Detailed information for compound 1347574

Basic information

Technical information
  • TDR Targets ID: 1347574
  • Name: (2R)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3- naphthalen-1-yloxypropan-2-ol
  • MW: 392.491 | Formula: C24H28N2O3
  • H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)C[C@H](COc1cccc2c1cccc2)O
  • InChi: 1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3/t20-/m1/s1
  • InChiKey: HRRBJVNMSRJFHQ-HXUWFJFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
  • (2R)-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)propan-2-ol
  • (2R)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxy-propan-2-ol
  • NCGC00024672-01
  • Tocris-0597
  • CAS-57149-08-3
  • NCGC00016882-01
  • Lopac-N-158
  • NCGC00015718-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Brugia malayi Serotonin receptor 0.004 0.0022 0.0022
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0001 0.0001
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0025 0.0023
Brugia malayi cytochrome P450 0.0017 0.0002 0.0001
Leishmania major cytochrome p450-like protein 0.0017 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0026 0.0337
Onchocerca volvulus 0.004 0.0022 0.0135
Onchocerca volvulus 0.004 0.0022 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0001 0.0001
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0026 0.0337
Schistosoma mansoni neuropeptide receptor 0.004 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0042 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0026 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0026 0.0044
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0001 0.0001
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0002 0.0002
Schistosoma mansoni adenoreceptor 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0022 0.0022
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.0172 0.2215
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0008 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Entamoeba histolytica hypothetical protein 0.0043 0.0025 0.0741
Schistosoma mansoni dihydrofolate reductase 1.1259 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0007 0.0007
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0007 0.0007
Echinococcus granulosus allatostatin A receptor 0.004 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0211 0.0211
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0017 0.0002 0.0003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0022 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0007 0.0007
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0025 0.0025
Schistosoma mansoni amine GPCR 0.004 0.0022 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0242 0.3115
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0007 0.0006
Echinococcus multilocularis g protein coupled receptor 0.004 0.0022 0.0022
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0002 0.0002
Echinococcus multilocularis cpg binding protein 0.0037 0.0019 0.0019
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.004 0.004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.004 0.0022 0.0022
Echinococcus granulosus phd:f box containing protein 0.0016 0.0001 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.0728 0.0727
Schistosoma mansoni myosin xvIII 0.004 0.0022 0.0022
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0014 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0019 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0022 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0026 0.0337
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.004 0.004
Brugia malayi G protein-coupled receptor 0.004 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0007 0.0006
Brugia malayi Doublecortin family protein 0.0024 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0019 0.0019
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.0177 0.0176
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.0251 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0041 0.0041
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0041 0.0069
Schistosoma mansoni amine GPCR 0.004 0.0022 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Onchocerca volvulus 0.004 0.0022 0.0135
Brugia malayi ORL1-like opioid receptor 0.004 0.0022 0.0022
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.004 0.0022 0.0022
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0026 0.0026
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0007 0.0007
Chlamydia trachomatis dihydrofolate reductase 1.1259 1 1
Schistosoma mansoni biogenic amine receptor 0.004 0.0022 0.0022
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0041 0.0068
Brugia malayi Serotonin receptor 0.004 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0043 0.0025 0.0741
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Leishmania major hypothetical protein, conserved 0.003 0.0014 0.0023
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0022 0.0022
Brugia malayi hypothetical protein 0.0043 0.0025 0.0024
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0022 0.0022
Brugia malayi G-protein coupled receptor 0.004 0.0022 0.0022
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0008
Brugia malayi thymidylate synthase 0.1865 0.1645 0.1644
Echinococcus multilocularis expressed protein 0.0451 0.0387 0.0387
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0014 0.0022
Schistosoma mansoni histamine h1 receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0017 0.0002 0.0001
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0001 0.0001
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0002 0.0003
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0016 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0008 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.006 0.004 0.0039
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0022 0.0022
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0026 0.0783
Leishmania major dihydrofolate reductase-thymidylate synthase 0.6725 0.5968 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.0177 0.0177
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0022 0.0022
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0002 0.0002
Brugia malayi hypothetical protein 0.003 0.0014 0.0013
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Brugia malayi Dopamine receptor 0.004 0.0022 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0022 0.0022
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0022 0.0022
Schistosoma mansoni polycystin 1-related 0.0024 0.0008 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0026 0.0337
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0022 0.0022
Echinococcus multilocularis fmrfamide receptor 0.004 0.0022 0.0022
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0008 0.0012
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0026 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0016 0.0016
Echinococcus granulosus g protein coupled receptor 0.004 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0024 0.0008 0.0007
Echinococcus granulosus neuropeptide receptor 0.004 0.0022 0.0022
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) thymidylate synthase 0.1865 0.1645 0.1645
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Brugia malayi RE15519p 0.004 0.0022 0.0022
Mycobacterium ulcerans thymidylate synthase 0.1865 0.1645 0.1643
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.004 0.004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0026 0.0044
Schistosoma mansoni lamin 0.0033 0.0016 0.0015
Brugia malayi hypothetical protein 0.0024 0.0008 0.0007
Schistosoma mansoni lamin 0.0033 0.0016 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0007 0.0006
Onchocerca volvulus 0.0033 0.0016 0.0094
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0022 0.0022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0007 0.0006
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0007 0.0007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0116 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis musashi 0.0033 0.0016 0.0015
Brugia malayi intermediate filament protein 0.0033 0.0016 0.0015
Echinococcus multilocularis neuropeptide receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0022 0.0022
Mycobacterium tuberculosis Hypothetical protein 0.0887 0.0775 0.0774
Schistosoma mansoni hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 0.0017 0.0002 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0026 0.0043
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0026 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0026 0.0026
Echinococcus granulosus microtubule associated protein 2 0.0833 0.0728 0.0728
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0426 0.0426
Onchocerca volvulus 0.004 0.0022 0.0135
Schistosoma mansoni single-minded 0.0059 0.0039 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0041 0.0531
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus lamin 0.0033 0.0016 0.0015
Echinococcus granulosus lamin dm0 0.0033 0.0016 0.0015
Brugia malayi neuropeptide F receptor 0.004 0.0022 0.0022
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0113 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0022 0.0022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0026 0.0044
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0016 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.004 0.0022 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0022 0.0022
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0026 0.0337
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Onchocerca volvulus 0.0037 0.0019 0.0116
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0022 0.0135
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0022 0.0022
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0022 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0887 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Onchocerca volvulus 0.0043 0.0025 0.0153
Brugia malayi PAS domain containing protein 0.0059 0.0039 0.0038
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0041 0.0069
Brugia malayi Dopamine receptor protein 1 0.004 0.0022 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0016 0.0016
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0019 0.0019
Schistosoma mansoni rab6-interacting 0.0024 0.0008 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Onchocerca volvulus 0.0033 0.0016 0.0094
Onchocerca volvulus 0.0024 0.0008 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0026 0.0026
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0008 0.0008
Brugia malayi sulfakinin receptor protein 0.004 0.0022 0.0022
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0008 0.0008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.004 0.004
Schistosoma mansoni opsin-like receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0019 0.0019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0008 0.0008
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0026 0.0026
Echinococcus granulosus tumor protein p63 0.0408 0.0349 0.0349
Onchocerca volvulus 0.004 0.0022 0.0135
Brugia malayi putative neuropeptide receptor 0.004 0.0022 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0426 0.0426
Echinococcus multilocularis dihydrofolate reductase 1.1259 1 1
Echinococcus granulosus fmrfamide receptor 0.004 0.0022 0.0022
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0007 0.0007
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.0023 0.0007 0.0006
Schistosoma mansoni amine GPCR 0.084 0.0734 0.0733
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0022 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0014 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Leishmania major protein kinase, putative 0.0016 0.0001 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Echinococcus multilocularis 0.0017 0.0002 0.0002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0007 0.0007
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Brugia malayi hypothetical protein 0.0197 0.0162 0.0161
Echinococcus granulosus g protein coupled receptor 0.004 0.0022 0.0022
Brugia malayi Dihydrofolate reductase 1.1259 1 1
Onchocerca volvulus 0.004 0.0022 0.0135
Brugia malayi neuropeptide F receptor 0.004 0.0022 0.0022
Schistosoma mansoni rab6-interacting 0.0024 0.0008 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Brugia malayi hypothetical protein 0.0023 0.0007 0.0006
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0008 0.0008
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0002 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0252 0.0211 0.021
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0008 0.0007
Onchocerca volvulus 0.1865 0.1645 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0001
Echinococcus granulosus neuropeptide receptor 0.004 0.0022 0.0022
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Brugia malayi Inositol-1 0.0045 0.0026 0.0025
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.004 0.0022 0.0022
Brugia malayi hypothetical protein 0.0024 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0008
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0001 0.0001
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus 0.004 0.0022 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis tumor protein p63 0.0408 0.0349 0.0349
Schistosoma mansoni amine GPCR 0.004 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.004 0.0022 0.0022
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0008 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0022 0.0022
Echinococcus granulosus expressed protein 0.0451 0.0387 0.0387
Brugia malayi hypothetical protein 0.002 0.0004 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.004 0.0022 0.0022
Schistosoma mansoni neuropeptide receptor 0.004 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0041 0.0531
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0022 0.0022
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0022 0.0022
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0014 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0002 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0197 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Echinococcus granulosus single minded 2 0.0043 0.0025 0.0025
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0026 0.0026
Echinococcus granulosus intermediate filament protein 0.0033 0.0016 0.0015
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0026 0.0043
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.6725 0.5968 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1865 0.1645 0.1643
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0037 0.0019 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0037 0.0019 0.0018
Onchocerca volvulus 0.006 0.004 0.024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0022 0.002
Entamoeba histolytica hypothetical protein 0.0043 0.0025 0.0741
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0113 0.0113
Echinococcus granulosus g-protein coupled receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0002 0.0002
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.0251 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1865 0.1645 0.1644
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0042 0.0042
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0022 0.0135
Brugia malayi Dopamine receptor protein 2 0.004 0.0022 0.0022
Brugia malayi AKH receptor 0.004 0.0022 0.0022
Onchocerca volvulus 0.004 0.0022 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0017 0.0002 0.0001
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0007 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0022 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0026 0.0026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0019 0.0019
Echinococcus multilocularis allatostatin A receptor 0.004 0.0022 0.0022
Trypanosoma brucei protein kinase, putative 0.0062 0.0041 0.0068
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0001 0.0001
Schistosoma mansoni inositol monophosphatase 0.0045 0.0026 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.006 0.004 0.0039
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0022 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Onchocerca volvulus 0.0287 0.0242 0.1468
Echinococcus granulosus somatostatin receptor 0.004 0.0022 0.0022
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0026 0.0785
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0007
Onchocerca volvulus 0.0035 0.0017 0.0105
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0041 0.0069
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0007 0.0007
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0007 0.0007
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.6725 0.5968 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0002 0.0003
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni lipoxygenase 0.0142 0.0113 0.0112
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0017 0.0017
Echinococcus multilocularis fmrfamide receptor 0.004 0.0022 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0022 0.0022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0022 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0022 0.0022
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0016 0.0015
Onchocerca volvulus 0.004 0.0022 0.0135
Schistosoma mansoni hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0022 0.0022
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0007 0.0006
Leishmania major protein kinase, putative 0.0016 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0022 0.0022
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0022 0.0022
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0007 0.0006
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Mycobacterium leprae putative cytochrome p450 0.0017 0.0002 0.0002
Schistosoma mansoni lipoxygenase 0.01 0.0075 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0026 0.0026
Echinococcus multilocularis thymidylate synthase 0.1865 0.1645 0.1645
Brugia malayi PXA domain containing protein 0.0023 0.0007 0.0006
Echinococcus multilocularis serotonin receptor 0.004 0.0022 0.0022
Echinococcus granulosus dihydrofolate reductase 1.1259 1 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0008 0.0008
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0041 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0001 0.0001
Echinococcus granulosus sex peptide receptor 0.004 0.0022 0.0022
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0007 0.0007
Plasmodium vivax SET domain protein, putative 0.0037 0.0019 0.0031
Brugia malayi Pre-SET motif family protein 0.0037 0.0019 0.0019
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1865 0.1645 0.1645
Echinococcus granulosus serotonin receptor 0.004 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0041 0.0531
Schistosoma mansoni hypothetical protein 0.004 0.0022 0.0022
Brugia malayi follicle stimulating hormone receptor 0.004 0.0022 0.0022
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0116 0.0116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0251 1
Brugia malayi Cytochrome P450 family protein 0.0017 0.0002 0.0001
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0022 0.0022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0022 0.0022
Brugia malayi jmjC domain containing protein 0.006 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0026 0.0026
Echinococcus granulosus cpg binding protein 0.0037 0.0019 0.0019
Schistosoma mansoni loxhd1 0.0024 0.0008 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.1259 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) inositol-1 0.0045 0.0026 0.0026
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0007 0.0006
Echinococcus multilocularis neuropeptide receptor 0.004 0.0022 0.0022
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0022 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0002 0.0002
Onchocerca volvulus 0.004 0.0022 0.0135
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0022 0.0022
Echinococcus granulosus hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.004 0.0022 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0022 0.0022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0026 0.0043
Onchocerca volvulus 0.004 0.0022 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0007 0.009
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0022 0.0022
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0494 0.0426 0.0425
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis orexin receptor type 2 0.004 0.0022 0.0022
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0022 0.0022
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0887 0.0775 0.1299
Brugia malayi G-protein coupled receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0008 0.0008
Echinococcus granulosus RUN 0.0024 0.0008 0.0008
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0026 0.0044
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0022 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0046 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0022 0.0022
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0039 0.0038
Schistosoma mansoni cytochrome P450 0.0017 0.0002 0.0001
Echinococcus multilocularis lamin 0.0033 0.0016 0.0015
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0026 0.0026
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0041 0.0041
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0041 0.0069
Brugia malayi hypoxia-induced factor 1 0.0182 0.0148 0.0148
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0022 0.0022
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0007 0.0006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0022 0.0022
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0022 0.0022
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0001 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0008 0.0008
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Loa Loa (eye worm) dihydrofolate reductase 1.1259 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0008 0.0007
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0007 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0022 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Brugia malayi larval opioid receptor 0.004 0.0022 0.0022
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.6725 0.5968 1
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0022 0.0022
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0022 0.0022
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.1259 1 1
Brugia malayi Cytochrome P450 family protein 0.0063 0.0043 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0025 0.0025
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0008 0.0008
Echinococcus granulosus thymidylate synthase 0.1865 0.1645 0.1645
Echinococcus multilocularis RUN 0.0024 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0041 0.0531
Entamoeba histolytica hypothetical protein 0.0043 0.0025 0.0741
Schistosoma mansoni intermediate filament proteins 0.0033 0.0016 0.0015
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.6725 0.5968 1
Echinococcus multilocularis lamin dm0 0.0033 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Brugia malayi MAP kinase sur-1 0.0062 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Echinococcus multilocularis serotonin receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0148 0.0148
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0007 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0022 0.0022
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0007 0.009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0041 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0025 0.0024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0042 0.0041
Echinococcus multilocularis g protein coupled receptor 0.004 0.0022 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0041 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0008 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0022 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0022 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0022 0.0022
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0019 0.0019
Echinococcus granulosus neuropeptide s receptor 0.004 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0022 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0022 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0042 0.0041
Onchocerca volvulus 0.004 0.0022 0.0135
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0041 0.0068
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0041 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0116 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0007 0.0006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0035 0.0017 0.0017
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0022 0.0022
Brugia malayi Melatonin receptor type 1A 0.004 0.0022 0.0022
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0001 0.0001
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0026 0.0026
Brugia malayi hypothetical protein 0.004 0.0022 0.0022
Brugia malayi GnHR receptor homolog 0.004 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0017 0.0002 0.0003
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0022 0.0022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0251 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0014 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0022 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0887 0.0775 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0001 0.0001
Echinococcus granulosus orexin receptor type 2 0.004 0.0022 0.0022
Echinococcus multilocularis g protein coupled receptor 0.004 0.0022 0.0022
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0007 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0043 0.0043
Brugia malayi jmjC domain containing protein 0.0062 0.0042 0.0041
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0022 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0025 0.0025
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0002 0.0003
Echinococcus multilocularis sex peptide receptor 0.004 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0251 0.3234
Echinococcus multilocularis somatostatin receptor 0.004 0.0022 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0019 0.0019
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.1259 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0022 0.0022
Brugia malayi CXXC zinc finger family protein 0.0035 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0022
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0041 0.0668
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0022 0.0022
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0022 0.0022
Onchocerca volvulus 0.0024 0.0008 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0014 0.0023
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.6725 0.5968 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0041 0.0041
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0026 0.0337

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.125892541 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.316227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.794328235 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.584893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (ADMET) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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