Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.0035 | 0.1129 | 0.0449 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0045 | 0.192 | 0.2321 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.765 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.1732 | 0.207 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.1129 | 0.1279 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.1129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2035 | 0.2035 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1129 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.755 | 0.9865 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5636 | 0.5302 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.192 | 0.2353 |
Schistosoma mansoni | kinase | 0.0058 | 0.2983 | 0.3797 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1129 | 0.1279 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.192 | 0.192 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.765 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4484 | 0.5836 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.1362 | 0.1574 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.5721 | 0.7516 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.4181 | 0.4181 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1129 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.2252 | 0.2766 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.1129 | 0.1262 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.755 | 0.755 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.1129 | 0.1262 |
Brugia malayi | jmjC domain containing protein | 0.0045 | 0.192 | 0.1301 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5216 | 0.5216 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.1129 | 0.1129 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0479 | 0.0396 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4132 | 0.5286 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2456 | 0.2456 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.192 | 0.2353 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1362 | 0.07 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.755 | 0.9865 |
Echinococcus granulosus | peregrin | 0.0038 | 0.1362 | 0.1574 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.2252 | 0.2766 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.755 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1129 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.765 | 0.747 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.755 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.755 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.755 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3177 | 0.3177 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1796 | 0.2155 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.755 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1129 | 0.1129 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0479 | 0.0391 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0479 | 0.0391 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.755 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0292 | 0.0141 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.755 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.755 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.755 | 0.7362 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2028 | 0.1417 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1796 | 0.2155 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2268 | 0.2268 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4132 | 0.5286 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.755 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9935 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.