Detailed information for compound 1351967

Basic information

Technical information
  • TDR Targets ID: 1351967
  • Name: 2-(3,5-dimethylphenoxy)-N-[4-[4-(furan-2-carb onyl)piperazin-1-yl]phenyl]acetamide
  • MW: 433.5 | Formula: C25H27N3O4
  • H donors: 1 H acceptors: 2 LogP: 3.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)N1CCN(CC1)C(=O)c1ccco1)COc1cc(C)cc(c1)C
  • InChi: 1S/C25H27N3O4/c1-18-14-19(2)16-22(15-18)32-17-24(29)26-20-5-7-21(8-6-20)27-9-11-28(12-10-27)25(30)23-4-3-13-31-23/h3-8,13-16H,9-12,17H2,1-2H3,(H,26,29)
  • InChiKey: XHHGRHOLSBDVGV-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(3,5-dimethylphenoxy)-N-[4-[4-(2-furyl-oxomethyl)-1-piperazinyl]phenyl]acetamide
  • 2-(3,5-dimethylphenoxy)-N-[4-(4-furan-2-ylcarbonylpiperazin-1-yl)phenyl]ethanamide
  • 2-(3,5-dimethylphenoxy)-N-{4-[4-(2-furoyl)-1-piperazinyl]phenyl}acetamide
  • MLS000582720
  • SMR000201423
  • STK180379

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0004 0.0004
Loa Loa (eye worm) notch protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0122 0.0843 0.4067
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.023 0.1108
Onchocerca volvulus 0.0031 0.0159 0.0884
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0025 0.0691
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0052 0.0077
Brugia malayi hypothetical protein 0.0051 0.0308 0.1485
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0159 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0339 0.0464
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Echinococcus multilocularis slit 2 protein 0.0017 0.0052 0.007
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0114 0.0151
Loa Loa (eye worm) hypothetical protein 0.0286 0.2072 1
Onchocerca volvulus 0.0025 0.0114 0.0626
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0024 0.0646
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0042 0.0199
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0187 0.0763
Schistosoma mansoni cpg binding protein 0.003 0.0146 0.0229
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0985 0.1368
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.023 0.1108
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0187 0.0253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0057
Echinococcus multilocularis heat shock protein 90 0.0026 0.0118 0.0161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0007
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0118 0.0558
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0108 0.0143
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0052 0.007
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.056
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0068 0.0103
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.023 0.1285
Onchocerca volvulus 0.003 0.0146 0.0807
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Schistosoma mansoni hypothetical protein 0.034 0.2482 0.4004
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Echinococcus granulosus heat shock protein 90 0.0032 0.0168 0.0269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0591 0.0774
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0121 0.0161
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1339 1 1
Onchocerca volvulus 0.0017 0.0052 0.0272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0025 0.0006
Brugia malayi nuclear receptor NHR-67 0.0019 0.0068 0.0328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0408
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0665 0.0921
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0068 0.0324
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.023 0.1108
Brugia malayi beta-lactamase 0.0035 0.0187 0.0904
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0068 0.0364
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0339 0.0542
Echinococcus multilocularis cpg binding protein 0.0031 0.0158 0.0216
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0052 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0069 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.0891
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.0891
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.023 0.0314
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0052 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0986 0.4487
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.023 0.0314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.023 0.0314
Echinococcus multilocularis GPCR, family 2 0.0016 0.0042 0.0057
Brugia malayi Animal haem peroxidase family protein 0.0053 0.032 0.1545
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0216 0.0897
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0108 0.0097
Echinococcus multilocularis protein jagged 1 0.0017 0.0052 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.023 0.1108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0187 0.0256
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0069 0.0331
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0118 0.044
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0027 0.0093
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0665 0.0921
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0024 0.0646
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0962 0.7159 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0069 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.023 0.1108
Echinococcus multilocularis heat shock protein 90 0.0032 0.0168 0.0229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0216 0.0294
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0024 0.0646
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0068 0.0328
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Loa Loa (eye worm) hypothetical protein 0.0042 0.0241 0.1158
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.023 0.1108
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0087
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0378 0.2764 0.2746
Onchocerca volvulus 0.0035 0.0187 0.1044
Onchocerca volvulus Peroxidase homolog 0.0053 0.032 0.18
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0068 0.0108
Brugia malayi Animal haem peroxidase family protein 0.0053 0.032 0.1545
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.2168 1
Schistosoma mansoni cell polarity protein 0.0017 0.0052 0.0077
Onchocerca volvulus 0.0035 0.0187 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0241 0.1146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0069 0.0044
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0187 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0069 0.0209
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0025 0.0691
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0665 0.0921
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0068 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Echinococcus granulosus protein jagged 1 0.0017 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Mycobacterium tuberculosis Conserved protein 0.0035 0.0187 0.0253
Loa Loa (eye worm) beta-lactamase 0.0035 0.0187 0.09
Schistosoma mansoni septate junction protein 0.0017 0.0052 0.0077
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0209 0.0238
Brugia malayi CXXC zinc finger family protein 0.003 0.0146 0.0703
Onchocerca volvulus 0.0244 0.1759 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0042 0.1259
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0209 0.0184
Schistosoma mansoni endoplasmin 0.0032 0.0168 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0251
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0068 0.0364
Leishmania major DNA polymerase kappa, putative 0.0019 0.0069 0.0209
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Echinococcus granulosus notch 0.0017 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0408
Trichomonas vaginalis MYB, putative 0.001 0.0001 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0087
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0118 0.0093
Loa Loa (eye worm) hypothetical protein 0.0052 0.0312 0.1503
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0069 0.0327
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0187 0.0904
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0665 0.0879
Plasmodium falciparum heat shock protein 90 0.0032 0.0168 0.5388
Toxoplasma gondii thioredoxin reductase 0.0039 0.0216 0.0778
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0239 0.1006
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0187 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0339 0.0542
Trypanosoma brucei trypanothione reductase 0.0039 0.0216 0.0897
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1008 0.4864
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2168 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0591 0.0817
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0069 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Schistosoma mansoni hypothetical protein 0.0287 0.2086 0.3364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.023 0.1104
Schistosoma mansoni hypothetical protein 0.0058 0.0362 0.0578
Brugia malayi conserved hypotetical protein 0.0019 0.0068 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.023 0.1104
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0085 0.0412
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0052 0.025
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Loa Loa (eye worm) hypothetical protein 0.005 0.0298 0.1434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0251 0.0343
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0052 0.0082
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0308 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Brugia malayi ecdysteroid receptor 0.0041 0.023 0.1108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0251 0.0403
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0025 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.023 0.1108
Echinococcus granulosus fibropellin Ia 0.0017 0.0052 0.0082
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0025 0.0006
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0069 0.0245
Plasmodium vivax glutathione reductase, putative 0.0039 0.0216 0.6983
Onchocerca volvulus 0.0017 0.0052 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0025 0.0021
Onchocerca volvulus 0.0053 0.032 0.18
Brugia malayi nuclear receptor RXR 0.0021 0.0085 0.0412
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0069 0.0324
Schistosoma mansoni nuclear receptor 0.0019 0.0068 0.0103
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0069 0.021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0068 0.0328
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0052 0.0082
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0168 0.0603
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2072 0.2841
Echinococcus granulosus protein jagged 2 0.0017 0.0052 0.0082
Schistosoma mansoni hypothetical protein 0.0041 0.0229 0.0364
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.022 0.0354
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0108 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.023 0.0364
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0168 0.0797
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0068 0.0324
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0052 0.025
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0378 0.2764 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Plasmodium vivax SET domain protein, putative 0.0031 0.0159 0.5112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0168 0.0671
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.1193
Brugia malayi isocitrate dehydrogenase 0.0016 0.0042 0.0204
Onchocerca volvulus Peroxidasin homolog 0.0053 0.032 0.18
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0057
Echinococcus granulosus neural cadherin 0.0017 0.0052 0.0082
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0121 0.0161
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0069 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.023 0.1285
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0004 0.0015
Giardia lamblia DINP protein human, muc B family 0.0019 0.0069 0.0323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Plasmodium vivax heat shock protein, putative 0.0013 0.0024 0.0646
Schistosoma mansoni zinc finger protein 0.0019 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.0153 0.1071 0.5167
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1759 0.8393
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Schistosoma mansoni cpg binding protein 0.0031 0.0158 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0308 0.1328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.023 0.1104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0251
Schistosoma mansoni cpg binding protein 0.0031 0.0158 0.0249
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2096 0.2076
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0168 0.0796
Echinococcus multilocularis notch 0.0017 0.0052 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Schistosoma mansoni heat shock protein 0.0032 0.0168 0.0264
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0069 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.023 0.0369
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0985 0.1328
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0025 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0052 0.007
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0339 0.0542
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0663 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.023 0.0314
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0339 0.0464
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0069 0.0209
Brugia malayi Hsp90 protein 0.0013 0.0024 0.0114
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0068 0.0103
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0025 0.0117
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0052 0.007
Schistosoma mansoni nuclear hormone receptor 0.0041 0.023 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Mycobacterium tuberculosis Conserved protein 0.0035 0.0187 0.0253
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0068 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.023 0.0314
Schistosoma mansoni slit 0.0017 0.0052 0.0077
Onchocerca volvulus Slit protein homolog 0.0017 0.0052 0.0272
Onchocerca volvulus 0.0019 0.0068 0.0364
Trichomonas vaginalis heat shock protein, putative 0.002 0.0073 0.0347
Brugia malayi nuclear hormone receptor 0.0041 0.023 0.1108
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0069 0.0044
Mycobacterium leprae Probable lipase LipE 0.0035 0.0187 0.0208
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0209 0.0284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0339 0.1634
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0108 0.0084
Brugia malayi nuclear receptor NHR-88 0.0041 0.023 0.1108
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6193 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0052 0.025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1608 0.2239
Brugia malayi hypothetical protein 0.0019 0.0068 0.0328
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0017 0.0079
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0052 0.0272
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0069 0.0209
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.023 0.1104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0408
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0591 0.0817
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0068 0.0092
Echinococcus granulosus cpg binding protein 0.0031 0.0158 0.0254
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.023 0.0369
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0042 0.0051
Onchocerca volvulus Putative cubilin 0.0017 0.0052 0.0272
Echinococcus multilocularis expressed conserved protein 0.0092 0.0618 0.0846
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0034
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0241 0.0329
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Onchocerca volvulus Peroxidasin homolog 0.0053 0.032 0.18
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0168 0.0797
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0024 0.0082
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0042 0.0203
Brugia malayi Thioredoxin reductase 0.0039 0.0216 0.1043
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1339 1 1
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Plasmodium falciparum glutathione reductase 0.0013 0.0025 0.0691
Giardia lamblia Grp94/Hsp90 0.0026 0.0118 0.0558
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0068 0.0092
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0308 0.111
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0024 0.0037
Schistosoma mansoni DNA polymerase eta 0.0019 0.0069 0.0104
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0663 0.1069
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.015
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.0671
Mycobacterium ulcerans hypothetical protein 0.0035 0.0187 0.0163
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0024 0.0082
Brugia malayi heat shock protein 90 0.0032 0.0168 0.0809
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0591 0.0817
Giardia lamblia High cysteine protein 0.0017 0.0052 0.0243
Trichomonas vaginalis endoplasmin, putative 0.002 0.0073 0.0347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0159 0.0217
Loa Loa (eye worm) hypothetical protein 0.0051 0.0308 0.1481
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0042 0.0087
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0025 0.0117
Brugia malayi nuclear receptor NHR-88 0.0019 0.0068 0.0328
Brugia malayi hypothetical protein 0.0021 0.0085 0.0412
Loa Loa (eye worm) hypothetical protein 0.0043 0.0247 0.1187
Schistosoma mansoni peroxidasin 0.0053 0.032 0.0511
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0069 0.0093
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Schistosoma mansoni thyroid hormone receptor 0.0041 0.023 0.0364
Brugia malayi CHE-14 protein 0.0042 0.0241 0.1162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.023 0.0364
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) endoplasmin 0.0032 0.0168 0.0805
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0962 0.7159 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0108 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Brugia malayi Animal haem peroxidase family protein 0.0053 0.032 0.1545
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.0671
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0339 0.0546
Brugia malayi MH2 domain containing protein 0.0144 0.1008 0.4866
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0068 0.0108
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.023 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.023 0.1108
Onchocerca volvulus 0.0047 0.0278 0.1561
Brugia malayi hypothetical protein 0.0021 0.0085 0.0412
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0025 0.0087
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0291 0.1403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0052 0.0184
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.023 0.0369
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0986 0.4487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.023 0.1108
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.023 0.0369
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.023 0.0364
Echinococcus multilocularis endoplasmin 0.0026 0.0118 0.0161
Onchocerca volvulus 0.0053 0.032 0.18
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0187 0.0253
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.023 0.1108
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0042 0.0203
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.023 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0403 0.0645
Mycobacterium ulcerans beta-lactamase 0.0035 0.0187 0.0163
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0039
Echinococcus multilocularis protein jagged 1 0.0017 0.0052 0.007
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.032 0.1541
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0125 0.0597
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0068 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0118 0.011
Echinococcus multilocularis protein jagged 2 0.0017 0.0052 0.007
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.007 0.0089
Mycobacterium tuberculosis Probable reductase 0.0089 0.0591 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0004 0.0016
Mycobacterium ulcerans hypothetical protein 0.0157 0.1106 0.1084
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0033
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0068 0.0205
Leishmania major hypothetical protein, conserved 0.0035 0.0187 0.0763
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0146 0.0699
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0241 0.0387
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0042 0.0087
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.032 0.1541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0052 0.025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0042 0.0087
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0362 0.1747
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0985 0.0962
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0353 0.1273
Trypanosoma brucei unspecified product 0.0019 0.0069 0.021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0296
Mycobacterium ulcerans lipase LipD 0.0035 0.0187 0.0163
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2072 0.3345
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Schistosoma mansoni peroxidasin 0.0053 0.032 0.0511
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0108 0.0084
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1339 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0085 0.0408
Mycobacterium ulcerans polyketide synthase 0.0026 0.0121 0.0096
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0108 0.0143
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0187 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.023 0.1104
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0216 0.1039
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0114 0.0546
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0052 0.0082
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0042 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0067
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.023 0.0369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0057
Echinococcus multilocularis protein patched 0.0042 0.0241 0.0329
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0168 0.0672
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0039 0.0014
Echinococcus multilocularis neural cadherin 0.0017 0.0052 0.007
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0093 0.0068
Brugia malayi hypothetical protein 0.0033 0.0172 0.0828
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0052 0.007
Loa Loa (eye worm) glutathione reductase 0.0039 0.0216 0.1039
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0096 0.013
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0068 0.0108
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0168 0.0671
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0216 0.6983
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Plasmodium falciparum glutathione reductase 0.0039 0.0216 0.6983
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0904
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0241 0.1158
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0025 0.0691
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0042 0.0057
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0121 0.0115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0085 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0298 0.1437
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Brugia malayi Muscle positioning protein 4 0.0017 0.0052 0.025
Brugia malayi Delta serrate ligand family protein 0.0017 0.0052 0.025
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0025 0.0691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.023 0.0369
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0986 0.4487
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0057
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0052 0.0272
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.023 0.1108
Loa Loa (eye worm) DR-78 0.0019 0.0068 0.0324
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1106 0.1538
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0004 0.0011
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Trichomonas vaginalis esterase, putative 0.0035 0.0187 0.0891
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0068 0.0108
Schistosoma mansoni hypothetical protein 0.0043 0.0251 0.0398
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0052 0.025
Onchocerca volvulus 0.0035 0.0187 0.1044
Brugia malayi notch-like transmembrane receptor 0.0017 0.0052 0.025
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0042 0.0204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0408
Echinococcus granulosus geminin 0.034 0.2482 0.4007
Onchocerca volvulus 0.0058 0.0362 0.2039
Leishmania major DNA polymerase eta, putative 0.0019 0.0069 0.0209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2096 1
Onchocerca volvulus 0.0017 0.0052 0.0272
Loa Loa (eye worm) hypothetical protein 0.0122 0.0843 0.4067
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0251 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0187 0.6036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0159 0.0251
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0069 0.0324
Plasmodium falciparum endoplasmin, putative 0.002 0.0073 0.2282
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0159 0.0251
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0108 0.0084
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.1193
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6193 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0042 0.0057
Brugia malayi Animal haem peroxidase family protein 0.0053 0.032 0.1545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.023 0.1104
Brugia malayi glutathione reductase 0.0039 0.0216 0.1043
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0118 0.0093
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0024 0.011
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0004 0.0011
Brugia malayi Peroxidasin 0.0053 0.032 0.1545
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0239 0.1006
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0004 0.002
Schistosoma mansoni survival motor neuron protein 0.0058 0.0362 0.0578
Onchocerca volvulus Dual oxidase homolog 0.0053 0.032 0.18
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0093 0.0122
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.056
Brugia malayi Endoplasmin precursor 0.0032 0.0168 0.0809
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.0763
Treponema pallidum heat shock protein 90 0.0026 0.0118 0.0093
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0024 0.0031
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2096 1
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Schistosoma mansoni hypothetical protein 0.0034 0.0179 0.0283
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2096 1
Brugia malayi hypothetical protein 0.0019 0.0068 0.0328
Brugia malayi steroid hormone receptor 0.0041 0.023 0.1108
Brugia malayi hypothetical protein 0.0153 0.1071 0.5169
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Echinococcus granulosus dna polymerase eta 0.0019 0.0069 0.0109
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0187 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.023 0.1108
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0085 0.0131
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Echinococcus granulosus dna polymerase kappa 0.0019 0.0069 0.0109
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0674 0.1083
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0068 0.0108
Brugia malayi Cadherin domain containing protein 0.0017 0.0052 0.025
Schistosoma mansoni patched 1 0.0042 0.0241 0.0383
Schistosoma mansoni heat shock protein 0.0013 0.0024 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0085 0.0408
Schistosoma mansoni hypothetical protein 0.0023 0.0096 0.0148
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Brugia malayi nuclear hormone receptor 0.0019 0.0068 0.0328
Mycobacterium ulcerans thioesterase 0.0023 0.0093 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Echinococcus granulosus slit 2 protein 0.0017 0.0052 0.0082
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0042 0.1259
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.032 0.1541
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Schistosoma mansoni endoplasmin 0.0032 0.0168 0.0264
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0199
Echinococcus granulosus protein jagged 1 0.0017 0.0052 0.0082
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0179 0.0866
Loa Loa (eye worm) Notch2 0.0017 0.0052 0.0246
Echinococcus multilocularis X box binding protein 1 0.0287 0.2086 0.286
Echinococcus multilocularis fibropellin Ia 0.0017 0.0052 0.007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.022 0.0301
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.023 0.0314
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0308 0.1324
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0187 0.0253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0004 0.0004
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0004 0.002
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Brugia malayi EGF-like domain containing protein 0.0017 0.0052 0.025
Echinococcus multilocularis dna polymerase eta 0.0019 0.0069 0.0093
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0024 0.011
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.023 0.0364
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0168 0.0603
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0108 0.0084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0765
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0187 0.0891
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0004 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0069 0.0087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0327
Echinococcus granulosus peroxidasin 0.0053 0.032 0.0515
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0239 0.1006
Echinococcus granulosus heat shock protein 0.0032 0.0168 0.0269
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0121 0.0434
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0085 0.0136
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0069 0.0324
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0024 0.011
Toxoplasma gondii ABC1 family protein 0.0035 0.0187 0.0674
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1537 0.7417
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.023 0.0369
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0068 0.0108
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0039 0.0014
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0168 0.0805
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0121 0.0096
Onchocerca volvulus 0.0017 0.0052 0.0272
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0093 0.0076
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0039 0.0047
Plasmodium falciparum thioredoxin reductase 0.0013 0.0025 0.0691
Echinococcus granulosus GPCR family 2 0.0016 0.0042 0.0067
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0121 0.0115
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0239 0.1006
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0068 0.0328
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0121 0.0115
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0056 0.0198
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0042 0.0067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.023 0.0364
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.0891
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0042 0.0062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0159 0.0573
Schistosoma mansoni heat shock protein 0.0032 0.0168 0.0264
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.023 0.0364
Echinococcus granulosus delta-like protein 1 0.0017 0.0052 0.0082
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0663 0.3159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0168 0.0672
Mycobacterium ulcerans polyketide synthase 0.0025 0.0108 0.0084
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0121 0.0161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0339 0.0546
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0168 0.0671
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0068 0.0324
Plasmodium falciparum thioredoxin reductase 0.0039 0.0216 0.6983
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Brugia malayi hypothetical protein 0.0043 0.0251 0.1209
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0862
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0187 0.0163
Loa Loa (eye worm) hypothetical protein 0.0098 0.0663 0.3195
Onchocerca volvulus 0.0017 0.0052 0.0272
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0068 0.0328
Schistosoma mansoni hypothetical protein 0.0041 0.0229 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0069 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6193 0.8494
Brugia malayi Blistered cuticle protein 3 0.0053 0.032 0.1545
Echinococcus granulosus FTZ F1 alpha 0.0041 0.023 0.0369
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0168 0.0672
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0024 0.0112
Echinococcus multilocularis heat shock protein 0.0032 0.0168 0.0229
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0308 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0187 0.0253
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0308 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0069 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0067
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0069 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0069 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0339 0.1637
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.023 0.1104
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0187 0.0163
Echinococcus granulosus X box binding protein 1 0.0287 0.2086 0.3367
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0308 0.1324
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0069 0.0093
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0308 0.1324
Brugia malayi beta-lactamase family protein 0.0035 0.0187 0.0904
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0187 0.0253
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0663 0.3198
Brugia malayi hypothetical protein 0.0053 0.032 0.1545
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.023 0.0364
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0241 0.0387
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0025 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0053 0.032 0.1545
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.023 0.1285
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0187 0.09
Onchocerca volvulus 0.0019 0.0068 0.0364
Loa Loa (eye worm) hypothetical protein 0.0053 0.032 0.1541
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0187 0.0296
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0591 0.0817
Schistosoma mansoni thyroid hormone receptor 0.0041 0.023 0.0364
Schistosoma mansoni hypothetical protein 0.0041 0.0229 0.0364
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.023 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.023 0.1108
Brugia malayi tailless protein 0.0019 0.0068 0.0328
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0025 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0069 0.021
Plasmodium vivax endoplasmin, putative 0.0032 0.0168 0.5388
Loa Loa (eye worm) brahma associated protein 0.0011 0.0004 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0096 0.0154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0069 0.0209
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0146 0.0234
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Onchocerca volvulus 0.0153 0.1071 0.6079
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0298 0.1434
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0118 0.0156
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0291 0.1633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0108 0.0523
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0378 0.2764 0.2761
Echinococcus granulosus endoplasmin 0.0026 0.0118 0.0189
Brugia malayi hypothetical protein 0.0122 0.0843 0.4069
Brugia malayi Pre-SET motif family protein 0.0031 0.0159 0.0769
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0068 0.0328
Leishmania major hypothetical protein, conserved 0.0051 0.0308 0.1324
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0168 0.0797
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.098 0.1581
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0118 0.044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0025 0.0087
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0121 0.0096
Onchocerca volvulus Huntingtin homolog 0.0122 0.0843 0.478
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0118 0.0189
Echinococcus multilocularis protein dispatched 1 0.0048 0.0286 0.0391
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.032 0.1541
Leishmania major trypanothione reductase 0.0039 0.0216 0.0897
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0069 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.023 0.1104
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.729 1
Schistosoma mansoni hypothetical protein 0.0041 0.0229 0.0364
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.023 0.0364
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.032 0.18
Loa Loa (eye worm) hypothetical protein 0.0035 0.0187 0.09
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0042 0.02
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0069 0.0041
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Echinococcus granulosus expressed conserved protein 0.0092 0.0618 0.0996
Brugia malayi hypothetical protein 0.0286 0.2072 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1008 0.4864
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.023 0.1108
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0209 0.0284
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0187 0.0891
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0025 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0085 0.0131
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.032 0.1541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Leishmania major heat shock protein 83-1 0.0032 0.0168 0.0671
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0004 0.0005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0121 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0114 0.055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2096 1
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0168 0.5388
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0052 0.007
Trypanosoma brucei heat shock protein, putative 0.0032 0.0168 0.0672
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0068 0.0328
Brugia malayi Pre-SET motif family protein 0.0214 0.1537 0.7419
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0068 0.0092
Echinococcus multilocularis peroxidasin 0.0053 0.032 0.0438
Schistosoma mansoni coup transcription factor 0.0041 0.023 0.0364
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0061
Onchocerca volvulus Peroxidase homolog 0.0053 0.032 0.18
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0378 0.2764 0.3827
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0187 0.0763
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0068 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0246
Schistosoma mansoni notch 0.0017 0.0052 0.0077
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0159 0.0256
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0118 0.044
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0052 0.0077
Brugia malayi nuclear receptor RXR 0.0019 0.0068 0.0328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0068 0.0092
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0298 0.1437
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.023 0.0369
Brugia malayi Cadherin domain containing protein 0.0017 0.0052 0.025
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0121 0.0161
Onchocerca volvulus Huntingtin homolog 0.0122 0.0843 0.478
Brugia malayi ecdysone receptor 0.0019 0.0068 0.0328
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0069 0.0087
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.1104
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0025 0.0115
Echinococcus granulosus protein jagged 2 0.0017 0.0052 0.0082
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0085 0.0412
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.2168 1
Schistosoma mansoni nuclear receptor 0.0019 0.0068 0.0103
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.1193
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.023 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0069 0.021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0591 0.0817
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.1193
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.2168 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0071 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0324
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0025 0.0006
Echinococcus multilocularis geminin 0.034 0.2482 0.3404
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.023 0.0314
Onchocerca volvulus 0.0041 0.023 0.1285
Echinococcus granulosus heat shock protein 90 0.0026 0.0118 0.0189
Mycobacterium tuberculosis Conserved protein 0.0035 0.0187 0.0253
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.098 0.1343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.023 0.0364
Toxoplasma gondii hypothetical protein 0.0048 0.0286 0.1031
Schistosoma mansoni hypothetical protein 0.034 0.2482 0.4004
Onchocerca volvulus 0.0053 0.032 0.18

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 1.9953 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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