Detailed information for compound 1350722

Basic information

Technical information
  • TDR Targets ID: 1350722
  • Name: ZINC02569171
  • MW: 195.242 | Formula: C8H9N3OS
  • H donors: 0 H acceptors: 2 LogP: 1.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1occc1c1nnc(n1C)S
  • InChi: 1S/C8H9N3OS/c1-5-6(3-4-12-5)7-9-10-8(13)11(7)2/h3-4H,1-2H3,(H,10,13)
  • InChiKey: LMFWZVZTQLDDBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS001018154
  • SMR000354448

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi NADH-dependent xylose reductase 0.0039 0.0486 0.0718
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Giardia lamblia Aldose reductase 0.0134 0.4285 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0676 0.0499
Echinococcus granulosus growth factor receptor bound protein 2 0.014 0.4497 0.664
Entamoeba histolytica aldose reductase, putative 0.0134 0.4285 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.6773 1
Plasmodium falciparum aldo-keto reductase, putative 0.0039 0.0486 0.5
Echinococcus granulosus aldo keto reductase 0.0134 0.4285 0.6327
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0669 0.0481
Mycobacterium leprae Probable lipase LipE 0.0043 0.0669 0.0481
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0669 0.0481
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.4285 0.6327
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.6773 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0056 0.1152 0.1701
Echinococcus multilocularis voltage gated potassium channel subunit 0.0039 0.0486 0.0718
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0669 0.0481
Schistosoma mansoni potassium channel beta 0.0039 0.0486 0.0856
Brugia malayi beta-lactamase family protein 0.0043 0.0669 0.0988
Onchocerca volvulus 0.0114 0.3469 0.7852
Mycobacterium leprae Conserved hypothetical protein 0.0095 0.2736 0.5922
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0676 0.0998
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0669 0.0192
Loa Loa (eye worm) hypothetical protein 0.0134 0.4285 0.6231
Mycobacterium tuberculosis Conserved protein 0.0043 0.0669 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0669 0.0481
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0669 0.0481
Echinococcus granulosus aldo keto reductase 0.0134 0.4285 0.6327
Mycobacterium tuberculosis Conserved protein 0.0043 0.0669 0.0192
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0676 0.0499
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Onchocerca volvulus 0.0043 0.0669 0.0481
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0134 0.4285 1
Entamoeba histolytica aldose reductase, putative 0.0134 0.4285 1
Brugia malayi Sex muscle abnormal protein 5 0.014 0.4497 0.664
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0669 0.0987
Echinococcus multilocularis aldo keto reductase 0.0134 0.4285 0.6327
Loa Loa (eye worm) oxidoreductase 0.0134 0.4285 0.6231
Echinococcus granulosus aldehyde reductase 0.0095 0.2736 0.404
Loa Loa (eye worm) oxidoreductase 0.0134 0.4285 0.6231
Schistosoma mansoni tyrosine kinase 0.0056 0.1152 0.2027
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.4285 0.6327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Schistosoma mansoni pol-related 0.0134 0.4285 0.7542
Schistosoma mansoni alpha-glucosidase 0.0169 0.5682 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Echinococcus multilocularis aldo keto reductase 0.0134 0.4285 0.6327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Brugia malayi protein-tyrosine kinase 0.0043 0.0669 0.0987
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.4285 0.6327
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0669 0.0481
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.4285 1
Trichomonas vaginalis esterase, putative 0.0043 0.0669 0.0481
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.1152 0.1701
Onchocerca volvulus 0.0134 0.4285 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Schistosoma mansoni aldo-keto reductase 0.0134 0.4285 0.7542
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Onchocerca volvulus 0.0134 0.4285 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.014 0.4497 0.6552
Giardia lamblia Aldose reductase 0.0134 0.4285 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0676 0.0499
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.4285 0.3993
Trypanosoma brucei aldo-keto reductase, putative 0.0134 0.4285 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.6773 1
Trypanosoma brucei glucosidase, putative 0.0044 0.0676 0.0499
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Schistosoma mansoni aldo-keto reductase 0.0134 0.4285 0.7542
Leishmania major prostaglandin f synthase, putative 0.0134 0.4285 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.1152 0.1701
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0039 0.0486 0.0475
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.1152 0.1701
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0669 0.0481
Schistosoma mansoni tyrosine kinase 0.0056 0.1152 0.2027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0676 0.0499
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0676 0.0499
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0676 0.0763
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0669 0.0988
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0585 0.0864
Mycobacterium ulcerans hypothetical protein 0.0043 0.0669 0.0481
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0669 0.0987
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Echinococcus granulosus hypothetical protein 0.0134 0.4285 0.6327
Loa Loa (eye worm) oxidoreductase 0.0134 0.4285 0.6231
Mycobacterium ulcerans lipase LipD 0.0043 0.0669 0.0481
Onchocerca volvulus 0.0134 0.4285 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0669 0.0481
Mycobacterium tuberculosis Conserved protein 0.0043 0.0669 0.0192
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.1152 0.1701
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.1152 0.1701
Toxoplasma gondii ABC1 family protein 0.0043 0.0669 0.0481
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.1152 0.1701
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0676 0.0499
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Echinococcus granulosus tyrosine kinase 0.0043 0.0669 0.0987
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.4285 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Onchocerca volvulus 0.0134 0.4285 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0173 0.0255
Loa Loa (eye worm) oxidoreductase 0.0134 0.4285 0.6231
Leishmania major aldo-keto reductase-like protein 0.0134 0.4285 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0669 0.0192
Onchocerca volvulus 0.0043 0.0669 0.0481
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Loa Loa (eye worm) TK protein kinase 0.0043 0.0669 0.0751
Loa Loa (eye worm) oxidoreductase 0.0134 0.4285 0.6231
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0676 0.0998
Mycobacterium ulcerans beta-lactamase 0.0043 0.0669 0.0481
Plasmodium falciparum aldehyde reductase, putative 0.0039 0.0486 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0669 0.0987
Trypanosoma cruzi aldo/keto reductase, putative 0.0134 0.4285 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0669 0.0988
Echinococcus granulosus voltage gated potassium channel subunit 0.0039 0.0486 0.0718
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0669 0.1177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0669 0.0192
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.4285 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0669 0.1177
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0676 0.0998
Echinococcus multilocularis aldo keto reductase 0.0134 0.4285 0.6327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0173 0.0255
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0669 0.0988
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0669 0.0481
Leishmania major hypothetical protein, conserved 0.0043 0.0669 0.0481
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.1152 0.1701
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Schistosoma mansoni alpha glucosidase 0.0044 0.0676 0.119
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0134 0.4285 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0039 0.0486 0.0718
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0669 0.0192
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0585 0.0864
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Brugia malayi beta-lactamase family protein 0.0043 0.0669 0.0988
Echinococcus multilocularis aldehyde reductase 0.0095 0.2736 0.404
Echinococcus granulosus aldo keto reductase 0.0134 0.4285 0.6327
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0669 0.0987
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0669 0.0192
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0134 0.4285 0.6327
Onchocerca volvulus 0.0134 0.4285 1
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.4497 0.7915
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.4285 1
Onchocerca volvulus 0.0134 0.4285 1
Toxoplasma gondii aldose reductase, putative 0.0134 0.4285 1
Trypanosoma cruzi aldo-keto reductase 0.0134 0.4285 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0669 1
Entamoeba histolytica aldose reductase, putative 0.0134 0.4285 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.1152 0.1701
Brugia malayi SRC-1 0.0056 0.1152 0.1701
Trichomonas vaginalis aldo/keto reductase, putative 0.0134 0.4285 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0676 0.0499
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0669 0.0987
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0676 0.1224
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Onchocerca volvulus 0.0043 0.0669 0.0481
Entamoeba histolytica alcohol dehydrogenase, putative 0.0039 0.0486 0.0763
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0669 0.0192
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.6773 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0676 0.0499
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0134 0.4285 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0669 0.0752
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0676 0.0499
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0669 0.0481
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.4497 0.7915
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0676 0.0499
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0676 0.1224
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0134 0.4285 0.6327
Schistosoma mansoni alpha-glucosidase 0.0169 0.5682 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.6773 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0669 0.0192
Echinococcus multilocularis growth factor receptor bound protein 2 0.014 0.4497 0.664
Echinococcus multilocularis aldo keto reductase 0.0134 0.4285 0.6327
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0669 0.0481
Trypanosoma brucei prostaglandin f synthase 0.0134 0.4285 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0676 0.0499
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0676 0.0499
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0134 0.4285 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.1152 0.1701
Mycobacterium ulcerans oxidoreductase 0.0134 0.4285 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0134 0.4285 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.1152 0.1701
Brugia malayi beta-lactamase 0.0043 0.0669 0.0988
Loa Loa (eye worm) SRC-1 0.0056 0.1152 0.1483
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0039 0.0486 0.0718
Entamoeba histolytica alcohol dehydrogenase, putative 0.0039 0.0486 0.0763
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0676 0.0499
Loa Loa (eye worm) beta-lactamase 0.0043 0.0669 0.0752
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0669 0.0752
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0134 0.4285 0.6327
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.1152 0.1701

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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