Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1H subunit | Starlite/ChEMBL | References |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0076 | 0.2944 | 0.2944 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2944 | 0.2944 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2944 | 0.3096 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2944 | 0.2944 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1133 | 0.1191 |
Echinococcus granulosus | geminin | 0.0205 | 0.951 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2944 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2944 | 0.2944 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2944 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2944 | 0.3096 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2944 | 0.2944 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.951 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1133 | 0.1133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2109 | 0.2109 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2944 | 0.2944 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2944 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6412 | 0.6412 |
Echinococcus multilocularis | geminin | 0.0205 | 0.951 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6412 | 0.6412 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6412 | 0.6412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2944 | 0.3096 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.951 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1133 | 0.1133 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2944 | 0.3096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.97 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 uM | Inhibition of human recombinant Cav3.2 channel | ChEMBL. | 26101566 |
Potency (functional) | 1.4581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.