Detailed information for compound 1348911

Basic information

Technical information
  • TDR Targets ID: 1348911
  • Name: (E)-3-(2,3-dimethoxyphenyl)-1-(3-nitrophenyl) prop-2-en-1-one
  • MW: 313.305 | Formula: C17H15NO5
  • H donors: 0 H acceptors: 3 LogP: 3.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(cccc1OC)/C=C/C(=O)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C17H15NO5/c1-22-16-8-4-5-12(17(16)23-2)9-10-15(19)13-6-3-7-14(11-13)18(20)21/h3-11H,1-2H3/b10-9+
  • InChiKey: KDFMVUZUVRTZJF-MDZDMXLPSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(2,3-dimethoxyphenyl)-1-(3-nitrophenyl)prop-2-en-1-one
  • ZINC05073034
  • CBMicro_041165
  • 3-(2,3-dimethoxyphenyl)-1-(3-nitrophenyl)-2-propen-1-one
  • MLS000684566
  • SMR000267915
  • BIM-0040958.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens neurotensin receptor 1 (high affinity) Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0177 0.0228
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0439 0.0565
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.2703 0.3484
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.4628 0.5827
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.14 0.2785
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0254 0.0254
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.776 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4963 0.4963
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0687 0.0885
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.1371 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.4628 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0177 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4963 0.6396
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0177 0.0228
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0394 0.0394
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.776 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0177 0.0228
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.5202 0.6638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Schistosoma mansoni hypothetical protein 0.0013 0.0242 0.0312
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0154 0.0154
Brugia malayi topoisomerase 0.0012 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0177 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1693 0.1693
Brugia malayi DKFZp564C0469 protein 0.0012 0.0154 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.4628 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0177 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0687 0.0885
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.14 0.2785
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0177 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0177 0.0177
Onchocerca volvulus 0.01 0.6742 0.8662
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0177 0.0228
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.5202 0.6705
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.1371 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.14 0.1624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0177 0.0228
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4963 0.6396
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.1371 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0177 0.0177
Brugia malayi hypothetical protein 0.0012 0.0154 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4963 0.6396
Trichomonas vaginalis dullard protein, putative 0.0013 0.0254 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.375 0.375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0021 0.0861 0.0861
Brugia malayi hypothetical protein 0.0012 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0019 0.0687 0.0687
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.1371 1
Schistosoma mansoni topbp1 0.0012 0.0154 0.0198
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.14 0.14
Schistosoma mansoni intermediate filament proteins 0.0033 0.1693 0.2182
Loa Loa (eye worm) hypothetical protein 0.0041 0.2332 0.2332
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4963 0.4963
Schistosoma mansoni hypothetical protein 0.0041 0.2332 0.3005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0861 0.5813
Loa Loa (eye worm) hypothetical protein 0.0012 0.0166 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.1371 0.272
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.6742 0.8689
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.14 0.2785
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0177 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0177 0.0177
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0154 0.0198
Loa Loa (eye worm) hypothetical protein 0.01 0.6742 0.6742
Echinococcus granulosus lamin 0.0033 0.1693 0.2182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0177 0.0228
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.776 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.3472 0.4363
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4963 0.6396
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0154 0.0198
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.0885
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0177 0.0228
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.14 0.1638
Echinococcus multilocularis nibrin 0.0012 0.0154 0.0198
Loa Loa (eye worm) transcription factor SMAD2 0.0144 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0177 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.4628 0.5964
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.4628 1
Trichomonas vaginalis dullard protein, putative 0.0013 0.0254 0.0132
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.4628 0.5964
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.1371 0.272
Echinococcus multilocularis lamin 0.0033 0.1693 0.2182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0177 0.0177
Brugia malayi intermediate filament protein 0.0033 0.1693 0.1693
Loa Loa (eye worm) hypothetical protein 0.0029 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0021 0.0861 0.0861
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0177 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.14 0.14
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.1371 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.14 0.2785
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0177 0.0228
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0177 0.0228
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0687 0.0687
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0013 0.0254 0.0132
Schistosoma mansoni DNA ligase IV 0.0012 0.0154 0.0198
Giardia lamblia Kinase, PLK 0.0114 0.776 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.14 0.1638
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0567 0.0567
Echinococcus granulosus GPCR family 2 0.0019 0.0687 0.0885
Echinococcus granulosus tar DNA binding protein 0.0076 0.4963 0.6396
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.776 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0166 0.0016
Schistosoma mansoni topbp1 0.0012 0.0154 0.0198
Schistosoma mansoni coup transcription factor 0.0012 0.0177 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0177 0.0177
Echinococcus multilocularis musashi 0.0033 0.1693 0.2182
Brugia malayi AMP-binding enzyme family protein 0.0029 0.14 0.14
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.3472 0.4363
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0154 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4963 0.6396
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0013 0.0254 0.0824
Echinococcus granulosus transcription factor Dp 1 0.0046 0.2703 0.3484
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0254 0.0327
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.776 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0861 0.5813
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0254 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.14 0.1527
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0254 0.0824
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0254 0.0327
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0254 0.0132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0177 0.0228
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.5202 0.6705
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.1371 0.1488
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0861 0.1581
Entamoeba histolytica hypothetical protein 0.0028 0.1371 0.16
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Echinococcus granulosus lamin dm0 0.0033 0.1693 0.2182
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0166 0.0016
Loa Loa (eye worm) hypothetical protein 0.006 0.375 0.375
Schistosoma mansoni lamin 0.0033 0.1693 0.2182
Echinococcus granulosus intermediate filament protein 0.0033 0.1693 0.2182
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0177 0.0177
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.5202 0.6638
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.1371 0.272
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.5202 0.6705
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0177 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0177 0.0228
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.14 0.1624
Brugia malayi steroid hormone receptor 0.0012 0.0177 0.0177
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0254 0.0327
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.0885
Onchocerca volvulus 0.0029 0.14 0.1638
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.14 0.1638
Brugia malayi AMP-binding enzyme family protein 0.0029 0.14 0.14
Onchocerca volvulus 0.0012 0.0177 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.0885
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.776 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1693 0.1693
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0177 0.0177
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0177 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.4628 0.5964
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Onchocerca volvulus 0.0033 0.1693 0.2024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0242 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.5202 0.6593
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.6742 0.6742
Loa Loa (eye worm) hypothetical protein 0.0015 0.0394 0.0394
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0177 0.0228
Trypanosoma brucei polo-like protein kinase 0.0114 0.776 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0177 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 1 1
Brugia malayi ecdysteroid receptor 0.0012 0.0177 0.0177
Mycobacterium leprae conserved hypothetical protein 0.0028 0.1371 0.9766
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0154
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0177 0.0228
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0687 0.0687
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0154 0.0198
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0254 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.14 0.2785
Loa Loa (eye worm) hypothetical protein 0.0021 0.0861 0.0861
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0177 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0177 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.776 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0177 0.0177
Mycobacterium ulcerans hypothetical protein 0.0029 0.14 0.2785
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.1371 0.272
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.5202 0.5202
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0861 0.5813
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.375 0.375
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.0021 0.0861 0.0861
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0254 0.0254
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.14 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0177 0.0177
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0254 0.0132
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.5202 0.5202
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.14 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0254 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0177 0.0177
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0254 0.0824
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.6742 0.8689
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Echinococcus granulosus nibrin 0.0012 0.0154 0.0198
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0013 0.0254 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Onchocerca volvulus 0.0033 0.1693 0.2024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.4628 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0177 0.0031
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0439 0.0565
Loa Loa (eye worm) hypothetical protein 0.0033 0.1693 0.1693
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0177 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.1371 0.16
Brugia malayi RNA binding protein 0.0076 0.4963 0.4963
Brugia malayi nuclear hormone receptor 0.0012 0.0177 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0177 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0177 0.0228
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.4628 0.5964
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.6742 0.8689
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0177 0.0177
Onchocerca volvulus 0.0013 0.0235 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0177 0.0177
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.14 0.2785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0177 0.0228
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0254 0.0327
Echinococcus multilocularis 0.0013 0.0254 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.776 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.14 0.2785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0861 0.0226
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0687 0.0885
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0177 0.0228
Echinococcus multilocularis GPCR, family 2 0.0019 0.0687 0.0885
Loa Loa (eye worm) RNA binding protein 0.0076 0.4963 0.4963
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0254 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0177 0.0177
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.776 0.776
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.776 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0166 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.4628 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0177 0.0177
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0177 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0687 0.0885
Echinococcus multilocularis lamin dm0 0.0033 0.1693 0.2182
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.14 0.1527
Brugia malayi AMP-binding enzyme family protein 0.0029 0.14 0.14
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0177 0.0228
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.5202 0.6638
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0687 0.0687
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4963 0.4963
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0177 0.0177
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.375 0.375
Trichomonas vaginalis dullard protein, putative 0.0013 0.0254 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0254 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0019 0.0687 0.0885
Schistosoma mansoni lamin 0.0033 0.1693 0.2182
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0254 0.0132
Brugia malayi nuclear receptor NHR-88 0.0012 0.0177 0.0177
Brugia malayi TAR-binding protein 0.0076 0.4963 0.4963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.5202 0.6638
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.1371 0.1548
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.776 0.776
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0032 0.1649 0.1649
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0177 0.0228
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0177 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.14 0.1527
Schistosoma mansoni kinase 0.0058 0.3584 0.4619
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4963 0.6396
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1693 0.1693
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 9.39 uM PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.7686 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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