Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.7863 | 0.7863 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.7863 | 0.7863 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0081 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0081 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.7863 | 0.7863 |
Onchocerca volvulus | Peroxidase homolog | 0.0081 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Onchocerca volvulus | 0.0081 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.7863 | 0.7863 |
Schistosoma mansoni | peroxidasin | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0081 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.7863 | 0.7863 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.7863 | 0.7863 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0081 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0081 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.