Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0175 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.