Detailed information for compound 1352231

Basic information

Technical information
  • TDR Targets ID: 1352231
  • Name: 2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamin o)-N-(phenylmethyl)propanamide; oxalic acid
  • MW: 416.424 | Formula: C21H24N2O7
  • H donors: 4 H acceptors: 5 LogP: -0.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(NCC1COc2c(O1)cccc2)C)NCc1ccccc1.OC(=O)C(=O)O
  • InChi: 1S/C19H22N2O3.C2H2O4/c1-14(19(22)21-11-15-7-3-2-4-8-15)20-12-16-13-23-17-9-5-6-10-18(17)24-16;3-1(4)2(5)6/h2-10,14,16,20H,11-13H2,1H3,(H,21,22);(H,3,4)(H,5,6)
  • InChiKey: DKYSDKCEMUESIX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(benzyl)-2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)propionamide; oxalic acid
  • 2-(2,3-dihydro-1,4-benzodioxin-2-ylmethylamino)-N-(phenylmethyl)propanamide; ethanedioic acid
  • SMR000353993
  • T0520-0245
  • MLS001017798

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0473 0.0449
Schistosoma mansoni phosphatidylserine receptor 0.003 0.051 0.051
Echinococcus granulosus chromobox protein 1 0.0084 0.2006 0.2006
Loa Loa (eye worm) hypothetical protein 0.01 0.2458 0.2458
Brugia malayi Protein cec-1. 0.0014 0.005 0.0066
Plasmodium falciparum importin beta, putative 0.0035 0.0635 0.9834
Echinococcus granulosus importin subunit beta 1 0.0035 0.0635 0.0635
Entamoeba histolytica hypothetical protein 0.0028 0.0452 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0978 0.0984
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.051 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.446 1
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.051 0.051
Plasmodium vivax importin-beta 2, putative 0.0035 0.0635 0.982
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.4847 0.4847
Loa Loa (eye worm) hypothetical protein 0.003 0.051 0.051
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1078 0.109
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0596 0.0579
Echinococcus granulosus chromobox protein 1 0.0084 0.2006 0.2006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.005 0.005
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0452 0.7002
Echinococcus multilocularis chromobox protein 1 0.0084 0.2006 0.2006
Echinococcus granulosus jumonji domain containing 1A 0.003 0.051 0.051
Echinococcus multilocularis Chromo domain 0.0014 0.005 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0452 0.8604
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.005 0.005
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.9478 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.038 0.5531
Brugia malayi PHD-finger family protein 0.0035 0.0646 0.0849
Giardia lamblia PHD finger protein 15 0.0035 0.0646 0.0682
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.038 0.6844
Entamoeba histolytica hypothetical protein 0.0028 0.0452 0.0426
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Plasmodium falciparum heterochromatin protein 1 0.0014 0.005 0.0776
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Loa Loa (eye worm) hypothetical protein 0.0037 0.0695 0.0695
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2826 0.2826
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.051 1
Schistosoma mansoni hypothetical protein 0.0205 0.5355 0.5355
Schistosoma mansoni jumonji/arid domain-containing protein 0.0114 0.2826 0.2826
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0212 0.272
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0635 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0452 0.6595
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.005 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.2826 0.2826
Schistosoma mansoni ran 0.0026 0.038 0.038
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.051 0.789
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0596 0.0579
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1029 0.1029
Schistosoma mansoni survival motor neuron protein 0.0058 0.1286 0.1286
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0452 0.8606
Brugia malayi Heterochromatin protein 1 0.0084 0.2006 0.2638
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2006 0.2075
Brugia malayi chromobox protein homolog 3 0.0047 0.0978 0.1286
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.038 0.0499
Echinococcus granulosus chromobox protein 2 0.0014 0.005 0.005
Echinococcus multilocularis phd:f box containing protein 0.003 0.051 0.051
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7605 0.7605
Echinococcus granulosus peregrin 0.0035 0.0646 0.0646
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.005 0.0066
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2006 0.2006
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0473 0.0473
Onchocerca volvulus Alhambra homolog 0.0035 0.0646 0.2474
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0304 0.0304
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.005 0.005
Leishmania major importin beta-1 subunit, putative 0.0028 0.0452 0.8604
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.038 0.038
Brugia malayi jmjC domain containing protein 0.0114 0.2826 0.3716
Brugia malayi jmjC domain containing protein 0.003 0.051 0.067
Brugia malayi hypothetical protein 0.0286 0.7605 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.446 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.051 0.051
Onchocerca volvulus 0.0037 0.0695 0.2678
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.038 0.038
Schistosoma mansoni jumonji domain containing protein 0.0163 0.4188 0.4188
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0635 0.9834
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.2458 0.2458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Schistosoma mansoni jumonji domain containing protein 0.003 0.051 0.051
Schistosoma mansoni chromobox protein 0.0084 0.2006 0.2006
Brugia malayi jmjC domain containing protein 0.0186 0.4847 0.6373
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.051 0.051
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1029 0.1029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Brugia malayi hypothetical protein 0.0014 0.005 0.0066
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.005 0.0066
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.005 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0452 0.0426
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0646 0.0646
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.038 0.0401
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.2458 0.2458
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.051 0.051
Brugia malayi Importin beta-1 subunit 0.0035 0.0635 0.0835
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0452 0.5
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.051 0.051
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.051 0.7663
Brugia malayi RNA, U transporter 1 0.0099 0.242 0.3182
Onchocerca volvulus 0.01 0.2458 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.051 0.789
Trichomonas vaginalis ran, putative 0.0026 0.038 0.035
Brugia malayi SET domain containing protein 0.0014 0.005 0.0066
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.005 0.0776
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0014 0.005 0.005
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0635 1
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0098 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0375 0.581
Schistosoma mansoni phd/f-box containing protein 0.003 0.051 0.051
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0635 0.0635
Loa Loa (eye worm) helicase 0.0014 0.005 0.005
Echinococcus multilocularis chromobox protein 1 0.0084 0.2006 0.2006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9478 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.005 0.0776
Brugia malayi jmjC domain containing protein 0.003 0.051 0.067
Schistosoma mansoni chromobox protein 0.0084 0.2006 0.2006
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.051 0.789
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.005 0.005
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.038 0.5245
Schistosoma mansoni hypothetical protein 0.0035 0.0646 0.0646
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.038 0.5878
Loa Loa (eye worm) RecQ helicase 0.0029 0.0473 0.0473
Schistosoma mansoni hypothetical protein 0.0058 0.1286 0.1286
Loa Loa (eye worm) jmjC domain-containing protein 0.0114 0.2826 0.2826
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Leishmania major GTP-binding protein, putative 0.0026 0.038 0.6844
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.3723 0.3723
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.005 0.0776
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Echinococcus granulosus bloom syndrome protein 0.0029 0.0473 0.0473
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0452 0.0426
Loa Loa (eye worm) hypothetical protein 0.0286 0.7605 0.7605
Entamoeba histolytica hypothetical protein 0.0014 0.005 0.00000000014548
Schistosoma mansoni ran 0.0026 0.038 0.038
Plasmodium falciparum phd finger protein, putative 0.0035 0.0646 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1286 0.1692
Echinococcus granulosus Chromobox protein 3 0.0014 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.051 0.051
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0646 0.0646
Brugia malayi Bromodomain containing protein 0.0035 0.0646 0.0849
Brugia malayi jmjC domain containing protein 0.003 0.051 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0978 0.0984
Echinococcus granulosus phd:f box containing protein 0.003 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0635 0.0635
Echinococcus granulosus lysine specific demethylase 5A 0.0114 0.2826 0.2826
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.038 0.6844
Echinococcus multilocularis Chromobox protein 3 0.0014 0.005 0.005
Leishmania major hypothetical protein, conserved 0.003 0.051 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2006 0.2075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0978 0.0978
Brugia malayi CHD4 protein 0.0014 0.005 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7605 0.7605
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0978 0.3854
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.005 0.0776
Plasmodium vivax hypothetical protein, conserved 0.0014 0.005 0.0000000023019
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0452 0.7002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1688 0.1688
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.038 0.038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.005 0.0776
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0452 0.7002
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.2458 0.3232
Loa Loa (eye worm) hypothetical protein 0.003 0.051 0.051
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.9478 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.4847 0.4847
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.446 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.005 0.00000000014548
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0646 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0372 1 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1078 0.109
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0452 0.5
Echinococcus multilocularis peregrin 0.0035 0.0646 0.0646
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0098 0.0051
Echinococcus multilocularis geminin 0.0205 0.5355 0.5355
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0473 0.0449
Schistosoma mansoni hypothetical protein 0.0205 0.5355 0.5355
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.051 0.051
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0452 0.6749
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.005 0.005
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.005 0.0066
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.005 0.005
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0646 0.0646
Entamoeba histolytica Ran family GTPase 0.0026 0.038 0.035
Schistosoma mansoni importin beta-1 0.0035 0.0635 0.0635
Schistosoma mansoni chromobox protein 0.0014 0.005 0.005
Brugia malayi jmjC domain containing protein 0.003 0.051 0.067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0206 0.3185
Schistosoma mansoni chromobox protein 0.0014 0.005 0.005
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.051 0.051
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0473 0.0622
Loa Loa (eye worm) hypothetical protein 0.0079 0.1872 0.1872
Schistosoma mansoni protein phosphatase 2C 0.003 0.051 0.051
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0646 0.0646
Brugia malayi Valyl-tRNA synthetase 0.0014 0.005 0.0066
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.2458 0.2458
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0646 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9478 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9478 1
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.005
Echinococcus granulosus Chromo domain 0.0014 0.005 0.005
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0646 0.0646
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1078 0.4268
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.038 0.5878
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.005 0.00000000014548
Plasmodium vivax JmjC domain containing protein 0.003 0.051 0.7713
Echinococcus multilocularis chromobox protein 2 0.0014 0.005 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0452 0.0426
Onchocerca volvulus 0.0058 0.1286 0.5134
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.051 0.051
Echinococcus granulosus geminin 0.0205 0.5355 0.5355

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0029 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 9.9763 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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