Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Schistosoma mansoni | thyroid hormone receptor | 0.0342 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0342 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0866 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.018 | 0.5098 | 0.5098 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0342 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0342 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0342 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0161 | 0.451 | 0.4474 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0342 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0076 | 0.1911 | 0.1858 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0161 | 0.451 | 0.451 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0161 | 0.451 | 0.4474 |
Schistosoma mansoni | coup transcription factor | 0.0342 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0342 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0342 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 0.0348 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0342 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0161 | 0.451 | 0.451 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0342 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0342 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5098 | 0.5098 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0161 | 0.451 | 0.399 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.0348 | 0.353 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0045 | 0.0968 | 0.0968 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0041 | 0.0866 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0866 | 0.0866 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0342 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0041 | 0.0866 | 0.0806 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0015 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0015 | 0.0065 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0015 | 0.0065 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0342 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.018 | 0.5098 | 0.5066 |
Brugia malayi | nuclear hormone receptor | 0.0342 | 1 | 1 |
Onchocerca volvulus | 0.0342 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.018 | 0.5098 | 0.5098 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0015 | 0.0065 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.018 | 0.5098 | 0.5066 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Brugia malayi | hypothetical protein | 0.018 | 0.5098 | 0.5066 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5098 | 0.5098 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0342 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0042 | 0.0892 | 0.0833 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0015 | 0.0065 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0342 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0161 | 0.451 | 0.4474 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5098 | 0.5098 |
Toxoplasma gondii | kringle domain-containing protein | 0.0041 | 0.0866 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0342 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0342 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0342 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0342 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0015 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0015 | 0.0065 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0161 | 0.451 | 0.4474 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.018 | 0.5098 | 0.5098 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0161 | 0.451 | 0.451 |
Schistosoma mansoni | nuclear hormone receptor | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0015 | 0.0065 | 0.5 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0161 | 0.451 | 0.451 |
Brugia malayi | tailless protein | 0.0161 | 0.451 | 0.4474 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0075 | 0.001 |
Schistosoma mansoni | cytochrome P450 | 0.0015 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5098 | 0.5098 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0161 | 0.451 | 0.451 |
Brugia malayi | Kringle domain containing protein | 0.0041 | 0.0866 | 0.0806 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 0.0348 | 0.0348 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0342 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0342 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0161 | 0.451 | 0.4474 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 0.0348 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0161 | 0.451 | 0.451 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0342 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0161 | 0.451 | 0.451 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0342 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0041 | 0.0866 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0161 | 0.451 | 0.451 |
Onchocerca volvulus | 0.0161 | 0.451 | 0.399 | |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0342 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0015 | 0.0065 | 0.5 |
Brugia malayi | hypothetical protein | 0.018 | 0.5098 | 0.5066 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.018 | 0.5098 | 0.5066 |
Brugia malayi | nuclear receptor NHR-88 | 0.0161 | 0.451 | 0.4474 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0015 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0015 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0015 | 0.0065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Onchocerca volvulus | 0.0161 | 0.451 | 0.399 | |
Brugia malayi | conserved hypotetical protein | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0161 | 0.451 | 0.451 |
Echinococcus granulosus | FTZ F1 alpha | 0.0342 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5098 | 0.5098 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Brugia malayi | hypothetical protein | 0.0161 | 0.451 | 0.4474 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0348 | 0.0284 |
Onchocerca volvulus | 0.0144 | 0.3985 | 0.3415 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0342 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0348 | 0.0284 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0342 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0161 | 0.451 | 0.4474 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0342 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0147 | 0.4087 | 0.3527 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0075 | 0.0075 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0161 | 0.451 | 0.4474 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0161 | 0.451 | 0.451 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0015 | 0.0065 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0041 | 0.0866 | 0.0866 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0161 | 0.451 | 0.451 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0161 | 0.451 | 0.4474 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0342 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0161 | 0.451 | 0.4474 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0342 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0342 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0342 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0161 | 0.451 | 0.399 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0015 | 0.0065 | 0.0065 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0342 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0158 | 0.4403 | 0.4366 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Schistosoma mansoni | nuclear receptor | 0.0161 | 0.451 | 0.451 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0161 | 0.451 | 0.451 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0161 | 0.451 | 0.4474 |
Schistosoma mansoni | zinc finger protein | 0.0161 | 0.451 | 0.451 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0342 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0342 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0161 | 0.451 | 0.4474 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.0348 | 0.353 |
Brugia malayi | ecdysone receptor | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0348 | 0.0348 |
Brugia malayi | nuclear receptor NHR-88 | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0015 | 0.0065 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0342 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0075 | 0.0075 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0866 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0015 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0015 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0161 | 0.451 | 0.451 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | DR-78 | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0161 | 0.451 | 0.4474 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0158 | 0.4403 | 0.4403 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0866 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.018 | 0.5098 | 0.5098 |
Brugia malayi | nuclear hormone receptor | 0.0161 | 0.451 | 0.4474 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0015 | 0.0065 | 0.0065 |
Brugia malayi | nuclear receptor RXR | 0.018 | 0.5098 | 0.5066 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0342 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0161 | 0.451 | 0.451 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0076 | 0.1911 | 0.1911 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0342 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0342 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0342 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 0.0348 | 0.353 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0342 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0015 | 0.0065 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0342 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.