Detailed information for compound 1350964

Basic information

Technical information
  • TDR Targets ID: 1350964
  • Name: STOCK4S-46020
  • MW: 445.489 | Formula: C25H24FN5O2
  • H donors: 1 H acceptors: 2 LogP: 2.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1c(=N)c(cc2c1nc1c(C)cccn1c2=O)C(=O)NC1CCCC1
  • InChi: 1S/C25H24FN5O2/c1-15-5-4-12-30-22(15)29-23-20(25(30)33)13-19(24(32)28-18-6-2-3-7-18)21(27)31(23)14-16-8-10-17(26)11-9-16/h4-5,8-13,18,27H,2-3,6-7,14H2,1H3,(H,28,32)
  • InChiKey: AAOGXTPEJATQRN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0205 0.0617 0.0685
Echinococcus granulosus expressed protein 0.0316 0.0969 0.1077
Echinococcus granulosus Regulator of G protein signaling 20 0.0316 0.0969 0.1077
Echinococcus granulosus regulator of G protein signaling 3 0.0316 0.0969 0.1077
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0014 0.0013 0.1557
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0143 0.0143
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.005 0.5788
Brugia malayi MH2 domain containing protein 0.0121 0.0351 0.0351
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.018 0.0538 0.0598
Schistosoma mansoni alkaline phosphatase 0.018 0.0538 0.0538
Brugia malayi Inositol-1 0.0037 0.0086 0.0086
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.005 0.63
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0086 0.0095
Echinococcus multilocularis Regulator of G protein signaling 20 0.0316 0.0969 0.1077
Schistosoma mansoni axis inhibition protein axin 0.0316 0.0969 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Echinococcus multilocularis axis inhibition protein axin 0.0316 0.0969 0.1077
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0086 0.0095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0032
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 1
Entamoeba histolytica hypothetical protein 0.0028 0.0058 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Trichomonas vaginalis ran, putative 0.0026 0.005 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.0993 0.0993
Brugia malayi Importin beta-1 subunit 0.0035 0.0079 0.0079
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0316 0.0969 0.0969
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.005 0.63
Schistosoma mansoni regulator of G protein signaling 0.0316 0.0969 0.0969
Loa Loa (eye worm) PXA domain-containing protein 0.0316 0.0969 0.0969
Echinococcus granulosus axis inhibition protein axin 0.0316 0.0969 0.1077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0143 0.0159
Echinococcus granulosus beta-adrenergic receptor kinase 0.0324 0.0993 0.1104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0029 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0316 0.0969 0.1077
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0316 0.0969 0.1077
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3167 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.005 0.005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0316 0.0969 0.0969
Echinococcus multilocularis beta adrenergic receptor kinase 0.0324 0.0993 0.1104
Echinococcus granulosus geminin 0.0205 0.0617 0.0685
Schistosoma mansoni inositol monophosphatase 0.0037 0.0086 0.0086
Plasmodium falciparum importin beta, putative 0.0035 0.0079 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 1
Entamoeba histolytica hypothetical protein 0.0316 0.0969 1
Brugia malayi hypothetical protein 0.0316 0.0969 0.0969
Echinococcus granulosus regulator of G protein signaling 3 0.0316 0.0969 0.1077
Echinococcus granulosus intestinal type alkaline phosphatase 0.018 0.0538 0.0598
Echinococcus granulosus alkaline phosphatase 0.018 0.0538 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0079 0.9187
Brugia malayi PXA domain containing protein 0.0316 0.0969 0.0969
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0086 0.0884
Schistosoma mansoni regulator of G protein signaling 0.0316 0.0969 0.0969
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0079 0.0087
Brugia malayi Regulator of G protein signaling domain containing protein 0.0316 0.0969 0.0969
Echinococcus multilocularis regulator of G protein signaling 7 0.0316 0.0969 0.1077
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2851 0.8999 0.8999
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0324 0.0993 0.0993
Schistosoma mansoni hypothetical protein 0.0041 0.0099 0.0099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0143 0.0159
Schistosoma mansoni alkaline phosphatase 0.018 0.0538 0.0538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0159 0.0159
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2851 0.8999 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0143 0.0159
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0086 1
Brugia malayi regulator of G-protein signaling egl-10 0.0316 0.0969 0.0969
Schistosoma mansoni hypothetical protein 0.0093 0.0264 0.0264
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0058 0.6752
Loa Loa (eye worm) hypothetical protein 0.0041 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0316 0.0969 0.0969
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.018 0.0538 0.0598
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0058 0.0597
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0086 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.005 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.0969 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0316 0.0969 0.0969
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.005 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0029
Schistosoma mansoni ran 0.0026 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0079
Schistosoma mansoni importin beta-1 0.0035 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0079 0.9187
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.018 0.0538 0.0598
Schistosoma mansoni regulator of G protein signaling 0.0316 0.0969 0.0969
Leishmania major importin beta-1 subunit, putative 0.0028 0.0058 0.2289
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0029 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.3167 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0086 1
Echinococcus granulosus snurportin 1 0.0372 0.1146 0.1273
Onchocerca volvulus 0.001 0 0.5
Schistosoma mansoni inositol monophosphatase 0.0037 0.0086 0.0086
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0086 0.0884
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0159 0.0159
Plasmodium vivax importin-beta 2, putative 0.0035 0.0079 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0079 0.9187
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.005 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0316 0.0969 0.0969
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2851 0.8999 1
Entamoeba histolytica hypothetical protein 0.0316 0.0969 1
Entamoeba histolytica Ran family GTPase 0.0026 0.005 0.0512
Brugia malayi PXA domain containing protein 0.0316 0.0969 0.0969
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0058 0.0597
Chlamydia trachomatis DNA ligase 0.001 0 0.5
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0316 0.0969 0.1077
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Loa Loa (eye worm) hypothetical protein 0.006 0.0159 0.0159
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0316 0.0969 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0159 0.0159
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.005 0.005
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2851 0.8999 0.8999
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1146 0.1146
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0029
Schistosoma mansoni ran 0.0026 0.005 0.005
Schistosoma mansoni regulator of G protein signaling 0.0316 0.0969 0.0969
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0086 0.0884
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.005 0.5788
Echinococcus multilocularis snurportin 1 0.0372 0.1146 0.1273
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.018 0.0538 0.0598
Echinococcus multilocularis alkaline phosphatase 0.018 0.0538 0.0598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0143 0.0143
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 1
Loa Loa (eye worm) inositol-1 0.0037 0.0086 0.0086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0316 0.0969 0.0969
Brugia malayi hypothetical protein 0.0316 0.0969 0.0969
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.005 0.5788
Schistosoma mansoni hypothetical protein 0.0372 0.1146 0.1146
Echinococcus multilocularis regulator of G protein signaling 0.0316 0.0969 0.1077
Schistosoma mansoni hypothetical protein 0.0205 0.0617 0.0617
Echinococcus granulosus regulator of G protein signaling 7 0.0316 0.0969 0.1077
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0099 0.0099
Echinococcus granulosus regulator of G protein signaling 7 0.0316 0.0969 0.1077
Schistosoma mansoni regulator of G protein signaling 0.0316 0.0969 0.0969
Echinococcus multilocularis expressed protein 0.0316 0.0969 0.1077
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0086 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0316 0.0969 0.1077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0143 0.0159
Brugia malayi RNA, U transporter 1 0.0099 0.0282 0.0282
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0029
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2851 0.8999 0.8999
Loa Loa (eye worm) RGS-3 protein 0.0316 0.0969 0.0969
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.5
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0058 0.0597
Schistosoma mansoni hypothetical protein 0.0205 0.0617 0.0617
Schistosoma mansoni axis inhibition protein axin 0.0316 0.0969 0.0969
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0029 0.0032
Echinococcus multilocularis axis inhibition protein axin 0.0316 0.0969 0.1077
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0351 0.0351
Echinococcus granulosus axis inhibition protein axin 0.0316 0.0969 0.1077
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.0029
Echinococcus multilocularis intestinal type alkaline phosphatase 0.018 0.0538 0.0598
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0086 0.0884
Echinococcus multilocularis GPCR, family 2 0.0019 0.0029 0.0032
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0079 0.0087
Schistosoma mansoni z-protein (S1r protein) 0.0316 0.0969 0.0969
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0351 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0143 0.0143
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0316 0.0969 0.0969
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.005 0.5788
Entamoeba histolytica hypothetical protein 0.0316 0.0969 1
Treponema pallidum DNA ligase (lig) 0.001 0 0.5
Echinococcus granulosus GPCR family 2 0.0019 0.0029 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0316 0.0969 0.1077
Brugia malayi A-kinase anchor protein 10, precursor 0.0316 0.0969 0.0969

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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