Detailed information for compound 1348625

Basic information

Technical information
  • TDR Targets ID: 1348625
  • Name: 6-methyl-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,3 -dihydrobenzimidazole-5-sulfonamide
  • MW: 393.414 | Formula: C17H19N3O6S
  • H donors: 3 H acceptors: 3 LogP: 1.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)NS(=O)(=O)c1cc2[nH]c(=O)[nH]c2cc1C
  • InChi: 1S/C17H19N3O6S/c1-9-5-11-12(19-17(21)18-11)8-15(9)27(22,23)20-10-6-13(24-2)16(26-4)14(7-10)25-3/h5-8,20H,1-4H3,(H2,18,19,21)
  • InChiKey: YOBHPPUFORPWHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-keto-6-methyl-N-(3,4,5-trimethoxyphenyl)-1,3-dihydrobenzimidazole-5-sulfonamide
  • NCGC00134573-01
  • G801-0290

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0182 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.5675 0.5675
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0182 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0086 0.4058 0.4058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.4694 0.4694
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3505 0.4203
Onchocerca volvulus 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Echinococcus multilocularis carbonic anhydrase 0.0112 0.5675 0.5675
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0096 0.4694 0.4694
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0101 0.0121
Leishmania major cathepsin L-like protease 0.0077 0.3505 0.4203
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0182 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0182 1 1
Echinococcus granulosus FTZ F1 alpha 0.0182 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.5675 0.5675
Loa Loa (eye worm) carbonic anhydrase 3 0.0112 0.5675 0.5675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Brugia malayi hypothetical protein 0.0096 0.4694 0.4694
Onchocerca volvulus 0.0182 1 1
Brugia malayi nuclear receptor RXR 0.0086 0.4058 0.4058
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0096 0.4694 0.4694
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0022 0.0101 0.0101
Echinococcus granulosus nuclear receptor nhr 48 0.0086 0.4058 0.4058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 1 1
Brugia malayi nuclear receptor RXR 0.0096 0.4694 0.4694
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.0101 0.0101
Echinococcus multilocularis carbonic anhydrase 0.0112 0.5675 0.5675
Brugia malayi ecdysone receptor 0.0086 0.4058 0.4058
Echinococcus granulosus carbonic anhydrase II 0.0112 0.5675 0.5675
Brugia malayi nuclear hormone receptor 0.0086 0.4058 0.4058
Loa Loa (eye worm) nuclear hormone receptor 0.0086 0.4058 0.4058
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0101 0.0121
Echinococcus granulosus synaptic glycoprotein sc2 0.0022 0.0101 0.0101
Trypanosoma brucei carbonic anhydrase-like protein 0.0112 0.5675 0.6767
Brugia malayi Nuclear hormone receptor-like 1 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0022 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0086 0.4058 0.4058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.4058 0.4058
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0112 0.5675 0.5675
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0182 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0182 1 1
Echinococcus granulosus carbonic anhydrase 0.0112 0.5675 0.5675
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0112 0.5675 0.5675
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3505 0.4203
Schistosoma mansoni RAR-like nuclear receptor 0.0182 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.3505 0.4203
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0112 0.5675 0.6806
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 1 1
Schistosoma mansoni thyroid hormone receptor 0.0182 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.2488 0.2984
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0101 0.0121
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.3505 0.4203
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0182 1 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0101 0.0121
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0086 0.4058 0.4058
Plasmodium vivax polyprenol reductase, putative 0.0022 0.0101 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0086 0.4058 0.4058
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.0101 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0182 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0086 0.4058 0.4058
Brugia malayi nuclear receptor NHR-88 0.0182 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0182 1 1
Onchocerca volvulus 0.0022 0.0101 0.0101
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0101 0.0121
Schistosoma mansoni coup transcription factor 0.0182 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 1 1
Leishmania major cathepsin L-like protease 0.0077 0.3505 0.4203
Loa Loa (eye worm) hypothetical protein 0.0096 0.4694 0.4694
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0086 0.4058 0.4058
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0182 1 1
Echinococcus granulosus carbonic anhydrase 0.0112 0.5675 0.5675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0182 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.5675 0.5675
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0155 0.8338 1
Plasmodium falciparum carbonic anhydrase 0.0112 0.5675 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.8338 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0112 0.5675 0.5675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0182 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.8338 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0182 1 1
Brugia malayi conserved hypotetical protein 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0022 0.0101 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0112 0.5675 0.5675
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0086 0.4058 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0182 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0155 0.8338 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Schistosoma mansoni nuclear hormone receptor 0.0086 0.4058 0.4058
Echinococcus multilocularis ecdysone induced protein 78C 0.0182 1 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.0101 0.0121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0096 0.4694 0.4694
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.5675 0.5675
Entamoeba histolytica hypothetical protein 0.0022 0.0101 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0101 0.0101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0182 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.5675 0.5675
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0112 0.5675 0.5675
Echinococcus multilocularis synaptic glycoprotein sc2 0.0022 0.0101 0.0101
Schistosoma mansoni zinc finger protein 0.0086 0.4058 0.4058
Leishmania major cathepsin L-like protease 0.0077 0.3505 0.4203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 1 1
Brugia malayi hypothetical protein 0.0086 0.4058 0.4058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.3092 0.3709
Echinococcus multilocularis carbonic anhydrase II 0.0112 0.5675 0.5675
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0101 0.0178
Plasmodium falciparum polyprenol reductase, putative 0.0022 0.0101 0.0178
Schistosoma mansoni nuclear receptor 0.0086 0.4058 0.4058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0096 0.4694 0.4694
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Brugia malayi nuclear receptor NHR-67 0.0086 0.4058 0.4058
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.5675 0.5675
Brugia malayi nuclear hormone receptor family member odr-7 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0112 0.5675 0.5675
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0112 0.5675 0.5675
Onchocerca volvulus Bile acid receptor homolog 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Schistosoma mansoni carbonic anhydrase 0.0112 0.5675 0.5675
Brugia malayi Nuclear hormone receptor E75 0.0086 0.4058 0.4058
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0101 0.0121
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0022 0.0101 0.0121
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0182 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0182 1 1
Leishmania major carbonic anhydrase-like protein 0.0112 0.5675 0.6806
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0182 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0182 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.4694 0.4694
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0112 0.5675 0.6806
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0182 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0182 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0182 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0086 0.4058 0.4058
Brugia malayi Synaptic glycoprotein SC2 0.0022 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0096 0.4694 0.4694
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0155 0.8338 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0182 1 1
Brugia malayi nuclear hormone receptor 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.4694 0.4694
Schistosoma mansoni nuclear hormone receptor 0.0086 0.4058 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0182 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.4058 0.4058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Mycobacterium ulcerans hypothetical protein 0.0155 0.8338 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Schistosoma mansoni nuclear receptor 0.0086 0.4058 0.4058
Brugia malayi tailless protein 0.0086 0.4058 0.4058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0182 1 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.8338 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.5675 0.5675
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Brugia malayi hypothetical protein 0.0086 0.4058 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0182 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0182 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0086 0.4058 0.4058
Onchocerca volvulus Protein ultraspiracle homolog 0.0182 1 1
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.4694 0.4694
Echinococcus granulosus carbonic anhydrase 0.0112 0.5675 0.5675
Brugia malayi Nuclear hormone receptor E75 0.0086 0.4058 0.4058
Echinococcus granulosus ecdysone induced protein 78C 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0086 0.4058 0.4058
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0155 0.8338 0.8338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.4058 0.4058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0182 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0182 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0096 0.4694 0.4694
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.8338 0.8338
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Brugia malayi nuclear hormone receptor family member nhr-6 0.0086 0.4058 0.4058
Brugia malayi steroid hormone receptor 0.0182 1 1
Loa Loa (eye worm) DR-78 0.0086 0.4058 0.4058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0022 0.0101 0.0121
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0182 1 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0155 0.8338 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.8338 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.3505 0.4132
Loa Loa (eye worm) nuclear receptor NHR-67 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0112 0.5675 0.5675
Echinococcus multilocularis thyroid hormone receptor alpha 0.0182 1 1
Onchocerca volvulus 0.0086 0.4058 0.4058
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0086 0.4058 0.4058
Echinococcus multilocularis FTZ F1 alpha 0.0182 1 1
Echinococcus multilocularis carbonic anhydrase 0.0112 0.5675 0.5675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.5675 0.5675
Schistosoma mansoni retinoic acid receptor RXR 0.0182 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0086 0.4058 0.4058
Loa Loa (eye worm) hypothetical protein 0.0112 0.5675 0.5675
Brugia malayi hypothetical protein 0.0096 0.4694 0.4694
Toxoplasma gondii hypothetical protein 0.0112 0.5675 0.6806
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.4058 0.4058
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0155 0.8338 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.4694 0.4694
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0112 0.5675 0.5675
Giardia lamblia Synaptic glycoprotein SC2 0.0022 0.0101 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0182 1 1
Brugia malayi nuclear receptor NHR-88 0.0086 0.4058 0.4058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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