Detailed information for compound 1350238

Basic information

Technical information
  • TDR Targets ID: 1350238
  • Name: 1-cyclohexyl-4-[1-[1-[(4-fluorophenyl)methyl] tetrazol-5-yl]butyl]piperazine hydrochloride
  • MW: 436.997 | Formula: C22H34ClFN6
  • H donors: 0 H acceptors: 3 LogP: 4.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nnnn1Cc1ccc(cc1)F)N1CCN(CC1)C1CCCCC1.Cl
  • InChi: 1S/C22H33FN6.ClH/c1-2-6-21(28-15-13-27(14-16-28)20-7-4-3-5-8-20)22-24-25-26-29(22)17-18-9-11-19(23)12-10-18;/h9-12,20-21H,2-8,13-17H2,1H3;1H
  • InChiKey: SFLZQGUPTCBCLR-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-cyclohexyl-4-[1-[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]butyl]piperazine hydrochloride
  • 1-cyclohexyl-4-[1-[1-(4-fluorobenzyl)tetrazol-5-yl]butyl]piperazine hydrochloride
  • 1-cyclohexyl-4-[1-[1-[(4-fluorophenyl)methyl]-1,2,3,4-tetrazol-5-yl]butyl]piperazine hydrochloride
  • 1-Cyclohexyl-4-{1-[1-(4-fluoro-benzyl)-1H-tetrazol-5-yl]-butyl}-piperazine
  • MLS000880454
  • SMR000004979
  • MLS000032945

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis heat shock protein 0.0032 0.0175 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0235 0.1021
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0015 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0235 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0209 0.0396
Plasmodium falciparum heat shock protein 90 0.0032 0.0175 0.5501
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0133
Echinococcus granulosus peroxidasin 0.0053 0.0332 0.063
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0313 1
Trichomonas vaginalis MYB, putative 0.001 0.0003 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0235 0.0378
Schistosoma mansoni brg-1 associated factor 0.0011 0.0006 0.0011
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0686 0.3036
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0164 0.4854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Giardia lamblia Grp94/Hsp90 0.0026 0.0123 0.702
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0175 0.2523
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0024 0.0082
Echinococcus multilocularis peroxidasin 0.0053 0.0332 0.0535
Plasmodium falciparum glutathione reductase 0.0038 0.0215 0.6815
Schistosoma mansoni hypothetical protein 0.034 0.2565 0.4866
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0055 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0589 0.0792
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0235 0.0378
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0175 0.5215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Plasmodium vivax endoplasmin, putative 0.0032 0.0175 0.5501
Brugia malayi hypothetical protein 0.0021 0.0087 0.0365
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0175 0.5215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0931 0.7159 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0589 0.0792
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0685 0.3031
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0235 0.0378
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0164 0.4854
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0164 0.0706
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.007 0.0286
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0133
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.1736 0.7723
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0024 0.0018
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.007 0.0133
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0055 0.0104
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0313 1
Onchocerca volvulus 0.0019 0.007 0.0286
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0175 0.0623
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0113
Echinococcus granulosus FTZ F1 alpha 0.004 0.0235 0.0445
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0664 0.0897
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0024 0.0597
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Loa Loa (eye worm) hypothetical protein 0.006 0.0387 0.1701
Echinococcus multilocularis endoplasmin 0.0026 0.0123 0.0199
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1297 1 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.007 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0006 0.0012
Echinococcus granulosus dnaJ subfamily B 0.0494 0.376 0.7134
Schistosoma mansoni cpg binding protein 0.0035 0.0192 0.0365
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0072 0.0137
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0133
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0031
Brugia malayi ecdysone receptor 0.0019 0.007 0.0286
Giardia lamblia DINP protein human, muc B family 0.0019 0.0072 0.4055
Loa Loa (eye worm) DR-78 0.0019 0.007 0.0286
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0366 0.2764 0.2746
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.0332 0.1456
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0175 0.0623
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0235 0.0445
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0848 0.376
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0123 0.01
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0589 0.0792
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0024 0.0597
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.025 0.0475
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.1672
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0072 0.1672
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.007 0.0113
Brugia malayi nuclear receptor RXR 0.0021 0.0087 0.0365
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Onchocerca volvulus Putative cubilin 0.0017 0.0055 0.022
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0024 0.125
Echinococcus granulosus heat shock protein 90 0.0032 0.0175 0.0331
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0235 0.1021
Echinococcus granulosus cpg binding protein 0.0037 0.0208 0.0394
Schistosoma mansoni hypothetical protein 0.0041 0.0238 0.0452
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0164 0.4854
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0235 0.0445
Treponema pallidum heat shock protein 90 0.0026 0.0123 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0235 0.0445
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0026 0.009
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0072 0.0327
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0332 0.1456
Leishmania major trypanothione reductase 0.0038 0.0215 0.6613
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.2118 0.9428
Onchocerca volvulus 0.0017 0.0055 0.022
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0235 0.1021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0164 0.4854
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Schistosoma mansoni coup transcription factor 0.004 0.0235 0.0445
Onchocerca volvulus 0.0053 0.0332 0.1456
Plasmodium falciparum thioredoxin reductase 0.0013 0.0024 0.0597
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0164 0.0197
Echinococcus multilocularis tumor protein p63 0.0408 0.3093 0.4982
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.4276 0.6889
Schistosoma mansoni thyroid hormone receptor 0.004 0.0235 0.0445
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0192 0.0832
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0311
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Brugia malayi Pax transcription factor protein 2 0.0233 0.1736 0.7723
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0297
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.0564
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0175 1
Echinococcus granulosus heat shock protein 0.0032 0.0175 0.0331
Brugia malayi CHE-14 protein 0.0042 0.025 0.1091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0589 0.0792
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0123 0.3439
Toxoplasma gondii thioredoxin reductase 0.0038 0.0215 0.077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0589 0.0792
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0026 0.0085
Echinococcus granulosus fibropellin Ia 0.0017 0.0055 0.0104
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2151 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0087 0.0141
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0133
Schistosoma mansoni slit 0.0017 0.0055 0.0104
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0215 0.0268
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0685 0.3031
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0006 0.0011
Trichomonas vaginalis endoplasmin, putative 0.002 0.0077 0.035
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.007 0.0113
Onchocerca volvulus 0.0299 0.2246 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0164 0.0311
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1013 0.1632
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.5271 0.8491
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0065
Brugia malayi CXXC zinc finger family protein 0.0035 0.0192 0.0832
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Schistosoma mansoni endoplasmin 0.0032 0.0175 0.0331
Brugia malayi tailless protein 0.0019 0.007 0.0286
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.0332 0.1456
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0072 0.1026
Leishmania major heat shock protein, putative 0.0013 0.0026 0.0067
Onchocerca volvulus Slit protein homolog 0.0017 0.0055 0.022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0193 0.0365
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0065
Brugia malayi ecdysteroid receptor 0.004 0.0235 0.1021
Plasmodium vivax SET domain protein, putative 0.0037 0.0209 0.6609
Brugia malayi notch-like transmembrane receptor 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0026 0.0348
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0235 0.1021
Echinococcus granulosus Protein patched homolog 1 0.0042 0.025 0.0475
Echinococcus multilocularis protein patched 0.0042 0.025 0.0403
Brugia malayi Endoplasmin precursor 0.0032 0.0175 0.0754
Onchocerca volvulus 0.0233 0.1736 0.7723
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0087 0.0166
Loa Loa (eye worm) Notch2 0.0017 0.0055 0.022
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Echinococcus granulosus protein jagged 2 0.0017 0.0055 0.0104
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0055 0.0104
Schistosoma mansoni patched 1 0.0042 0.025 0.0475
Trypanosoma brucei unspecified product 0.0019 0.0072 0.1672
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0024 0.0597
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Brugia malayi nuclear receptor NHR-67 0.0019 0.007 0.0286
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0026
Brugia malayi Delta serrate ligand family protein 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Echinococcus granulosus slit 2 protein 0.0017 0.0055 0.0104
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0175 0.5215
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0024 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0848 0.376
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0055 0.0104
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0215 0.0934
Echinococcus granulosus neural cadherin 0.0017 0.0055 0.0104
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.007 0.0133
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0235 0.1021
Schistosoma mansoni peroxidasin 0.0053 0.0332 0.063
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Echinococcus granulosus neuropeptide s receptor 0.056 0.4276 0.8112
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0026 0.066
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0123 0.0234
Brugia malayi hypothetical protein 0.0299 0.2246 1
Trichomonas vaginalis heat shock protein, putative 0.002 0.0077 0.035
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0133
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0235 0.0378
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0046
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0055 0.019
Echinococcus multilocularis protein jagged 1 0.0017 0.0055 0.0089
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.007 0.0133
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0332 0.1456
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Onchocerca volvulus 0.0019 0.007 0.0286
Plasmodium falciparum glutathione reductase 0.0013 0.0024 0.0597
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.6208 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0209 0.0747
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0235 0.0445
Onchocerca volvulus 0.0017 0.0055 0.022
Schistosoma mansoni thyroid hormone receptor 0.004 0.0235 0.0445
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0235 0.1021
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0164 0.0586
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.025 0.1091
Echinococcus multilocularis dna polymerase eta 0.0019 0.0072 0.0117
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0055 0.0104
Leishmania major DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0164 0.5161
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0387 0.0734
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.0564
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0505 0.0957
Schistosoma mansoni heat shock protein 0.0032 0.0175 0.0331
Echinococcus multilocularis protein dispatched 1 0.0048 0.0296 0.0478
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.007 0.0113
Loa Loa (eye worm) notch protein 0.0017 0.0055 0.022
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0175 0.5215
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0011
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0164 0.5161
Brugia malayi Peroxidasin 0.0053 0.0332 0.1456
Brugia malayi nuclear hormone receptor 0.0019 0.007 0.0286
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0313 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0235 0.1021
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0164 0.0265
Schistosoma mansoni cpg binding protein 0.0037 0.0208 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.0098 0.0685 0.3031
Echinococcus multilocularis protein jagged 2 0.0017 0.0055 0.0089
Plasmodium vivax glutathione reductase, putative 0.0038 0.0215 0.6815
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0215 0.6815
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0024 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0072 0.1672
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0235 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0235 0.1021
Echinococcus multilocularis geminin 0.034 0.2565 0.4132
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0123 0.01
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0026 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0235 0.1021
Onchocerca volvulus 0.0035 0.0192 0.0832
Loa Loa (eye worm) hypothetical protein 0.0098 0.0686 0.3036
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0444 0.1955
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0235 0.1021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.007 0.0113
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Schistosoma mansoni peroxidasin 0.0053 0.0332 0.063
Brugia malayi nuclear receptor NHR-88 0.004 0.0235 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0026 0.0049
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1013 0.1922
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Schistosoma mansoni hypothetical protein 0.0041 0.0238 0.0452
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0055 0.0104
Echinococcus multilocularis protein jagged 1 0.0017 0.0055 0.0089
Onchocerca volvulus 0.004 0.0235 0.1021
Brugia malayi conserved hypotetical protein 0.0019 0.007 0.0286
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1297 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0123 0.702
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0087 0.0166
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0313 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0235 0.0445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0209 0.0396
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0006 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0209 0.0396
Echinococcus multilocularis fibropellin Ia 0.0017 0.0055 0.0089
Loa Loa (eye worm) hypothetical protein 0.0122 0.0872 0.3868
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0219 0.0415
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0686 0.1301
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0313 1
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0026 0.0067
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0026 0.0042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0072 0.0068
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.007 0.0133
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0235 0.0445
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0235 0.0445
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Brugia malayi heat shock protein 90 0.0032 0.0175 0.0754
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Echinococcus granulosus endoplasmin 0.0026 0.0123 0.0234
Echinococcus granulosus microtubule associated protein 2 0.0688 0.5271 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Plasmodium falciparum thioredoxin reductase 0.0038 0.0215 0.6815
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0164 0.0265
Loa Loa (eye worm) hypothetical protein 0.0052 0.0324 0.142
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Schistosoma mansoni DNA polymerase eta 0.0019 0.0072 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0072 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Brugia malayi isocitrate dehydrogenase 0.0031 0.0164 0.0708
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0286
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0235 0.0445
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0006 0.0012
Echinococcus granulosus tumor protein p63 0.0408 0.3093 0.5868
Brugia malayi hypothetical protein 0.0053 0.0332 0.1456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0046
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0664 0.0897
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0366 0.2764 0.3753
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0164 0.0706
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0026 0.0111
Brugia malayi Hsp90 protein 0.0013 0.0026 0.009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0235 0.0445
Echinococcus multilocularis heat shock protein 90 0.0026 0.0123 0.0199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0685 0.3031
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0332 0.1456
Schistosoma mansoni septate junction protein 0.0017 0.0055 0.0104
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0332 0.1456
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0235 0.0445
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0026 0.066
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Schistosoma mansoni endoplasmin 0.0032 0.0175 0.0331
Onchocerca volvulus 0.0053 0.0332 0.1456
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0024 0.0597
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.0048
Onchocerca volvulus 0.0017 0.0055 0.022
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.007 0.0133
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0098 0.0185
Loa Loa (eye worm) hypothetical protein 0.0122 0.0872 0.3868
Onchocerca volvulus 0.006 0.0387 0.1701
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus granulosus dna polymerase eta 0.0019 0.0072 0.0137
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0011
Brugia malayi hypothetical protein 0.0032 0.0175 0.0754
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0026 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0164 0.0265
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0235 0.0445
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.007 0.0286
Onchocerca volvulus Peroxidase homolog 0.0053 0.0332 0.1456
Schistosoma mansoni hypothetical protein 0.0287 0.2156 0.409
Brugia malayi nuclear hormone receptor 0.004 0.0235 0.1021
Brugia malayi hypothetical protein 0.0019 0.007 0.0286
Echinococcus granulosus GPCR family 2 0.0031 0.0164 0.0311
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0133
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0175 0.5215
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0215 0.6613
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1297 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0072 0.0327
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1881 0.8371
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0175 0.0803
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0175 0.5215
Echinococcus granulosus dna polymerase kappa 0.0019 0.0072 0.0137
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0055 0.0089
Echinococcus multilocularis notch 0.0017 0.0055 0.0089
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0072 0.0137
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0055 0.022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0087 0.0365
Echinococcus multilocularis cpg binding protein 0.0037 0.0208 0.0334
Schistosoma mansoni heat shock protein 0.0013 0.0026 0.0049
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0098 0.0157
Echinococcus multilocularis neural cadherin 0.0017 0.0055 0.0089
Brugia malayi glutathione reductase 0.0038 0.0215 0.0934
Echinococcus multilocularis heat shock protein 90 0.0032 0.0175 0.0281
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0164 0.0311
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Echinococcus multilocularis X box binding protein 1 0.0287 0.2156 0.3473
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0706
Plasmodium vivax heat shock protein, putative 0.0013 0.0026 0.066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.0117
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0235 0.0445
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.007 0.0286
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0006 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0072 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0365
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0003 0.0002
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0235 0.1021
Onchocerca volvulus Huntingtin homolog 0.0122 0.0872 0.3868
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0164 0.0586
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0235 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0113
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0055 0.022
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0299 0.2246 1
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0311
Schistosoma mansoni hypothetical protein 0.034 0.2565 0.4866
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0164 0.0264
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0072 0.0048
Loa Loa (eye worm) endoplasmin 0.0032 0.0175 0.0754
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0313 0.1124
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0286
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0087 0.0365
Brugia malayi nuclear receptor RXR 0.0019 0.007 0.0286
Brugia malayi Blistered cuticle protein 3 0.0053 0.0332 0.1456
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0235 0.1021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0209 0.0396
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0332 0.1456
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0072 0.0297
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0072 0.1672
Loa Loa (eye worm) hypothetical protein 0.0042 0.025 0.1091
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0123 0.3439
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0072 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.1672
Echinococcus granulosus heat shock protein 90 0.0026 0.0123 0.0234
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0055 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0235 0.0445
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus granulosus expressed conserved protein 0.0092 0.064 0.1213
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0072 0.1672
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0209 0.0396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0164 0.0264
Onchocerca volvulus 0.0017 0.0055 0.022
Brugia malayi MH2 domain containing protein 0.0119 0.0848 0.376
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0235 0.1021
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0055 0.0089
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0164 0.0312
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Echinococcus granulosus protein jagged 1 0.0017 0.0055 0.0104
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Brugia malayi hypothetical protein 0.0021 0.0087 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0235 0.1021
Brugia malayi Pre-SET motif family protein 0.0037 0.0209 0.0906
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0209 0.0336
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.0067 0.0444 0.1955
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0175 0.2523
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.025 0.1154
Onchocerca volvulus 0.0053 0.0332 0.1456
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0235 0.1021
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0931 0.7159 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0215 0.0934
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0164 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0235 0.1021
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0175 0.5215
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0332 0.1456
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0164 0.0708
Echinococcus granulosus protein jagged 1 0.0017 0.0055 0.0104
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0072 0.0297
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Echinococcus multilocularis expressed conserved protein 0.0092 0.064 0.103
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0164 0.0708
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0686 0.1105
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.007 0.0286
Onchocerca volvulus 0.0287 0.2151 0.9575
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.007 0.0286
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0123 0.3439
Echinococcus granulosus delta-like protein 1 0.0017 0.0055 0.0104
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0235 0.0378
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0664 0.0768
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.007 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.056 0.4276 0.6889
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0235 0.0445
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0123 0.0139
Brugia malayi hypothetical protein 0.0122 0.0872 0.3868
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0365
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Brugia malayi hypothetical protein 0.0019 0.007 0.0286
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0589 0.0662
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0311
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0164 0.0706
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0313 1
Onchocerca volvulus 0.0017 0.0055 0.022
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0332 0.1456
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0123 0.0564
Echinococcus multilocularis GPCR, family 2 0.0031 0.0164 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0235 0.1021
Trypanosoma brucei heat shock protein, putative 0.0032 0.0175 0.5215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0164 0.0265
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.007 0.0286
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0286
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0055 0.0089
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0444 0.1597
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0235 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0365
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Leishmania major hypothetical protein, conserved 0.005 0.0313 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0235 0.0378
Onchocerca volvulus 0.0037 0.0209 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0235 0.1021
Loa Loa (eye worm) hypothetical protein 0.004 0.0235 0.1021
Brugia malayi Muscle positioning protein 4 0.0017 0.0055 0.022
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.025 0.0403
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Mycobacterium tuberculosis Probable reductase 0.0086 0.0589 0.0792
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0332 0.1456
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0164 0.4854
Brugia malayi follicle stimulating hormone receptor 0.0283 0.2118 0.9428
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi steroid hormone receptor 0.004 0.0235 0.1021
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0332 0.1456
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Echinococcus granulosus notch 0.0017 0.0055 0.0104
Schistosoma mansoni hypothetical protein 0.0041 0.0238 0.0452
Brugia malayi Cadherin domain containing protein 0.0017 0.0055 0.022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0219 0.0353
Schistosoma mansoni hypothetical protein 0.0023 0.0098 0.0185
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0175 0.0754
Schistosoma mansoni hypothetical protein 0.0041 0.0238 0.0452
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0087 0.0365
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.5271 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0072 0.1672
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.1456
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0235 0.1021
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0026 0.066
Echinococcus granulosus protein jagged 2 0.0017 0.0055 0.0104
Schistosoma mansoni cell polarity protein 0.0017 0.0055 0.0104
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0037 0.0209 0.0906
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0235 0.1021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0366 0.2764 0.276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0235 0.1021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0664 0.0897
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0055 0.022
Schistosoma mansoni notch 0.0017 0.0055 0.0104
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0072 0.0297
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0024 0.0102
Schistosoma mansoni nuclear hormone receptor 0.004 0.0235 0.0445
Brugia malayi Thioredoxin reductase 0.0038 0.0215 0.0934
Brugia malayi EGF-like domain containing protein 0.0017 0.0055 0.022
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0055 0.022
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0332 0.1456
Schistosoma mansoni hypothetical protein 0.0494 0.376 0.7134
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0209 0.0336
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0686 1
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0235 0.0445
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0175 0.5501
Schistosoma mansoni cpg binding protein 0.0037 0.0208 0.0394
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.007 0.0286
Trypanosoma brucei trypanothione reductase 0.0038 0.0215 0.6613
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.376 0.6058
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0366 0.2764 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0235 0.1021
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0055 0.0089
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0071 0.1641
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0332 0.1456
Brugia malayi Cadherin domain containing protein 0.0017 0.0055 0.022
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0365
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.0133
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.007 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1672
Brugia malayi hypothetical protein 0.005 0.0313 0.1371
Echinococcus granulosus X box binding protein 1 0.0287 0.2156 0.409
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0065
Leishmania major heat shock protein 83-1 0.0032 0.0175 0.5215
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0235 0.1021
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0175 0.5215
Schistosoma mansoni hypothetical protein 0.0067 0.0444 0.0842
Brugia malayi Pre-SET motif family protein 0.0252 0.1881 0.8371
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.022
Plasmodium falciparum endoplasmin, putative 0.002 0.0077 0.233
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0698 0.1323
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0164 0.0312
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0235 0.1021
Onchocerca volvulus Peroxidase homolog 0.0053 0.0332 0.1456
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0065
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0286
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0003 0.0002
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0055 0.022
Echinococcus granulosus neuropeptide receptor A26 0.056 0.4276 0.8112
Schistosoma mansoni heat shock protein 0.0032 0.0175 0.0331
Loa Loa (eye worm) hypothetical protein 0.005 0.0313 0.1371
Onchocerca volvulus Dual oxidase homolog 0.0053 0.0332 0.1456
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0235 0.0378
Echinococcus multilocularis slit 2 protein 0.0017 0.0055 0.0089
Onchocerca volvulus Huntingtin homolog 0.0122 0.0872 0.3868
Giardia lamblia High cysteine protein 0.0017 0.0055 0.3047
Echinococcus granulosus geminin 0.034 0.2565 0.4866
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0087 0.0166
Loa Loa (eye worm) hypothetical protein 0.0021 0.0087 0.0365
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0024 0.0078

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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