Detailed information for compound 1349994

Basic information

Technical information
  • TDR Targets ID: 1349994
  • Name: 2-(2-chlorophenyl)-N-(5-methyl-1,2-oxazol-3-y l)quinoline-4-carboxamide
  • MW: 363.797 | Formula: C20H14ClN3O2
  • H donors: 1 H acceptors: 3 LogP: 4.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1onc(c1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1Cl
  • InChi: 1S/C20H14ClN3O2/c1-12-10-19(24-26-12)23-20(25)15-11-18(14-7-2-4-8-16(14)21)22-17-9-5-3-6-13(15)17/h2-11H,1H3,(H,23,24,25)
  • InChiKey: DFZAEKCDWHTONF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-chlorophenyl)-N-(5-methylisoxazol-3-yl)quinoline-4-carboxamide
  • 2-(2-chlorophenyl)-N-(5-methyl-3-isoxazolyl)-4-quinolinecarboxamide
  • 2-(2-chlorophenyl)-N-(5-methylisoxazol-3-yl)cinchoninamide
  • IVK/9119131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0019 0.0246 0.0246
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0088 0.5006 0.5006
Trypanosoma cruzi CYC2-like cyclin, putative 0.0101 0.5858 1
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.011 0.6492 1
Brugia malayi ecdysteroid receptor 0.002 0.0297 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Giardia lamblia Kinase, CMGC CDK 0.0043 0.188 0.2926
Plasmodium falciparum protein kinase 5 0.0043 0.188 0.2678
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.188 0.2919
Schistosoma mansoni nuclear hormone receptor 0.002 0.0297 0.0297
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.5858 0.5858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0297 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.3073 0.3073
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.188 0.188
Brugia malayi Protein kinase domain containing protein 0.0043 0.188 0.188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0297 0.0297
Mycobacterium ulcerans putative transglutaminase-like protein 0.007 0.3776 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0235 0.0235
Plasmodium vivax protein kinase Crk2 0.0043 0.188 0.2678
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0246 0.0246
Entamoeba histolytica cyclin, putative 0.0101 0.5858 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.5342 0.9119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0297 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Trypanosoma brucei polo-like protein kinase 0.0093 0.5342 0.9119
Echinococcus granulosus cyclin B3 1 0.0052 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Echinococcus granulosus Transglutaminase 0.007 0.3776 0.3776
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.188 0.321
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0087 0.4936 0.4936
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4193 0.4193
Trichomonas vaginalis cyclin B, putative 0.0101 0.5858 0.9977
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Onchocerca volvulus 0.007 0.3776 0.6256
Mycobacterium ulcerans hypothetical protein 0.007 0.3776 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0235 0.0235
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.5342 0.9082
Echinococcus granulosus tar DNA binding protein 0.0076 0.4193 0.4193
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0297 0.0297
Schistosoma mansoni cyclin B3 0.0161 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0297 0.0297
Mycobacterium tuberculosis Long conserved protein 0.007 0.3776 1
Trichomonas vaginalis cyclin B, putative 0.0052 0.2518 0.4051
Trichomonas vaginalis cyclins, putative 0.0101 0.5858 0.9977
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0235 0.0235
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.5342 0.9119
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0297 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.188 0.2919
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4193 0.4193
Trypanosoma brucei cdc2-related kinase 3 0.0043 0.188 0.321
Leishmania major DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus granulosus GPCR family 2 0.0019 0.0246 0.0246
Echinococcus multilocularis kinase protein 0.0087 0.4936 0.4936
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1765 0.1765
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.5342 0.5342
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.188 0.188
Echinococcus granulosus dna polymerase eta 0.0019 0.0235 0.0235
Mycobacterium leprae Conserved hypothetical protein 0.007 0.3776 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0297 0.0297
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0043 0.188 0.321
Entamoeba histolytica cyclin, putative 0.0052 0.2518 0.406
Brugia malayi Thioredoxin family protein 0.007 0.3776 0.3776
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0297 0.0297
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0235 0.0402
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0297 0.0297
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.188 0.321
Trypanosoma cruzi cyclin, putative 0.0101 0.5858 1
Echinococcus granulosus cyclin dependent kinase 5 0.0043 0.188 0.188
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0297 0.0297
Loa Loa (eye worm) RNA binding protein 0.0076 0.4193 0.4193
Giardia lamblia G2/mitotic-specific cyclin B 0.0101 0.5858 1
Leishmania major cyclin 0.0101 0.5858 1
Trichomonas vaginalis cyclins, putative 0.0101 0.5858 0.9977
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0297 0.0297
Brugia malayi RNA binding protein 0.0076 0.4193 0.4193
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0118 0.7021 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0297 0.0297
Giardia lamblia Kinase, CMGC CDK 0.0043 0.188 0.2926
Giardia lamblia Kinase, PLK 0.0093 0.5342 0.9082
Brugia malayi nuclear hormone receptor 0.002 0.0297 0.0297
Trichomonas vaginalis cyclins, putative 0.0061 0.3141 0.5156
Echinococcus granulosus cyclins 0.0052 0.2518 0.2518
Giardia lamblia Transglutaminase/protease, putative 0.007 0.3776 0.6297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.188 0.188
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0043 0.188 0.188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.5342 0.5342
Onchocerca volvulus 0.0101 0.5858 1
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0297 0.0297
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0297 0.0297
Mycobacterium ulcerans transglutaminase family protein 0.007 0.3776 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0246 0.0246
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis cyclin b3 0.0052 0.2518 0.2518
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0087 0.4936 0.4936
Echinococcus multilocularis Transglutaminase 0.007 0.3776 0.3776
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0246 0.0246
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.3776 1
Trichomonas vaginalis cyclin B, putative 0.0101 0.5858 0.9977
Schistosoma mansoni cyclins 0.0052 0.2518 0.2518
Trichomonas vaginalis cyclin D, putative 0.0052 0.2518 0.4051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0297 0.0297
Trypanosoma brucei cdc2-related kinase 1 0.0043 0.188 0.321
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0235 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.007 0.3776 0.3776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0297 0.0297
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4193 0.4193
Loa Loa (eye worm) hypothetical protein 0.0041 0.1765 0.1765
Toxoplasma gondii hypothetical protein 0.004 0.1654 0.2548
Giardia lamblia Hypothetical protein 0.0052 0.2518 0.406
Loa Loa (eye worm) cyclin domain-containing protein 0.0161 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0297 0.0297
Echinococcus granulosus dna polymerase kappa 0.0019 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Trypanosoma brucei mitotic cyclin 6 0.0101 0.5858 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0235 0.0623
Echinococcus granulosus cyclins 0.0052 0.2518 0.2518
Echinococcus multilocularis cyclin B 0.0101 0.5858 0.5858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0297 0.0297
Echinococcus granulosus cyclin b3 0.0052 0.2518 0.2518
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0235 0.0402
Schistosoma mansoni hypothetical protein 0.0041 0.1765 0.1765
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.2134 0.3369
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0087 0.4936 0.4936
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4193 0.4193
Giardia lamblia Cyclin A 0.0052 0.2518 0.406
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Echinococcus granulosus cyclin B 0.0101 0.5858 0.5858
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.241 0.3867
Trypanosoma cruzi cyclin 6, putative 0.0101 0.5858 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0297 0.0297
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0297 0.0297
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0297 0.0297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0049 0.2277 0.2277
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0246 0.0246
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.188 0.188
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0235 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis GPCR, family 2 0.0019 0.0246 0.0246
Trichomonas vaginalis cyclin D, putative 0.0052 0.2518 0.4051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0246 0.0246
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0161 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0297 0.0297
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.5858 0.5858
Echinococcus multilocularis dna polymerase eta 0.0019 0.0235 0.0235
Schistosoma mansoni thyroid hormone receptor 0.002 0.0297 0.0297
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0161 1 1
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0087 0.4936 0.4936
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Mycobacterium tuberculosis Hypothetical protein 0.007 0.3776 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.5342 0.9119
Brugia malayi TAR-binding protein 0.0076 0.4193 0.4193
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0297 0.0297
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.188 0.188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0297 0.0297
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0101 0.5858 0.5858
Mycobacterium tuberculosis Conserved protein 0.007 0.3776 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0297 0.0297
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0101 0.5858 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0235 0.0235
Echinococcus granulosus cyclin dependent kinase 1 0.0043 0.188 0.188
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0297 0.0297
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0297 0.0297
Trichomonas vaginalis cyclins, putative 0.0101 0.5858 0.9977
Loa Loa (eye worm) hypothetical protein 0.0019 0.0246 0.0246
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Trypanosoma cruzi cyclin, putative 0.0101 0.5858 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0297 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.2134 0.3369
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4193 0.4193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.3073 0.3073
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4193 0.4193
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4193 0.4193
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.5342 0.5342
Schistosoma mansoni coup transcription factor 0.002 0.0297 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0019 0.0246 0.0246
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0235 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.5871 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Mycobacterium ulcerans hypothetical protein 0.007 0.3776 1
Trichomonas vaginalis cyclin B, putative 0.0101 0.5858 0.9977
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.188 0.321
Brugia malayi cell division control protein 2 homolog 0.0043 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.002 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0297 0.0297
Schistosoma mansoni hypothetical protein 0.0019 0.0246 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.188 0.2919
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0235 0.0402
Brugia malayi nuclear receptor NHR-88 0.002 0.0297 0.0297
Trichomonas vaginalis cyclins, putative 0.0052 0.2518 0.4051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0297 0.0297
Echinococcus multilocularis cyclins 0.0052 0.2518 0.2518
Echinococcus multilocularis cyclin dependent kinase 0.0043 0.188 0.188
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.006 0.3073 0.3073
Echinococcus granulosus cyclins 0.0052 0.2518 0.2518
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0235 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Mycobacterium leprae Conserved hypothetical protein 0.007 0.3776 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.2518 0.4051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0246 0.0246
Trichomonas vaginalis peptide N-glycanase, putative 0.007 0.3776 0.6282
Brugia malayi Protein kinase domain containing protein 0.0088 0.5006 0.5006
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0087 0.4936 0.4936
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0297 0.0297
Trichomonas vaginalis cyclin A, putative 0.0101 0.5858 0.9977
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0297 0.0297
Entamoeba histolytica cyclin family protein 0.0052 0.2518 0.406
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0043 0.188 0.321
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0235 0.0623
Giardia lamblia Hypothetical protein 0.007 0.3776 0.6297
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0297 0.0297
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0088 0.5006 0.5006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0246 0.0246
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0043 0.188 0.2897
Schistosoma mansoni hypothetical protein 0.0019 0.0246 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0297 0.0297
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0297 0.0297
Trichomonas vaginalis cyclins, putative 0.0101 0.5858 0.9977
Plasmodium falciparum MO15-related protein kinase 0.0118 0.7021 1
Trichomonas vaginalis cyclin B, putative 0.0101 0.5858 0.9977
Schistosoma mansoni cyclin B 0.0101 0.5858 0.5858
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0297 0.0297
Echinococcus granulosus cyclin dependent kinase 0.0043 0.188 0.188
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0297 0.0297
Schistosoma mansoni thyroid hormone receptor 0.002 0.0297 0.0297
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0087 0.4936 0.4936
Leishmania major DNA polymerase eta, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis cyclin B3 1 0.0052 0.2518 0.2518
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.188 0.2926
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.5342 0.9061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0101 0.5858 0.5858
Trypanosoma brucei unspecified product 0.0019 0.0235 0.0402
Loa Loa (eye worm) hypothetical protein 0.0042 0.1808 0.1808
Entamoeba histolytica cyclin family protein 0.0052 0.2518 0.406
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0088 0.5006 0.5006
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.188 0.188
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0235 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4193 0.4193
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4193 0.4193
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.3776 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.3073 0.3073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0297 0.0297
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0235 0.0235
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0297 0.0297
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0297 0.0297
Echinococcus granulosus cyclins 0.0052 0.2518 0.2518
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.188 0.188
Echinococcus multilocularis cyclin dependent kinase 5 0.0043 0.188 0.188
Schistosoma mansoni kinase 0.0048 0.2218 0.2218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0235 0.0402
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0297 0.0297
Echinococcus multilocularis kinase protein 0.0087 0.4936 0.4936
Echinococcus granulosus FTZ F1 alpha 0.002 0.0297 0.0297
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.188 0.321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0297 0.0297
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.5342 0.5342
Schistosoma mansoni DNA polymerase eta 0.0019 0.0235 0.0235
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.5342 0.5342
Brugia malayi steroid hormone receptor 0.002 0.0297 0.0297
Plasmodium falciparum cyclin 0.0052 0.2518 0.3587
Echinococcus granulosus cyclins 0.0052 0.2518 0.2518
Trichomonas vaginalis cyclin B3, putative 0.0052 0.2518 0.4051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0297 0.0297
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.5342 0.9072

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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