Detailed information for compound 1349184

Basic information

Technical information
  • TDR Targets ID: 1349184
  • Name: 2-chloro-5-[(1,3-dioxo-2-phenylinden-2-yl)ami no]benzoic acid
  • MW: 391.804 | Formula: C22H14ClNO4
  • H donors: 2 H acceptors: 4 LogP: 4.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc(ccc1Cl)NC1(c2ccccc2)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C22H14ClNO4/c23-18-11-10-14(12-17(18)21(27)28)24-22(13-6-2-1-3-7-13)19(25)15-8-4-5-9-16(15)20(22)26/h1-12,24H,(H,27,28)
  • InChiKey: OMZDAAANGIUQRZ-UHFFFAOYSA-N  


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Synonyms

  • 2-chloro-5-[(1,3-dioxo-2-phenyl-indan-2-yl)amino]benzoic acid
  • 2-chloro-5-[(1,3-dioxo-2-phenyl-2-indanyl)amino]benzoic acid
  • 2-chloro-5-[(1,3-diketo-2-phenyl-indan-2-yl)amino]benzoic acid
  • 2-chloro-5-[(1,3-dioxo-2-phenyl-inden-2-yl)amino]benzoic acid
  • E938-0099
  • NCGC00126338-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi p450 reductase, putative 0.0331 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0524 0.0633
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0038 0.0524 0.0524
Trichomonas vaginalis sulfite reductase, putative 0.0331 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0713 0.0861
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0712 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0713 0.0713
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0713 0.0861
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0331 1 1
Brugia malayi FAD binding domain containing protein 0.0204 0.5911 0.5901
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0127 0.3399 0.3033
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.1773 0.1754
Loa Loa (eye worm) glutaminase 2 0.033 0.9971 0.9971
Schistosoma mansoni glutaminase 0.033 0.9971 0.9971
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0234 0.0234
Entamoeba histolytica type A flavoprotein, putative 0.0127 0.3399 1
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.1512
Mycobacterium tuberculosis Possible oxygenase 0.0038 0.0524 0.0633
Plasmodium vivax hypothetical protein, conserved 0.0127 0.3399 0.3399
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.1512
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0331 1 1
Plasmodium falciparum ferredoxin--NADP reductase 0.0038 0.0524 0.0524
Entamoeba histolytica type A flavoprotein, putative 0.0127 0.3399 1
Leishmania major reductase, putative 0.0038 0.0524 0.0298
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.2 0.1981
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0038 0.0524 0.0503
Onchocerca volvulus 0.0043 0.0713 1
Leishmania major hypothetical protein, conserved 0.0043 0.0713 0.0491
Plasmodium falciparum nitric oxide synthase, putative 0.0331 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0234 0.0282
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0331 1 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0331 1 1
Loa Loa (eye worm) flavodoxin family protein 0.0127 0.3399 0.3399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Entamoeba histolytica type A flavoprotein, putative 0.0127 0.3399 1
Leishmania major NADH-dependent fumarate reductase, putative 0.0038 0.0524 0.0298
Leishmania major NADH-cytochrome b5 reductase, putative 0.0038 0.0524 0.0298
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0331 1 1
Leishmania major hypothetical protein, conserved 0.0127 0.3399 0.3241
Onchocerca volvulus 0.0043 0.0713 1
Echinococcus multilocularis methionine synthase reductase 0.0204 0.5911 0.5901
Mycobacterium ulcerans monooxygenase 0.0038 0.0524 0.0524
Chlamydia trachomatis sulfite reductase 0.0204 0.5911 1
Brugia malayi diaphorase 0.0038 0.0524 0.0503
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0713 0.0713
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0127 0.3399 0.2891
Entamoeba histolytica type A flavoprotein, putative 0.0127 0.3399 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0234 0.0211
Leishmania major nitrate reductase, putative 0.0038 0.0524 0.0298
Mycobacterium tuberculosis Conserved protein 0.0043 0.0713 0.0861
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0713 0.0199
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0038 0.0524 0.0503
Leishmania major cytochrome-b5 reductase, putative 0.0038 0.0524 0.0298
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0713 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0713 0.0199
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0713 0.0713
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0234 0.0234
Brugia malayi hypothetical protein 0.0043 0.0712 0.0691
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0127 0.3399 0.3399
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Mycobacterium ulcerans hypothetical protein 0.0029 0.0234 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0713 0.0692
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0234
Brugia malayi flavodoxin family protein 0.0127 0.3399 0.3383
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0713 0.0861
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0331 1 1
Leishmania major cytochrome-b5 reductase, putative 0.0038 0.0524 0.0298
Schistosoma mansoni cytochrome B5 0.0038 0.0524 0.0503
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0713 0.0692
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0293 0.8785 0.8691
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0038 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Schistosoma mansoni diflavin oxidoreductase 0.0164 0.4614 0.4601
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.2 0.1981
Mycobacterium tuberculosis Conserved protein 0.0043 0.0713 0.0861
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.1512
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.1773 0.1754
Toxoplasma gondii flavodoxin domain-containing protein 0.0164 0.4614 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0331 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0127 0.3399 1
Schistosoma mansoni cytochrome P450 reductase 0.0331 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0713 0.0861
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0234
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0234 0.0234
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0331 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0234 0.0282
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0234 0.0234
Schistosoma mansoni NADPH flavin oxidoreductase 0.0167 0.4695 0.4683
Loa Loa (eye worm) diaphorase 0.0038 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.0234
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.1773 0.1754
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0234 0.0234
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.1773 0.1773
Echinococcus multilocularis cytochrome b5 reductase 4 0.0038 0.0524 0.0503
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0331 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0234 0.0211
Mycobacterium tuberculosis Conserved protein 0.0043 0.0713 0.0861
Mycobacterium ulcerans hypothetical protein 0.0043 0.0713 0.0713
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0127 0.3399 0.2891
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0331 1 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0204 0.5911 0.5901
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0331 1 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0331 1 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0038 0.0524 0.0633
Toxoplasma gondii flavodoxin domain-containing protein 0.0164 0.4614 1
Giardia lamblia Hypothetical protein 0.0293 0.8785 1
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0038 0.0524 0.0633
Toxoplasma gondii ABC1 family protein 0.0043 0.0713 0.0462
Plasmodium vivax flavodoxin domain containing protein 0.0293 0.8785 0.8785
Mycobacterium tuberculosis Probable monooxygenase 0.0038 0.0524 0.0633
Onchocerca volvulus 0.0038 0.0524 0.6062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0713 0.0692
Leishmania major NADH-dependent fumarate reductase-like protein 0.0038 0.0524 0.0298
Mycobacterium ulcerans oxygenase 0.0038 0.0524 0.0524
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0127 0.3399 0.3033
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0127 0.3399 0.3033
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.1512
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0713 0.0713
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0234 0.0234
Onchocerca volvulus 0.0043 0.0713 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0713 0.0713
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0713 1
Leishmania major cytochrome P450 reductase, putative 0.0293 0.8785 0.8756
Leishmania major oxidoreductase-like protein 0.0038 0.0524 0.0298
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0038 0.0524 0.0887
Echinococcus granulosus cytochrome b5 reductase 4 0.0038 0.0524 0.0503
Brugia malayi beta-lactamase 0.0043 0.0713 0.0692
Loa Loa (eye worm) hypothetical protein 0.0043 0.0713 0.0713
Trichomonas vaginalis glutaminase, putative 0.033 0.9971 0.9969
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0331 1 1
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0038 0.0524 0.0503
Mycobacterium ulcerans glutaminase 0.033 0.9971 0.9971
Brugia malayi glutaminase DH11.1 0.033 0.9971 0.9971
Loa Loa (eye worm) hypothetical protein 0.0066 0.1448 0.1448
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0713 0.0861
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0331 1 1
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0038 0.0524 0.0524
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0127 0.3399 0.2891
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0127 0.3399 0.2891
Brugia malayi FAD binding domain containing protein 0.0331 1 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0038 0.0524 0.0298
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0038 0.0524 0.0524
Brugia malayi beta-lactamase family protein 0.0043 0.0713 0.0692
Brugia malayi beta-lactamase family protein 0.0043 0.0713 0.0692
Treponema pallidum flavodoxin 0.0127 0.3399 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0713 0.0861
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0038 0.0524 0.0524
Loa Loa (eye worm) FAD binding domain-containing protein 0.0331 1 1
Echinococcus granulosus methionine synthase reductase 0.0204 0.5911 0.5901
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0713 0.0692
Leishmania major p450 reductase, putative 0.0331 1 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0713 0.0713
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0331 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0713 0.0861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0713 0.0692
Giardia lamblia Nitric oxide synthase, inducible 0.0293 0.8785 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0038 0.0524 0.0503
Mycobacterium ulcerans oxidoreductase 0.0038 0.0524 0.0524
Loa Loa (eye worm) FAD binding domain-containing protein 0.0204 0.5911 0.5911
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0234 0.0234
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0712 0.0691
Leishmania major NADH-cytochrome b5 reductase, putative 0.0038 0.0524 0.0298
Mycobacterium leprae Probable lipase LipE 0.0043 0.0713 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0127 0.3399 0.3399
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0127 0.3399 0.3033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.1611 0.0967
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0038 0.0524 0.0503
Mycobacterium ulcerans electron transfer protein FdxB 0.0038 0.0524 0.0524
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0038 0.0524 0.0524
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0712 0.0691
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0023
Loa Loa (eye worm) glutaminase 0.033 0.9971 0.9971
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.1611 0.0967
Loa Loa (eye worm) beta-lactamase 0.0043 0.0713 0.0713
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.8281 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0234 0.0211
Schistosoma mansoni hypothetical protein 0.0043 0.0712 0.0691

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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