Detailed information for compound 1349132

Basic information

Technical information
  • TDR Targets ID: 1349132
  • Name: N-(3-chloro-4-methoxyphenyl)-2-(6-morpholin-4 -ylsulfonyl-2-oxo-3,4-dihydroquinolin-1-yl)ac etamide
  • MW: 493.96 | Formula: C22H24ClN3O6S
  • H donors: 1 H acceptors: 4 LogP: 1.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)NC(=O)CN1C(=O)CCc2c1ccc(c2)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C22H24ClN3O6S/c1-31-20-6-3-16(13-18(20)23)24-21(27)14-26-19-5-4-17(12-15(19)2-7-22(26)28)33(29,30)25-8-10-32-11-9-25/h3-6,12-13H,2,7-11,14H2,1H3,(H,24,27)
  • InChiKey: YDAZVEQEZHUAGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chloro-4-methoxy-phenyl)-2-(6-morpholinosulfonyl-2-oxo-3,4-dihydroquinolin-1-yl)acetamide
  • N-(3-chloro-4-methoxyphenyl)-2-(6-morpholinosulfonyl-2-oxo-3,4-dihydroquinolin-1-yl)acetamide
  • N-(3-chloro-4-methoxy-phenyl)-2-(2-keto-6-morpholinosulfonyl-3,4-dihydroquinolin-1-yl)acetamide
  • N-(3-chloro-4-methoxy-phenyl)-2-(6-morpholin-4-ylsulfonyl-2-oxo-3,4-dihydroquinolin-1-yl)ethanamide
  • G406-1325
  • NCGC00130919-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi follicle stimulating hormone receptor 0.0027 0.1581 0.1581
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi neuropeptide F receptor 0.0027 0.1581 0.1581
Echinococcus granulosus lamin 0.0033 0.2561 0.1163
Brugia malayi AKH receptor 0.0027 0.1581 0.1581
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Onchocerca volvulus 0.0033 0.2561 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.1581 0.1581
Brugia malayi sulfakinin receptor protein 0.0027 0.1581 0.1581
Brugia malayi TAR-binding protein 0.0076 1 1
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Echinococcus multilocularis lamin dm0 0.0033 0.2561 0.1163
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi putative neuropeptide receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Dopamine receptor protein 1 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.2561 0.2561
Schistosoma mansoni intermediate filament proteins 0.0033 0.2561 0.1163
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi RE15519p 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Serotonin receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Melatonin receptor type 1A 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Schistosoma mansoni lamin 0.0033 0.2561 0.1163
Brugia malayi Dopamine receptor protein 2 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi intermediate filament protein 0.0033 0.2561 0.2561
Brugia malayi G protein-coupled receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi neuropeptide F receptor 0.0027 0.1581 0.1581
Brugia malayi ORL1-like opioid receptor 0.0027 0.1581 0.1581
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi Serotonin receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.1581 0.1581
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.1581 0.1581
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Brugia malayi Dopamine receptor 0.0027 0.1581 0.1581
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Echinococcus multilocularis lamin 0.0033 0.2561 0.1163
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Echinococcus granulosus lamin dm0 0.0033 0.2561 0.1163
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi G-protein coupled receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi GnHR receptor homolog 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.1581 0.1581
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.1581 0.1581
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Onchocerca volvulus 0.0033 0.2561 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Echinococcus granulosus intermediate filament protein 0.0033 0.2561 0.1163
Loa Loa (eye worm) hypothetical protein 0.0032 0.246 0.246
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Echinococcus multilocularis musashi 0.0033 0.2561 0.1163
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.1581 0.1581
Brugia malayi larval opioid receptor 0.0027 0.1581 0.1581
Loa Loa (eye worm) intermediate filament protein 0.0033 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Schistosoma mansoni lamin 0.0033 0.2561 0.1163
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.2561 0.2561
Loa Loa (eye worm) hypothetical protein 0.0027 0.1581 0.1581
Loa Loa (eye worm) hypothetical protein 0.0033 0.2561 0.2561
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.1581 0.1581
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.1581 0.1581
Brugia malayi G-protein coupled receptor 0.0027 0.1581 0.1581

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.