Detailed information for compound 1349814

Basic information

Technical information
  • TDR Targets ID: 1349814
  • Name: 1-(benzoyl)-N-[2-(1H-indol-3-yl)ethyl]-2-meth yl-1-azaspiro[4.5]dec-3-ene-2-carboxamide
  • MW: 441.565 | Formula: C28H31N3O2
  • H donors: 2 H acceptors: 2 LogP: 5.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1C2(CCCCC2)C=CC1(C)C(=O)NCCc1c[nH]c2c1cccc2)c1ccccc1
  • InChi: 1S/C28H31N3O2/c1-27(26(33)29-19-14-22-20-30-24-13-7-6-12-23(22)24)17-18-28(15-8-3-9-16-28)31(27)25(32)21-10-4-2-5-11-21/h2,4-7,10-13,17-18,20,30H,3,8-9,14-16,19H2,1H3,(H,29,33)
  • InChiKey: LBIANGDADQNXOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(1H-indol-3-yl)ethyl]-2-methyl-1-(oxo-phenylmethyl)-1-azaspiro[4.5]dec-3-ene-2-carboxamide
  • N-[2-(1H-indol-3-yl)ethyl]-2-methyl-1-phenylcarbonyl-1-azaspiro[4.5]dec-3-ene-2-carboxamide
  • SDCCGMLS-0091315.P001
  • UPCMLD08ADHK001124
  • CMLD4_000416

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0793 0.4853 0.4853
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.082 0.082
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Brugia malayi cathepsin L-like precursor 0.0545 0.3315 0.3315
Leishmania major cysteine peptidase A (CPA) 0.0793 0.4853 1
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.2597 0.172
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0183 0.1059 0.1059
Plasmodium vivax unspecified product 0.0247 0.1462 0.1062
Trypanosoma cruzi cysteine peptidase, putative 0.0793 0.4853 0.4243
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.043 0.2597 0.2597
Brugia malayi Papain family cysteine protease containing protein 0.0793 0.4853 0.4853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Toxoplasma gondii cathepsin B 0.0627 0.3824 0.7289
Trypanosoma cruzi cysteine protease, putative 0.043 0.2597 0.172
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Echinococcus multilocularis cathepsin b 0.1621 1 1
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0793 0.4853 1
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1059 0.1059
Plasmodium vivax vivapain-1 0.043 0.2597 0.4054
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0183 0.1059 0.1059
Echinococcus multilocularis cathepsin L 0.043 0.2597 0.2597
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.2597 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0183 0.1059 0.1059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3315 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Plasmodium vivax vivapain-2 0.0793 0.4853 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.1462 0.1462
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Brugia malayi MH2 domain containing protein 0.0144 0.082 0.082
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Brugia malayi Papain family cysteine protease containing protein 0.043 0.2597 0.2597
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Schistosoma mansoni cathepsin B (C01 family) 0.0183 0.1059 0.1059
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Trypanosoma cruzi cysteine peptidase, putative 0.0793 0.4853 0.4243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Entamoeba histolytica cysteine proteinase, putative 0.0793 0.4853 1
Onchocerca volvulus 0.0793 0.4853 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0627 0.3824 0.3093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0545 0.3315 0.5946
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0793 0.4853 0.4853
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0247 0.1462 0.1462
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Giardia lamblia Cathepsin B precursor 0.0627 0.3824 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.0545 0.3315 0.3315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0183 0.1059 0.1059
Trypanosoma cruzi cysteine peptidase, putative 0.0793 0.4853 0.4243
Giardia lamblia Cathepsin B precursor 0.0627 0.3824 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Loa Loa (eye worm) hypothetical protein 0.0545 0.3315 0.3315
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.0627 0.3824 0.544
Echinococcus multilocularis cysteine protease 0.0793 0.4853 0.4853
Plasmodium vivax unspecified product 0.043 0.2597 0.4054
Entamoeba histolytica cysteine protease, putative 0.0793 0.4853 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0793 0.4853 0.4853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1621 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0183 0.1059 0.1059
Onchocerca volvulus Cathepsin L homolog 0.0183 0.1059 0.2183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0183 0.1059 0.1059
Plasmodium vivax vivapain-2 0.0793 0.4853 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0793 0.4853 0.4853
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1621 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Trypanosoma cruzi cysteine proteinase, putative 0.043 0.2597 0.172
Trypanosoma cruzi cruzipain precursor, putative 0.0793 0.4853 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Brugia malayi Papain family cysteine protease containing protein 0.043 0.2597 0.2597
Brugia malayi Cathepsin L-like precursor 0.0545 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Brugia malayi fibroinase precursor 0.0183 0.1059 0.1059
Trypanosoma cruzi cruzipain precursor, putative 0.0247 0.1462 0.0451
Entamoeba histolytica cysteine proteinase 1, putative 0.043 0.2597 0.4054
Onchocerca volvulus 0.0183 0.1059 0.2183
Echinococcus granulosus cathepsin b 0.1621 1 1
Entamoeba histolytica cysteine proteinase, putative 0.043 0.2597 0.4054
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Onchocerca volvulus Cathepsin L homolog 0.0793 0.4853 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Entamoeba histolytica cysteine proteinase 2 0.043 0.2597 0.4054
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Loa Loa (eye worm) hypothetical protein 0.0793 0.4853 0.4853
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.043 0.2597 0.172
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Plasmodium falciparum cysteine proteinase falcipain 1 0.043 0.2597 0.4054
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0183 0.1059 0.1059
Onchocerca volvulus 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0627 0.3824 0.7289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Echinococcus granulosus cathepsin l1 0.0793 0.4853 0.4853
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Onchocerca volvulus 0.0545 0.3315 0.6831
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0545 0.3315 0.2523
Loa Loa (eye worm) hypothetical protein 0.0247 0.1462 0.1462
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0183 0.1059 0.1059
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1621 1 1
Loa Loa (eye worm) fibroinase 0.0793 0.4853 0.4853
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Brugia malayi Cathepsin L-like precursor 0.0793 0.4853 0.4853
Echinococcus multilocularis cathepsin L cysteine protease 0.0793 0.4853 0.4853
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Entamoeba histolytica cysteine proteinase, putative 0.0545 0.3315 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.043 0.2597 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0793 0.4853 1
Brugia malayi Cathepsin L-like precursor 0.0545 0.3315 0.3315
Echinococcus granulosus cysteine protease 0.043 0.2597 0.2597
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0793 0.4853 1
Onchocerca volvulus 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.082 0.082
Brugia malayi cathepsin F-like cysteine proteinase 0.0247 0.1462 0.1462
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0183 0.1059 0.1059
Brugia malayi cathepsin L precursor 0.0183 0.1059 0.1059
Schistosoma mansoni cathepsin F (C01 family) 0.0793 0.4853 0.4853
Loa Loa (eye worm) cathepsin B 0.0627 0.3824 0.3824
Schistosoma mansoni cathepsin S (C01 family) 0.0183 0.1059 0.1059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Echinococcus granulosus cathepsin L 0.043 0.2597 0.2597
Echinococcus multilocularis cathepsin L 0.0183 0.1059 0.1059
Plasmodium vivax vivapain-3 0.043 0.2597 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0793 0.4853 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0247 0.1462 0.1462
Schistosoma mansoni cathepsin F (C01 family) 0.0545 0.3315 0.3315
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.043 0.2597 0.2597
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0183 0.1059 0.1059
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1621 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0183 0.1059 0.1059
Echinococcus multilocularis cysteine protease 0.0793 0.4853 0.4853
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1621 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0793 0.4853 1
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.043 0.2597 0.2597
Loa Loa (eye worm) ctsf protein 0.0793 0.4853 0.4853
Trypanosoma cruzi cysteine peptidase, putative 0.0793 0.4853 0.4243
Toxoplasma gondii cathepsin CPL 0.0793 0.4853 1
Schistosoma mansoni cathepsin s 0.0247 0.1462 0.1462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Echinococcus multilocularis cathepsin b 0.1621 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0793 0.4853 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0793 0.4853 0.4853
Echinococcus granulosus cathepsin l cysteine peptidase 0.0793 0.4853 0.4853
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0793 0.4853 0.4853
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1059 0.1059
Brugia malayi Cathepsin L-like precursor 0.0247 0.1462 0.1462
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0183 0.1059 0.1059
Onchocerca volvulus 0.0793 0.4853 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0545 0.3315 0.3315
Entamoeba histolytica cysteine proteinase, putative 0.043 0.2597 0.4054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0183 0.1059 0.1059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Entamoeba histolytica cysteine proteinase, putative 0.043 0.2597 0.4054
Echinococcus granulosus cathepsin L cysteine protease 0.043 0.2597 0.2597
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0183 0.1059 0.1059
Echinococcus granulosus cathepsin b 0.1621 1 1
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0793 0.4853 1
Trypanosoma cruzi cysteine proteinase, putative 0.043 0.2597 0.172
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Onchocerca volvulus 0.0793 0.4853 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0183 0.1059 0.1059
Onchocerca volvulus 0.0793 0.4853 1
Loa Loa (eye worm) hypothetical protein 0.0183 0.1059 0.1059
Onchocerca volvulus 0.0793 0.4853 1
Echinococcus granulosus cathepsin L 0.0183 0.1059 0.1059
Entamoeba histolytica cysteine proteinase, putative 0.0793 0.4853 1
Leishmania major cathepsin L-like protease 0.0793 0.4853 1
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.1059 0.1059
Trypanosoma cruzi cysteine peptidase, putative 0.0247 0.1462 0.0451
Loa Loa (eye worm) cysteine protease 0.0793 0.4853 0.4853
Brugia malayi cathepsin L-like cysteine proteinase 0.0183 0.1059 0.1059
Brugia malayi cathepsin F-like cysteine proteinase 0.0183 0.1059 0.1059
Plasmodium falciparum cysteine proteinase falcipain 3 0.0793 0.4853 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0627 0.3824 0.3824
Loa Loa (eye worm) hypothetical protein 0.1621 1 1
Entamoeba histolytica cysteine proteinase, putative 0.043 0.2597 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0793 0.4853 1
Giardia lamblia Cathepsin B precursor 0.0627 0.3824 1
Schistosoma mansoni cathepsin C 0.0183 0.1059 0.1059
Schistosoma mansoni cathepsin F (C01 family) 0.0793 0.4853 0.4853
Entamoeba histolytica cysteine protease, putative 0.043 0.2597 0.4054
Echinococcus granulosus cathepsin l1 0.0545 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.0247 0.1462 0.1462

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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