Detailed information for compound 1349611

Basic information

Technical information
  • TDR Targets ID: 1349611
  • Name: N-tert-butyl-2-oxo-8-prop-2-enylchromene-3-ca rboxamide
  • MW: 285.338 | Formula: C17H19NO3
  • H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCc1cccc2c1oc(=O)c(c2)C(=O)NC(C)(C)C
  • InChi: 1S/C17H19NO3/c1-5-7-11-8-6-9-12-10-13(16(20)21-14(11)12)15(19)18-17(2,3)4/h5-6,8-10H,1,7H2,2-4H3,(H,18,19)
  • InChiKey: BJCOQPDQHMYFER-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-allyl-N-tert-butyl-2-oxo-chromene-3-carboxamide
  • 8-allyl-N-tert-butyl-2-oxo-3-chromenecarboxamide
  • 8-allyl-N-tert-butyl-2-keto-chromene-3-carboxamide
  • N-tert-butyl-2-oxo-8-prop-2-enyl-chromene-3-carboxamide
  • 8-allyl-N-(tert-butyl)-2-oxo-2H-chromene-3-carboxamide
  • MLS000066569
  • SMR000082411
  • ZINC01068826
  • T5576035

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DR-78 0.0015 0.0097 0.0228
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0253 0.331 0.782
Brugia malayi nuclear hormone receptor 0.0031 0.0316 0.0746
Schistosoma mansoni hypothetical protein 0.0173 0.2231 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0316 0.0746
Echinococcus multilocularis expressed protein 0.0008 0.0012 0.0012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1829 0.1829
Echinococcus granulosus dnaJ subfamily B 0.0408 0.5388 0.5388
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0316 0.0316
Echinococcus multilocularis sentrin specific protease 1 0.0027 0.0268 0.0268
Echinococcus granulosus sentrin specific protease 8 0.0027 0.0268 0.0268
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0261 0.0379
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0119 0.0178
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0017 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0316 0.0316
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0123 0.0123
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0119 0.0169
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0133 0.1694 0.4001
Mycobacterium leprae putative cytochrome p450 0.0016 0.0119 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.0751 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0832 0.1966
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.012 0.012
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0322 0.4233 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.136 0.136
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0261 0.0414
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1853 0.4379
Onchocerca volvulus 0.0029 0.0286 0.0847
Schistosoma mansoni nuclear receptor 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0119 0.0116
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0316 0.0316
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0097 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0346 0.0346
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0097 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.012 0.0284
Trypanosoma brucei SUMO1/Ulp2, putative 0.0027 0.0268 0.0397
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0261 0.0618
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.042 0.0396
Schistosoma mansoni Smad4 0.0017 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.006 0.0705 0.0705
Echinococcus granulosus ferritin 0.0008 0.0012 0.0012
Echinococcus multilocularis GPCR, family 2 0.008 0.0979 0.0979
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0377 0.089
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0377 0.0606
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1995 0.2152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0316 0.0316
Brugia malayi tailless protein 0.0015 0.0097 0.0228
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0455 0.6026 0.6527
Leishmania major cytochrome p450-like protein 0.0027 0.0261 0.0379
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0377 0.089
Loa Loa (eye worm) acetyltransferase 0.0143 0.1829 0.4321
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0119 0.0116
Loa Loa (eye worm) Ulp1 protease 0.0027 0.0268 0.0634
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0119 0.0116
Toxoplasma gondii ABC1 family protein 0.0109 0.136 0.2235
Loa Loa (eye worm) hypothetical protein 0.009 0.1112 0.2627
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0012 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.2955 0.6981
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.046 0.0906
Brugia malayi nuclear hormone receptor 0.0015 0.0097 0.0228
Toxoplasma gondii hypothetical protein 0.0048 0.0542 0.0873
Brugia malayi hypothetical protein 0.0015 0.0097 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.1522 0.2511
Mycobacterium ulcerans lipase LipD 0.0109 0.136 0.2242
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0017 0.0041
Onchocerca volvulus Huntingtin homolog 0.0133 0.1694 0.5017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0634
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0377 0.0396
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0121 0.1522 0.2511
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0377 0.089
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0097 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0377 0.089
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0316 0.0746
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0427 0.0427
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0316 0.0316
Schistosoma mansoni ferritin light chain 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0133 0.1694 0.4001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0377 0.0685
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0634
Brugia malayi hypothetical protein 0.0009 0.0017 0.0041
Onchocerca volvulus 0.0033 0.0346 0.1025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0316 0.0316
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0455 0.6026 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1112 0.2627
Schistosoma mansoni apoferritin-2 0.0008 0.0012 0.0012
Echinococcus granulosus expressed conserved protein 0.0286 0.3743 0.3743
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0097 0.0097
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0027 0.0268 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1853 0.1853
Onchocerca volvulus 0.0109 0.136 0.4029
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0377 0.0598
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0017 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0121 0.1522 0.2511
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0017 0.0017
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0027 0.0268 0.0418
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.012 0.012
Loa Loa (eye worm) Ulp1 protease 0.0027 0.0268 0.0634
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0316 0.0316
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0705 0.1667
Onchocerca volvulus 0.0015 0.0097 0.0286
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.5388 0.5388
Mycobacterium ulcerans peptide deformylase 0.0455 0.6026 1
Schistosoma mansoni ferritin 0.0008 0.0012 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.136 0.3303
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0027 0.0268 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.1522 0.2511
Leishmania major hypothetical protein, conserved 0.0109 0.136 0.3303
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0832 0.089
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0119 0.0116
Leishmania major polypeptide deformylase-like protein, putative 0.0174 0.2238 0.5639
Brugia malayi nuclear receptor NHR-88 0.0015 0.0097 0.0228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0694 0.1126
Echinococcus granulosus smad 0.0017 0.0123 0.0123
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0377 0.0188
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0316 0.0316
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0119 0.0116
Brugia malayi hypothetical protein 0.0016 0.012 0.0284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1853 0.4379
Brugia malayi hypothetical protein 0.0133 0.1694 0.4001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0316 0.0746
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0123 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0316 0.0746
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0316 0.0746
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0316 0.0316
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.136 0.2242
Brugia malayi nuclear receptor RXR 0.0015 0.0097 0.0228
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.3876 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0316 0.0316
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0316 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0119 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.008 0.0979 0.0979
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3876 1
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0413
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0097 0.0097
Loa Loa (eye worm) nuclear factor I 0.0009 0.0024 0.0056
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0119 0.0178
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0119 0.0178
Onchocerca volvulus 0.0031 0.0316 0.0936
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0017 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0109 0.136 0.1463
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.1522 0.3263
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0455 0.6026 1
Brugia malayi MH2 domain containing protein 0.0017 0.0123 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0316 0.0746
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0119 0.0178
Echinococcus multilocularis sentrin specific protease 8 0.0027 0.0268 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0121 0.1522 0.3596
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0377 0.0377
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0027 0.0268 0.0761
Brugia malayi Cytochrome P450 family protein 0.0058 0.0678 0.1601
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0261 0.0618
Echinococcus multilocularis geminin 0.0525 0.6957 0.6957
Brugia malayi MH1 domain containing protein 0.0009 0.0024 0.0056
Brugia malayi MH1 domain containing protein 0.0009 0.0024 0.0056
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0377 0.0598
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0377 0.0606
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.3166 0.748
Onchocerca volvulus 0.0109 0.136 0.4029
Brugia malayi DnaJ domain containing protein 0.006 0.0705 0.1667
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0015 0.0097 0.0228
Onchocerca volvulus 0.0109 0.136 0.4029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1782 0.4426
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0017 0.0041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.012 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1853 0.1853
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0097 0.0228
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0979 0.0979
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0678 0.1601
Loa Loa (eye worm) histone methyltransferase 0.001 0.0036 0.0085
Echinococcus multilocularis cpg binding protein 0.003 0.0308 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4233 0.4233
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0316 0.0316
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0705 0.2061
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0123 0.0123
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0377 0.0282
Mycobacterium ulcerans beta-lactamase 0.0109 0.136 0.2242
Brugia malayi Calcitonin receptor-like protein seb-1 0.0253 0.331 0.782
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0468 0.1354
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0316 0.0746
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0261 0.0618
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0041
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.136 0.2242
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0017 0.0017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0316 0.0316
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0316 0.0316
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0377 0.0396
Schistosoma mansoni hypothetical protein 0.0016 0.0119 0.0119
Trichomonas vaginalis set domain proteins, putative 0.0258 0.3376 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0173 0.2231 0.5271
Onchocerca volvulus 0.0121 0.1522 0.4509
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0377 0.0606
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0377 0.1084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1782 0.4426
Brugia malayi hypothetical protein 0.0009 0.0017 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0427 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0346 0.0346
Onchocerca volvulus Huntingtin homolog 0.0133 0.1694 0.5017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0468 0.0749
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0027 0.0268 0.0634
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0027 0.0268 0.0634
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0119 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0468 0.0468
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0027 0.0268 0.0634
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0377 0.089
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0121 0.1522 0.3596
Schistosoma mansoni dep domain containing protein 0.0009 0.0017 0.0017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0832 0.1364
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1775 0.1775
Brugia malayi beta-lactamase family protein 0.0109 0.136 0.3213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1853 0.1853
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0097 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0316 0.0746
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0284
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0316 0.0936
Trypanosoma brucei Polypeptide deformylase 1 0.0174 0.2238 0.5639
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0377 0.0606
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Schistosoma mansoni ferritin 0.0008 0.0012 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.1522 0.3734
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0012
Schistosoma mansoni smad1 5 8 and 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.136 0.1463
Chlamydia trachomatis peptide deformylase 0.0455 0.6026 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1853 0.1853
Brugia malayi hypothetical protein 0.0016 0.012 0.0284
Brugia malayi RNA recognition motif domain containing protein 0.0322 0.4233 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.3166 0.748
Schistosoma mansoni hypothetical protein 0.0525 0.6957 0.6957
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1853 0.1853
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0832 0.1898
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0979 0.0979
Treponema pallidum polypeptide deformylase (def) 0.0455 0.6026 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0286 0.0675
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0979 0.2314
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0377 0.089
Brugia malayi Cytochrome P450 family protein 0.0016 0.0119 0.0281
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Loa Loa (eye worm) hypothetical protein 0.009 0.1112 0.2627
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0693 0.9226 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0119 0.0178
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.009 0.1112 0.2627
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.1522 0.1639
Onchocerca volvulus 0.0009 0.0017 0.0051
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0027 0.0268 0.0397
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0034 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0468 0.1354
Brugia malayi Cytochrome P450 family protein 0.0027 0.0261 0.0618
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0097 0.0097
Trypanosoma brucei Peptide deformylase 2 0.0174 0.2238 0.5639
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0377 0.0606
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1829 0.4321
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1782 0.4426
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.136 0.3213
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0027 0.0268 0.0418
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0097 0.0228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0121 0.1522 0.2511
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0308
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1853 0.1853
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0316 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.136 0.3303
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0119 0.0178
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.012 0.012
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0377 0.0396
Brugia malayi RNA binding protein 0.0322 0.4233 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0321 0.0321
Echinococcus granulosus GPCR family 2 0.008 0.0979 0.0979
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.046 0.0906
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0035 0.0377 0.0606
Schistosoma mansoni smad 0.0017 0.0123 0.0123
Echinococcus granulosus sentrin specific protease 7 0.0313 0.4111 0.4111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.1046 0.1122
Loa Loa (eye worm) hypothetical protein 0.0121 0.1522 0.3596
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0097 0.0228
Loa Loa (eye worm) hypothetical protein 0.0035 0.0377 0.089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0377 0.089
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.136 0.1463
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0377 0.0377
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.008 0.0979 0.2314
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0377 0.1084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Onchocerca volvulus 0.0027 0.0268 0.0795
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0377 0.0606
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0097 0.0286
Mycobacterium leprae conserved hypothetical protein 0.0109 0.136 0.2242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0734 0.0734
Echinococcus multilocularis microtubule associated protein 2 0.0751 1 1
Schistosoma mansoni ferritin 0.0008 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4233 0.4233
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0119 0.0178
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Mycobacterium leprae Probable lipase LipE 0.0109 0.136 0.2242
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0121 0.1522 0.3596
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0316 0.0316
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0377 0.0396
Schistosoma mansoni dishevelled 0.0009 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.008 0.0979 0.0979
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0119 0.0116
Mycobacterium tuberculosis Conserved protein 0.0109 0.136 0.1463
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0705 0.0705
Brugia malayi Cytochrome P450 family protein 0.0027 0.0261 0.0618
Loa Loa (eye worm) hypothetical protein 0.0033 0.0346 0.0817
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0377 0.0685
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0316 0.0316
Echinococcus multilocularis Smad4 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0468 0.0346
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.2238 0.5639
Plasmodium falciparum peptide deformylase 0.0455 0.6026 1
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.136 0.1463
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0261 0.0379
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.1522 0.3734
Echinococcus granulosus Smad4 0.0017 0.0123 0.0123
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0119 0.0178
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0017 0.0017
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0377 0.0396
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0316 0.0936
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.3876 1
Loa Loa (eye worm) Smad1 0.0017 0.0123 0.0291
Loa Loa (eye worm) TAR-binding protein 0.0322 0.4233 1
Loa Loa (eye worm) cytochrome P450 0.0016 0.0119 0.0281
Brugia malayi hypothetical protein 0.0039 0.0427 0.1009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0316 0.0316
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0316 0.0746
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0582 0.1232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0377 0.0396
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.136 0.136
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0377 0.0685
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0346 0.0346
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0119 0.0178
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.136 0.3303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Schistosoma mansoni ferritin 0.0008 0.0012 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.1522 0.2511
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0316 0.0316
Plasmodium vivax peptide deformylase, putative 0.0455 0.6026 1
Onchocerca volvulus 0.0015 0.0097 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.136 0.1463
Schistosoma mansoni hypothetical protein 0.008 0.0979 0.0979
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0346 0.0547
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0027 0.0268 0.0397
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0413
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0377 0.0396
Onchocerca volvulus 0.0258 0.3376 1
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0413
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0316 0.0316
Entamoeba histolytica acyl-coA synthetase, putative 0.0121 0.1522 0.3263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1853 0.1853
Loa Loa (eye worm) hypothetical protein 0.0253 0.331 0.782
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0377 0.0188
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0027 0.0268 0.0418
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.2238 0.5639
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0119 0.0116
Schistosoma mansoni cytochrome P450 0.0016 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0284
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0316 0.0936
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.1522 0.3263
Schistosoma mansoni ferritin light chain 0.0008 0.0012 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.136 0.136
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0097 0.0097
Brugia malayi ecdysteroid receptor 0.0031 0.0316 0.0746
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0036 0.0036
Brugia malayi steroid hormone receptor 0.0031 0.0316 0.0746
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0377 0.0685
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Onchocerca volvulus 0.0035 0.0377 0.1116
Loa Loa (eye worm) hypothetical protein 0.009 0.1112 0.2627
Brugia malayi MH1 domain containing protein 0.0017 0.0123 0.0291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0316 0.0316
Echinococcus granulosus tar DNA binding protein 0.0322 0.4233 0.4233
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0017 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0979 0.0979
Brugia malayi Latrophilin receptor protein 2 0.008 0.0979 0.2314
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0316 0.0746
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0097 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0121 0.1522 0.3596
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0832 0.0832
Brugia malayi TAR-binding protein 0.0322 0.4233 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0027 0.0268 0.0761
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0097 0.0228
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0097 0.0097
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.046 0.0906
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.2273 0.6732
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0316 0.0746
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0012 0.0012
Brugia malayi beta-lactamase 0.0109 0.136 0.3213
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0097 0.0286
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0017 0.0017
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0377 0.0598
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0097 0.0097
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0377 0.0606
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0097 0.0228
Echinococcus granulosus expressed protein 0.0008 0.0012 0.0012
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0377 0.0685
Brugia malayi N-terminal motif family protein 0.0176 0.2273 0.5369
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0316 0.0316
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0316 0.0746
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0468 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0346 0.0346
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0284
Echinococcus granulosus geminin 0.0525 0.6957 0.6957
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0832 0.1364
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0017 0.0041
Echinococcus multilocularis expressed conserved protein 0.0286 0.3743 0.3743
Mycobacterium ulcerans hypothetical protein 0.0109 0.136 0.2242
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.2238 0.5639
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0035 0.0377 0.0606
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0316 0.0746
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0316 0.0316
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.042 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0316 0.0746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0017 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.136 0.4008
Loa Loa (eye worm) hypothetical protein 0.0109 0.136 0.3213
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0268 0.0761
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0377 0.0606
Schistosoma mansoni apoferritin-2 0.0008 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0121 0.1522 0.3596
Schistosoma mansoni hypothetical protein 0.0039 0.0427 0.0427
Plasmodium vivax SET domain protein, putative 0.0033 0.0346 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0316 0.0746
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.1522 0.2511
Trypanosoma cruzi hypothetical protein 0.0027 0.0268 0.0397
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0253 0.331 0.782
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.042 0.0264
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0427 0.0427
Brugia malayi beta-lactamase family protein 0.0109 0.136 0.3213
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0097 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.136 0.1463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0316 0.0746
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0377 0.0396
Loa Loa (eye worm) hypothetical protein 0.0009 0.0024 0.0056
Schistosoma mansoni hypothetical protein 0.008 0.0979 0.0979
Schistosoma mansoni dishevelled 0.0009 0.0017 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0316 0.0746
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0377 0.0685
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.136 0.1463
Brugia malayi ecdysone receptor 0.0015 0.0097 0.0228
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0119 0.0116
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.031 0.0324
Plasmodium vivax acyl-CoA synthetase, putative 0.009 0.1112 0.1466
Schistosoma mansoni nuclear receptor 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0119 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0316 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4233 0.4233
Brugia malayi nuclear receptor RXR 0.0016 0.012 0.0284
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0119 0.0178
Loa Loa (eye worm) hypothetical protein 0.0176 0.2273 0.5369
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0097 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0119 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.012 0.0284
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0316 0.0746
Echinococcus multilocularis 0.0016 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0634
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Toxoplasma gondii hypothetical protein 0.0455 0.6026 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0027 0.0268 0.0397
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.2238 0.5639
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0377 0.0396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0316 0.0746
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0119 0.0116
Brugia malayi cytochrome P450 0.0016 0.0119 0.0281
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.009 0.1112 0.1466
Brugia malayi conserved hypotetical protein 0.0015 0.0097 0.0228
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0316 0.0316
Brugia malayi nuclear receptor NHR-88 0.0031 0.0316 0.0746
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0097 0.0097
Brugia malayi Pre-SET motif family protein 0.0227 0.2955 0.6981
Schistosoma mansoni smad1 5 8 and 0.0017 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0243 0.3166 0.748
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Echinococcus granulosus cpg binding protein 0.003 0.0308 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4233 0.4233
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0119 0.0116
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0036 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0284
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0525 0.6957 0.6957
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0017 0.0017
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0313 0.4111 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0316 0.0746
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3876 1
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.136 0.4008
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0119 0.0178
Echinococcus granulosus sentrin specific protease 1 0.0027 0.0268 0.0268
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0377 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0316 0.0746
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0119 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.1522 0.3734
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0261 0.0379
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0119 0.0116
Echinococcus multilocularis ferritin 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0109 0.136 0.1463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.1046 0.1122
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.012 0.012
Brugia malayi Smad1 0.0017 0.0123 0.0291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.009 0.1112 0.1829
Loa Loa (eye worm) oxidoreductase 0.0035 0.0377 0.089
Trichomonas vaginalis esterase, putative 0.0109 0.136 0.4008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0316 0.0316
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0119 0.0178
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0377 0.0606
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0017 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0123 0.0291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0316 0.0316
Mycobacterium ulcerans hypothetical protein 0.0121 0.1522 0.2511
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0121 0.1522 0.1639
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.136 0.136
Onchocerca volvulus 0.0035 0.0377 0.1116
Echinococcus multilocularis tar DNA binding protein 0.0322 0.4233 0.4233
Brugia malayi DIX domain containing protein 0.0009 0.0017 0.0041
Schistosoma mansoni zinc finger protein 0.0015 0.0097 0.0097
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0832 0.0832
Schistosoma mansoni cpg binding protein 0.0029 0.0286 0.0286
Entamoeba histolytica hypothetical protein 0.0039 0.0427 0.0413
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.077 0.1818
Onchocerca volvulus 0.004 0.0439 0.1301
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.136 0.4008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0346 0.0346
Brugia malayi CXXC zinc finger family protein 0.0029 0.0286 0.0675
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0097 0.0228
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0316 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.1046 0.1122
Plasmodium falciparum acyl-CoA synthetase 0.009 0.1112 0.1466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0979 0.2314
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.136 0.1463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.1046 0.1122
Mycobacterium ulcerans hypothetical protein 0.0156 0.1995 0.3297
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0316 0.0316
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0027 0.0268 0.0761
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0123 0.0123
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0377 0.0396
Schistosoma mansoni coup transcription factor 0.0031 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0031 0.0316 0.0746
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1829 0.1829
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.1522 0.2511
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0377 0.0685
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0313 0.4111 0.4111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.136 0.3213
Echinococcus multilocularis sentrin specific protease 7 0.0313 0.4111 0.4111
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.136 0.4008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0109 0.136 0.1896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0316 0.0746
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0377 0.089
Loa Loa (eye worm) RNA binding protein 0.0322 0.4233 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0377 0.0396
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.009 0.1112 0.1194
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0119 0.0116
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0377 0.0685
Brugia malayi MH1 domain containing protein 0.0017 0.0123 0.0291
Onchocerca volvulus 0.0035 0.0377 0.1116
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0027 0.0268 0.0268
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0377 0.089
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.2231 0.5271
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0119 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0119 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0979 0.0979
Schistosoma mansoni smad1 5 8 and 0.0017 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.012 0.0284
Brugia malayi Pre-SET motif family protein 0.0033 0.0346 0.0817
Brugia malayi MH2 domain containing protein 0.0017 0.0123 0.0291
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0119 0.0178
Loa Loa (eye worm) beta-lactamase 0.0109 0.136 0.3213
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0123 0.0123
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0121 0.1522 0.2511
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0408 0.5388 0.5388
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0316 0.0746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0228
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0377 0.0685
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0017 0.0017
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0832 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0322 0.4233 0.4233
Echinococcus multilocularis smad 0.0017 0.0123 0.0123
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0119 0.0178
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.0101
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0027 0.0268 0.0634
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0097 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.136 0.4008
Brugia malayi nuclear receptor NHR-67 0.0015 0.0097 0.0228
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0119 0.0178
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0377 0.0606
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.046 0.0906

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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