Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1766 | 0.1515 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2725 | 0.3601 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2725 | 0.3601 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7043 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0652 | 0.0368 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1536 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1075 | 0.0803 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.036 | 0.0066 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0652 | 0.0368 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1766 | 0.2179 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0652 | 0.1468 |
Onchocerca volvulus | 0.0027 | 0.1075 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0296 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1075 | 0.0803 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.068 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1075 | 0.3207 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1153 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1536 | 0.1279 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0473 | 0.3078 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1536 | 0.1279 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0433 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0334 | 0.0058 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.036 | 0.0066 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1153 | 0.1271 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1075 | 0.0803 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0652 | 0.0368 |
Schistosoma mansoni | lamin | 0.0027 | 0.1075 | 0.0803 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0652 | 0.1468 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0846 | 0.0567 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2725 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1075 | 0.3207 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0652 | 0.0368 |
Onchocerca volvulus | 0.0027 | 0.1075 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1766 | 0.6051 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0368 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0976 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1075 | 0.1155 |
Schistosoma mansoni | lamin | 0.0027 | 0.1075 | 0.0803 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1536 | 0.1279 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0433 | 0.0204 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1536 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1153 | 0.3529 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1536 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1536 | 0.1279 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0368 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.1075 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1049 | 0.1117 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0652 | 0.0368 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1075 | 0.1155 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1536 | 0.5107 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0652 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0652 | 0.0368 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1075 | 0.0803 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0334 | 0.0058 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0652 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.036 | 0.0095 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0668 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0652 | 0.0529 |
Echinococcus granulosus | lamin | 0.0027 | 0.1075 | 0.0803 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1536 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1075 | 0.1155 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1075 | 0.0803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.