Detailed information for compound 1351439

Basic information

Technical information
  • TDR Targets ID: 1351439
  • Name: N-[2-(1-cyclohexenyl)ethyl]-2-(1,3-dimethyl-2 ,6-dioxopurin-9-yl)acetamide
  • MW: 345.396 | Formula: C17H23N5O3
  • H donors: 1 H acceptors: 4 LogP: 1.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1cnc2c1n(C)c(=O)n(c2=O)C)NCCC1=CCCCC1
  • InChi: 1S/C17H23N5O3/c1-20-15-14(16(24)21(2)17(20)25)19-11-22(15)10-13(23)18-9-8-12-6-4-3-5-7-12/h6,11H,3-5,7-10H2,1-2H3,(H,18,23)
  • InChiKey: XCTFJDSLNRYQFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1-cyclohexenyl)ethyl]-2-(1,3-dimethyl-2,6-dioxo-purin-9-yl)acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-(1,3-dimethyl-2,6-dioxo-9-purinyl)acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-(2,6-diketo-1,3-dimethyl-purin-9-yl)acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-(1,3-dimethyl-2,6-dioxo-purin-9-yl)ethanamide
  • SMR000076610
  • BAS 07603041
  • ZINC00609417
  • MLS000064367
  • N-[2-(1-cyclohexen-1-yl)ethyl]-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-9H-purin-9-yl)acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cyclin dependent kinase 0.0117 0.082 0.1621
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2544 1
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0077 0.0398 0.2943
Loa Loa (eye worm) thyroid receptor interactor 0.0079 0.0411 0.0411
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Trichomonas vaginalis STE family protein kinase 0.0083 0.0454 0.1787
Trichomonas vaginalis CMGC family protein kinase 0.0127 0.093 0.3812
Giardia lamblia Kinase, CMGC MAPK 0.008 0.0429 0.1924
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Giardia lamblia Kinase, NEK 0.0135 0.1013 0.4978
Entamoeba histolytica serine/threonine protein kinase, putative 0.0086 0.0492 0.1857
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0086 0.0492 0.2359
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Echinococcus granulosus serine:threonine protein kinase N2 0.0135 0.1015 0.2011
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0086 0.049 0.1849
Onchocerca volvulus 0.0043 0.0034 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0404 0.1572
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0268 0.2442 0.4867
Schistosoma mansoni tyrosine kinase 0.0144 0.1114 0.2299
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0224 0.1973 0.3928
Brugia malayi Pleckstrin Homology Domain 0.0054 0.0149 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0052
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0086 0.049 0.0962
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.062 0.1221
Plasmodium falciparum casein kinase 2, alpha subunit 0.0097 0.0611 0.4799
Echinococcus granulosus insulin growth factor 1 receptor beta 0.02 0.1707 0.3396
Echinococcus granulosus mitogen activated protein kinase 11 0.0159 0.127 0.2521
Schistosoma mansoni protein kinase 0.0083 0.0454 0.0926
Onchocerca volvulus 0.0304 0.2827 0.8245
Loa Loa (eye worm) hypothetical protein 0.048 0.4715 0.4715
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0153 0.1208 0.4998
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.082 0.1687
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0089 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Onchocerca volvulus 0.0127 0.093 0.2694
Brugia malayi Protein kinase domain containing protein 0.0164 0.1325 0.1317
Echinococcus multilocularis N chimaerin 0.0054 0.0145 0.0272
Entamoeba histolytica hypothetical protein 0.005 0.0103 0.0183
Echinococcus granulosus RNA directed DNA polymerase 0.0083 0.0453 0.0888
Brugia malayi protein kinase C3,putative 0.0164 0.1321 0.1313
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.036 0.3427 0.6836
Echinococcus multilocularis Rac GTPase activating protein 1 0.005 0.0103 0.0187
Schistosoma mansoni rac gtpase activating protein 0.005 0.0103 0.0195
Entamoeba histolytica protein kinase, putative 0.0086 0.049 0.1849
Entamoeba histolytica protein kinase, putative 0.012 0.0858 0.3434
Schistosoma mansoni tyrosine kinase 0.0144 0.1114 0.2299
Loa Loa (eye worm) TK/INSR protein kinase 0.0197 0.168 0.168
Echinococcus multilocularis casein kinase I alpha 0.0106 0.0707 0.1395
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0454 0.089
Loa Loa (eye worm) hypothetical protein 0.0203 0.1742 0.1742
Loa Loa (eye worm) AGC/PKN protein kinase 0.0286 0.2634 0.2634
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.008 0.0429 0.2033
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0086 0.049 0.3881
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.1208 0.2495
Loa Loa (eye worm) AUR protein kinase 0.0086 0.049 0.049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0034 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.082 0.3344
Echinococcus granulosus casein kinase I alpha 0.0106 0.0707 0.1395
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0159 0.127 0.6367
Brugia malayi Protein kinase domain containing protein 0.036 0.3427 0.3421
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0061 0.0107
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0086 0.0492 0.2359
Schistosoma mansoni pyruvate dehydrogenase 0.0118 0.0829 0.1706
Schistosoma mansoni protein kinase C mu 0.0226 0.199 0.4121
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.005 0.0104 0.0361
Giardia lamblia Kinase, PLK 0.0225 0.1974 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0208 0.0208
Trichomonas vaginalis STE family protein kinase 0.006 0.0212 0.0757
Brugia malayi Ras association domain family 1 isoform A 0.005 0.0103 0.0094
Echinococcus granulosus protein kinase 0.0153 0.1203 0.2388
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.049 0.1849
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0153 0.1208 0.5098
Brugia malayi Hr1 repeat family protein 0.0286 0.2634 0.2627
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0042 0.0015 0.0012
Entamoeba histolytica serine/threonine protein kinase, putative 0.0225 0.1974 0.8239
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0113 0.0775 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Echinococcus multilocularis protein kinase c eta type 0.005 0.0103 0.0187
Echinococcus multilocularis rac serine:threonine kinase 0.0139 0.1058 0.2097
Brugia malayi Protein kinase domain containing protein 0.0078 0.0404 0.0395
Brugia malayi Fes/CIP4 homology domain containing protein 0.0079 0.0411 0.0402
Brugia malayi Protein kinase domain containing protein 0.0201 0.1723 0.1716
Giardia lamblia Kinase, CAMK CAMKL 0.0086 0.0492 0.2254
Plasmodium falciparum glycogen synthase kinase 3 0.0127 0.093 0.7574
Giardia lamblia Aurora kinase 0.0086 0.049 0.2244
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0069 0.0309 0.1192
Trypanosoma brucei SNF1-related protein kinases, putative 0.0086 0.0492 0.1948
Echinococcus multilocularis dual specificity 0.0083 0.0454 0.0889
Echinococcus multilocularis casein kinase I gamma 0.0215 0.1873 0.3728
Entamoeba histolytica casein kinase 1, putative 0.0106 0.0707 0.2782
Brugia malayi Protein kinase domain containing protein 0.0215 0.1873 0.1865
Trypanosoma cruzi cdc2-related kinase 3 0.0117 0.082 0.4049
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0153 0.1203 0.1203
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.082 0.3344
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0127 0.093 0.093
Brugia malayi Protein kinase domain containing protein 0.0058 0.0185 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Schistosoma mansoni protein kinase C mu 0.005 0.0103 0.0195
Schistosoma mansoni tyrosine kinase 0.0045 0.0048 0.0081
Giardia lamblia Kinase, STE STE20 0.0081 0.0439 0.1978
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0124 0.0894 0.3661
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0061 0.0111
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0046 0.0061 0.0135
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0127 0.093 0.093
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0135 0.1012 0.8288
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0404 0.0404
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0153 0.1208 0.1208
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0061 0.0111
Schistosoma mansoni tyrosine kinase 0.0229 0.2018 0.4179
Loa Loa (eye worm) hypothetical protein 0.0126 0.0915 0.0915
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.008 0.0429 0.1679
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0422 0.0858
Trypanosoma brucei casein kinase I, isoform 2 0.0106 0.0707 0.2862
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.3121 0.6476
Entamoeba histolytica protein kinase domain containing protein 0.0127 0.093 0.3743
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0492 0.1948
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0069 0.0309 0.1169
Trichomonas vaginalis STE family protein kinase 0.0046 0.0061 0.0111
Brugia malayi C1-like domain containing protein 0.0226 0.199 0.1982
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0135 0.1012 0.2005
Echinococcus granulosus serine:threonine kinase SAD 1 0.0086 0.0492 0.0966
Trypanosoma brucei aurora B kinase 0.0086 0.049 0.1939
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0106 0.0707 0.0707
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.062 0.1221
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.008 0.0429 0.2033
Loa Loa (eye worm) protein kinase domain-containing protein 0.0215 0.1873 0.1873
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0112 0.0768 0.0768
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0404 0.3891 0.7765
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0125 0.0903 0.4479
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0202 0.1734 0.3449
Loa Loa (eye worm) hypothetical protein 0.0149 0.1162 0.1162
Trypanosoma cruzi Protein kinase B 0.0139 0.1058 0.5276
Toxoplasma gondii diacylglycerol kinase, putative 0.005 0.0103 0.0298
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0054 0.0145 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1234 0.5107
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.082 0.1687
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.012 0.0858 0.3507
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Brugia malayi Immunoglobulin I-set domain containing protein 0.0366 0.3492 0.3486
Leishmania major protein kinase, putative 0.0153 0.1208 0.6052
Leishmania major protein kinase A catalytic subunit isoform 2 0.0069 0.0309 0.1415
Trypanosoma brucei NIMA-related protein kinase 0.0046 0.0061 0.0111
Entamoeba histolytica protein kinase, putative 0.0151 0.1188 0.4854
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0309 0.0624
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0127 0.093 0.1842
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0098 0.062 0.1221
Brugia malayi P38 map kinase family protein 2 0.0159 0.127 0.1261
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0204 0.1755 0.1755
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0164 0.1325 0.2632
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0429 0.1679
Schistosoma mansoni protein kinase 0.0086 0.049 0.1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0115 0.0804 0.1589
Trypanosoma cruzi NIMA-related kinase, putative 0.0046 0.0061 0.0135
Brugia malayi RhoGEF domain containing protein 0.005 0.0103 0.0094
Entamoeba histolytica diacylglycerol kinase, putative 0.005 0.0103 0.0183
Leishmania major protein kinase, putative 0.0153 0.1208 0.6052
Brugia malayi probable protein kinase 0.0269 0.2449 0.2442
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.049 0.1
Mycobacterium ulcerans lipase LipD 0.0043 0.0034 0.5
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0117 0.082 0.082
Toxoplasma gondii casein kinase I 0.0106 0.0707 0.2919
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0098 0.062 0.4984
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0103 0.0195
Loa Loa (eye worm) hypothetical protein 0.0089 0.0526 0.0526
Echinococcus granulosus nervana 2 0.0107 0.0718 0.1418
Schistosoma mansoni protein kinase 0.0269 0.2449 0.5078
Echinococcus multilocularis nervana 2 0.0107 0.0718 0.1418
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0422 0.1649
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0044 0.0035 0.0005
Loa Loa (eye worm) CAMK protein kinase 0.0041 0.0009 0.0009
Echinococcus granulosus Glutaredoxin protein 5 0.0107 0.0718 0.1418
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1188 0.2453
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0117 0.082 0.3411
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0044 0.0035 0.0004
Trypanosoma cruzi Serine/threonine-protein kinase NEK16, putative 0.0046 0.0061 0.0135
Loa Loa (eye worm) hypothetical protein 0.0059 0.0198 0.0198
Trypanosoma cruzi cdc2-related kinase 1 0.0117 0.082 0.4049
Toxoplasma gondii histone kinase SNF1, putative 0.0086 0.0492 0.1987
Loa Loa (eye worm) TK/EGFR protein kinase 0.0229 0.2018 0.2018
Echinococcus granulosus hypothetical protein 0.0126 0.0915 0.1811
Onchocerca volvulus 0.0053 0.0131 0.0356
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0083 0.0454 0.2161
Schistosoma mansoni ste20-related kinase 0.0207 0.1783 0.3691
Brugia malayi Kinase associated domain 1 family protein 0.0064 0.0251 0.0241
Echinococcus multilocularis serine:threonine protein kinase 0.0112 0.0768 0.1517
Entamoeba histolytica protein kinase, putative 0.0127 0.093 0.3743
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0176 0.1449 0.2881
Brugia malayi protein kinase C II. 0.0204 0.175 0.1743
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0054 0.0145 0.0283
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.0904 0.3704
Brugia malayi Protein kinase domain containing protein 0.0202 0.1734 0.1726
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1734 0.3589
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0858 0.1767
Entamoeba histolytica p21-activated kinase 0.0087 0.05 0.1893
Schistosoma mansoni protein kinase 0.0445 0.4334 0.9001
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0239 0.2126 0.2126
Echinococcus multilocularis RNA directed DNA polymerase 0.0083 0.0453 0.0888
Entamoeba histolytica protein kinase, putative 0.0101 0.0648 0.2528
Brugia malayi hypothetical protein 0.0059 0.0198 0.0189
Plasmodium vivax glycogen synthase kinase 3, putative 0.0127 0.093 0.7628
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0061 0.0111
Echinococcus granulosus serine/threonine protein kinase 0.0139 0.1058 0.2097
Schistosoma mansoni tyrosine kinase 0.0144 0.1114 0.2299
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Echinococcus granulosus protein kinase c iota type 0.0287 0.2647 0.5276
Echinococcus multilocularis myosin iiia 0.0081 0.0439 0.086
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0117 0.082 0.1621
Schistosoma mansoni atypical protein kinase C 0.0294 0.2715 0.563
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0153 0.1208 0.4998
Schistosoma mansoni hypothetical protein 0.005 0.0103 0.0195
Echinococcus granulosus serine:threonine protein kinase 3 0.0261 0.2359 0.4701
Brugia malayi serine/threonine-protein kinase PAK 7 0.0235 0.2083 0.2076
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0044 0.0035 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.1208 0.4998
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0034 0.0034
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0151 0.1188 0.2358
Trypanosoma cruzi casein kinase, putative 0.0106 0.0707 0.3466
Echinococcus granulosus mitogen activated protein kinase 3 0.008 0.0429 0.0839
Echinococcus multilocularis casein kinase I delta 0.0106 0.0707 0.1395
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0224 0.1973 0.3928
Trypanosoma brucei cdc2-related kinase 1 0.0117 0.082 0.3344
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0355 0.1268
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0187 0.1567 0.3116
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0164 0.1325 0.1325
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1567 0.3242
Echinococcus granulosus insulin receptor 0.0197 0.168 0.3342
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0135 0.1012 0.5039
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0081 0.0439 0.1629
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Echinococcus granulosus aurora kinase A 0.0086 0.049 0.0962
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.1973 0.4087
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0127 0.093 0.1842
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.036 0.3427 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0069 0.0309 0.1415
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0858 0.3434
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1188 0.4911
Brugia malayi serine/threonine-protein kinase plk-2 0.0225 0.1974 0.1967
Onchocerca volvulus Tyrosine kinase homolog 0.0348 0.3301 0.9631
Trypanosoma cruzi polo-like protein kinase, putative 0.0225 0.1974 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0336 0.3167 0.3167
Echinococcus multilocularis dual specificity 0.012 0.0858 0.1698
Schistosoma mansoni serine/threonine-protein kinase 0.0139 0.1058 0.2182
Schistosoma mansoni pyruvate dehydrogenase 0.0125 0.0903 0.186
Toxoplasma gondii AGC kinase 0.0259 0.2337 1
Toxoplasma gondii AGC kinase 0.0069 0.0309 0.1192
Onchocerca volvulus 0.0145 0.1117 0.324
Echinococcus granulosus protein kinase c epsilon type 0.0204 0.175 0.3483
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0034 0.5
Echinococcus multilocularis roundabout 2 0.0043 0.0027 0.0035
Brugia malayi RhoGAP domain containing protein 0.0054 0.0145 0.0136
Entamoeba histolytica protein kinase domain containing protein 0.0127 0.093 0.3743
Entamoeba histolytica protein kinase, putative 0.0064 0.0258 0.0851
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0225 0.1974 0.3931
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0239 0.2126 0.4234
Trichomonas vaginalis CK1 family protein kinase 0.0106 0.0707 0.2862
Echinococcus multilocularis serine:threonine protein kinase N2 0.0135 0.1015 0.2011
Brugia malayi casein kinase I 0.0106 0.0707 0.0698
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0815 0.4024
Giardia lamblia Kinase, CMGC GSK 0.0127 0.093 0.4543
Trypanosoma brucei Serine/threonine-protein kinase NEK11, putative 0.0046 0.0061 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Giardia lamblia Kinase, CMGC GSK 0.0127 0.093 0.4543
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.127 0.6367
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0069 0.0309 0.1169
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.1755 0.7293
Giardia lamblia Kinase, CMGC CLK 0.0153 0.1208 0.5998
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0104 0.0198
Echinococcus granulosus calcium dependent protein kinase 0.0071 0.0326 0.0633
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0116 0.0815 0.1677
Echinococcus granulosus raf serine:threonine protein kinase 0.0062 0.0233 0.0447
Echinococcus granulosus nervana 2 0.0107 0.0718 0.1418
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.1208 0.6052
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0083 0.0454 0.0454
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0086 0.049 0.1849
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.036 0.3427 0.6836
Echinococcus granulosus mitogen activated protein kinase 14 0.0159 0.127 0.2521
Echinococcus granulosus cyclin dependent kinase 1 0.0117 0.082 0.1621
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0492 0.1005
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1188 0.4911
Schistosoma mansoni vav2 0.0058 0.0191 0.0379
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0502
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0083 0.0454 0.1821
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0429 0.1679
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0375 0.3585 0.7153
Brugia malayi hypothetical protein 0.0224 0.1973 0.1966
Echinococcus granulosus casein kinase I alpha 0.0106 0.0707 0.1395
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0226 0.199 0.199
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.005 0.0104 0.0095
Onchocerca volvulus 0.0106 0.0707 0.2041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.062 0.1221
Brugia malayi diacylglycerol kinase 0.005 0.0103 0.0094
Loa Loa (eye worm) AGC/PKA protein kinase 0.0069 0.0309 0.0309
Echinococcus multilocularis 0.0153 0.1203 0.2388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Echinococcus granulosus N chimaerin 0.0054 0.0145 0.0272
Giardia lamblia Kinase, NEK 0.0135 0.1013 0.4978
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0224 0.1973 0.1973
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0492 0.1005
Loa Loa (eye worm) hypothetical protein 0.0098 0.062 0.062
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0404 0.0404
Loa Loa (eye worm) AGC/PKA protein kinase 0.0069 0.0309 0.0309
Brugia malayi serine/threonine protein kinase 6 0.0086 0.049 0.0481
Brugia malayi Protein kinase c protein 2 0.0163 0.1309 0.1301
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0375 0.3585 0.3585
Trypanosoma brucei protein kinase, putative 0.008 0.0429 0.1679
Giardia lamblia Kinase, CMGC DYRK 0.0083 0.0454 0.2054
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0707 0.1451
Trichomonas vaginalis AGC family protein kinase 0.0086 0.049 0.1939
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0116 0.0815 0.1612
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0115 0.0804 0.1589
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0098 0.062 0.4984
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.008 0.0429 0.0429
Echinococcus granulosus calcium activated potassium channel 0.0091 0.0544 0.107
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Leishmania major protein kinase, putative,serine/threonine-protein kinase Nek1, putative 0.0046 0.0061 0.0135
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.008 0.0429 0.2033
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0069 0.0309 0.1415
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0135 0.1013 0.8338
Trypanosoma cruzi p21-activated kinase 3, putative 0.005 0.0104 0.0361
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0151 0.1188 0.2358
Trypanosoma cruzi casein kinase, putative 0.0106 0.0707 0.3466
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0309 0.0624
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0127 0.093 0.4617
Schistosoma mansoni protein kinase 0.0194 0.1645 0.3405
Brugia malayi Casein kinase II, alpha chain 0.0097 0.0611 0.0603
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0054 0.0145 0.0283
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0106 0.0707 0.3466
Echinococcus multilocularis hypothetical protein 0.0064 0.0251 0.0483
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0127 0.093 0.3889
Trypanosoma brucei Casein kinase II 0.0097 0.0611 0.2456
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0176 0.1449 0.2881
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0106 0.0707 0.0707
Echinococcus multilocularis serine:threonine protein kinase 0.0112 0.0768 0.1517
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.2442 0.5063
Schistosoma mansoni protein kinase 0.0445 0.4334 0.9001
Echinococcus granulosus expressed protein 0.008 0.0422 0.0825
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0034 0.5
Trichomonas vaginalis AGC family protein kinase 0.0151 0.1188 0.4911
Giardia lamblia Kinase, AGC PKA 0.0069 0.0309 0.1298
Echinococcus multilocularis ephrin type A receptor 4 A 0.0079 0.0412 0.0806
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0098 0.062 0.1221
Onchocerca volvulus 0.0116 0.0815 0.2357
Echinococcus multilocularis aurora kinase A 0.0086 0.049 0.0962
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0117 0.082 0.082
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0069 0.0309 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.2635 0.5464
Echinococcus granulosus ephrin type A receptor 4 A 0.0079 0.0412 0.0806
Brugia malayi beta-lactamase 0.0043 0.0034 0.0025
Toxoplasma gondii NEK kinase 0.0046 0.0061 0.0114
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.012 0.0858 0.4247
Trichomonas vaginalis AGC family protein kinase 0.0086 0.049 0.1939
Brugia malayi Protein kinase domain containing protein 0.0197 0.168 0.1672
Loa Loa (eye worm) TK/EPH protein kinase 0.0097 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0093 0.0564 0.0564
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.008 0.0422 0.1682
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0119 0.0847 0.4187
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0139 0.1058 0.5276
Schistosoma mansoni tyrosine kinase 0.0197 0.168 0.3477
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0042 0.0015 0.0012
Brugia malayi Temporarily assigned gene name protein 59 0.0116 0.0815 0.0806
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0086 0.0492 0.0966
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0097 0.0611 0.0611
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Loa Loa (eye worm) AGC/NDR protein kinase 0.0151 0.1188 0.1188
Echinococcus multilocularis cyclin dependent kinase 5 0.0117 0.082 0.1621
Echinococcus multilocularis Diacylglycerol kinase theta 0.005 0.0103 0.0187
Echinococcus multilocularis protein kinase c epsilon type 0.0204 0.175 0.3483
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0025
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0046 0.0061 0.0223
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.0439 0.2086
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0053 0.0131 0.0244
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0422 0.1997
Giardia lamblia Kinase, CAMK CAMKL 0.0086 0.0492 0.2254
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1449 0.2997
Leishmania major protein kinase A catalytic subunit 0.0069 0.0309 0.1415
Trypanosoma brucei developmentally regulated phosphoprotein 0.0125 0.0903 0.3699
Plasmodium falciparum calcium-dependent protein kinase 4 0.0098 0.062 0.487
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0611 0.2372
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.062 0.127
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.2635 0.5464
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0086 0.0492 0.3898
Brugia malayi Protein kinase domain containing protein 0.0087 0.0499 0.049
Trypanosoma brucei cdc2-related kinase 3 0.0117 0.082 0.3344
Plasmodium falciparum calcium-dependent protein kinase 5 0.0098 0.062 0.487
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0046 0.0061 0.0223
Brugia malayi Protein kinase domain containing protein 0.0375 0.3585 0.3579
Brugia malayi Furin-like cysteine rich region family protein 0.0229 0.2018 0.201
Echinococcus granulosus casein kinase ii subunit alpha 0.0097 0.0611 0.1204
Echinococcus multilocularis expressed protein 0.008 0.0422 0.0825
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.0904 0.3704
Brugia malayi Protein kinase domain containing protein 0.0112 0.0768 0.0759
Brugia malayi Cam kinase protein 1 0.0098 0.062 0.0611
Loa Loa (eye worm) hypothetical protein 0.0067 0.0283 0.0283
Echinococcus multilocularis serine:threonine protein kinase N2 0.0151 0.1188 0.2358
Schistosoma mansoni diacylglycerol kinase theta 0.005 0.0103 0.0195
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0107 0.0718 0.1418
Echinococcus granulosus cyclin dependent kinase 5 0.0117 0.082 0.1621
Brugia malayi Protein kinase domain containing protein 0.0151 0.1188 0.118
Echinococcus granulosus rho-associated protein kinase 1 0.0332 0.3121 0.6224
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0204 0.1755 0.3491
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0347 0.3283 0.3283
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Brugia malayi Doublecortin family protein 0.015 0.1177 0.1169
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0098 0.062 0.0611
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0117 0.082 0.082
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0429 0.0873
Schistosoma mansoni tyrosine kinase 0.0197 0.168 0.3477
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.008 0.0422 0.1997
Loa Loa (eye worm) hypothetical protein 0.0194 0.1651 0.1651
Plasmodium falciparum calcium-dependent protein kinase 1 0.0098 0.062 0.487
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0077 0.0398 0.1581
Echinococcus multilocularis casein kinase I alpha 0.0106 0.0707 0.1395
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0187 0.1567 0.3116
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0069 0.0309 0.1415
Mycobacterium ulcerans beta-lactamase 0.0043 0.0034 0.5
Leishmania major casein kinase II, putative 0.0097 0.0611 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.1755 0.3632
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0083 0.0454 0.089
Plasmodium falciparum serine/threonine protein kinase 0.008 0.0422 0.3147
Loa Loa (eye worm) hypothetical protein 0.0093 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.036 0.3427 0.7113
Echinococcus granulosus Vam6:Vps39 protein 0.0116 0.0815 0.1612
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Echinococcus granulosus Protein kinase C brain isozyme 0.0286 0.2635 0.5252
Entamoeba histolytica protein kinase, putative 0.008 0.0422 0.1555
Echinococcus granulosus casein kinase I delta 0.0106 0.0707 0.1395
Entamoeba histolytica protein kinase, putative 0.0078 0.0404 0.1477
Trichomonas vaginalis STE family protein kinase 0.0135 0.1013 0.4167
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0078 0.0404 0.0789
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0454 0.1692
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.082 0.3344
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0544 0.2171
Schistosoma mansoni serine/threonine protein kinase 0.049 0.4814 1
Plasmodium falciparum serine/threonine protein kinase KIN 0.0086 0.0492 0.3759
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Loa Loa (eye worm) hypothetical protein 0.0112 0.0768 0.0768
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0226 0.199 0.1982
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0034 0.5
Brugia malayi MAP kinase sur-1 0.008 0.0429 0.042
Entamoeba histolytica casein kinase, putative 0.0097 0.0611 0.2372
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.005 0.0104 0.0298
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Onchocerca volvulus Netrin receptor homolog 0.0041 0.0011 0.0005
Echinococcus granulosus NDR protein kinase 0.0151 0.1188 0.2358
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0083 0.0454 0.089
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.1734 0.1734
Onchocerca volvulus 0.0325 0.3051 0.8901
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Schistosoma mansoni rap gtpase-activating protein 0.0116 0.0815 0.1677
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Brugia malayi Protein kinase domain containing protein 0.0194 0.1645 0.1638
Toxoplasma gondii AGC kinase 0.0069 0.0309 0.1192
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0404 0.3891 0.7765
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0454 0.0925
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0069 0.0309 0.2164
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0204 0.175 0.175
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0454 0.089
Plasmodium falciparum casein kinase 1 0.0106 0.0707 0.563
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.127 0.2521
Echinococcus multilocularis tumor protein p63 0.0408 0.3939 0.786
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0375 0.3585 0.7153
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Echinococcus granulosus casein kinase I delta 0.0106 0.0707 0.1395
Leishmania major serine/threonine-protein kinase, putative 0.0046 0.0061 0.0135
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.012 0.0858 0.4247
Echinococcus multilocularis calcium activated potassium channel 0.0091 0.0544 0.107
Brugia malayi Protein kinase domain containing protein 0.0117 0.082 0.0811
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0492 0.1005
Schistosoma mansoni ephrin receptor 0.0079 0.0412 0.0839
Loa Loa (eye worm) camk/dcamkl protein kinase 0.015 0.1177 0.1177
Brugia malayi putative serine/threonine kinase SADA gamma 0.0086 0.0492 0.0483
Loa Loa (eye worm) hypothetical protein 0.0145 0.1117 0.1117
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Echinococcus multilocularis protein kinase shaggy 0.0127 0.093 0.1842
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Entamoeba histolytica protein kinase, putative 0.008 0.0422 0.1555
Entamoeba histolytica hypothetical protein 0.012 0.0858 0.3434
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0454 0.089
Brugia malayi diacylglycerol kinase 0.005 0.0103 0.0094
Echinococcus multilocularis serine:threonine protein kinase 38 0.0151 0.1188 0.2358
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0244 0.2184 0.4349
Echinococcus multilocularis dual specificity 0.0083 0.0454 0.0889
Loa Loa (eye worm) hypothetical protein 0.0116 0.0815 0.0815
Toxoplasma gondii NEK kinase 0.0046 0.0061 0.0114
Echinococcus multilocularis mitogen activated protein kinase 0.008 0.0429 0.0839
Loa Loa (eye worm) raf kinase 0.005 0.0103 0.0103
Brugia malayi kinase, mitochondrial precursor 0.0125 0.0903 0.0895
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.1188 0.2453
Schistosoma mansoni kinase 0.0127 0.0932 0.1921
Echinococcus multilocularis rho associated protein kinase 0.0332 0.3121 0.6224
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0117 0.082 0.4049
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.012 0.0858 0.0858
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0098 0.062 0.062
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0061 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Brugia malayi phosphoinositide-dependent protein kinase I 0.0078 0.0404 0.0395
Brugia malayi serine/threonine kinase 12 0.0086 0.049 0.0481
Trypanosoma cruzi cdc2-related kinase 1 0.0117 0.082 0.4049
Echinococcus multilocularis raf serine:threonine protein kinase 0.0062 0.0233 0.0447
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0125 0.0903 0.1788
Brugia malayi Immunoglobulin I-set domain containing protein 0.0127 0.0924 0.0915
Loa Loa (eye worm) hypothetical protein 0.0055 0.016 0.016
Entamoeba histolytica protein kinase, putative 0.006 0.0212 0.0653
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0083 0.0454 0.0445
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0098 0.062 0.1221
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0098 0.062 0.4984
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0176 0.1449 0.2881
Onchocerca volvulus 0.0332 0.3121 0.9105
Onchocerca volvulus 0.0043 0.0034 0.0073
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0086 0.0492 0.2359
Echinococcus granulosus roundabout 2 0.0043 0.0027 0.0035
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0153 0.1208 0.6052
Echinococcus multilocularis casein kinase i 0.0106 0.0707 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0233 0.0465
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0117 0.082 0.4049
Brugia malayi Protein kinase domain containing protein 0.0151 0.1188 0.118
Brugia malayi Stress-activated protein kinase jnk-1 0.0268 0.2442 0.2435
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Brugia malayi Protein kinase domain containing protein 0.008 0.0422 0.0413
Brugia malayi RhoGAP domain containing protein 0.005 0.0103 0.0094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0086 0.0492 0.0492
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.1244 0.2469
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.175 0.3624
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0069 0.0309 0.2339
Trypanosoma brucei polo-like protein kinase 0.0225 0.1974 0.8258
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0159 0.127 0.127
Echinococcus granulosus casein kinase I alpha 0.0106 0.0707 0.1395
Schistosoma mansoni pyruvate dehydrogenase 0.0118 0.0829 0.1706
Onchocerca volvulus 0.0079 0.0413 0.1181
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0127 0.093 0.4617
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.2184 0.4525
Plasmodium vivax unspecified product 0.0097 0.0611 0.4915
Brugia malayi Protein kinase domain containing protein 0.0263 0.2383 0.2376
Loa Loa (eye worm) hypothetical protein 0.0124 0.0895 0.0895
Giardia lamblia Kinase, CMGC CK2 0.0097 0.0611 0.2879
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Trypanosoma brucei protein kinase, putative 0.0127 0.093 0.3812
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0115 0.0804 0.1589
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0091 0.0544 0.0544
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0429 0.1679
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Schistosoma mansoni protein kinase 0.0375 0.3585 0.7442
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.008 0.0429 0.2033
Loa Loa (eye worm) hypothetical protein 0.0053 0.0131 0.0131
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0159 0.127 0.5258
Loa Loa (eye worm) hypothetical protein 0.0054 0.0149 0.0149
Brugia malayi hypothetical protein 0.0116 0.0815 0.0806
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.008 0.0429 0.1712
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0078 0.0404 0.0789
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0544 0.1113
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.005 0.0103 0.0103
Echinococcus multilocularis dual specificity protein kinase clk2 0.0153 0.1208 0.2399
Echinococcus granulosus fibroblast growth factor receptor 4 0.0115 0.0804 0.1589
Echinococcus granulosus myotubularin protein 13 0.0054 0.0149 0.0279
Loa Loa (eye worm) variant SH3 domain-containing protein 0.005 0.0103 0.0103
Entamoeba histolytica diacylglycerol kinase, putative 0.005 0.0103 0.0183
Echinococcus granulosus protein kinase shaggy 0.0127 0.093 0.1842
Entamoeba histolytica protein kinase, putative 0.0086 0.049 0.1849
Trichomonas vaginalis AGC family protein kinase 0.0086 0.049 0.1939
Onchocerca volvulus 0.0067 0.0283 0.08
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0097 0.0611 0.4915
Toxoplasma gondii NEK kinase 0.0046 0.0061 0.0114
Schistosoma mansoni vam6/vps39 related 0.0116 0.0815 0.1677
Loa Loa (eye worm) AUR protein kinase 0.0086 0.049 0.049
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0309 0.1169
Brugia malayi Protein kinase domain containing protein 0.012 0.0858 0.085
Echinococcus granulosus Rac GTPase activating protein 1 0.005 0.0103 0.0187
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0355 0.1268
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0404 0.3891 0.3891
Echinococcus multilocularis cyclin dependent kinase 1 0.0117 0.082 0.1621
Echinococcus granulosus Diacylglycerol kinase theta 0.005 0.0103 0.0187
Echinococcus multilocularis serine:threonine protein kinase 3 0.0261 0.2359 0.4701
Entamoeba histolytica protein kinase, putative 0.012 0.0858 0.3434
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.0439 0.2086
Loa Loa (eye worm) RasGEF domain-containing protein 0.005 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0104 0.0198
Entamoeba histolytica protein kinase, putative 0.0263 0.2383 1
Brugia malayi cell division control protein 2 homolog 0.0117 0.082 0.0811
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0286 0.2635 0.5252
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0081 0.0439 0.1629
Brugia malayi serine/threonine-protein kinase 6 0.0086 0.049 0.0481
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0508 0.5008 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0098 0.062 0.2541
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.127 0.2521
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0242 0.2155 0.4293
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0815 0.3323
Schistosoma mansoni serine/threonine kinase 0.0091 0.0544 0.1113
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0544 0.1113
Trypanosoma cruzi casein kinase, putative 0.0106 0.0707 0.3466
Echinococcus multilocularis cyclin dependent kinase 0.0117 0.082 0.1621
Loa Loa (eye worm) hypothetical protein 0.0075 0.0369 0.0369
Echinococcus multilocularis nervana 2 0.0107 0.0718 0.1418
Echinococcus multilocularis Glutaredoxin protein 5 0.0107 0.0718 0.1418
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0187 0.1567 0.1559
Echinococcus granulosus serine:threonine protein kinase N2 0.0286 0.2634 0.525
Trichomonas vaginalis STE family protein kinase 0.0083 0.0454 0.1787
Echinococcus multilocularis casein kinase I alpha 0.0106 0.0707 0.1395
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0261 0.2359 0.2359
Echinococcus multilocularis casein kinase ii subunit alpha 0.0097 0.0611 0.1204
Trichomonas vaginalis AGC family protein kinase 0.0135 0.1013 0.4167
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Schistosoma mansoni protein kinase 0.0097 0.0611 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.016 0.0537
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0025
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0079 0.0413 0.1952
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0244 0.2184 0.4349
Giardia lamblia Kinase, NEK 0.0135 0.1013 0.4978
Plasmodium vivax serine/threonine protein kinase, putative 0.008 0.0422 0.3299
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0107 0.0718 0.1418
Echinococcus granulosus epidermal growth factor receptor 0.0229 0.2018 0.4017
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0086 0.0492 0.0492
Plasmodium vivax serine/threonine kinase-1, putative 0.0153 0.1208 1
Echinococcus multilocularis dual specificity 0.0083 0.0454 0.0889
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0225 0.1974 0.3931
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0034 0.005
Brugia malayi Protein kinase domain containing protein 0.0153 0.1208 0.12
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Echinococcus granulosus serine threonine protein kinase nrc 0.0135 0.1012 0.2005
Trichomonas vaginalis CK1 family protein kinase 0.0106 0.0707 0.2862
Echinococcus multilocularis mitogen activated protein kinase 3 0.008 0.0429 0.0839
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0404 0.0821
Entamoeba histolytica protein kinase 2, putative 0.0135 0.1012 0.4095
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1325 0.2738
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0309 0.0624
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0048 0.0086 0.0086
Echinococcus granulosus dual specificity 0.0083 0.0454 0.0889
Trypanosoma cruzi casein kinase, putative 0.0106 0.0707 0.3466
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.127 0.6367
Echinococcus granulosus twitchin 0.0061 0.0217 0.0416
Schistosoma mansoni tyrosine kinase 0.0115 0.0804 0.1654
Schistosoma mansoni protein kinase 0.0445 0.4334 0.9001
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Giardia lamblia Kinase, CMGC CDK 0.0117 0.082 0.3968
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0492 0.1005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.0251
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0054 0.0145 0.0272
Trypanosoma cruzi cdc2-related kinase 3 0.0117 0.082 0.4049
Mycobacterium ulcerans hypothetical protein 0.0043 0.0034 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.2126 0.4405
Schistosoma mansoni hypothetical protein 0.0116 0.0815 0.1677
Echinococcus granulosus dual specificity 0.0083 0.0454 0.0889
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0508 0.5008 1
Loa Loa (eye worm) casein kinase 0.0188 0.1579 0.1579
Leishmania major developmentally regulated phosphoprotein-like protein 0.0125 0.0903 0.4479
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0098 0.062 0.2491
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0194 0.1645 0.1645
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0098 0.062 0.062
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0098 0.062 0.2541
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0208 0.0414
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0116 0.0815 0.1612
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0544 0.1113
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0176 0.1449 0.2881
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0135 0.1012 0.2005
Entamoeba histolytica protein kinase, putative 0.0259 0.2337 0.9802
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0259 0.2337 0.2337
Echinococcus granulosus c-Jun N-terminal kinases 0.0268 0.2442 0.4867
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.1058 0.4293
Brugia malayi Serine/threonine-protein kinase SULU 0.0224 0.1973 0.1966
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.008 0.0422 0.0422
Leishmania major protein kinase, putative 0.0046 0.0061 0.0135
Trypanosoma brucei Serine/threonine-protein kinase NEK16, putative 0.0046 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Echinococcus granulosus serine:threonine protein kinase 0.0112 0.0768 0.1517
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.1208 0.6052
Entamoeba histolytica protein kinase , putative 0.0086 0.049 0.1849
Leishmania major protein kinase, putative 0.0086 0.049 0.2349
Trypanosoma cruzi Serine/threonine-protein kinase NEK11, putative 0.0046 0.0061 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Schistosoma mansoni protein kinase 0.0106 0.0707 0.1451
Loa Loa (eye worm) hypothetical protein 0.0199 0.1696 0.1696
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0454 0.1785
Schistosoma mansoni protein kinase 0.006 0.0212 0.0423
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0235 0.2083 0.2083
Entamoeba histolytica protein kinase, putative 0.0064 0.0258 0.0851
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0404 0.1572
Entamoeba histolytica casein kinase, putative 0.0106 0.0707 0.2782
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0164 0.1325 0.2632
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.3891 0.8079
Echinococcus multilocularis calcium dependent protein kinase 0.0071 0.0326 0.0633
Echinococcus multilocularis serine:threonine protein kinase N2 0.0286 0.2634 0.525
Onchocerca volvulus Serine\/threonine kinase homolog 0.0164 0.1325 0.3849
Loa Loa (eye worm) hypothetical protein 0.0059 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0502
Echinococcus multilocularis myotubularin protein 13 0.0054 0.0149 0.0279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0445 0.4334 0.8651
Trypanosoma brucei rac serine-threonine kinase, putative 0.0263 0.2383 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0098 0.062 0.4984
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.02 0.1707 0.3396
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0366 0.3492 0.3492
Leishmania major protein kinase, putative 0.0098 0.062 0.3017
Echinococcus granulosus tumor protein p63 0.0408 0.3939 0.786
Trypanosoma cruzi casein kinase, putative 0.0106 0.0707 0.3466
Schistosoma mansoni protein kinase C 0.0053 0.0131 0.0254
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.008 0.0429 0.2033
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0104 0.0104
Loa Loa (eye worm) AGC/AKT protein kinase 0.0263 0.2383 0.2383
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0069 0.0309 0.1415
Onchocerca volvulus 0.0199 0.1696 0.4935
Loa Loa (eye worm) hypothetical protein 0.0116 0.0815 0.0815
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0974 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.127 0.2521
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0125 0.0903 0.1788
Schistosoma mansoni serine/threonine kinase 0.0151 0.1188 0.2453
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0086 0.049 0.0962
Echinococcus multilocularis 0.0066 0.0278 0.0538
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0151 0.1188 0.2358
Loa Loa (eye worm) TK protein kinase 0.0127 0.0924 0.0924
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0086 0.049 0.1849
Plasmodium falciparum NIMA related kinase 1 0.0135 0.1013 0.83
Plasmodium vivax tyrosine kinase-like protein, putative 0.0077 0.0398 0.3101
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.017 0.1389 0.1389
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0069 0.0309 0.1415
Brugia malayi intracellular kinase 0.0127 0.093 0.0922
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0151 0.1188 0.1188
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0404 0.1572
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0135 0.1012 0.8326
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0204 0.1755 0.3491
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0034 0.005
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0151 0.1188 0.2358
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0454 0.089
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0053 0.0131 0.0244
Echinococcus granulosus dual specificity 0.012 0.0858 0.1698
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.005 0.0104 0.0104
Trichomonas vaginalis CK1 family protein kinase 0.0106 0.0707 0.2862
Echinococcus multilocularis unc 13 (munc13) 0.0053 0.0131 0.0244
Plasmodium falciparum calcium-dependent protein kinase 3 0.0098 0.062 0.487
Loa Loa (eye worm) CAMK/PIM protein kinase 0.036 0.3427 0.3427
Trichomonas vaginalis STE family protein kinase 0.0083 0.0454 0.1787
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0225 0.1974 0.1974
Onchocerca volvulus 0.006 0.0208 0.0583
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0225 0.1974 1
Trichomonas vaginalis STE family protein kinase 0.0083 0.0454 0.1787
Brugia malayi Temporarily assigned gene name protein 59 0.0134 0.1007 0.0999
Leishmania major protein kinase, putative 0.0081 0.0439 0.2086
Echinococcus granulosus casein kinase I gamma 0.0215 0.1873 0.3728
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0116 0.0815 0.4024
Plasmodium vivax protein kinase Crk2 0.0117 0.082 0.6691
Plasmodium falciparum serine/threonine protein kinase, putative 0.0086 0.049 0.3741
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.1974 0.4089
Echinococcus multilocularis casein kinase I delta 0.0106 0.0707 0.1395
Loa Loa (eye worm) hypothetical protein 0.0069 0.0309 0.0309
Trypanosoma cruzi aurora B kinase, putative 0.0086 0.049 0.2349
Trypanosoma cruzi polo-like protein kinase, putative 0.0225 0.1974 1
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0081 0.0439 0.1723
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0187 0.1567 0.1567
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0347 0.3283 0.3277
Leishmania major casein kinase, putative 0.0106 0.0707 0.3466
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0144 0.1109 0.2199
Loa Loa (eye worm) beta-lactamase 0.0043 0.0034 0.0034
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0153 0.1208 0.6052
Giardia lamblia Kinase, CMGC CDK 0.0117 0.082 0.3968
Loa Loa (eye worm) CAMK/PIM protein kinase 0.036 0.3427 0.3427
Loa Loa (eye worm) hypothetical protein 0.0149 0.1162 0.1162
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0098 0.062 0.2541
Plasmodium falciparum calcium-dependent protein kinase 2 0.0098 0.062 0.487
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1449 0.2997
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.1244 0.2469
Loa Loa (eye worm) hypothetical protein 0.0116 0.0815 0.0815
Trichomonas vaginalis AGC family protein kinase 0.0086 0.049 0.1939
Loa Loa (eye worm) hypothetical protein 0.005 0.0103 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0263 0.2383 1
Brugia malayi Protein kinase domain containing protein 0.0091 0.0544 0.0535
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0176 0.1455 0.1455
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0125 0.0903 0.1788
Brugia malayi p70 ribosomal S6 kinase beta 0.0259 0.2337 0.233
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0083 0.0454 0.1785
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0075 0.0132
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0202 0.1734 0.3449
Brugia malayi ephrin receptor 1 precursor 0.0044 0.0035 0.0026
Loa Loa (eye worm) AUR protein kinase 0.0086 0.049 0.049
Echinococcus granulosus dual specificity protein kinase clk2 0.0153 0.1208 0.2399
Toxoplasma gondii aurora kinase 0.0086 0.049 0.1978
Echinococcus granulosus casein kinase i 0.0106 0.0707 0.1395
Schistosoma mansoni tyrosine kinase 0.0156 0.1244 0.2569
Brugia malayi Variant SH3 domain containing protein 0.0054 0.0145 0.0136
Echinococcus multilocularis protein kinase c iota type 0.0287 0.2647 0.5276
Onchocerca volvulus Serine\/threonine kinase homolog 0.0225 0.1974 0.5749
Loa Loa (eye worm) hypothetical protein 0.0145 0.1117 0.1117
Echinococcus granulosus mitogen activated protein kinase 0.008 0.0429 0.0839
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.012 0.0858 0.4247
Trichomonas vaginalis STE family protein kinase 0.0081 0.0439 0.1723
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0429 0.1679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0052
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0131 0.0254
Brugia malayi Serine/threonine-protein kinase Pim-3 0.036 0.3427 0.3421
Schistosoma mansoni tyrosine kinase 0.0156 0.1244 0.2569
Echinococcus granulosus protein kinase c eta type 0.005 0.0103 0.0187
Plasmodium vivax casein kinase 1, putative 0.0106 0.0707 0.5727
Schistosoma mansoni serine/threonine-protein kinase 0.0139 0.1058 0.2182
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0115 0.0801 0.0792
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0239 0.2126 0.4234
Entamoeba histolytica cell division protein kinase 2, putative 0.0117 0.082 0.3269
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.062 0.2491
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1873 0.3879
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0083 0.0454 0.2161
Entamoeba histolytica protein kinase, putative 0.0083 0.0454 0.1692
Brugia malayi map kinase activated protein kinase protein 2 0.0404 0.3891 0.3886
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0106 0.0707 0.0707
Echinococcus multilocularis epidermal growth factor receptor 0.0229 0.2018 0.4017
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0083 0.0453 0.0888
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.1244 0.2469
Giardia lamblia Kinase, AGC PKA 0.0135 0.1012 0.4971
Echinococcus multilocularis insulin receptor 0.0197 0.168 0.3342
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0204 0.1755 0.1747
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.2634 0.5462
Entamoeba histolytica protein kinase, putative 0.0083 0.0454 0.1695
Echinococcus granulosus dual specificity 0.0083 0.0454 0.0889
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0054 0.0145 0.0272
Entamoeba histolytica PH domain containing protein kinase, putative 0.0139 0.1058 0.4293
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0445 0.4334 0.8651
Giardia lamblia Kinase, CK1 Casein kinase 0.0106 0.0707 0.3377
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.2184 0.4525
Onchocerca volvulus 0.0203 0.1742 0.507
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.127 0.2521
Loa Loa (eye worm) hypothetical protein 0.0083 0.0453 0.0453
Onchocerca volvulus 0.0043 0.0034 0.0073
Plasmodium falciparum protein serine/threonine kinase-1 0.0153 0.1208 1
Giardia lamblia Kinase, AGC AKT 0.0115 0.0801 0.3867
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0309 0.0599
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0611 0.2456
Echinococcus multilocularis serine threonine protein kinase 0.0236 0.2101 0.4183
Loa Loa (eye worm) hypothetical protein 0.0132 0.0987 0.0987
Entamoeba histolytica protein kinase, putative 0.0098 0.062 0.2407
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0135 0.1013 0.425
Toxoplasma gondii CMGC kinase, CK2 family 0.0097 0.0611 0.2506
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0034
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0268 0.2442 0.2442
Echinococcus multilocularis 0.0126 0.0915 0.1811
Mycobacterium leprae Probable lipase LipE 0.0043 0.0034 0.5
Brugia malayi STE20-like kinase MST 0.0261 0.2359 0.2352
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.008 0.0429 0.2033
Echinococcus multilocularis cyclin dependent kinase 1 0.0117 0.082 0.1621
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0492 0.2359
Onchocerca volvulus 0.0149 0.1162 0.3372
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0492 0.1948
Brugia malayi casein kinase 1, delta 0.0106 0.0707 0.0698
Trypanosoma cruzi casein kinase II, putative 0.0097 0.0611 0.2975
Echinococcus granulosus unc 13 munc13 0.0053 0.0131 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0225 0.1974 0.8258
Brugia malayi Protein kinase domain 0.0083 0.0454 0.0445
Giardia lamblia Kinase, STE STE20 0.0083 0.0454 0.2057
Entamoeba histolytica cell division protein kinase 2, putative 0.0117 0.082 0.3269
Loa Loa (eye worm) hypothetical protein 0.0125 0.0903 0.0903
Trichomonas vaginalis CMGC family protein kinase 0.0127 0.093 0.3812
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0116 0.0815 0.1677
Echinococcus granulosus serine:threonine protein kinase 0.0112 0.0768 0.1517
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0768 0.3121
Loa Loa (eye worm) hypothetical protein 0.0242 0.2155 0.2155
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0127 0.093 0.1916
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.1208 0.2495
Schistosoma mansoni protein kinase 0.0083 0.0454 0.0926
Schistosoma mansoni protein kinase 0.0153 0.1203 0.2484
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.0212 0.0406
Giardia lamblia Kinase, CMGC SRPK 0.008 0.0422 0.1887
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0041 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.2339 0.4848
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0069 0.0309 0.1169
Loa Loa (eye worm) hypothetical protein 0.0145 0.1117 0.1117
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.005 0.011 0.0326
Entamoeba histolytica protein kinase, putative 0.0263 0.2383 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.2736 0.2736
Plasmodium falciparum protein kinase 5 0.0117 0.082 0.6615
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0131 0.0254
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0144 0.1109 0.2199
Echinococcus granulosus protein kinase C gamma type 0.0236 0.2101 0.4183
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0044 0.0035 0.0005

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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