Detailed information for compound 134837

Basic information

Technical information
  • TDR Targets ID: 134837
  • Name: 7-chloro-4-oxo-5H-[1,2,4]triazolo[1,5-a]quino xaline-2-carboxylic acid ethyl ester
  • MW: 292.678 | Formula: C12H9ClN4O3
  • H donors: 1 H acceptors: 5 LogP: 2.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nn2c(n1)c(O)nc1c2ccc(c1)Cl
  • InChi: 1S/C12H9ClN4O3/c1-2-20-12(19)9-15-10-11(18)14-7-5-6(13)3-4-8(7)17(10)16-9/h3-5H,2H2,1H3,(H,14,18)
  • InChiKey: DXAANXIRAMZBPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-4-keto-5H-[1,2,4]triazolo[1,5-a]quinoxaline-2-carboxylic acid ethyl ester
  • 7-chloro-4-oxo-5H-[1,2,4]triazolo[5,1-c]quinoxaline-2-carboxylic acid ethyl ester
  • 7-chloro-4-keto-5H-[1,2,4]triazolo[5,1-c]quinoxaline-2-carboxylic acid ethyl ester
  • ethyl 7-chloro-4-oxo-5H-[1,2,4]triazolo[1,5-a]quinoxaline-2-carboxylate
  • ethyl 7-chloro-4-oxo-5H-[1,2,4]triazolo[5,1-c]quinoxaline-2-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate receptor ionotropic, AMPA Starlite/ChEMBL References
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 Glutamate receptor ionotropic, AMPA   907 aa 948 aa 30.6 %
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Echinococcus multilocularis glutamate receptor 2 Glutamate receptor ionotropic, AMPA   907 aa 868 aa 30.4 %
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Onchocerca volvulus Glutamate receptor ionotropic, AMPA   907 aa 796 aa 40.5 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 779 aa 33.4 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 886 aa 34.2 %
Echinococcus granulosus glutamate receptor 2 Glutamate receptor ionotropic, AMPA   907 aa 875 aa 30.4 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 809 aa 34.1 %
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 Glutamate receptor ionotropic, AMPA   907 aa 959 aa 30.9 %
Schistosoma mansoni glutamate receptor kainate Glutamate receptor ionotropic, AMPA   907 aa 753 aa 33.2 %
Onchocerca volvulus Putative 39S ribosomal protein L45, mitochondrial Glutamate receptor ionotropic, AMPA   907 aa 799 aa 37.7 %
Drosophila melanogaster Glutamate receptor IIB Glutamate receptor ionotropic, AMPA   907 aa 863 aa 27.8 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 888 aa 34.0 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 779 aa 33.4 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, AMPA   907 aa 809 aa 33.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ferritin 0.0019 0.0108 0.0215
Chlamydia trachomatis glutamine binding protein 0.0052 0.0466 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0095 0.1029
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Echinococcus granulosus GPCR family 2 0.0035 0.0287 0.036
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.1928 0.1928
Echinococcus multilocularis glutamate receptor 2 0.0039 0.0329 0.0329
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0095 0.0216
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0069 0.0658 0.0825
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.1966 0.6881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0557
Schistosoma mansoni ferritin 0.0019 0.0108 0.0215
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0349 0.0927
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.0944 0.0944
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0278 0.0557
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0019 0.0108 0.0221
Brugia malayi Receptor family ligand binding region containing protein 0.001 0.0012 0.0027
Echinococcus multilocularis protein dispatched 1 0.0055 0.0499 0.0499
Onchocerca volvulus 0.001 0.0012 0.0041
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.1144 0.229
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0349 0.0793
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0.0012 0.0027
Echinococcus multilocularis protein patched 0.0048 0.0425 0.0425
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.041 0.4397 0.8805
Echinococcus granulosus nmda type glutamate receptor 0.0106 0.1058 0.1326
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0278 0.0348
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.1651 0.207
Brugia malayi Carboxylesterase family protein 0.041 0.4397 1
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Schistosoma mansoni tyrosine kinase 0.001 0.0012 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0107 0.021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0349 0.0793
Echinococcus multilocularis BC026374 protein (S09 family) 0.0069 0.0658 0.0658
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.1928 0.4384
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0221 0.0221
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0052 0.0466 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0066 0.1608
Trichomonas vaginalis spcc417.12 protein, putative 0.0069 0.0658 0.1943
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.9188
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0066 0.1608
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0425 0.0425
Echinococcus granulosus carboxylesterase 5A 0.041 0.4397 0.5512
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0687 0.1563
Brugia malayi Carboxylesterase family protein 0.0069 0.0658 0.1497
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0349 0.0437
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0468 0.1065
Echinococcus granulosus receptor type guanylyl cyclase 0.001 0.0012 0.0015
Schistosoma mansoni cpg binding protein 0.0034 0.0276 0.0554
Entamoeba histolytica hypothetical protein 0.0077 0.0749 0.6623
Brugia malayi hypothetical protein 0.001 0.0012 0.0027
Echinococcus granulosus glutamate receptor 2 0.005 0.0443 0.0555
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0069 0.0658 0.1943
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0105 0.1051 0.2391
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0256 0.0582
Echinococcus granulosus atrial natriuretic peptide receptor 0.001 0.0012 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0937
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0278 0.4713
Loa Loa (eye worm) hypothetical protein 0.0112 0.1125 0.2558
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.027
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0443 0.0555
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Brugia malayi Pre-SET motif family protein 0.0035 0.0278 0.0632
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0066 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0194 0.1367
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0738 0.1679
Echinococcus multilocularis tyrosine kinase 0.001 0.0012 0.0012
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0329 0.066
Echinococcus multilocularis geminin 0.0192 0.2009 0.2009
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0687 0.1376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0749 0.0939
Schistosoma mansoni ferritin light chain 0.0019 0.0108 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0287 0.0653
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0349 0.0927
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.0944 0.1183
Plasmodium vivax SET domain protein, putative 0.0035 0.0278 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0287 0.036
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.1679
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1127 0.2563
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0021 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Schistosoma mansoni hypothetical protein 0.0464 0.4994 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0349 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0194 0.044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0077 0.0749 0.6623
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0329 0.066
Echinococcus multilocularis NMDA receptor 0.002 0.012 0.012
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0095 0.1612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.2499 0.5683
Echinococcus granulosus BC026374 protein S09 family 0.0069 0.0658 0.0825
Schistosoma mansoni tyrosine kinase 0.001 0.0012 0.0024
Echinococcus multilocularis atrial natriuretic peptide receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0033 0.0256 0.0896
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.1928 0.2417
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.002 0.012 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0287 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0658 0.1318
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0321 0.278
Loa Loa (eye worm) glutamate receptor 0.001 0.0012 0.0027
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0321 0.3395
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0687 0.1376
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0019 0.0108 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0105 0.1051 0.1051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0107 0.021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0277 0.3229
Onchocerca volvulus 0.0069 0.0658 0.2305
Echinococcus granulosus cpg binding protein 0.0034 0.0276 0.0346
Loa Loa (eye worm) voltage-gated potassium channel 0.0102 0.1016 0.231
Echinococcus granulosus expressed conserved protein 0.0105 0.105 0.1317
Schistosoma mansoni hypothetical protein 0.0035 0.0287 0.0575
Loa Loa (eye worm) hypothetical protein 0.0112 0.1127 0.2563
Loa Loa (eye worm) hypothetical protein 0.0027 0.0194 0.044
Brugia malayi Pre-SET motif family protein 0.0237 0.2499 0.5683
Schistosoma mansoni ferritin 0.0019 0.0108 0.0215
Onchocerca volvulus 0.0069 0.0658 0.2305
Loa Loa (eye worm) carboxylesterase 0.0069 0.0658 0.1497
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0425 0.0532
Echinococcus multilocularis glutamate receptor 2 0.005 0.0443 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0468 0.0468
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0194 0.1749
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0443 0.0555
Echinococcus granulosus metabotropic glutamate receptor 5 0.001 0.0012 0.0015
Brugia malayi Metabotropic glutamate receptor precursor. 0.001 0.0012 0.0027
Schistosoma mansoni hypothetical protein 0.0076 0.0738 0.1478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0937
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0066 0.1608
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0443 0.0555
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1127 0.2563
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.4994 0.4994
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0443 0.0443
Schistosoma mansoni neuroligin 3 (S09 family) 0.0069 0.0658 0.1318
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0293 0.3115 0.7085
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0052 0.0466 0.5698
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0329 0.066
Loa Loa (eye worm) RGC/RGC protein kinase 0.001 0.0012 0.0027
Echinococcus multilocularis nmda type glutamate receptor 0.0106 0.1058 0.1058
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0349 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0052 0.0466 1
Echinococcus multilocularis acetylcholinesterase 0.041 0.4397 0.4397
Onchocerca volvulus 0.0269 0.2857 1
Loa Loa (eye worm) acetylcholinesterase 1 0.041 0.4397 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0119 0.0181
Onchocerca volvulus 0.001 0.0012 0.0041
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.002 0.012 0.012
Schistosoma mansoni patched 1 0.0048 0.0425 0.085
Loa Loa (eye worm) carboxylesterase 0.0069 0.0658 0.1497
Schistosoma mansoni hypothetical protein 0.0046 0.0406 0.0812
Onchocerca volvulus 0.0107 0.1072 0.3753
Echinococcus multilocularis acetylcholinesterase 0.041 0.4397 0.4397
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0321 0.0403
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0349 0.0927
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.1928 0.4384
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0749 0.15
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0687 0.1376
Mycobacterium ulcerans ion transport protein 0.0076 0.0737 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.002 0.012 0.015
Echinococcus granulosus glutamate receptor 2 0.0029 0.0221 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0557
Brugia malayi Carboxylesterase family protein 0.0069 0.0658 0.1497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0468 0.0468
Brugia malayi TAR-binding protein 0.0072 0.0687 0.1563
Onchocerca volvulus 0.0069 0.0658 0.2305
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.2123 0.6745
Echinococcus multilocularis para nitrobenzyl esterase 0.0069 0.0658 0.0658
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0194 0.1367
Echinococcus granulosus metabotropic glutamate receptor 2 0.001 0.0012 0.0015
Echinococcus multilocularis metabotropic glutamate receptor 2 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0046 0.0406 0.0812
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0349 0.0349
Loa Loa (eye worm) glutamate receptor 2 0.0039 0.0329 0.0749
Trichomonas vaginalis ferritin, putative 0.0019 0.0108 0.0136
Brugia malayi CXXC zinc finger family protein 0.0033 0.0256 0.0582
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0425 0.0532
Brugia malayi RNA binding protein 0.0072 0.0687 0.1563
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.002 0.012 0.015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0194 0.1367
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0039 0.0329 0.0329
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0194 0.1749
Echinococcus multilocularis GPCR, family 2 0.0035 0.0287 0.0287
Echinococcus granulosus neuroligin 0.0069 0.0658 0.0825
Echinococcus granulosus tumor protein p63 0.0736 0.7977 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0349 0.0927
Schistosoma mansoni inositol monophosphatase 0.0039 0.0321 0.0643
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0119 0.1305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0293 0.3115 0.7085
Loa Loa (eye worm) inositol-1 0.0039 0.0321 0.0731
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0119 0.0424
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0194 0.5397
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0278 0.0278
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0321 0.5448
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0443 0.0443
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.001 0.0012 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0287 0.0653
Trichomonas vaginalis set domain proteins, putative 0.0269 0.2857 0.9152
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0425 0.0966
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0658 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0443 0.0443
Echinococcus granulosus geminin 0.0192 0.2009 0.2519
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0687 0.1563
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0287 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0194 0.5397
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0468 0.0937
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0066 0.0231
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.1125 0.141
Onchocerca volvulus 0.0027 0.0194 0.0678
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.1081 0.2164
Schistosoma mansoni metabotropic glutamate receptor 0.001 0.0012 0.0024
Schistosoma mansoni protein kinase 0.001 0.0012 0.0024
Echinococcus multilocularis ferritin 0.0019 0.0108 0.0108
Brugia malayi Glutamate receptor 1 precursor 0.0039 0.0329 0.0749
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.2471
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Echinococcus granulosus tyrosine kinase 0.001 0.0012 0.0015
Loa Loa (eye worm) glutamate receptor 1 0.0039 0.0329 0.0749
Schistosoma mansoni apoferritin-2 0.0019 0.0108 0.0215
Brugia malayi Guanylyl cyclase protein 23 0.001 0.0012 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.059 1
Schistosoma mansoni hypothetical protein 0.0035 0.0287 0.0575
Loa Loa (eye worm) hypothetical protein 0.0035 0.0278 0.0632
Echinococcus multilocularis metabotropic glutamate receptor 5 0.001 0.0012 0.0012
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0349 0.0927
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0194 0.5397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0194 0.044
Schistosoma mansoni BC026374 protein (S09 family) 0.0069 0.0658 0.1318
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0687 0.1563
Brugia malayi metabotropic GABA-B receptor subtype 2 0.001 0.0012 0.0027
Brugia malayi Carboxylesterase family protein 0.0069 0.0658 0.1497
Loa Loa (eye worm) carboxylesterase 0.041 0.4397 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0349 0.0927
Schistosoma mansoni hypothetical protein 0.0192 0.2009 0.4023
Echinococcus multilocularis glutamate receptor subunit protein glur 0.002 0.012 0.012
Onchocerca volvulus 0.0108 0.1081 0.3783
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0194 0.1367
Loa Loa (eye worm) RGC/RGC protein kinase 0.001 0.0012 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0194 0.1367
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0095 0.1612
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0066 0.0486
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0001 0.0001
Echinococcus multilocularis tumor protein p63 0.0736 0.7977 0.7977
Schistosoma mansoni alpha-glucosidase 0.0159 0.1645 0.3295
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0321 0.0837
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0749 0.0749
Schistosoma mansoni alpha glucosidase 0.0041 0.0349 0.0698
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0051
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.1125 0.2558
Brugia malayi Receptor family ligand binding region containing protein 0.001 0.0012 0.0027
Brugia malayi N-terminal motif family protein 0.0188 0.1966 0.4471
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0349 1
Brugia malayi CHE-14 protein 0.0048 0.0425 0.0966
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.9188
Brugia malayi isocitrate dehydrogenase 0.0018 0.0095 0.0216
Loa Loa (eye worm) hypothetical protein 0.041 0.4397 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0194 0.1633
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0105 0.1051 0.2105
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0095 0.2471
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0658 0.1318
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0072 0.0688 0.0688
Trypanosoma brucei glucosidase, putative 0.0041 0.0349 1
Brugia malayi hypothetical protein 0.0069 0.0658 0.1497
Loa Loa (eye worm) RNA binding protein 0.0072 0.0687 0.1563
Schistosoma mansoni glutamate receptor AMPA 0.0039 0.0329 0.066
Schistosoma mansoni hypothetical protein 0.002 0.012 0.024
Onchocerca volvulus 0.0069 0.0658 0.2305
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0278 0.0278
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0277 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0095 0.0216
Schistosoma mansoni hypothetical protein 0.0077 0.0749 0.15
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0001 0.0001
Schistosoma mansoni acetylcholinesterase 0.0069 0.0658 0.1318
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0105 0.1051 0.1318
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0194 0.044
Echinococcus multilocularis nmda type glutamate receptor 0.0167 0.1734 0.1734
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0443 0.0443
Schistosoma mansoni alpha-glucosidase 0.0159 0.1645 0.3295
Echinococcus multilocularis expressed conserved protein 0.0105 0.105 0.105
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0687 0.1376
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0095
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0321 0.0321
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.1125 1
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Echinococcus granulosus glutamate NMDA receptor subunit 0.0039 0.0329 0.0413
Loa Loa (eye worm) RGC/RGC protein kinase 0.001 0.0012 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0039 0.0329 0.066
Onchocerca volvulus 0.0035 0.0278 0.0973
Brugia malayi metabotropic glutamate receptor type 2 0.001 0.0012 0.0027
Echinococcus multilocularis cpg binding protein 0.0034 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0188 0.1966 0.4471
Echinococcus multilocularis carboxylesterase 5A 0.041 0.4397 0.4397
Echinococcus granulosus ferritin 0.0019 0.0108 0.0135
Brugia malayi Carboxylesterase family protein 0.041 0.4397 1
Entamoeba histolytica hypothetical protein 0.0077 0.0749 0.6623
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.002 0.012 0.015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0543 0.1235
Mycobacterium ulcerans carboxylesterase, LipT 0.0069 0.0658 0.8749
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0349 0.5911
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0425 0.0966
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0194 0.1367
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0194 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0425 0.1176
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0256 0.0321
Mycobacterium tuberculosis Carboxylesterase LipT 0.0069 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.041 0.4397 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0052 0.0466 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0349 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Echinococcus granulosus dnaJ subfamily B 0.0464 0.4994 0.626
Echinococcus granulosus acetylcholinesterase 0.041 0.4397 0.5512
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0349 0.0927
Schistosoma mansoni ferritin light chain 0.0019 0.0108 0.0215
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0194 0.5081
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0321 0.0837
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.001 0.0012 0.0027
Schistosoma mansoni glutamate receptor NMDA 0.0145 0.1489 0.2982
Schistosoma mansoni hypothetical protein 0.0035 0.0287 0.0575
Echinococcus multilocularis neuroligin 0.0069 0.0658 0.0658
Brugia malayi Carboxylesterase family protein 0.0069 0.0658 0.1497
Echinococcus multilocularis receptor type guanylyl cyclase 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0192 0.2009 0.4023
Schistosoma mansoni cpg binding protein 0.0033 0.0256 0.0513
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0052 0.0466 0.6589
Schistosoma mansoni cpg binding protein 0.0034 0.0276 0.0554
Echinococcus granulosus acetylcholinesterase 0.041 0.4397 0.5512
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0095 0.0095
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.1651 0.1651
Echinococcus granulosus tar DNA binding protein 0.0072 0.0687 0.0862
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.9032
Mycobacterium ulcerans hypothetical protein 0.0027 0.0194 0.1367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0468 0.0587
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1127 0.2563
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0349 0.3026
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.3115 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.002 0.012 0.015
Schistosoma mansoni inositol monophosphatase 0.0039 0.0321 0.0643
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0687 0.0687
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0095
Schistosoma mansoni gliotactin 0.0069 0.0658 0.1318
Schistosoma mansoni apoferritin-2 0.0019 0.0108 0.0215
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0194 0.5081
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0287 0.0653
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0095 0.0095
Brugia malayi hypothetical protein 0.0077 0.0749 0.1703
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Echinococcus granulosus nmda type glutamate receptor 0.0167 0.1734 0.2173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0321 0.0837
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0653
Echinococcus multilocularis expressed protein 0.0019 0.0108 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0468 0.0587
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0278 0.0557
Schistosoma mansoni hypothetical protein 0.0035 0.0287 0.0575
Schistosoma mansoni hypothetical protein 0.0046 0.0406 0.0812
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.2471
Schistosoma mansoni hypothetical protein 0.0046 0.0406 0.0812
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.2123 0.6745
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.027
Schistosoma mansoni glutamate receptor NMDA 0.0039 0.0329 0.066
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.2009 0.6372
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0443 0.0555
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0468 0.1065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0287 0.036
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.027
Schistosoma mansoni ATP-binding cassette transporter 0.0039 0.0329 0.066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.1928 0.1928
Echinococcus granulosus para nitrobenzyl esterase 0.0069 0.0658 0.0825
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0107 0.021
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0.0012 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0671 0.1343
Schistosoma mansoni metabotropic glutamate receptor 0.001 0.0012 0.0024
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0069 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0194 0.044
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0095 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0107 0.021
Brugia malayi Inositol-1 0.0039 0.0321 0.0731
Onchocerca volvulus Glucosylceramidase homolog 0.0192 0.2009 0.7033
Echinococcus granulosus expressed protein 0.0019 0.0108 0.0135
Entamoeba histolytica hypothetical protein 0.0077 0.0749 0.6623
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0194 0.1633
Loa Loa (eye worm) hypothetical protein 0.0108 0.1081 0.2458
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0321 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0687 0.1376
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0194 0.1633
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0194 0.1367
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0095 0.1029
Schistosoma mansoni ferritin 0.0019 0.0108 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.027
Brugia malayi Glutamate receptor 2 precursor 0.0039 0.0329 0.0749
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0027
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0095 0.0119
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0349 0.3026
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0069 0.0658 0.0658
Onchocerca volvulus 0.0069 0.0658 0.2305
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.9188
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0028
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0658 0.1318
Loa Loa (eye worm) hypothetical protein 0.0069 0.0658 0.1497
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0349 0.0927
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.1125 0.1125

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 22.1 uM Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking agent [3H]-(+)-MK-801 ChEMBL. 10395489
EC50 (binding) = 22.1 uM Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking agent [3H]-(+)-MK-801 ChEMBL. 10395489
Inhibition (binding) = 15.2 % Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 20 uM ChEMBL. 16335918
Inhibition (binding) = 15.2 % Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 20 uM ChEMBL. 16335918
Inhibition (binding) = 48 % Percentage inhibition of [3H]CHA binding to adenosine A1 receptor in bovine cerebral cortical membranes at 20 uM ChEMBL. 16335918
Inhibition (binding) = 48 % Percentage inhibition of [3H]CHA binding to adenosine A1 receptor in bovine cerebral cortical membranes at 20 uM ChEMBL. 16335918
Ki (binding) = 340 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 340 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 2.6 uM Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by using [3H]- AMPA ChEMBL. 12954059
Ki (binding) = 2.6 uM Binding affinity towards ionotropic glutamate receptor AMPA in rat cortical membranes using [3H]-AMPA radioligand ChEMBL. 10395489
Ki (binding) = 2.6 uM Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by using [3H]- AMPA ChEMBL. 12954059
Ki (binding) = 2.6 uM Binding affinity towards ionotropic glutamate receptor AMPA in rat cortical membranes using [3H]-AMPA radioligand ChEMBL. 10395489
Ki (binding) = 3 uM Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA ChEMBL. 12954059
Ki (binding) = 3 uM Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand ChEMBL. 10395489
Ki (binding) = 3 uM Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determined by using [3H]- glycine/NMDA ChEMBL. 12954059
Ki (binding) = 3 uM Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortical membranes using [3H]-glycine as radioligand ChEMBL. 10395489

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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