TDR Targets

Basic information

Technical information

TDR Targets ID: 1351689
Name: 4-[(2-nitrophenyl)sulfanylamino]cyclohexane-1 -carboxylic acid
MW: 296.342 | Formula: C13H16N2O4S
H donors: 2 H acceptors: 4 LogP: 0.14 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1CCC(CC1)NSc1ccccc1[N+](=O)[O-]
InChi: 1S/C13H16N2O4S/c16-13(17)9-5-7-10(8-6-9)14-20-12-4-2-1-3-11(12)15(18)19/h1-4,9-10,14H,5-8H2,(H,16,17)
InChiKey: OVWRPFFTNXDLSN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[(2-nitrophenyl)thio]amino]-1-cyclohexanecarboxylic acid
4-[[(2-nitrophenyl)thio]amino]cyclohexane-1-carboxylic acid
STOCK1S-66833
4-(2-Nitro-phenylsulfanylamino)-cyclohexanecarboxylic acid
MLS000777709
SMR000414137

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0057	0.0503	0.0474
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0418	0.3302
Schistosoma mansoni	hypothetical protein	0.0123	0.1312	0.1285
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0065	0.0042
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0065	0.0034
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0531	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0531	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0739	0.0711
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0418	0.3302
Echinococcus granulosus	somatostatin receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0065	0.0034
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0531	1
Echinococcus granulosus	hypothetical protein	0.0021	0.0065	0.0034
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0065	0.0034
Brugia malayi	G protein-coupled receptor	0.0021	0.0065	0.0042
Brugia malayi	neuropeptide F receptor	0.0021	0.0065	0.0042
Onchocerca volvulus		0.0057	0.0503	0.0545
Brugia malayi	Carboxylesterase family protein	0.0057	0.0503	0.0585
Giardia lamblia	Kinase, PLK	0.0115	0.1205	1
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Brugia malayi	hypothetical protein	0.0679	0.8112	1
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0089	0.0058
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0418	0.0389
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0089	0.0735
Schistosoma mansoni	hypothetical protein	0.0021	0.0065	0.0034
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0089	0.1155
Brugia malayi	RNA binding protein	0.0076	0.0739	0.0877
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0503	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	dna polymerase eta	0.0023	0.0089	0.0058
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0136	0.013
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0089	0.1155
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0065	0.0034
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0089	0.0071
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0089	0.0735
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0115	0.1205	0.1417
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0418	0.0389
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0089	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0679	0.8112	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0739	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Leishmania major	DNA polymerase eta, putative	0.0023	0.0089	0.0492
Echinococcus granulosus	acetylcholinesterase	0.0339	0.3946	0.3927
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	acetylcholinesterase	0.0339	0.3946	0.3927
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.1312	0.1285
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0531	0.0502
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0089	0.0492
Leishmania major	cytochrome p450-like protein	0.0027	0.0136	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0065	0.0034
Brugia malayi	RE15519p	0.0021	0.0065	0.0042
Schistosoma mansoni	hypothetical protein	0.0169	0.1873	0.1848
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0136	0.013
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0065	0.0034
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0019	0.0031	0.0255
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0136	0.0894
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0408	0.0467
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuroligin	0.0057	0.0503	0.0474
Echinococcus granulosus	BC026374 protein S09 family	0.0057	0.0503	0.0474
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.05	0.3685
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0065	0.0034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0089	0.0492
Echinococcus granulosus	geminin	0.0169	0.1873	0.1848
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0065	0.0034
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0418	0.3302
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.1251	0.151
Mycobacterium ulcerans	carboxylesterase, LipT	0.0057	0.0503	0.945
Trichomonas vaginalis	CAMK family protein kinase	0.0057	0.05	0.3685
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	carboxylesterase 5A	0.0339	0.3946	0.3927
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0065	0.0034
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0065	0.0042
Onchocerca volvulus		0.0057	0.0503	0.0545
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	serotonin receptor	0.0021	0.0065	0.0034
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0418	0.3473
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0418	0.3302
Brugia malayi	G-protein coupled receptor	0.0021	0.0065	0.0042
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Loa Loa (eye worm)	carboxylesterase	0.0057	0.0503	0.0585
Brugia malayi	G-protein coupled receptor	0.0021	0.0065	0.0042
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0089	0.0058
Brugia malayi	serine/threonine-protein kinase plk-2	0.0115	0.1205	0.1453
Onchocerca volvulus		0.0057	0.0503	0.0545
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.1312	0.1285
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0089	0.0058
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0089	0.1155
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0065	0.0034
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0065	0.0042
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0739	0.0877
Schistosoma mansoni	amine GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0739	0.0877
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0065	0.0034
Brugia malayi	MAP kinase sur-1	0.005	0.0418	0.048
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0089	0.0071
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0065	0.0034
Mycobacterium leprae	putative cytochrome p450	0.0019	0.0031	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0065	0.0034
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0065	0.0042
Brugia malayi	Carboxylesterase family protein	0.0057	0.0503	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Onchocerca volvulus		0.0057	0.0503	0.0545
Trypanosoma brucei	polo-like protein kinase	0.0115	0.1205	1
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	serotonin receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	hypothetical protein	0.0021	0.0065	0.0034
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0065	0.0042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0939	0.0911
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0065	0.0034
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.1433	0.1406
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0089	0.0058
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0065	0.0034
Loa Loa (eye worm)	carboxylesterase	0.0339	0.3946	0.4845
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0531	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0089	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	myosin xvIII	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0939	0.0911
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0136	0.013
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0531	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	CYP4Cod1	0.0027	0.0136	0.013
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0408	0.0467
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.1205	1
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0065	0.0042
Brugia malayi	Carboxylesterase family protein	0.0339	0.3946	0.4845
Echinococcus multilocularis	geminin	0.0169	0.1873	0.1848
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0939	0.0911
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0065	0.0034
Brugia malayi	Serotonin receptor	0.0021	0.0065	0.0042
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0503	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Trypanosoma brucei	protein kinase, putative	0.005	0.0418	0.3473
Schistosoma mansoni	gliotactin	0.0057	0.0503	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0339	0.3946	0.4845
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0065	0.0034
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0418	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0089	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0739	0.0711
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0136	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0065	0.0034
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0531	0.0502
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0418	0.2955
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0089	0.1155
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	amine GPCR	0.0021	0.0065	0.0034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Schistosoma mansoni	acetylcholinesterase	0.0057	0.0503	0.0474
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0065	0.0034
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0408	0.0467
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0057	0.0503	0.0474
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0065	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0115	0.1205	0.1453
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0418	0.3302
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0057	0.0503	0.0474
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Onchocerca volvulus		0.0679	0.8112	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0065	0.0042
Schistosoma mansoni	hypothetical protein	0.0021	0.0065	0.0034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0739	0.0711
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.1205	0.1177
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0065	0.0034
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0057	0.0503	0.3717
Schistosoma mansoni	kinase	0.0058	0.0518	0.0489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0065	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.1251	0.151
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0057	0.0503	0.945
Schistosoma mansoni	amine GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	amine GPCR	0.0021	0.0065	0.0034
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0418	0.0389
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0418	0.2955
Mycobacterium leprae	Conserved hypothetical protein	0.0019	0.0031	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0065	0.0034
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0939	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0065	0.0042
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0065	0.0042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0065	0.0034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Echinococcus multilocularis	carboxylesterase 5A	0.0339	0.3946	0.3927
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Trypanosoma brucei	cytochrome P450, putative	0.0027	0.0136	0.1127
Echinococcus granulosus	acetylcholinesterase	0.0339	0.3946	0.3927
Loa Loa (eye worm)	hypothetical protein	0.0679	0.8112	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0739	0.0877
Brugia malayi	Dopamine receptor	0.0021	0.0065	0.0042
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0136	0.013
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0939	0.1124
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0089	0.0058
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0065	0.0034
Brugia malayi	Carboxylesterase family protein	0.0339	0.3946	0.4845
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0115	0.1205	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0939	0.0911
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0065	0.0042
Echinococcus granulosus	neuroligin	0.0057	0.0503	0.0474
Brugia malayi	larval opioid receptor	0.0021	0.0065	0.0042
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0408	0.0467
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	opsin-like receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.1433	0.1406
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Brugia malayi	MH2 domain containing protein	0.0118	0.1251	0.151
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0089	0.0492
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0089	0.0492
Schistosoma mansoni	adenoreceptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0065	0.0034
Trypanosoma brucei	unspecified product	0.0023	0.0089	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0065	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0089	0.0492
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0027	0.0136	0.2099
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0065	0.0042
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0065	0.0034
Brugia malayi	GnHR receptor homolog	0.0021	0.0065	0.0042
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0065	0.0034
Onchocerca volvulus		0.0057	0.0503	0.0545
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0057	0.0503	0.945
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Trypanosoma cruzi	polo-like protein kinase, putative	0.0115	0.1205	1
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0065	0.0034
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0065	0.0042
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0065	0.0042
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0065	0.0042
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0057	0.0503	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0739	0.0711
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0065	0.0034
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0739	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0418	0.0389
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0065	0.0042
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0418	0.2955
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0418	0.2955
Echinococcus multilocularis	para nitrobenzyl esterase	0.0057	0.0503	0.0474
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0089	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	amine GPCR	0.0021	0.0065	0.0034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0065	0.0034
Brugia malayi	putative neuropeptide receptor	0.0021	0.0065	0.0042
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0065	0.0042
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Brugia malayi	AKH receptor	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0217	0.023
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0065	0.0034
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0133	0.1433	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0065	0.0042
Echinococcus granulosus	sex peptide receptor	0.0021	0.0065	0.0034
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0065	0.0042
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0065	0.0034
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	opsin-like receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0065	0.0034
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0739	0.0711
Trichomonas vaginalis	CAMK family protein kinase	0.0115	0.1205	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0418	0.3302
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Echinococcus multilocularis	acetylcholinesterase	0.0339	0.3946	0.3927
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0089	0.0735
Brugia malayi	hypothetical protein	0.0057	0.0503	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0065	0.0034
Schistosoma mansoni	hypothetical protein	0.0169	0.1873	0.1848
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0065	0.0042
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0503	0.0474
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0939	0.1124
Brugia malayi	sulfakinin receptor protein	0.0021	0.0065	0.0042
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0065	0.0034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0531	0.0502
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0065	0.0034
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0339	0.3946	0.4845
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0089	0.0735
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0418	0.048
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0739	0.0711
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0115	0.1205	0.1177
Brugia malayi	Serotonin receptor	0.0021	0.0065	0.0042
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	BC026374 protein (S09 family)	0.0057	0.0503	0.0474
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0065	0.0034
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0065	0.0034
Brugia malayi	neuropeptide F receptor	0.0021	0.0065	0.0042
Brugia malayi	Carboxylesterase family protein	0.0057	0.0503	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0503	0.0585
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0065	0.0034
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0418	0.7751
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0057	0.0503	0.945
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0057	0.0503	0.0474
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0089	0.0058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0939	0.0911
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0939	0.0911
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0065	0.0034
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0531	0.426
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0065	0.0034
Schistosoma mansoni	hypothetical protein	0.0021	0.0065	0.0034
Brugia malayi	Carboxylesterase family protein	0.0057	0.0503	0.0585
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0115	0.1205	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0339	0.3946	0.3927
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0065	0.0034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0065	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0065	0.0042
Schistosoma mansoni	opsin-like receptor	0.0021	0.0065	0.0034
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0065	0.0034
Brugia malayi	TAR-binding protein	0.0076	0.0739	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0065	0.0042
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0115	0.1205	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0531	0.0502
Trichomonas vaginalis	spcc417.12 protein, putative	0.0057	0.0503	0.3717
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0089	0.0071
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0065	0.0034
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0418	0.2955
Brugia malayi	hypothetical protein	0.0021	0.0065	0.0042
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0065	0.0034
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0089	0.0735
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0065	0.0034
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0065	0.0042
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0089	0.0058
Echinococcus granulosus	serotonin receptor	0.0021	0.0065	0.0034
Schistosoma mansoni	hypothetical protein	0.0034	0.0217	0.0186
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0217	0.023
Loa Loa (eye worm)	acetylcholinesterase 1	0.0339	0.3946	0.4845
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0065	0.0034
Loa Loa (eye worm)	carboxylesterase	0.0057	0.0503	0.0585

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.3778 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1459041

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1351689