-protein kinase 6 0.016 0.0244 0.0236
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0188 0.086
Onchocerca volvulus 0.0142 0.0188 0.1132
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0385 0.1079
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0245 0.0503 0.0489
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0306 0.0693 0.0693
Loa Loa (eye worm) AGC/NDR protein kinase 0.0184 0.0318 0.031
Trypanosoma cruzi casein kinase, putative 0.0121 0.0122 0.0122
Toxoplasma gondii aurora kinase 0.016 0.0244 0.0214
Echinococcus multilocularis serine:threonine protein kinase 0.0127 0.014 0.0126
Brugia malayi Prion-like- 0.0146 0.0198 0.0191
Onchocerca volvulus 0.0622 0.1663 1
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.01 0.0059 0.0029
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0176 0.0291 0.0277
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0122 0.0274
Giardia lamblia Kinase, CMGC CDK 0.0132 0.0156 0.0361
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.018 0.0305 0.0291
Plasmodium falciparum apical sushi protein 0.0622 0.1663 0.1637
Echinococcus granulosus protein jagged 1 0.0337 0.0786 0.0773
Giardia lamblia Kinase, NEK 0.015 0.0213 0.0536
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0146 0.0199 0.0185
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0291 0.0284
Echinococcus multilocularis casein kinase I gamma 0.0233 0.0467 0.0453
Brugia malayi Protein kinase domain containing protein 0.0382 0.0927 0.092
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Echinococcus granulosus serine/threonine protein kinase 0.0182 0.031 0.0296
Echinococcus granulosus protein kinase c epsilon type 0.0231 0.046 0.0446
Plasmodium falciparum glutathione reductase 0.1155 0.3302 0.3282
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0122 0.0274
Echinococcus multilocularis c4b binding protein beta chain 0.0622 0.1663 0.1651
Echinococcus granulosus neuroglian 0.0338 0.0791 0.0778
Giardia lamblia Kinase, CK1 Casein kinase 0.0121 0.0122 0.0258
Echinococcus granulosus casein kinase I gamma 0.0233 0.0467 0.0453
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0275 0.0595 0.0588
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0094 0.004 0.001
Echinococcus multilocularis tyrosine protein kinase Srms 0.0204 0.0377 0.0363
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0306 0.0693 0.0665
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0132 0.0156 0.0126
Brugia malayi Protein kinase domain containing protein 0.0233 0.0467 0.046
Onchocerca volvulus Serine\/threonine kinase homolog 0.0294 0.0655 0.3942
Entamoeba histolytica protein kinase, putative 0.016 0.0244 0.1121
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0126 0.0137 0.0107
Trichomonas vaginalis mercuric reductase, putative 0.1155 0.3302 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0113 0.0096 0.0066
Echinococcus granulosus CDC7 cell division cycle 7 0.0101 0.006 0.0046
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0091 0.0031 0.0001
Loa Loa (eye worm) TK protein kinase 0.0146 0.0198 0.0191
Onchocerca volvulus 0.0109 0.0087 0.0523
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0294 0.0655 0.0642
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0184 0.0318 0.0304
Echinococcus granulosus neuroglian 0.0714 0.1948 0.1936
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0197 0.0356 0.0342
Schistosoma mansoni cell adhesion molecule 0.0146 0.0198 0.0187
Echinococcus multilocularis mitogen activated protein kinase 14 0.0175 0.0289 0.0275
Echinococcus granulosus protein kinase 0.0169 0.0269 0.0255
Schistosoma mansoni septate junction protein 0.0176 0.0291 0.028
Plasmodium vivax glutathione reductase, putative 0.3332 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0306 0.0693 0.068
Loa Loa (eye worm) hypothetical protein 0.0585 0.1551 0.1545
Onchocerca volvulus Putative cubilin 0.0337 0.0786 0.4727
Echinococcus multilocularis NCK adaptor protein 0.0101 0.0062 0.0047
Echinococcus multilocularis epidermal growth factor receptor 0.0657 0.1772 0.176
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Trypanosoma cruzi polo-like protein kinase, putative 0.0294 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Toxoplasma gondii CMGC kinase, CK2 family 0.0112 0.0094 0.0064
Echinococcus multilocularis tyrosine protein kinase Blk 0.0204 0.0377 0.0363
Echinococcus multilocularis netrin receptor unc 5 0.0207 0.0387 0.0373
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0744 0.2041 0.2029
Giardia lamblia NADH oxidase lateral transfer candidate 0.1155 0.3302 1
Brugia malayi Protein kinase domain containing protein 0.0308 0.0699 0.0692
Echinococcus multilocularis N chimaerin 0.0103 0.0067 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Brugia malayi Myb-like DNA-binding domain containing protein 0.0146 0.0198 0.0191
Schistosoma mansoni hypothetical protein 0.0109 0.0086 0.0075
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Schistosoma mansoni vesicular amine transporter 0.0569 0.15 0.149
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0294 0.0655 0.0642
Loa Loa (eye worm) CAMK protein kinase 0.0202 0.0372 0.0365
Brugia malayi Immunoglobulin I-set domain containing protein 0.0338 0.0791 0.0784
Schistosoma mansoni tyrosine kinase 0.0245 0.0503 0.0492
Trypanosoma brucei SNF1-related protein kinases, putative 0.01 0.0059 0.0029
Echinococcus granulosus serine:threonine protein kinase N2 0.0139 0.0178 0.0164
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1155 0.3302 1
Echinococcus multilocularis protein tyrosine kinase 0.0594 0.1578 0.1565
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0208 0.0197
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0434 0.1085 0.1072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Brugia malayi Protein kinase domain containing protein 0.0184 0.0318 0.031
Loa Loa (eye worm) hypothetical protein 0.0383 0.093 0.0923
Brugia malayi phosphoinositide-dependent protein kinase I 0.0092 0.0033 0.0025
Loa Loa (eye worm) TK/FAK protein kinase 0.06 0.1597 0.1591
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.1155 0.3302 0.3292
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Echinococcus granulosus ephrin type A receptor 4 A 0.012 0.0119 0.0105
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.01 0.0059 0.0051
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0169 0.0271 0.0263
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1155 0.3302 0.3282
Echinococcus granulosus NCK adaptor protein 0.0099 0.0055 0.0041
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0155 0.0226 0.0212
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0149 0.0208 0.0194
Entamoeba histolytica disulphide oxidoreductase, putative 0.0306 0.0693 0.3237
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Echinococcus granulosus mitogen activated protein kinase 11 0.0175 0.0289 0.0275
Trypanosoma brucei rac serine-threonine kinase, putative 0.0327 0.0755 0.0727
Trichomonas vaginalis AGC family protein kinase 0.0206 0.0385 0.1079
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Trypanosoma cruzi aurora B kinase, putative 0.016 0.0244 0.0244
Echinococcus multilocularis down syndrome cell adhesion 0.0146 0.0198 0.0184
Echinococcus multilocularis tyrosine protein kinase shark 0.0338 0.0791 0.0778
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus granulosus neurogenic locus notch protein 0.0337 0.0786 0.0773
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0135 0.0167 0.0137
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0109 0.0087 0.0383
Echinococcus granulosus tyrosine protein kinase HCK 0.0146 0.0198 0.0184
Echinococcus granulosus tyrosine protein kinase otk 0.0321 0.0739 0.0726
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.006 0.0084
Onchocerca volvulus Peroxidasin homolog 0.0146 0.0198 0.1193
Brugia malayi hypothetical protein 0.0585 0.1551 0.1545
Loa Loa (eye worm) projectin 0.0162 0.025 0.0243
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0172 0.028 0.0266
Entamoeba histolytica serine/threonine protein kinase, putative 0.0294 0.0655 0.3059
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0275 0.0595 0.0582
Loa Loa (eye worm) hypothetical protein 0.089 0.2489 0.2483
Brugia malayi Protein kinase domain containing protein 0.0109 0.0087 0.0079
Toxoplasma gondii NADPH-glutathione reductase 0.1155 0.3302 0.3282
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0188 0.086
Entamoeba histolytica casein kinase 1, putative 0.0121 0.0122 0.055
Schistosoma mansoni hemicentin 0.0162 0.025 0.0239
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.015 0.0213 0.0202
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0306 0.0693 0.0094
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Brugia malayi Protein kinase domain containing protein 0.06 0.1597 0.1591
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Echinococcus granulosus tyrosine protein kinase Lyn 0.0284 0.0625 0.0612
Brugia malayi Fibronectin type III domain containing protein 0.0585 0.1551 0.1545
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.1155 0.3302 0.3297
Giardia lamblia Kinase, CMGC GSK 0.0142 0.0188 0.046
Brugia malayi Protein kinase domain containing protein 0.0212 0.0403 0.0396
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0176 0.0291 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0137 0.0126
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0306 0.0693 0.0665
Treponema pallidum NADH oxidase 0.1155 0.3302 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0045 0.0037
Brugia malayi protein unc-22 0.0202 0.0372 0.0365
Loa Loa (eye worm) AGC/PKN protein kinase 0.0324 0.0745 0.0738
Schistosoma mansoni protein kinase 0.0258 0.0543 0.0532
Echinococcus granulosus serine:threonine protein kinase 0.0127 0.014 0.0126
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0169 0.0269 0.0262
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1014 0.2871 0.2865
Entamoeba histolytica protein kinase, putative 0.0113 0.0096 0.0428
Onchocerca volvulus 0.0337 0.0786 0.4727
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1011 0.286 0.2855
Echinococcus multilocularis serine threonine protein kinase 0.0228 0.0453 0.0439
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0184 0.0318 0.0304
Echinococcus multilocularis serine:threonine protein kinase N2 0.0324 0.0745 0.0732
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.0198 0.0191
Brugia malayi Protein kinase domain containing protein 0.0109 0.0087 0.0079
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0132 0.0156 0.0142
Trichomonas vaginalis STE family protein kinase 0.0097 0.0048 0.0046
Onchocerca volvulus 0.0146 0.0198 0.1193
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.016 0.0244 0.1121
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0321 0.0739 0.0732
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0095 0.0043 0.0043
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0162 0.025 0.0236
Loa Loa (eye worm) TK protein kinase 0.0308 0.0699 0.0692
Brugia malayi casein kinase 1, delta 0.0121 0.0122 0.0115
Trypanosoma brucei casein kinase I, isoform 2 0.0121 0.0122 0.0092
Brugia malayi Leucine Rich Repeat family protein 0.0146 0.0199 0.0192
Loa Loa (eye worm) CDC7 protein kinase 0.0101 0.006 0.0052
Onchocerca volvulus Neurogenic locus notch homolog 0.0337 0.0786 0.4727
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0132 0.0156 0.0148
Schistosoma mansoni g1/s-specific cyclin C 0.1529 0.4454 0.4448
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0059 0.0047
Echinococcus granulosus serine:threonine protein kinase 12 B 0.016 0.0244 0.023
Brugia malayi Protein kinase domain containing protein 0.022 0.0426 0.0419
Giardia lamblia Kinase, CMGC CK2 0.0112 0.0094 0.0172
Echinococcus multilocularis neurogenic locus notch protein 0.0337 0.0786 0.0773
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0306 0.0693 0.202
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0038 0.0026
Schistosoma mansoni netrin receptor unc5 0.0176 0.0291 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0137 0.0125
Plasmodium vivax glycogen synthase kinase 3, putative 0.0142 0.0188 0.0158
Echinococcus granulosus glutamate synthase 0.0306 0.0693 0.068
Echinococcus multilocularis dual specificity 0.0135 0.0167 0.0153
Loa Loa (eye worm) hypothetical protein 0.0176 0.0291 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0372 0.0361
Onchocerca volvulus Putative titin 0.0146 0.0198 0.1193
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0153 0.0222 0.0193
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.01 0.0059 0.0029
Echinococcus multilocularis protein kinase c epsilon type 0.0231 0.046 0.0446
Schistosoma mansoni protein kinase 0.0398 0.0974 0.0963
Schistosoma mansoni sulfide quinone reductase 0.0306 0.0693 0.0682
Brugia malayi Immunoglobulin I-set domain containing protein 0.0338 0.0791 0.0784
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0377 0.0366
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Loa Loa (eye worm) hypothetical protein 0.0306 0.0693 0.0686
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0088 0.002 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.1155 0.3302 0.3282
Mycobacterium tuberculosis Probable dehydrogenase 0.0306 0.0693 0.0094
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0113 0.0096 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.004 0.0023
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0135 0.0167 0.0167
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Mycobacterium ulcerans ferredoxin reductase 0.0306 0.0693 0.1889
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Giardia lamblia Kinase, PLK 0.0294 0.0655 0.1891
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1155 0.3302 0.3302
Echinococcus multilocularis cyclin dependent kinase 1 0.0132 0.0156 0.0142
Loa Loa (eye worm) hypothetical protein 0.0691 0.1877 0.1871
Trypanosoma cruzi cdc2-related kinase 1 0.0132 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0208 0.0389 0.0382
Plasmodium falciparum serine/threonine protein kinase 0.0094 0.0038 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.1155 0.3302 0.3282
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0306 0.0693 0.0665
Trichomonas vaginalis AGC family protein kinase 0.016 0.0244 0.0646
Brugia malayi serine/threonine kinase 12 0.016 0.0244 0.0236
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Brugia malayi Protein kinase domain containing protein 0.0109 0.0087 0.0079
Loa Loa (eye worm) hypothetical protein 0.0113 0.0096 0.0089
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0244 0.0232
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0273 0.0591 0.0577
Echinococcus granulosus Glutaredoxin protein 5 0.0133 0.0158 0.0144
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.016 0.0241 0.0227
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Onchocerca volvulus 0.0353 0.0836 0.503
Brugia malayi Protein kinase domain containing protein 0.1011 0.286 0.2855
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.003 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0143 0.0339
Schistosoma mansoni nephrin 0.0338 0.0791 0.078
Giardia lamblia Kinase, STE STE20 0.0095 0.0043 0.0016
Loa Loa (eye worm) hypothetical protein 0.0257 0.0541 0.0534
Plasmodium falciparum serine/threonine protein kinase KIN 0.01 0.0059 0.0029
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0306 0.0693 0.068
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0094 0.0038 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.0476 0.0465
Echinococcus multilocularis activin receptor type 0.0091 0.003 0.0016
Brugia malayi basement membrane proteoglycan precursor 0.0176 0.0291 0.0284
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0306 0.0693 0.0094
Onchocerca volvulus 0.0146 0.0198 0.1193
Brugia malayi cell division control protein 2 homolog 0.0132 0.0156 0.0148
Echinococcus multilocularis rac serine:threonine kinase 0.0182 0.031 0.0296
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0113 0.0096 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.1155 0.3302 0.3281
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.002 0.0009
Schistosoma mansoni nck2/grb4 0.0099 0.0055 0.0044
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0306 0.0693 0.0686
Loa Loa (eye worm) TK/INSR protein kinase 0.0483 0.1236 0.1229
Brugia malayi Protein kinase domain containing protein 0.0109 0.0087 0.0079
Echinococcus granulosus casein kinase I delta 0.0121 0.0122 0.0108
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.1155 0.3302 0.2871
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0435 0.1088 0.1075
Schistosoma mansoni peroxidasin 0.0176 0.0292 0.0281
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0033 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0848 0.2359 0.2354
Schistosoma mansoni cell adhesion molecule 0.0162 0.025 0.0239
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Loa Loa (eye worm) hypothetical protein 0.0092 0.0033 0.0026
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0162 0.025 0.0243
Brugia malayi Protein kinase domain 0.0097 0.0048 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Entamoeba histolytica protein kinase, putative 0.0327 0.0755 0.3529
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Giardia lamblia Kinase, CMGC DYRK 0.0153 0.0222 0.0565
Trypanosoma brucei protein kinase, putative 0.0103 0.0066 0.0036
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.1155 0.3302 0.3282
Echinococcus granulosus titin 0.0202 0.0372 0.0358
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0055 0.0048
Loa Loa (eye worm) CAMK/PHK protein kinase 0.018 0.0305 0.0298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1155 0.3302 0.3302
Schistosoma mansoni tyrosine kinase 0.0383 0.0927 0.0917
Brugia malayi C1-like domain containing protein 0.0238 0.0482 0.0474
Entamoeba histolytica protein kinase domain containing protein 0.016 0.0244 0.1121
Loa Loa (eye worm) hypothetical protein 0.0744 0.2041 0.2035
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0197 0.0356 0.0342
Echinococcus granulosus c-Jun N-terminal kinases 0.0288 0.0636 0.0622
Onchocerca volvulus 0.0109 0.0087 0.0523
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3282
Echinococcus multilocularis mitogen activated protein kinase 14 0.0175 0.0289 0.0275
Echinococcus multilocularis epidermal growth factor receptor 0.0434 0.1085 0.1072
Brugia malayi kettin 0.0146 0.0198 0.0191
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Schistosoma mansoni protein kinase 0.016 0.0244 0.0232
Schistosoma mansoni protein kinase 0.0211 0.04 0.0389
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0306 0.0693 0.068
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0126 0.0137 0.0137
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0249 0.0515 0.0502
Entamoeba histolytica protein kinase, putative 0.0184 0.0318 0.147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0848 0.2359 0.2354
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus granulosus neural cadherin 0.0337 0.0786 0.0773
Loa Loa (eye worm) hypothetical protein 0.012 0.0119 0.0111
Brugia malayi MAP kinase sur-1 0.0094 0.004 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0059 0.0047
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0622 0.1663 0.1656
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Echinococcus multilocularis titin 0.0202 0.0372 0.0358
Echinococcus multilocularis dual specificity 0.0153 0.0222 0.0208
Loa Loa (eye worm) hypothetical protein 0.0585 0.1551 0.1545
Echinococcus granulosus expressed protein 0.0094 0.0038 0.0024
Trichomonas vaginalis STE family protein kinase 0.0097 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0958 0.2698 0.2693
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0099 0.0055 0.0044
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0094 0.004 0.0033
Giardia lamblia Kinase, AGC AKT 0.013 0.015 0.0343
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.012 0.0119 0.0119
Echinococcus granulosus cyclin dependent kinase 0.0132 0.0156 0.0142
Echinococcus granulosus cyclin dependent kinase 1 0.0132 0.0156 0.0142
Loa Loa (eye worm) LAD-2 short isoform 0.0176 0.0291 0.0284
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0094 0.0038 0.003
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Trichomonas vaginalis apoptosis inducing factor, putative 0.0306 0.0693 0.202
Schistosoma mansoni nephrin related 0.0146 0.0198 0.0187
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Echinococcus granulosus tyrosine kinase 0.0109 0.0087 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0188 0.0476
Echinococcus granulosus serine threonine protein kinase nrc 0.0172 0.028 0.0266
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.014 0.0179 0.015
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0149 0.0208 0.0194
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1093 0.3112 0.3102
Echinococcus multilocularis CDC7 cell division cycle 7 0.0101 0.006 0.0046
Onchocerca volvulus 0.0109 0.0087 0.0523
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0209 0.0197
Trypanosoma cruzi Protein kinase B 0.0182 0.031 0.031
Echinococcus granulosus cGMP dependent protein kinase 1 0.0149 0.0208 0.0194
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0306 0.0693 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.0476 0.0465
Plasmodium vivax apical sushi protein, putative 0.0622 0.1663 0.1637
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0306 0.0693 0.0693
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0306 0.0693 0.0665
Echinococcus granulosus casein kinase I alpha 0.0121 0.0122 0.0108
Echinococcus multilocularis hemicentin 1 0.0321 0.0739 0.0726
Toxoplasma gondii selenide, water dikinase 0.0306 0.0693 0.0665
Onchocerca volvulus 0.0337 0.0786 0.4727
Giardia lamblia Glutamate synthase 0.0306 0.0693 0.2007
Leishmania major protein kinase, putative 0.0169 0.0271 0.0241
Trypanosoma brucei cdc2-related kinase 1 0.0132 0.0156 0.0126
Brugia malayi Temporarily assigned gene name protein 59 0.0138 0.0176 0.0168
Entamoeba histolytica protein kinase, putative 0.0153 0.0222 0.102
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Plasmodium vivax unspecified product 0.0112 0.0094 0.0063
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.0222 0.102
Entamoeba histolytica protein kinase, putative 0.0094 0.0038 0.0153
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0169 0.0271 0.0271
Entamoeba histolytica casein kinase, putative 0.0121 0.0122 0.055
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0176 0.0291 0.028
Onchocerca volvulus 0.0121 0.0122 0.0735
Brugia malayi Variant SH3 domain containing protein 0.0103 0.0067 0.006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0338 0.0791 0.0784
Brugia malayi Thioredoxin reductase 0.3332 1 1
Onchocerca volvulus 0.0109 0.0087 0.0523
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0306 0.0693 0.0686
Brugia malayi p70 ribosomal S6 kinase beta 0.0317 0.0726 0.0719
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0264 0.0562 0.0548
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0094 0.004 0.004
Echinococcus multilocularis notch 0.0337 0.0786 0.0773
Giardia lamblia High cysteine protein 0.0337 0.0786 0.2291
Echinococcus multilocularis roundabout 2 0.0907 0.254 0.2529
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0306 0.0693 0.0094
Onchocerca volvulus Tyrosine kinase homolog 0.0532 0.1386 0.8336
Echinococcus multilocularis neuroglian 0.0714 0.1948 0.1936
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0113 0.0096 0.0089
Echinococcus granulosus low density lipoprotein receptor ldl 0.0176 0.0291 0.0277
Loa Loa (eye worm) TK protein kinase 0.0204 0.0377 0.037
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.022 0.0426 0.0419
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0142 0.0188 0.0181
Echinococcus multilocularis expressed conserved protein 0.0149 0.0208 0.0194
Schistosoma mansoni serine/threonine-protein kinase 0.0182 0.031 0.0299
Schistosoma mansoni titin 0.0146 0.0198 0.0187
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.016 0.0242 0.0227
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0306 0.0693 0.1889
Echinococcus granulosus nervana 2 0.0133 0.0158 0.0144
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0097 0.0048 0.0033
Schistosoma mansoni cell polarity protein 0.0337 0.0786 0.0775
Echinococcus granulosus roundabout 2 0.0338 0.0791 0.0778
Giardia lamblia Kinase, STE STE20 0.0097 0.0048 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3282
Loa Loa (eye worm) hypothetical protein 0.0127 0.014 0.0133
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0306 0.0693 0.1889
Trypanosoma cruzi cdc2-related kinase 3 0.0132 0.0156 0.0156
Schistosoma mansoni disulfide oxidoreductase 0.0306 0.0693 0.0682
Schistosoma mansoni cell adhesion molecule 0.0321 0.0739 0.0729
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0172 0.028 0.0266
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Schistosoma mansoni hypothetical protein 0.0176 0.0291 0.028
Brugia malayi ribosomal protein S6 kinase alpha 3 0.013 0.015 0.0143
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Loa Loa (eye worm) TK/ROR protein kinase 0.0197 0.0356 0.0349
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0126 0.0137 0.0137
Brugia malayi RhoGAP domain containing protein 0.0103 0.0067 0.006
Onchocerca volvulus 0.0337 0.0786 0.4727
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0306 0.0693 0.0665
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0113 0.0096 0.0089
Leishmania major protein kinase, putative 0.016 0.0244 0.0214
Plasmodium vivax casein kinase 1, putative 0.0121 0.0122 0.0091
Brugia malayi Immunoglobulin I-set domain containing protein 0.0585 0.1551 0.1545
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0112 0.0094 0.0087
Loa Loa (eye worm) hypothetical protein 0.0495 0.1272 0.1266
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0306 0.0693 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Echinococcus granulosus tyrosine protein kinase 0.0308 0.0699 0.0685
Toxoplasma gondii AGC kinase 0.0126 0.0137 0.0107
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Giardia lamblia Kinase, AGC PKA 0.0172 0.028 0.0743
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.012 0.0119 0.0119
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0122 0.0108
Echinococcus granulosus protein jagged 1 0.0337 0.0786 0.0773
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0382 0.0927 0.092
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Loa Loa (eye worm) TK protein kinase 0.0377 0.0909 0.0902
Trypanosoma cruzi NADH dehydrogenase, putative 0.0306 0.0693 0.0693
Brugia malayi Cyclin, N-terminal domain containing protein 0.0763 0.2096 0.209
Echinococcus granulosus delta-like protein 1 0.0337 0.0786 0.0773
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0146 0.0198 0.0184
Schistosoma mansoni septate junction protein 0.0176 0.0291 0.028
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0398 0.0974 0.0967
Brugia malayi Sex muscle abnormal protein 5 0.0099 0.0055 0.0048
Echinococcus granulosus casein kinase I delta 0.0121 0.0122 0.0108
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0398 0.0974 0.0961
Schistosoma mansoni titin 0.0146 0.0198 0.0187
Loa Loa (eye worm) hypothetical protein 0.0109 0.0086 0.0079
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0236 0.0476 0.0463
Echinococcus multilocularis cyclin dependent kinase 1 0.0132 0.0156 0.0142
Schistosoma mansoni titin 0.0321 0.0739 0.0729
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0427 0.1064 0.1051
Plasmodium falciparum protein serine/threonine kinase-1 0.0169 0.0271 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1155 0.3302 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0306 0.0693 0.1889
Echinococcus granulosus C type lectin domian containing protein 0.0622 0.1663 0.1651
Echinococcus multilocularis cyclin dependent kinase 9 0.0088 0.002 0.0006
Trichomonas vaginalis CK1 family protein kinase 0.0121 0.0122 0.0274
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1155 0.3302 0.2871
Brugia malayi Protein kinase domain containing protein 0.018 0.0305 0.0298
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0126 0.0137 0.0107
Loa Loa (eye worm) hypothetical protein 0.012 0.0119 0.0111
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.016 0.0244 0.023
Echinococcus multilocularis tyrosine protein kinase otk 0.0321 0.0739 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Brugia malayi Heparan sulfate 0.0176 0.0291 0.0284
Brugia malayi intracellular kinase 0.0142 0.0188 0.0181
Loa Loa (eye worm) one IG domain family member 0.0146 0.0198 0.0191
Onchocerca volvulus 0.0622 0.1663 1
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0306 0.0693 0.0686
Schistosoma mansoni hypothetical protein 0.0162 0.025 0.0239
Loa Loa (eye worm) hypothetical protein 0.0569 0.1501 0.1494
Echinococcus granulosus thioredoxin glutathione reductase 0.3332 1 1
Schistosoma mansoni cell adhesion molecule 0.0338 0.0791 0.078
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Loa Loa (eye worm) hypothetical protein 0.0087 0.0019 0.0012
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.1155 0.3302 1
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0318 0.0307
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Echinococcus granulosus mitogen activated protein kinase 0.0094 0.004 0.0026
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0258 0.0543 0.053
Plasmodium falciparum calcium-dependent protein kinase 5 0.0113 0.0096 0.0066
Trypanosoma cruzi cdc2-related kinase 3 0.0132 0.0156 0.0156
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0648 0.1743 0.1737
Schistosoma mansoni serine/threonine-protein kinase 0.0182 0.031 0.0299
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0146 0.0198 0.0191
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0534 0.1395 0.1382
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0167 0.076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0291 0.0284
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus granulosus fibroblast growth factor receptor 4 0.0264 0.0562 0.0548
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0204 0.0377 0.0369
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0382 0.0927 0.092
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0122 0.0108
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Trichomonas vaginalis AGC family protein kinase 0.016 0.0244 0.0646
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0569 0.15 0.1487
Echinococcus granulosus calcium activated potassium channel 0.0149 0.0209 0.0195
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.0122 0.0115
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0113 0.0096 0.0082
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Plasmodium falciparum ferrodoxin reductase-like protein 0.0306 0.0693 0.0665
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0169 0.0271 0.0241
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0357 0.0849 0.0842
Onchocerca volvulus 0.0101 0.006 0.036
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0288 0.0636 0.0628
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0306 0.0693 0.0094
Loa Loa (eye worm) hypothetical protein 0.0223 0.0437 0.043
Giardia lamblia Kinase, CAMK CAMKL 0.0109 0.0085 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Echinococcus granulosus casein kinase i 0.0121 0.0122 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0435 0.1088 0.1081
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus granulosus tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.0636 0.0625
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.1155 0.3302 0.3282
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0306 0.0693 0.3237
Brugia malayi Prion-like- 0.0146 0.0198 0.0191
Schistosoma mansoni cell adhesion molecule 0.0338 0.0791 0.078
Trypanosoma brucei trypanothione reductase 0.3332 1 1
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus multilocularis protein jagged 2 0.0337 0.0786 0.0773
Brugia malayi Protein kinase domain containing protein 0.0398 0.0974 0.0967
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0222 0.0432 0.0418
Brugia malayi hypothetical protein 0.0243 0.0497 0.049
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Leishmania major protein kinase, putative 0.0169 0.0271 0.0241
Mycobacterium ulcerans NADH dehydrogenase 0.0306 0.0693 0.1889
Onchocerca volvulus 0.0622 0.1663 1
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.002 0.007
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0128 0.0143 0.0129
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.047 0.1195 0.1182
Echinococcus granulosus netrin receptor unc 5 0.0207 0.0387 0.0373
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0135 0.0167 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.0681 0.1984
Echinococcus multilocularis dual specificity 0.0153 0.0222 0.0208
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0306 0.0693 0.3237
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1155 0.3302 0.3282
Brugia malayi serine/threonine-protein kinase plk-2 0.0294 0.0655 0.0648
Echinococcus multilocularis c src tyrosine kinase 0.015 0.0213 0.0199
Entamoeba histolytica protein kinase, putative 0.0135 0.0167 0.076
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0539 0.0528
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0204 0.0377 0.0363
Giardia lamblia Kinase, NEK 0.015 0.0213 0.0536
Loa Loa (eye worm) TK protein kinase 0.041 0.101 0.1003
Echinococcus multilocularis insulin receptor 0.0483 0.1236 0.1223
Echinococcus multilocularis cyclin dependent kinase 5 0.0132 0.0156 0.0142
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.012 0.0119 0.0105
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0222 0.0432 0.0425
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0126 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0648 0.1743 0.1737
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Entamoeba histolytica protein kinase 2, putative 0.0172 0.028 0.1294
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0382 0.0927 0.092
Brugia malayi hypothetical protein 0.0109 0.0087 0.0079
Loa Loa (eye worm) Notch2 0.0337 0.0786 0.0779
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0113 0.0096 0.0066
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0097 0.0048 0.0033
Loa Loa (eye worm) hypothetical protein 0.0176 0.0291 0.0284
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.018 0.0304 0.0297
Echinococcus granulosus protein jagged 2 0.0337 0.0786 0.0773
Onchocerca volvulus Peroxidasin homolog 0.0146 0.0199 0.1199
Schistosoma mansoni kinase 0.0314 0.0716 0.0705
Echinococcus granulosus epidermal growth factor receptor 0.0434 0.1085 0.1072
Onchocerca volvulus 0.0146 0.0199 0.1199
Schistosoma mansoni cell adhesion molecule 0.0176 0.0291 0.028
Schistosoma mansoni glutamate synthase 0.0306 0.0693 0.0682
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0485 0.1243 0.1237
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0193 0.0343 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.0605 0.0594
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1155 0.3302 0.3282
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0204 0.0377 0.0363
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.047 0.1195 0.1182
Echinococcus granulosus growth factor receptor bound protein 2 0.0101 0.0062 0.0047
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Brugia malayi Immunoglobulin I-set domain containing protein 0.0202 0.0372 0.0365
Echinococcus multilocularis protein jagged 1 0.0337 0.0786 0.0773
Toxoplasma gondii rhoptry neck protein RON1 0.0622 0.1663 0.1637
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0126 0.0137 0.0129
Loa Loa (eye worm) hypothetical protein 0.0149 0.0208 0.0201
Echinococcus multilocularis 0.0129 0.0148 0.0134
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0317 0.0726 0.0719
Schistosoma mansoni nephrin 0.0731 0.1999 0.199
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0176 0.0291 0.0277
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0427 0.1064 0.1057
Brugia malayi basement membrane proteoglycan 0.0176 0.0291 0.0284
Schistosoma mansoni protein kinase C mu 0.0238 0.0482 0.0471
Onchocerca volvulus Serine\/threonine kinase homolog 0.018 0.0305 0.1835
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Entamoeba histolytica PH domain containing protein kinase, putative 0.0135 0.0166 0.0756
Loa Loa (eye worm) hypothetical protein 0.0176 0.0291 0.0284
Onchocerca volvulus 0.0101 0.006 0.036
Brugia malayi Protein kinase domain containing protein 0.0205 0.0382 0.0374
Echinococcus multilocularis casein kinase I alpha 0.0121 0.0122 0.0108
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.012 0.0119 0.0108
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0146 0.0198 0.0191
Echinococcus granulosus leucine rich repeat containing protein 4 0.0146 0.0198 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0096 0.0085
Schistosoma mansoni protein kinase 0.0169 0.0269 0.0258
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Onchocerca volvulus 0.0146 0.0198 0.1193
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.004 0.0023
Schistosoma mansoni tyrosine kinase 0.015 0.0213 0.0202
Giardia lamblia Kinase, CDC7 0.0101 0.006 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Echinococcus granulosus cyclin dependent kinase 19 0.1011 0.286 0.285
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0338 0.0791 0.078
Echinococcus multilocularis serine:threonine kinase SAD 1 0.01 0.0059 0.0044
Onchocerca volvulus 0.0153 0.0221 0.1332
Echinococcus granulosus dual specificity 0.0153 0.0222 0.0208
Schistosoma mansoni myosin-binding protein-related 0.0162 0.025 0.0239
Echinococcus multilocularis transfer RNA-Phe 0.0162 0.025 0.0236
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0306 0.0693 0.0094
Loa Loa (eye worm) AUR protein kinase 0.016 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.0176 0.0291 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Loa Loa (eye worm) AGC/PKA protein kinase 0.0126 0.0137 0.0129
Schistosoma mansoni tyrosine kinase 0.0338 0.0791 0.0781
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0094 0.0417
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0169 0.0271 0.0271
Brugia malayi Fes/CIP4 homology domain containing protein 0.0122 0.0126 0.0119
Loa Loa (eye worm) programmed cell death 8 0.0306 0.0693 0.0686
Schistosoma mansoni c4b-binding protein beta chain 0.0622 0.1663 0.1653
Brugia malayi STE20-like kinase MST 0.028 0.0611 0.0604
Echinococcus multilocularis titin 0.0146 0.0198 0.0184
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0121 0.0122 0.0122
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0204 0.0377 0.0363
Echinococcus multilocularis serine:threonine protein kinase 38 0.0184 0.0318 0.0304
Schistosoma mansoni basigin related 0.0176 0.0291 0.028
Schistosoma mansoni tyrosine kinase 0.0383 0.0927 0.0917
Loa Loa (eye worm) hypothetical protein 0.0126 0.0137 0.0129
Echinococcus granulosus down syndrome cell adhesion 0.0146 0.0198 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0305 0.0294
Schistosoma mansoni tyrosine kinase 0.0483 0.1236 0.1225
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.016 0.0244 0.1121
Echinococcus multilocularis protein kinase shaggy 0.0142 0.0188 0.0174
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0375 0.0903 0.0896
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0126 0.0137 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0188 0.0476
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0306 0.0693 0.0094
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.022 0.0426 0.0412
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0098 0.0052 0.0217
Loa Loa (eye worm) TK/EPH protein kinase 0.0139 0.0177 0.017
Schistosoma mansoni glutamate synthase 0.0306 0.0693 0.0682
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0337 0.0786 0.4727
Loa Loa (eye worm) thioredoxin reductase 0.3332 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.014 0.0182 0.0829
Mycobacterium tuberculosis Probable oxidoreductase 0.1155 0.3302 0.2871
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0142 0.0188 0.0174
Schistosoma mansoni protein kinase 0.047 0.1195 0.1185
Echinococcus granulosus fibropellin Ia 0.0337 0.0786 0.0773
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0306 0.0693 0.0686
Brugia malayi Immunoglobulin I-set domain containing protein 0.041 0.101 0.1003
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.016 0.0242 0.0227
Entamoeba histolytica protein kinase , putative 0.016 0.0244 0.1121
Onchocerca volvulus 0.0622 0.1663 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0293 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0169 0.0271 0.0241
Schistosoma mansoni slit 0.0337 0.0787 0.0776
Plasmodium falciparum glycogen synthase kinase 3 0.0142 0.0188 0.0158
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0175 0.0289 0.0289
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0132 0.0156 0.0126
Brugia malayi map kinase activated protein kinase protein 2 0.0427 0.1064 0.1057
Echinococcus granulosus raf serine:threonine protein kinase 0.0096 0.0046 0.0032
Leishmania major casein kinase, putative 0.0121 0.0122 0.0092
Echinococcus multilocularis fibropellin Ia 0.0337 0.0786 0.0773
Brugia malayi Protein kinase domain containing protein 0.0094 0.0038 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.0155 0.0226 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0143 0.0339
Echinococcus multilocularis nervana 2 0.0133 0.0158 0.0144
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0172 0.028 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0306 0.0693 0.068
Echinococcus granulosus twitchin 0.0754 0.207 0.2058
Echinococcus granulosus slit 2 protein 0.0367 0.088 0.0867
Echinococcus granulosus c src tyrosine kinase 0.015 0.0213 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus granulosus tyrosine protein kinase Src64B 0.0245 0.0503 0.0489
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0256 0.0539 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Entamoeba histolytica protein kinase, putative 0.0146 0.0198 0.0907
Brugia malayi Protein kinase domain containing protein 0.0237 0.048 0.0472
Loa Loa (eye worm) hypothetical protein 0.0585 0.1551 0.1545
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0103 0.0067 0.0056
Schistosoma mansoni basigin related 0.0176 0.0291 0.028
Loa Loa (eye worm) hypothetical protein 0.0569 0.15 0.1493
Plasmodium falciparum thioredoxin reductase 0.1155 0.3302 0.3282
Echinococcus multilocularis fat cadherin tumor suppressor 0.0337 0.0786 0.0773
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.01 0.0059 0.0051
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0245 0.0503 0.0489
Echinococcus granulosus cGMP dependent protein kinase 0.0149 0.0208 0.0194
Schistosoma mansoni tyrosine kinase 0.0594 0.1578 0.1568
Schistosoma mansoni protein kinase 0.047 0.1195 0.1185
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0046 0.0035
Echinococcus multilocularis raf serine:threonine protein kinase 0.0096 0.0046 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0327 0.0755 0.221
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0306 0.0693 0.0693
Brugia malayi Protein kinase domain containing protein 0.0169 0.0271 0.0263
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.0038 0.0008
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0149 0.0208 0.0178
Brugia malayi protein kinase C II. 0.0231 0.046 0.0453
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.1155 0.3302 1
Echinococcus multilocularis insulin growth factor binding 0.0146 0.0198 0.0184
Onchocerca volvulus 0.0335 0.078 0.4693
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0306 0.0693 0.0665
Brugia malayi hypothetical protein 0.012 0.0119 0.0111
Brugia malayi Cadherin domain containing protein 0.0337 0.0786 0.0779
Echinococcus multilocularis cyclin 0.0763 0.2096 0.2085
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0253 0.0529 0.0522
Echinococcus granulosus Immunoglobulin 0.0176 0.0291 0.0277
Entamoeba histolytica hypothetical protein 0.0408 0.1004 0.47
Onchocerca volvulus Slit protein homolog 0.0367 0.088 0.5295
Echinococcus multilocularis dual specificity protein kinase clk2 0.0169 0.0271 0.0257
Entamoeba histolytica protein kinase, putative 0.0098 0.0052 0.0217
Echinococcus multilocularis tyrosine protein kinase 0.0308 0.0699 0.0685
Trypanosoma brucei Casein kinase II 0.0112 0.0094 0.0064
Onchocerca volvulus 0.0313 0.0714 0.4295
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.004 0.0023
Entamoeba histolytica casein kinase, putative 0.0112 0.0094 0.0417
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0094 0.004 0.001
Echinococcus granulosus phosphorylase kinase gamma subunit 0.018 0.0305 0.0291
Loa Loa (eye worm) hypothetical protein 0.0321 0.0739 0.0732
Entamoeba histolytica PH domain containing protein kinase, putative 0.0135 0.0166 0.0756
Echinococcus multilocularis growth factor receptor bound protein 2 0.0099 0.0055 0.0041
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0121 0.0122 0.0115
Leishmania major protein kinase, putative 0.0095 0.0043 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0059 0.0047
Entamoeba histolytica protein kinase, putative 0.0142 0.0188 0.086
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0184 0.0318 0.0304
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0169 0.0271 0.0271
Echinococcus multilocularis rho associated protein kinase 0.0353 0.0836 0.0823
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0357 0.0849 0.0842
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0338 0.0791 0.0778
Loa Loa (eye worm) hypothetical protein 0.012 0.0119 0.0111
Loa Loa (eye worm) cyclin domain-containing protein 0.0763 0.2096 0.209
Entamoeba histolytica protein kinase, putative 0.0097 0.0048 0.0198
Onchocerca volvulus 0.0109 0.0087 0.0523
Echinococcus granulosus tyrosine protein kinase Src42A 0.0245 0.0503 0.0489
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0097 0.0048 0.0033
Mycobacterium ulcerans flavoprotein disulfide reductase 0.1155 0.3302 1
Onchocerca volvulus 0.0109 0.0087 0.0523
Echinococcus granulosus hemicentin 1 0.0321 0.0739 0.0726
Echinococcus granulosus cyclin 0.0763 0.2096 0.2085
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0146 0.0199 0.0185
Brugia malayi SH2 domain containing protein 0.0435 0.1088 0.1081
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0497 0.0486
Echinococcus granulosus peroxidasin 0.0322 0.074 0.0727
Brugia malayi GCC2 and GCC3 family protein 0.0958 0.2698 0.2693
Echinococcus multilocularis serine:threonine protein kinase N2 0.0139 0.0178 0.0164
Brugia malayi Protein kinase domain containing protein 0.0092 0.0033 0.0025
Plasmodium falciparum serine/threonine protein kinase, putative 0.016 0.0244 0.0214
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.01 0.0059 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus multilocularis slit 2 protein 0.0367 0.088 0.0867
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0142 0.0188 0.0174
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0436 0.1093 0.108
Mycobacterium ulcerans monoxygenase 0.0306 0.0693 0.1889
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.0503 0.0489
Onchocerca volvulus 0.0622 0.1663 1
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.028 0.0611 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.0745 0.0735
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0182 0.031 0.031
Onchocerca volvulus 0.0622 0.1663 1
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0094 0.0188
Brugia malayi Hr1 repeat family protein 0.0324 0.0745 0.0738
Loa Loa (eye worm) hypothetical protein 0.01 0.0059 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0211 0.04 0.0393
Brugia malayi Furin-like cysteine rich region family protein 0.0657 0.1772 0.1766
Echinococcus multilocularis 0.0169 0.0269 0.0255
Loa Loa (eye worm) hypothetical protein 0.0249 0.0515 0.0508
Brugia malayi Egg laying defective protein 4 0.0149 0.0208 0.02
Schistosoma mansoni serine/threonine protein kinase 0.1011 0.286 0.2852
Giardia lamblia Aurora kinase 0.016 0.0244 0.063
Brugia malayi Protein kinase c protein 2 0.0128 0.0145 0.0138
Leishmania major hypothetical protein, conserved 0.0306 0.0693 0.0665
Echinococcus multilocularis aurora kinase A 0.016 0.0244 0.023
Toxoplasma gondii rhoptry neck protein RON9 0.0622 0.1663 0.1637
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0337 0.0786 0.0779
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0243 0.0497 0.049
Loa Loa (eye worm) hypothetical protein 0.0322 0.074 0.0733
Trypanosoma brucei polo-like protein kinase 0.0294 0.0655 0.0627
Echinococcus granulosus dual specificity 0.0135 0.0167 0.0153
Echinococcus multilocularis serine:threonine protein kinase 3 0.028 0.0611 0.0597
Brugia malayi Immunoglobulin domain containing protein 0.0176 0.0291 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0142 0.0188 0.0158
Giardia lamblia Kinase, CAMK CAMKL 0.0109 0.0085 0.0143
Echinococcus multilocularis protein jagged 1 0.0337 0.0786 0.0773
Trypanosoma cruzi hypothetical protein, conserved 0.0306 0.0693 0.0693
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0153 0.0222 0.0215
Echinococcus granulosus cyclin dependent kinase 9 0.0096 0.0046 0.0032
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0121 0.0122 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0595 0.0584
Schistosoma mansoni vam6/vps39 related 0.012 0.0119 0.0108
Loa Loa (eye worm) TK/ALK protein kinase 0.0305 0.0688 0.0681
Trypanosoma brucei hypothetical protein, conserved 0.0306 0.0693 0.0665
Loa Loa (eye worm) AGC/PKG protein kinase 0.0149 0.0208 0.02
Echinococcus granulosus neurogenic locus protein delta 0.0337 0.0786 0.0773
Onchocerca volvulus 0.0149 0.0208 0.1251
Schistosoma mansoni septate junction protein 0.0321 0.0739 0.0729
Brugia malayi casein kinase I 0.0121 0.0122 0.0115
Loa Loa (eye worm) hypothetical protein 0.089 0.2489 0.2483
Echinococcus multilocularis casein kinase I delta 0.0121 0.0122 0.0108
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0237 0.048 0.0472
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0175 0.0289 0.0259
Echinococcus granulosus Protein kinase C brain isozyme 0.0273 0.0591 0.0577
Echinococcus multilocularis tyrosine protein kinase HCK 0.0146 0.0198 0.0184
Echinococcus multilocularis casein kinase i 0.0121 0.0122 0.0108
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1131 0.3228 0.3223
Loa Loa (eye worm) hypothetical protein 0.0194 0.0346 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Echinococcus granulosus protein tyrosine kinase 0.0594 0.1578 0.1565
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1155 0.3302 0.2871
Echinococcus multilocularis Immunoglobulin 0.0176 0.0291 0.0277
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0306 0.0693 0.0693
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0306 0.0693 0.1889
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0132 0.0156 0.0148
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0382 0.0927 0.5574
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0092 0.0033 0.0018
Toxoplasma gondii AGC kinase 0.0317 0.0726 0.0698
Onchocerca volvulus 0.0306 0.0693 0.4169
Schistosoma mansoni protein kinase 0.0091 0.003 0.0019
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0153 0.0222 0.0193
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0321 0.0739 0.0732
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0306 0.0693 0.202
Echinococcus granulosus serine:threonine kinase SAD 1 0.01 0.0059 0.0044
Echinococcus multilocularis serine:threonine protein kinase N2 0.0184 0.0318 0.0304
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0337 0.0786 0.0775
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193 0.0343 0.0336
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0243 0.0497 0.0483
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0321 0.0739 0.4446
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.022 0.0426 0.0412
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0206 0.0385 0.0378
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0306 0.0693 0.0665
Schistosoma mansoni nephrin related 0.0176 0.0291 0.028
Plasmodium vivax serine/threonine protein kinase 6, putative 0.016 0.0244 0.0213
Echinococcus granulosus Vam6:Vps39 protein 0.012 0.0119 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0109 0.0087 0.008
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0146 0.0198 0.0184
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0294 0.0655 0.0648
Entamoeba histolytica protein kinase, putative 0.0327 0.0755 0.3529
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0209 0.0197
Echinococcus granulosus mitogen activated protein kinase 3 0.0094 0.004 0.0026
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0175 0.0289 0.0259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Trichomonas vaginalis CMGC family protein kinase 0.0169 0.0271 0.0728
Schistosoma mansoni titin 0.0202 0.0372 0.0361
Entamoeba histolytica cyclin C, putative 0.0774 0.213 1
Entamoeba histolytica protein kinase domain containing protein 0.0222 0.0432 0.2009
Schistosoma mansoni cell adhesion molecule 0.0761 0.2092 0.2083
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Trichomonas vaginalis CAMK family protein kinase 0.0294 0.0655 0.1905
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0432 0.0421
Plasmodium vivax thioredoxin reductase, putative 0.3332 1 1
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus granulosus cyclin dependent kinase 5 0.0132 0.0156 0.0142
Echinococcus granulosus titin 0.0146 0.0198 0.0184
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Trichomonas vaginalis STE family protein kinase 0.0097 0.0048 0.0046
Plasmodium falciparum calcium-dependent protein kinase 1 0.0113 0.0096 0.0066
Brugia malayi pregnancy-associated plasma protein-A 0.0622 0.1663 0.1656
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.025 0.0243
Echinococcus granulosus titin 0.0202 0.0372 0.0358
Echinococcus granulosus casein kinase I alpha 0.0121 0.0122 0.0108
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0096 0.0089
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0176 0.0291 0.0277
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0156 0.0377
Echinococcus granulosus protein kinase C gamma type 0.0228 0.0453 0.0439
Loa Loa (eye worm) AGC/AKT protein kinase 0.0327 0.0755 0.0748
Brugia malayi Immunoglobulin I-set domain containing protein 0.0321 0.0739 0.0732
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1155 0.3302 0.3282
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0534 0.1395 0.1382
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0275 0.0595 0.0582
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0113 0.0096 0.0066
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0243 0.0497 0.0483
Echinococcus granulosus aurora kinase A 0.016 0.0244 0.023
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0321 0.0739 0.0726
Echinococcus granulosus mitogen activated protein kinase 14 0.0175 0.0289 0.0275
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Giardia lamblia Kinase, CMGC CLK 0.0169 0.0271 0.0713
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0294 0.0655 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0382 0.0927 0.0916
Loa Loa (eye worm) gastrulation defective protein 1 0.0971 0.2738 0.2732
Schistosoma mansoni kinase 0.0088 0.002 0.0009
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0306 0.0693 0.068
Schistosoma mansoni hypothetical protein 0.0146 0.0198 0.0187
Echinococcus granulosus basement membrane specific heparan sulfate 0.0176 0.0291 0.0277
Leishmania major NADH dehydrogenase, putative 0.0306 0.0693 0.0665
Brugia malayi Animal haem peroxidase family protein 0.0146 0.0198 0.0191
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0132 0.0156 0.0126
Onchocerca volvulus 0.0622 0.1663 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0142 0.0188 0.0158
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0306 0.0693 0.0094
Echinococcus multilocularis cyclin dependent kinase 19 0.1011 0.286 0.285
Echinococcus granulosus dual specificity protein kinase clk2 0.0169 0.0271 0.0257
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0245 0.0503 0.0489
Entamoeba histolytica p21-activated kinase 0.0106 0.0077 0.0337
Leishmania major protein kinase A catalytic subunit 0.0126 0.0137 0.0107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0176 0.0292 0.0285
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0306 0.0693 0.202
Plasmodium falciparum thioredoxin reductase 0.3332 1 1
Brugia malayi Peroxidasin 0.0322 0.074 0.0733
Echinococcus granulosus cGMP dependent protein kinase 1 0.0149 0.0208 0.0194
Brugia malayi Protein kinase domain containing protein 0.0101 0.006 0.0052
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0321 0.0739 0.0729
Echinococcus multilocularis mitogen activated protein kinase 11 0.0175 0.0289 0.0275
Echinococcus granulosus neurogenic locus notch protein 0.0337 0.0786 0.0773
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0231 0.046 0.0453
Onchocerca volvulus 0.0208 0.0389 0.2339
Schistosoma mansoni titin 0.0162 0.025 0.0239
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0306 0.0693 0.0664
Leishmania major protein kinase A catalytic subunit isoform 2 0.0126 0.0137 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0306 0.0693 0.0693
Echinococcus multilocularis mitogen activated protein kinase 0.0094 0.004 0.0026
Entamoeba histolytica protein kinase, putative 0.0094 0.0038 0.0153
Loa Loa (eye worm) hypothetical protein 0.0383 0.093 0.0923
Echinococcus multilocularis cyclin dependent kinase 0.0132 0.0156 0.0142
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0132 0.0156 0.0148
Brugia malayi SRC-1 0.0245 0.0503 0.0496
Schistosoma mansoni titin 0.0146 0.0198 0.0187
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0176 0.0291 0.0277
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0162 0.025 0.0243
Trypanosoma cruzi casein kinase II, putative 0.0112 0.0094 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0222 0.058
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0176 0.0293 0.0285
Loa Loa (eye worm) hypothetical protein 0.0622 0.1663 0.1656
Loa Loa (eye worm) hypothetical protein 0.0149 0.0208 0.0201
Brugia malayi protein-tyrosine kinase 0.0204 0.0377 0.037
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0137 0.0125
Loa Loa (eye worm) disorganized muscle protein 1 0.0146 0.0198 0.0191
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0156 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0167 0.0156
Toxoplasma gondii casein kinase I 0.0121 0.0122 0.0092
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0113 0.0096 0.0066
Loa Loa (eye worm) hypothetical protein 0.0338 0.0791 0.0784
Giardia lamblia Kinase, NEK 0.015 0.0213 0.0536
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0222 0.0432 0.0418
Trichomonas vaginalis glutamate synthase, putative 0.0306 0.0693 0.202
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0142 0.0188 0.0181
Schistosoma mansoni notch 0.0337 0.0786 0.0775
Brugia malayi EGF-like domain containing protein 0.0337 0.0786 0.0779
Brugia malayi Tyrosine-protein kinase abl-1 0.015 0.0213 0.0205
Plasmodium falciparum calcium-dependent protein kinase 2 0.0113 0.0096 0.0066
Brugia malayi Protein kinase domain containing protein 0.0211 0.04 0.0393
Schistosoma mansoni tyrosine kinase 0.0434 0.1085 0.1075
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0103 0.0067 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0132 0.0156 0.0377
Leishmania major casein kinase II, putative 0.0112 0.0094 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0198 0.0191
Schistosoma mansoni septate junction protein 0.0337 0.0786 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.006 0.0048
Schistosoma mansoni cell adhesion molecule 0.0162 0.025 0.0239
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0142 0.0188 0.0188
Brugia malayi Protein kinase domain containing protein 0.0135 0.0167 0.016
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.016 0.0241 0.0227
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.048 0.1367
Loa Loa (eye worm) hypothetical protein 0.0153 0.0221 0.0214
Entamoeba histolytica protein kinase, putative 0.016 0.0244 0.1121
Schistosoma mansoni protein kinase 0.0258 0.0543 0.0532
Echinococcus multilocularis Immunoglobulin 0.0569 0.15 0.1487
Echinococcus granulosus roundabout 2 0.0338 0.0791 0.0778
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0146 0.0198 0.0184
Echinococcus granulosus c4b binding protein beta chain 0.0622 0.1663 0.1651
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.015 0.0213 0.0182
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0238 0.0482 0.0474
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Echinococcus multilocularis tyrosine protein kinase Abl 0.015 0.0213 0.0199
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0398 0.0974 0.0961
Trichomonas vaginalis glutamate synthase, putative 0.0306 0.0693 0.202
Giardia lamblia Thioredoxin reductase 0.0306 0.0693 0.2007
Echinococcus granulosus rho-associated protein kinase 1 0.0353 0.0836 0.0823
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1155 0.3302 0.3302
Schistosoma mansoni hypothetical protein 0.0337 0.0786 0.0775
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0099 0.0055 0.0048
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0126 0.0137 0.0107
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0095 0.0043 0.0013
Echinococcus granulosus cyclin dependent kinase 9 0.0088 0.002 0.0006
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0306 0.0693 0.0665
Brugia malayi Doublecortin family protein 0.0166 0.0261 0.0254
Brugia malayi Muscle positioning protein 4 0.0337 0.0786 0.0779
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.014 0.0329
Schistosoma mansoni neuroglian 0.0338 0.0791 0.078
Echinococcus granulosus tyrosine protein kinase Srms 0.0547 0.1432 0.1419
Schistosoma mansoni tyrosine kinase 0.0434 0.1085 0.1075
Plasmodium vivax serine/threonine protein kinase, putative 0.0094 0.0038 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.1155 0.3302 0.3292
Schistosoma mansoni hypothetical protein 0.012 0.0119 0.0108
Trichomonas vaginalis glutathione reductase, putative 0.1155 0.3302 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0233 0.0467 0.046
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0094 0.004 0.001
Loa Loa (eye worm) animal heme peroxidase 0.0146 0.0198 0.0191
Brugia malayi Calcium binding EGF domain containing protein 0.0337 0.0786 0.0779
Loa Loa (eye worm) hypothetical protein 0.0149 0.0208 0.0201
Echinococcus granulosus lachesin 0.0321 0.0739 0.0726
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0133 0.0158 0.0144
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0094 0.004 0.004
Echinococcus multilocularis Immunoglobulin 0.0569 0.15 0.1487
Brugia malayi hypothetical protein 0.0176 0.0291 0.0284
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0427 0.1064 0.1051
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0126 0.0137 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0059 0.008
Entamoeba histolytica cell division protein kinase 2, putative 0.0132 0.0156 0.0707
Brugia malayi Immunoglobulin I-set domain containing protein 0.1131 0.3228 0.3223
Trypanosoma cruzi trypanothione reductase, putative 0.1155 0.3302 0.3302
Brugia malayi Protein kinase domain containing protein 0.0485 0.1243 0.1237
Echinococcus multilocularis expressed protein 0.0094 0.0038 0.0024
Echinococcus multilocularis ephrin type A receptor 4 A 0.012 0.0119 0.0105
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0109 0.0087 0.0073
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0176 0.0291 0.0277
Echinococcus multilocularis hypothetical protein 0.0109 0.0086 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.0591 0.058
Onchocerca volvulus 0.0146 0.0198 0.1193
Onchocerca volvulus 0.0162 0.025 0.1504
Schistosoma mansoni glutamate synthase 0.0306 0.0693 0.0682
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.01 0.0059 0.0059
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Echinococcus multilocularis Glutaredoxin protein 5 0.0133 0.0158 0.0144
Echinococcus multilocularis mitogen activated protein kinase 11 0.0175 0.0289 0.0275
Loa Loa (eye worm) thyroid receptor interactor 0.0122 0.0126 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0318 0.0307
Schistosoma mansoni protein kinase 0.0112 0.0094 0.0083
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0135 0.0167 0.0167
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0763 0.2096 0.2085
Schistosoma mansoni netrin receptor unc5 0.0207 0.0387 0.0376
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0382 0.0927 0.0914
Entamoeba histolytica protein kinase, putative 0.0092 0.0033 0.0127
Plasmodium falciparum NIMA related kinase 1 0.015 0.0213 0.0183
Echinococcus multilocularis mitogen activated protein kinase 3 0.0094 0.004 0.0026
Brugia malayi hypothetical protein 0.0622 0.1663 0.1656
Loa Loa (eye worm) TK/EGFR protein kinase 0.0657 0.1772 0.1766
Echinococcus multilocularis death associated protein kinase 1 0.0914 0.2562 0.2551
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0306 0.0693 0.1889
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0094 0.004 0.001
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0094 0.0038 0.0008
Loa Loa (eye worm) hypothetical protein 0.0333 0.0776 0.0769
Loa Loa (eye worm) notch protein 0.0337 0.0786 0.0779
Onchocerca volvulus 0.0146 0.0198 0.1193
Schistosoma mansoni tyrosine kinase 0.0264 0.0562 0.0551
Schistosoma mansoni tyrosine kinase 0.028 0.0612 0.0601
Trypanosoma cruzi casein kinase, putative 0.0121 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0337 0.0786 0.0779
Schistosoma mansoni serine/threonine kinase 0.0184 0.0318 0.0307
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0091 0.003 0.003
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0382 0.0927 0.0914
Echinococcus granulosus protein kinase shaggy 0.0142 0.0188 0.0174
Echinococcus granulosus contactin 0.0338 0.0791 0.0778
Onchocerca volvulus 0.0083 0.0005 0.003
Schistosoma mansoni serine/threonine protein kinase 0.022 0.0426 0.0415
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0245 0.0503 0.0489
Brugia malayi P38 map kinase family protein 2 0.0175 0.0289 0.0281
Plasmodium falciparum casein kinase 2, alpha subunit 0.0112 0.0094 0.0064
Echinococcus multilocularis casein kinase I delta 0.0121 0.0122 0.0108
Echinococcus granulosus defective proboscis extension response 0.0569 0.15 0.1487
Loa Loa (eye worm) hypothetical protein 0.0146 0.0198 0.0191
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0306 0.0693 0.0665
Plasmodium vivax ferrodoxin reductase, putative 0.0306 0.0693 0.0664
Loa Loa (eye worm) hypothetical protein 0.0176 0.0291 0.0284
Echinococcus granulosus activin receptor type 0.0091 0.003 0.0016
Echinococcus granulosus casein kinase ii subunit alpha 0.0112 0.0094 0.008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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