Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.387 | 0.6116 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0871 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.387 | 0.387 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3738 | 0.3738 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.387 | 0.387 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5775 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5775 | 0.5775 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0516 | 0.0516 |
Echinococcus multilocularis | musashi | 0.0033 | 0.387 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0.387 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0871 | 0.1977 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0871 |
Echinococcus granulosus | lamin | 0.0033 | 0.387 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0871 | 0.1977 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0871 | 0.1977 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.387 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.387 | 0.3537 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5775 | 0.5545 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.387 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0871 | 0.1977 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0871 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0871 | 0.0871 |
Echinococcus multilocularis | lamin | 0.0033 | 0.387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0132 | 0.0132 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.387 | 0.3537 |
Schistosoma mansoni | lamin | 0.0033 | 0.387 | 0.6116 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.387 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.387 | 0.387 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.