Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1578 | 0.4975 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1468 | 0.4626 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1578 | 0.4975 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2387 | 0.2387 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0401 | 0.1265 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1578 | 0.4975 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1468 | 0.1468 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1578 | 0.4975 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3173 | 0.3173 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0401 | 0.0401 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1578 | 0.1578 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2387 | 0.2387 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2387 | 0.2387 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1578 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0401 | 0.0401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.