Detailed information for compound 134816

Basic information

Technical information
  • TDR Targets ID: 134816
  • Name: methyl (E,5S)-7-[(1S,2R,3R,5S)-3,5-dihydroxy- 2-[(Z)-oct-2-enyl]cyclopentyl]-5-hydroxyhept- 6-enoate
  • MW: 368.508 | Formula: C21H36O5
  • H donors: 3 H acceptors: 4 LogP: 3.23 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C[C@H]1[C@H](O)C[C@@H]([C@H]1/C=C/[C@H](CCCC(=O)OC)O)O
  • InChi: 1S/C21H36O5/c1-3-4-5-6-7-8-11-17-18(20(24)15-19(17)23)14-13-16(22)10-9-12-21(25)26-2/h7-8,13-14,16-20,22-24H,3-6,9-12,15H2,1-2H3/b8-7-,14-13+/t16-,17+,18-,19+,20-/m0/s1
  • InChiKey: PMJFULFRSGAFPL-ZUBLXNSRSA-N  

Network

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Synonyms

  • methyl (E,5S)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(Z)-oct-2-enyl]cyclopentyl]-5-hydroxy-hept-6-enoate
  • (E,5S)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(Z)-oct-2-enyl]cyclopentyl]-5-hydroxy-6-heptenoic acid methyl ester
  • (E,5S)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(Z)-oct-2-enyl]cyclopentyl]-5-hydroxy-hept-6-enoic acid methyl ester
  • (E,5S)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(Z)-oct-2-enyl]cyclopentyl]-5-hydroxyhept-6-enoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0205 0.0192
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0304 0.0512
Entamoeba histolytica hypothetical protein 0.0262 0.277 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1028 0.3625
Brugia malayi nuclear receptor RXR 0.0048 0.0361 0.0612
Brugia malayi tailless protein 0.0043 0.0304 0.0512
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1172 0.4063
Brugia malayi MH1 domain containing protein 0.0024 0.0096 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0144 0.0236
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.009 0.0841 0.0841
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2418 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.009 0.0841 0.1454
Onchocerca volvulus 0.0043 0.0304 0.0501
Onchocerca volvulus 0.0259 0.2737 0.8146
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0533 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.0841 0.1442
Mycobacterium leprae Probable lipase LipE 0.0036 0.0231 0.0976
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0096 0.0096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.009 0.0841 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-3 0.009 0.0841 0.1442
Brugia malayi MH2 domain containing protein 0.0024 0.0096 0.0153
Schistosoma mansoni hypothetical protein 0.049 0.534 0.5334
Echinococcus granulosus dnaJ subfamily B 0.049 0.534 0.534
Echinococcus multilocularis FTZ F1 alpha 0.009 0.0841 0.0841
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1071 0.1059
Leishmania major hypothetical protein, conserved 0.0036 0.0231 0.0704
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0231 0.0976
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Brugia malayi MH2 domain containing protein 0.0024 0.0096 0.0153
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0109 0.0114
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0718 0.2857
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0653
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.0715 0.1236
Brugia malayi Nuclear hormone receptor family member nhr-49 0.009 0.0841 0.1442
Schistosoma mansoni DNA polymerase eta 0.0019 0.0038 0.0025
Brugia malayi Pre-SET motif family protein 0.0034 0.0205 0.0341
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0065
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0096 0.0096
Entamoeba histolytica hypothetical protein 0.0111 0.1071 0.378
Schistosoma mansoni smad 0.0024 0.0096 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.0841 0.0841
Schistosoma mansoni nuclear hormone receptor 0.009 0.0841 0.0829
Brugia malayi TAR-binding protein 0.0529 0.5783 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.2983 0.5159
Loa Loa (eye worm) hypothetical protein 0.0034 0.0205 0.0355
Brugia malayi hypothetical protein 0.0311 0.3328 0.5749
Schistosoma mansoni hypothetical protein 0.002 0.0051 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0529 0.0914
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.0168
Echinococcus multilocularis transcription factor btf3 0.0262 0.277 0.277
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.009 0.0841 0.0841
Echinococcus granulosus survival motor neuron protein 1 0.0283 0.3013 0.3013
Echinococcus multilocularis musashi 0.0032 0.0188 0.0188
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.0146
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0304 0.0304
Brugia malayi hypothetical protein 0.0111 0.1071 0.184
Brugia malayi hypothetical protein 0.0283 0.3013 0.5204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.009 0.0841 0.0829
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0205 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0215 0.2246 0.2246
Loa Loa (eye worm) hypothetical protein 0.0028 0.0144 0.0249
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.137 0.2358
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1028 0.1028
Brugia malayi beta-NAC-like protein 0.0262 0.277 0.4783
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0533 0.0533
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0078 0.0146
Brugia malayi 6-phosphofructokinase 0.0107 0.1028 0.1767
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0718 0.2379
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0231 0.0704
Mycobacterium ulcerans beta-lactamase 0.0036 0.0231 0.1942
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.0841 0.0841
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.0841 0.0841
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1028 0.3625
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0304 0.0304
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.005 0.0051
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.1897 0.5507
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0013 0.0013
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0056 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1028 0.3362
Schistosoma mansoni survival motor neuron protein 0.0058 0.0475 0.0463
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0144 0.107
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0231 0.0808
Schistosoma mansoni hypothetical protein 0.0064 0.054 0.0528
Brugia malayi Pre-SET motif family protein 0.0228 0.2386 0.4117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.0841 0.1442
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0895 0.0884
Entamoeba histolytica hypothetical protein 0.0111 0.1071 0.378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.009 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Echinococcus multilocularis thyroid hormone receptor alpha 0.009 0.0841 0.0841
Onchocerca volvulus 0.0032 0.0188 0.0138
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0096 0.0166
Echinococcus granulosus retinoic acid receptor rxr beta a 0.009 0.0841 0.0841
Echinococcus multilocularis cpg binding protein 0.0066 0.0569 0.0569
Echinococcus multilocularis lamin dm0 0.0032 0.0188 0.0188
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.015 0.0408
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1028 0.3625
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.0146
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.015 0.0379
Schistosoma mansoni hypothetical protein 0.0111 0.1071 0.1059
Brugia malayi CXXC zinc finger family protein 0.0063 0.0529 0.0901
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0188
Schistosoma mansoni smad1 5 8 and 0.0024 0.0096 0.0084
Brugia malayi beta-lactamase 0.0036 0.0231 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0653
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0013 0.0013
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.0715 0.1224
Schistosoma mansoni transient receptor potential channel 0.0095 0.0895 0.0884
Mycobacterium ulcerans hypothetical protein 0.0036 0.0231 0.1942
Echinococcus granulosus FTZ F1 alpha 0.009 0.0841 0.0841
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0385
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.054 0.0933
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0533 0.0533
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0144 0.0445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0205 0.0192
Loa Loa (eye worm) RNA binding protein 0.0529 0.5783 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0144 0.0445
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.0841 0.1442
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Loa Loa (eye worm) hypothetical protein 0.0283 0.3013 0.5211
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.0653
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0361 0.0361
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.0258
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0188 0.0312
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0718 0.249
Schistosoma mansoni tar DNA-binding protein 0.0529 0.5783 0.5777
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0063 0.0106
Echinococcus granulosus tar DNA binding protein 0.0529 0.5783 0.5783
Onchocerca volvulus 0.0036 0.0231 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.009 0.0841 0.1442
Brugia malayi hypothetical protein 0.0048 0.0361 0.0612
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0038 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0078 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Trypanosoma brucei transcription factor BTF3, putative 0.0262 0.277 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0135
Loa Loa (eye worm) beta-lactamase 0.0036 0.0231 0.0399
Schistosoma mansoni tar DNA-binding protein 0.0529 0.5783 0.5777
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.009 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.011
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.034 0.034
Schistosoma mansoni lamin 0.0032 0.0188 0.0176
Loa Loa (eye worm) hypothetical protein 0.0032 0.0187 0.0323
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.054 0.054
Schistosoma mansoni smad1 5 8 and 0.0024 0.0096 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0231 0.0808
Brugia malayi MH2 domain containing protein 0.0354 0.3813 0.6589
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0144 0.107
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0144 0.107
Brugia malayi 6-phosphofructokinase 0.0107 0.1028 0.1767
Schistosoma mansoni cpg binding protein 0.0063 0.0529 0.0516
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.015 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0718 0.1242
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0808
Toxoplasma gondii ABC1 family protein 0.0036 0.0231 0.0566
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0808
Onchocerca volvulus 0.009 0.0841 0.2188
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0361 0.0349
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0715 0.2476
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0304 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.0841 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.009 0.0841 0.1454
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0144 0.107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0361 0.0349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.054 0.054
Brugia malayi hypothetical protein 0.0147 0.1477 0.2543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.005 0.0051
Schistosoma mansoni hypothetical protein 0.0904 1 1
Echinococcus granulosus lamin 0.0032 0.0188 0.0188
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0304 0.0291
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0144 0.0388
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.009 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0718 0.249
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.0653
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0361 0.0361
Brugia malayi ecdysone receptor 0.0043 0.0304 0.0512
Echinococcus granulosus dna polymerase eta 0.0019 0.0038 0.0038
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0718 0.2379
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0231 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0529 0.5783 0.5777
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.011
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0895 0.0895
Schistosoma mansoni thyroid hormone receptor 0.009 0.0841 0.0829
Echinococcus multilocularis Smad4 0.0024 0.0096 0.0096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0718 0.0718
Echinococcus multilocularis survival motor neuron protein 1 0.0283 0.3013 0.3013
Brugia malayi hypothetical protein 0.0025 0.0109 0.0174
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0078 0.0146
Trypanosoma cruzi transcription factor btf3, putative 0.0262 0.277 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0718 0.0718
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0176 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1331 0.132
Schistosoma mansoni Smad4 0.0024 0.0096 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0144 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0231 0.1942
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0205 0.0192
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0625
Brugia malayi nuclear hormone receptor 0.009 0.0841 0.1442
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0304 0.0291
Echinococcus granulosus Smad4 0.0024 0.0096 0.0096
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1071 0.1071
Brugia malayi conserved hypotetical protein 0.0043 0.0304 0.0512
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1028 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0013 0.0013
Schistosoma mansoni zinc finger protein 0.0043 0.0304 0.0291
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0188 0.0325
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0808
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0144 0.0236
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1028 0.1017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.009 0.0841 0.0829
Echinococcus multilocularis ecdysone induced protein 78C 0.009 0.0841 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0529 0.5783 0.5777
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0718 0.242
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0078 0.0403
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1028 0.1778
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Echinococcus multilocularis dna polymerase eta 0.0019 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0025 0.0109 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.009 0.0841 0.1454
Echinococcus granulosus lamin dm0 0.0032 0.0188 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2085 0.3606
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Plasmodium vivax SET domain protein, putative 0.0034 0.0205 0.0523
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.0841 0.1442
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.277 0.9275
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0078 0.0078
Schistosoma mansoni transient receptor potential channel 0.0063 0.0533 0.0521
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0475 0.0809
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.015 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.009 0.0841 0.1454
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0718 0.0718
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Schistosoma mansoni tar DNA-binding protein 0.0529 0.5783 0.5777
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0625
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0718 0.0718
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.0715 0.2476
Onchocerca volvulus Huntingtin homolog 0.0147 0.1477 0.4185
Brugia malayi nuclear receptor NHR-88 0.0043 0.0304 0.0512
Onchocerca volvulus Protein ultraspiracle homolog 0.009 0.0841 0.2188
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0304 0.0304
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0144 0.0388
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0144 0.0388
Loa Loa (eye worm) Smad1 0.0024 0.0096 0.0166
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0304 0.0304
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0718 0.249
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.086 0.086
Leishmania major basic transcription factor 3a, putative 0.0262 0.277 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.009 0.0841 0.0829
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0231 0.0808
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Schistosoma mansoni steroid hormone receptor ad4bp 0.009 0.0841 0.0829
Schistosoma mansoni intermediate filament proteins 0.0032 0.0188 0.0176
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0096 0.0166
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.009 0.0841 0.0841
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.015 0.0319
Schistosoma mansoni retinoic acid receptor RXR 0.009 0.0841 0.0829
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.015 0.0754
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0019 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.009 0.0841 0.0829
Entamoeba histolytica transcription factor BTF3, putative 0.0262 0.277 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0205 0.0205
Loa Loa (eye worm) ICD-1 protein 0.0262 0.277 0.479
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0304 0.0291
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.0715 0.2476
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0205 0.0471
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.015 0.0319
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0223 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-31 0.009 0.0841 0.1442
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0078 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0718 0.249
Brugia malayi photoreceptor-specific nuclear receptor 0.009 0.0841 0.1442
Brugia malayi RNA binding protein 0.0529 0.5783 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0718 0.249
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0231 0.1942
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2386 0.4125
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.0715 0.0715
Schistosoma mansoni nuclear receptor 0.0043 0.0304 0.0291
Loa Loa (eye worm) hypothetical protein 0.0352 0.3792 0.6557
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0223 0.0223
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0718 0.0706
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1028 0.416
Brugia malayi RNA recognition motif domain containing protein 0.0529 0.5783 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0231 0.0617
Onchocerca volvulus 0.0036 0.0231 0.0271
Loa Loa (eye worm) steroid hormone receptor 0.009 0.0841 0.1454
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0144 0.107
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0135
Brugia malayi nuclear receptor NHR-88 0.009 0.0841 0.1442
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0715 0.2476
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0078 0.3577
Loa Loa (eye worm) hypothetical protein 0.0032 0.0188 0.0325
Entamoeba histolytica hypothetical protein 0.0111 0.1071 0.378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0314
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0231 0.0399
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0188 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1028 0.3362
Brugia malayi hypothetical protein 0.0043 0.0304 0.0512
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0078 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2009 0.6691
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0223 0.0223
Brugia malayi steroid hormone receptor 0.009 0.0841 0.1442
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1028 0.1778
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.0841 0.1442
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0144 0.0249
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0144 0.0236
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0304 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-41 0.009 0.0841 0.1442
Echinococcus multilocularis dnaJ subfamily B 0.049 0.534 0.534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.009 0.0841 0.1454
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0147 0.1477 0.2554
Brugia malayi Steroid receptor seven-up type 2 0.009 0.0841 0.1442
Echinococcus multilocularis GPCR, family 2 0.0064 0.054 0.054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0144 0.0388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0625
Echinococcus granulosus dna polymerase kappa 0.0019 0.0038 0.0038
Toxoplasma gondii NAC domain-containing protein 0.0262 0.277 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0304 0.0501
Schistosoma mansoni cpg binding protein 0.0066 0.0569 0.0557
Plasmodium vivax basic transcription factor 3b, putative 0.0262 0.277 1
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2009 0.6691
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0625
Loa Loa (eye worm) hypothetical protein 0.006 0.0497 0.0859
Schistosoma mansoni hypothetical protein 0.0904 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.015 0.0319
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0718 0.123
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.009 0.0841 0.2188
Onchocerca volvulus 0.0311 0.3328 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0144 0.107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.3792 0.6552
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.277 0.9275
Schistosoma mansoni retinoid-x-receptor (RXR) 0.009 0.0841 0.0829
Onchocerca volvulus 0.0036 0.0231 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.0653
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0137 0.137 0.1359
Brugia malayi Latrophilin receptor protein 2 0.0064 0.054 0.0921
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0304 0.0304
Onchocerca volvulus 0.0043 0.0304 0.0501
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Loa Loa (eye worm) hypothetical protein 0.0137 0.137 0.2369
Onchocerca volvulus 0.0032 0.0188 0.0138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.054 0.0921
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0304 0.0304
Loa Loa (eye worm) DR-78 0.0043 0.0304 0.0525
Brugia malayi hypothetical protein 0.0043 0.0304 0.0512
Schistosoma mansoni hypothetical protein 0.0064 0.054 0.0528
Brugia malayi MH1 domain containing protein 0.0024 0.0096 0.0153
Trichomonas vaginalis esterase, putative 0.0036 0.0231 0.0653
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0361 0.0625
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0304 0.0304
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0715 0.2476
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0304 0.0512
Trichomonas vaginalis set domain proteins, putative 0.0259 0.2737 0.9164
Schistosoma mansoni hypothetical protein 0.0064 0.054 0.0528
Trypanosoma cruzi transcription factor btf3, putative 0.0262 0.277 1
Brugia malayi nuclear hormone receptor 0.0043 0.0304 0.0512
Brugia malayi nuclear receptor RXR 0.0043 0.0304 0.0512
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0304 0.0512
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.2983 0.5153
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1028 0.3625
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0096 0.0084
Brugia malayi hypothetical protein 0.0048 0.0361 0.0612
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0231 0.0808
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0304 0.0304
Echinococcus multilocularis lamin 0.0032 0.0188 0.0188
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0304 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.277 0.9275
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0231 0.0808
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.0054
Schistosoma mansoni nuclear receptor 0.0043 0.0304 0.0291
Loa Loa (eye worm) TAR-binding protein 0.0529 0.5783 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1028 0.3362
Echinococcus multilocularis smad 0.0024 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0311 0.3328 0.5754
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0215 0.2246 0.2246
Schistosoma mansoni thyroid hormone receptor 0.009 0.0841 0.0829
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0304 0.0512
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0304 0.0525
Loa Loa (eye worm) MH2 domain-containing protein 0.0354 0.3813 0.6594
Schistosoma mansoni hypothetical protein 0.0064 0.054 0.0528
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0078 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2983 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0019 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0718 0.0718
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0718 0.0718
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.0258
Schistosoma mansoni cpg binding protein 0.0066 0.0569 0.0557
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0056 0.0056
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0147 0.1477 0.2554
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0038 0.0066
Brugia malayi ecdysteroid receptor 0.009 0.0841 0.1442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.0704
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1028 0.3625
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0038 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.015 0.0379
Echinococcus multilocularis tar DNA binding protein 0.0529 0.5783 0.5783
Loa Loa (eye worm) hypothetical protein 0.0048 0.0361 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-40 0.009 0.0841 0.1442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1071 0.1071
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0361 0.0612
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0095 0.0895 0.1548
Brugia malayi isocitrate dehydrogenase 0.0079 0.0718 0.123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.005 0.0051
Mycobacterium ulcerans lipase LipD 0.0036 0.0231 0.1942
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.015 0.0266
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0533 0.0533
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.0704
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.011
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0109 0.0258
Mycobacterium ulcerans hypothetical protein 0.0028 0.0144 0.107
Echinococcus granulosus intermediate filament protein 0.0032 0.0188 0.0188
Onchocerca volvulus Bile acid receptor homolog 0.009 0.0841 0.2188
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0231 0.0808
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0718 0.242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0399
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0304 0.0525
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0218
Schistosoma mansoni coup transcription factor 0.009 0.0841 0.0829
Plasmodium falciparum basic transcription factor 3b, putative 0.0262 0.277 1
Schistosoma mansoni hypothetical protein 0.0058 0.0475 0.0463
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0144 0.107
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.1897 0.6312
Onchocerca volvulus 0.0063 0.0529 0.1207
Schistosoma mansoni transient receptor potential channel 0.0063 0.0533 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-1 0.009 0.0841 0.1442
Onchocerca volvulus 0.0034 0.0205 0.0191
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.009 0.0841 0.1454
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0205 0.0192
Echinococcus granulosus smad 0.0024 0.0096 0.0096
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0304 0.0291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.015 1
Schistosoma mansoni lamin 0.0032 0.0188 0.0176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0205 0.0205
Brugia malayi phosphofructokinase 0.0107 0.1028 0.1767
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0066
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.015 0.0266
Brugia malayi intermediate filament protein 0.0032 0.0188 0.0312
Brugia malayi Smad1 0.0024 0.0096 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.005 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.009 0.0841 0.0841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.009 0.0841 0.1454
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.0168
Echinococcus granulosus GPCR family 2 0.0064 0.054 0.054
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0065
Onchocerca volvulus 0.0058 0.0475 0.1039
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1028 0.3362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0385
Brugia malayi nuclear receptor NHR-67 0.0043 0.0304 0.0512
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0052
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0096 0.0096
Brugia malayi Nuclear hormone receptor-like 1 0.009 0.0841 0.1442
Echinococcus granulosus cpg binding protein 0.0066 0.0569 0.0569
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1028 0.1028
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.086 0.086
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0053 0.0078
Echinococcus granulosus transcription factor Dp 1 0.0046 0.034 0.034
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0144 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0361 0.0612
Schistosoma mansoni transcription factor btf3 0.0262 0.277 0.276
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0063 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0304 0.0525
Entamoeba histolytica hypothetical protein 0.0111 0.1071 0.378
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.015 1
Echinococcus multilocularis geminin 0.0904 1 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.0715 0.0715
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.015 0.0319
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0304 0.0291
Echinococcus granulosus transcription factor btf3 0.0262 0.277 0.277
Loa Loa (eye worm) hypothetical protein 0.0064 0.054 0.0933
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0144 0.0388
Onchocerca volvulus Huntingtin homolog 0.0147 0.1477 0.4185
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0038 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0354 0.3813 0.6594
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1028 0.1017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.009 0.0841 0.0829
Schistosoma mansoni smad1 5 8 and 0.0024 0.0096 0.0084
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0109 0.0168
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.0054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0231 0.0385
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0385
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0304 0.0501
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0895 0.0895
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1028 0.1778
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0529 0.5783 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.0715 0.0703
Schistosoma mansoni Tr4/Tr2 (homologue) 0.009 0.0841 0.0829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.009 0.0841 0.1454
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1028 0.3625
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2085 0.3597
Echinococcus granulosus ecdysone induced protein 78C 0.009 0.0841 0.0841
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0078 0.0168

Activities

Activity type Activity value Assay description Source Reference
pD2 (functional) 0 Effect of compound on rat thoracic aorta constriction in rat at 10e-5 M concentration; No effect ChEMBL. 11549454

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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