Detailed information for compound 1350787

Basic information

Technical information
  • TDR Targets ID: 1350787
  • Name: N-(2,6-dimethylphenyl)-2-(2-methoxyethyl)-3-o xo-1H-isoindole-4-carboxamide
  • MW: 338.4 | Formula: C20H22N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1Cc2c(C1=O)c(ccc2)C(=O)Nc1c(C)cccc1C
  • InChi: 1S/C20H22N2O3/c1-13-6-4-7-14(2)18(13)21-19(23)16-9-5-8-15-12-22(10-11-25-3)20(24)17(15)16/h4-9H,10-12H2,1-3H3,(H,21,23)
  • InChiKey: CYSRDUONSJZCIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,6-dimethylphenyl)-2-(2-methoxyethyl)-3-oxo-isoindoline-4-carboxamide
  • N-(2,6-dimethylphenyl)-2-(2-methoxyethyl)-3-oxo-4-isoindolinecarboxamide
  • N-(2,6-dimethylphenyl)-3-keto-2-(2-methoxyethyl)isoindoline-4-carboxamide
  • N-(2,6-dimethylphenyl)-2-(2-methoxyethyl)-3-oxoisoindoline-4-carboxamide
  • SMR000026598
  • MLS000044994

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0208 0.0735
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0208 0.0352
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0383 0.0649
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0207 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2782 0.4687
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0383 0.0649
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1346 0.228
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0298 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0208 0.0352
Brugia malayi hypothetical protein 0.0033 0.051 0.0864
Trypanosoma brucei unspecified product 0.0019 0.0207 0.1464
Onchocerca volvulus 0.0071 0.1379 0.8862
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0287 0.0491
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0187 0.1359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0066 0.0112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.2795 0.2654
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1379 0.2336
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0207 0.035
Plasmodium falciparum glutathione reductase 0.0053 0.0968 0.8799
Schistosoma mansoni hypothetical protein 0.0193 0.4118 0.6977
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2071 0.3508
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0102 0.072
Onchocerca volvulus 0.0019 0.0208 0.0957
Onchocerca volvulus 0.0079 0.1548 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0298 0.0511
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0208 0.1343
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0066 0.0427
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0191 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0207 0.1464
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0191 0.1354
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0191 0.1354
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0504 0.0864
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.1548 0.2375
Brugia malayi glutaminase DH11.1 0.0272 0.5903 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0082 0.0139
Loa Loa (eye worm) hypothetical protein 0.005 0.0911 0.1502
Leishmania major cathepsin L-like protease 0.0073 0.1413 0.9067
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0208 0.1472
Brugia malayi AMP-binding enzyme family protein 0.0079 0.1548 0.2622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1886 0.3234
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1379 0.9761
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0028 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0911 0.8277
Plasmodium vivax glutathione reductase, putative 0.0053 0.0968 0.7023
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0298 0.136
Brugia malayi Muscleblind-like protein 0.0147 0.3074 0.5208
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0208 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0208 0.1329
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1379 0.2336
Leishmania major cathepsin L-like protease 0.0019 0.0208 0.0735
Brugia malayi beta-lactamase family protein 0.0071 0.1379 0.2336
Schistosoma mansoni hypothetical protein 0.0032 0.0504 0.0854
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1379 0.1211
Echinococcus granulosus GPCR family 2 0.0032 0.0504 0.0864
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1372 0.2325
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0208 0.0356
Brugia malayi TAR-binding protein 0.0071 0.1372 0.2325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Onchocerca volvulus 0.0023 0.0298 0.1568
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0298 0.0188
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0191 0.1738
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0207 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Loa Loa (eye worm) RNA binding protein 0.0071 0.1372 0.2288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0191 0.1354
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.1413 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0298 0.0188
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0066 0.0112
Loa Loa (eye worm) hypothetical protein 0.0079 0.1548 0.2586
Loa Loa (eye worm) hypothetical protein 0.0059 0.11 0.1825
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0191 0.1738
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.1548 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.1413 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1379 0.2364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.1548 0.5004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0504 0.0854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1886 0.3234
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0298 0.0109
Leishmania major cathepsin L-like protease 0.0019 0.0208 0.0735
Echinococcus granulosus bloom syndrome protein 0.0027 0.0383 0.0656
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0298 0.0505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1886 0.3196
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.5834 1
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.5834 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1379 0.208
Loa Loa (eye worm) hypothetical protein 0.0019 0.0208 0.0306
Loa Loa (eye worm) hypothetical protein 0.007 0.1346 0.2242
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1379 0.1211
Brugia malayi hypothetical protein 0.005 0.0911 0.1543
Echinococcus granulosus cathepsin l1 0.0013 0.0066 0.0113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0191 0.0324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0208 0.0356
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Onchocerca volvulus 0.0019 0.0208 0.0957
Schistosoma mansoni hypothetical protein 0.0055 0.1014 0.1718
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0298 0.0188
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0298 0.0505
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0968 0.166
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1379 0.9761
Echinococcus granulosus geminin 0.0193 0.4118 0.7059
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1138 0.1657
Plasmodium falciparum thioredoxin reductase 0.0053 0.0968 0.8799
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1886 0.3196
Echinococcus multilocularis muscleblind protein 1 0.0147 0.3074 0.5269
Schistosoma mansoni glutaminase 0.0272 0.5903 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0911 0.6606
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0207 0.0027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.0619
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0504 0.0864
Leishmania major cathepsin L-like protease 0.0019 0.0208 0.0735
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0298 0.0109
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.1548 0.2375
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0191 0.0324
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0028 0.0049
Mycobacterium tuberculosis Conserved protein 0.0071 0.1379 0.1211
Echinococcus granulosus tar DNA binding protein 0.0071 0.1372 0.2352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1886 0.3234
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Loa Loa (eye worm) hypothetical protein 0.0059 0.11 0.1825
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0298 0.0505
Loa Loa (eye worm) hypothetical protein 0.0147 0.3074 0.5185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Plasmodium vivax vivapain-2 0.0019 0.0208 0.1508
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.1548 0.2375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1379 0.2336
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0298 0.136
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.1271 0.8997
Brugia malayi AMP-binding enzyme family protein 0.0079 0.1548 0.2622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Leishmania major trypanothione reductase 0.0053 0.0968 0.5994
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.2795 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0207 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1372 0.2325
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0298 0.0109
Echinococcus granulosus dna polymerase kappa 0.0019 0.0207 0.0354
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Leishmania major hypothetical protein, conserved 0.0071 0.1379 0.8834
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0207 0.1464
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0298 0.2112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0208 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.1548 0.2375
Schistosoma mansoni hypothetical protein 0.0032 0.0504 0.0854
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0298 0.0109
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Loa Loa (eye worm) hypothetical protein 0.0059 0.11 0.1825
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0102 0.072
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0298 0.2112
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0298 0.0505
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0208 0.0352
Brugia malayi glutathione reductase 0.0053 0.0968 0.1641
Loa Loa (eye worm) glutathione reductase 0.0053 0.0968 0.16
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.2492 0.2345
Onchocerca volvulus 0.0019 0.0208 0.0957
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0383 0.0656
Loa Loa (eye worm) hypothetical protein 0.0102 0.2071 0.3477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.1028 0.0853
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1138 0.1928
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0207 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0524
Loa Loa (eye worm) RecQ helicase 0.0027 0.0383 0.0604
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1886 0.3163
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1379 0.9761
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0207 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0207 0.0727
Mycobacterium ulcerans lipase LipD 0.0071 0.1379 0.208
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1379 0.1211
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0208 0.0957
Plasmodium vivax vivapain-2 0.0019 0.0208 0.1508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0383 0.0649
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2071 0.3508
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0207 0.0304
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.1548 0.1383
Loa Loa (eye worm) oxidoreductase 0.0023 0.0298 0.046
Toxoplasma gondii ABC1 family protein 0.0071 0.1379 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0298 0.1999
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0287 0.0491
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0102 0.0172
Echinococcus granulosus dna polymerase eta 0.0019 0.0207 0.0354
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0208 0.0356
Echinococcus multilocularis cysteine protease 0.0019 0.0208 0.0356
Leishmania major cathepsin L-like protease 0.0019 0.0208 0.0735
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.031 0.2813
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0207 0.035
Brugia malayi Thioredoxin reductase 0.0053 0.0968 0.1641
Mycobacterium tuberculosis Conserved protein 0.0071 0.1379 0.1211
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1372 0.2325
Onchocerca volvulus 0.0023 0.0298 0.1568
Leishmania major DNA polymerase kappa, putative 0.0019 0.0207 0.0727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0191 0.1354
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.1372 0.2288
Treponema pallidum NADH oxidase 0.0018 0.0191 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0911 0.6448
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.1548 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0207 0.035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1138 0.195
Echinococcus granulosus cathepsin l1 0.0019 0.0208 0.0356
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0298 0.0188
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.2795 0.2654
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.1548 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0504 0.0864
Schistosoma mansoni DNA polymerase eta 0.0019 0.0207 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1886 0.3234
Mycobacterium tuberculosis Conserved protein 0.0071 0.1379 0.1211
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0298 0.0109
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0102 0.0657
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0911 0.6534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0298 0.046
Loa Loa (eye worm) fibroinase 0.0019 0.0208 0.0306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0028 0.0049
Schistosoma mansoni hypothetical protein 0.007 0.1346 0.228
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0208 0.1889
Mycobacterium ulcerans hypothetical protein 0.0079 0.1548 0.2375
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0911 0.6448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Onchocerca volvulus 0.0055 0.1014 0.64
Loa Loa (eye worm) hypothetical protein 0.0269 0.5834 0.9884
Leishmania major cathepsin L-like protease 0.0073 0.1413 0.9067
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0298 0.0505
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0082 0.0139
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0028 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.1548 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0191 0.0324
Brugia malayi hypothetical protein 0.0269 0.5834 0.9884
Brugia malayi Cathepsin L-like precursor 0.0013 0.0066 0.0112
Loa Loa (eye worm) hypothetical protein 0.0135 0.2818 0.4749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0207 0.0354
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0911 0.6448
Echinococcus multilocularis tar DNA binding protein 0.0071 0.1372 0.2352
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.1548 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0298 0.2112
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1138 0.1928
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1379 0.2364
Trypanosoma brucei unspecified product 0.0013 0.0074 0.0524
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0207 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0208 0.1889
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0298 0.0109
Echinococcus multilocularis muscleblind protein 0.0147 0.3074 0.5269
Mycobacterium ulcerans beta-lactamase 0.0071 0.1379 0.208
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0191 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.1028 0.0853
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1379 0.2336
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1138 0.7167
Leishmania major hypothetical protein, conserved 0.005 0.0911 0.5597
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0208 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0191 0.1354
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0298 0.1999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.11 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1379 0.1211
Leishmania major cathepsin L-like protease 0.0019 0.0208 0.0735
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.1413 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0207 0.0727
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0298 0.0505
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0064
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1138 0.8215
Onchocerca volvulus 0.0023 0.0298 0.1568
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.1548 0.5004
Echinococcus multilocularis dna polymerase eta 0.0019 0.0207 0.0354
Loa Loa (eye worm) hypothetical protein 0.0059 0.11 0.1825
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0191 0.1387
Trypanosoma brucei unspecified product 0.0013 0.0074 0.0524
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1379 0.1211
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0298 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1886 0.3196
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0207 0.1464
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0298 0.2112
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1372 0.2325
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0028 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Loa Loa (eye worm) hypothetical protein 0.0032 0.0504 0.081
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.2492 0.2345
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1379 0.2299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Brugia malayi beta-lactamase 0.0071 0.1379 0.2336
Leishmania major cathepsin L-like protease 0.0073 0.1413 0.9067
Onchocerca volvulus 0.0019 0.0208 0.0957
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0298 0.0109
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0191 0.1354
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0968 0.6855
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0298 0.0109
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0298 0.0505
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1379 0.208
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.1548 0.2375
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0208 0.1889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1886 0.3196
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0208 0.1343
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0207 0.1336
Loa Loa (eye worm) glutaminase 2 0.0272 0.5903 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0504 0.0864
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0208 0.0957
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.1413 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0298 0.0109
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0207 0.1464
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0208 0.0306
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.2492 0.2345
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1379 0.2336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Loa Loa (eye worm) hypothetical protein 0.0079 0.1548 0.2586
Loa Loa (eye worm) hypothetical protein 0.0019 0.0207 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Onchocerca volvulus 0.0023 0.0298 0.1568
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Onchocerca volvulus 0.0071 0.1379 0.8862
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.2492 0.8787
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2071 0.3477
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0298 0.1928
Entamoeba histolytica cysteine protease, putative 0.0019 0.0208 0.1343
Schistosoma mansoni hypothetical protein 0.0032 0.0504 0.0854
Schistosoma mansoni tar DNA-binding protein 0.0071 0.1372 0.2325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Onchocerca volvulus 0.0019 0.0208 0.0957
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0298 0.2164
Schistosoma mansoni hypothetical protein 0.0023 0.0287 0.0486
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1379 0.1211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0298 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0079 0.1548 0.2622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0256 0.0433
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.2492 0.2345
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0207 0.035
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1379 0.2336
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0968 0.16
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0298 0.2112
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1138 0.1657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.1028 0.0853
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.1063 0.7525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Plasmodium falciparum thioredoxin reductase 0.0018 0.0191 0.1738
Mycobacterium leprae Probable lipase LipE 0.0071 0.1379 0.4329
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0028 0.0048
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.11 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Brugia malayi Cathepsin L-like precursor 0.0013 0.0066 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.1548 0.2375
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.11 0.7981
Mycobacterium ulcerans glutaminase 0.0272 0.5903 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.11 0.0927
Loa Loa (eye worm) TAR-binding protein 0.0071 0.1372 0.2288
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0028 0.0048
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0208 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1138 0.1657
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.2795 0.2654
Schistosoma mansoni DNA helicase recq1 0.0011 0.0028 0.0048
Schistosoma mansoni hypothetical protein 0.0032 0.0504 0.0854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0208 0.0352
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0066 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.1413 1
Trypanosoma brucei trypanothione reductase 0.0053 0.0968 0.6855
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1138 0.195
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0191 0.1206
Echinococcus multilocularis geminin 0.0193 0.4118 0.7059
Brugia malayi MH2 domain containing protein 0.0134 0.2782 0.4713
Schistosoma mansoni hypothetical protein 0.0193 0.4118 0.6977
Echinococcus multilocularis cysteine protease 0.0019 0.0208 0.0356
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0208 0.0356
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0207 0.035
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0968 0.7023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0968 0.0792
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.1548 0.2375
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0504 0.0864
Loa Loa (eye worm) glutaminase 0.0272 0.5903 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.0968 0.696
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.1548 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1379 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1379 0.4329
Brugia malayi beta-lactamase family protein 0.0071 0.1379 0.2336
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0208 0.0356
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0191 0.1354
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0191 0.0324
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0191 0.0619
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0298 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.046
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0191 0.1206
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1138 0.0965
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.1372 0.2325
Schistosoma mansoni DNA helicase recq5 0.0011 0.0028 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1379 0.2336
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0524
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0191 0.0619
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.2492 0.2345
Onchocerca volvulus 0.0071 0.1379 0.8862
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0298 0.0188
Giardia lamblia DINP protein human, muc B family 0.0019 0.0207 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0074 0.0524
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0191 0.0328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0968 0.166
Loa Loa (eye worm) hypothetical protein 0.0147 0.3074 0.5185
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0504 0.0854
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0298 0.136
Brugia malayi Cathepsin L-like precursor 0.0019 0.0208 0.0352
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0298 0.0505
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1014 0.1718
Loa Loa (eye worm) cysteine protease 0.0019 0.0208 0.0306
Mycobacterium ulcerans hypothetical protein 0.0071 0.1379 0.208
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0191 0.0328
Loa Loa (eye worm) beta-lactamase 0.0071 0.1379 0.2299
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0298 0.0511
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1379 0.1211
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0028 0.00000000084042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0191 0.1387
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0298 0.2711
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0298 0.1999
Trichomonas vaginalis glutaminase, putative 0.0272 0.5903 1
Trichomonas vaginalis esterase, putative 0.0071 0.1379 0.2336
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0298 0.0109
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0911 0.8277
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0298 0.2112
Onchocerca volvulus 0.0019 0.0208 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0208 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Echinococcus granulosus muscleblind protein 0.0147 0.3074 0.5269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.046
Loa Loa (eye worm) ctsf protein 0.0019 0.0208 0.0306
Onchocerca volvulus 0.0019 0.0208 0.0957
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0298 0.0188
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0504 0.081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.1028 0.0853
Plasmodium falciparum glutathione reductase 0.0018 0.0191 0.1738
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2782 0.4687
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0298 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0207 0.1464
Schistosoma mansoni survival motor neuron protein 0.0055 0.1014 0.1718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0066 0.0112
Brugia malayi cathepsin L-like precursor 0.0013 0.0066 0.0112
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1379 0.2336
Loa Loa (eye worm) hypothetical protein 0.0059 0.11 0.1825
Mycobacterium tuberculosis Probable reductase 0.0121 0.2492 0.2345
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0064
Brugia malayi RNA binding protein 0.0071 0.1372 0.2325
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0191 0.9128
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0298 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0191 0.1354
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0183 0.1142
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0226 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.11 0.1592
Loa Loa (eye worm) hypothetical protein 0.0071 0.1379 0.2299
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0207 0.1464
Loa Loa (eye worm) hypothetical protein 0.0079 0.1548 0.2586
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0298 0.0188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.1548 0.1383
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0208 0.0356

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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