Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0256 | 0.4727 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0516 | 1 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0059 | 0.0724 | 0.0724 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0197 | 0.3538 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0516 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0516 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0516 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0516 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0059 | 0.0724 | 0.0724 |
Echinococcus granulosus | methionine synthase reductase | 0.0319 | 0.5997 | 0.5997 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0197 | 0.3538 | 0.2791 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0516 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.1141 | 0.1141 |
Brugia malayi | flavodoxin family protein | 0.0197 | 0.3538 | 0.3538 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0059 | 0.0724 | 0.5 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0059 | 0.0724 | 0.0724 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0059 | 0.0724 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.1141 | 0.1141 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0516 | 1 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0059 | 0.0724 | 0.0724 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0516 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0516 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0197 | 0.3538 | 0.5 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0197 | 0.3538 | 0.2791 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0516 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0256 | 0.4727 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0059 | 0.0724 | 0.0724 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0516 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0319 | 0.5997 | 0.5997 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0457 | 0.881 | 0.8717 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0059 | 0.0724 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.0724 | 0.5 | |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0197 | 0.3538 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0197 | 0.3538 | 0.5 |
Brugia malayi | diaphorase | 0.0059 | 0.0724 | 0.0724 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0516 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0516 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0197 | 0.3538 | 0.2791 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.1141 | 0.1141 |
Plasmodium vivax | hypothetical protein, conserved | 0.0197 | 0.3538 | 0.3033 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0197 | 0.3538 | 0.3033 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0197 | 0.3538 | 0.3538 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0516 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0516 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0457 | 0.881 | 0.8673 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0059 | 0.0724 | 0.0724 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0059 | 0.0724 | 0.0724 |
Schistosoma mansoni | cytochrome B5 | 0.0059 | 0.0724 | 0.0724 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0516 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0197 | 0.3538 | 0.3033 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0319 | 0.5997 | 0.5997 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0197 | 0.3538 | 0.2791 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.1141 | 0.1141 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0516 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0516 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0319 | 0.5997 | 0.5997 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0059 | 0.0724 | 0.0724 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0197 | 0.3538 | 0.5 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0059 | 0.0724 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0457 | 0.881 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0319 | 0.5997 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0087 | 0.1289 | 0.1289 |
Leishmania major | hypothetical protein, conserved | 0.0197 | 0.3538 | 0.3033 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0197 | 0.3538 | 0.3033 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0059 | 0.0724 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0516 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0256 | 0.4727 | 0.4727 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0197 | 0.3538 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0457 | 0.881 | 0.8717 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0087 | 0.1289 | 0.1289 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0319 | 0.5997 | 0.5997 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.026 | 0.4807 | 0.4807 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0516 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0059 | 0.0724 | 0.0724 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0197 | 0.3538 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0197 | 0.3538 | 0.3033 |
Giardia lamblia | Hypothetical protein | 0.0457 | 0.881 | 1 |
Treponema pallidum | flavodoxin | 0.0197 | 0.3538 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.